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Protein

Exosome complex exonuclease RRP46 homolog

Gene

RRP46

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'-untranslated regions.By similarity

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease, Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-ATH-429958. mRNA decay by 3' to 5' exoribonuclease.
R-ATH-450604. KSRP (KHSRP) binds and destabilizes mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex exonuclease RRP46 homologCurated (EC:3.1.13.-Curated)
Alternative name(s):
Exosome component 5Curated
Ribosomal RNA-processing protein 46Curated
Gene namesi
Name:RRP46Curated
Ordered Locus Names:At3g46210Imported
ORF Names:F12M12.180Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G46210.

Subcellular locationi

  • Nucleusnucleolus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Exosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Exosome complex exonuclease RRP46 homologPRO_0000435320Add
BLAST

Proteomic databases

PaxDbiQ9LX74.

PTM databases

iPTMnetiQ9LX74.

Interactioni

Subunit structurei

Probable component of the RNA exosome complex.By similarity

Protein-protein interaction databases

IntActiQ9LX74. 2 interactions.
STRINGi3702.AT3G46210.1.

Structurei

3D structure databases

SMRiQ9LX74. Positions 5-233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family.Curated

Phylogenomic databases

eggNOGiKOG1069. Eukaryota.
COG0689. LUCA.
HOGENOMiHOG000229515.
KOiK12590.
OMAiICCCLTE.

Family and domain databases

Gene3Di3.30.230.70. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9LX74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIDREDGRT PNQLRPLACS RNILHRPHGS ASWSQGDTKV LAAVYGPKAG
60 70 80 90 100
TKKNENAEKA CFEVIWKPKS GQIGKVEKEY EMILKRTIQS ICVLTVNPNT
110 120 130 140 150
TTSVIIQVVH DDGSLLPCAI NAACAALVDA GIPMKHLAVA ICCCLAENGY
160 170 180 190 200
LVLDPNKLEE KKMTAFAYLV FPNTTLSVLP EGSSVAEGEP VEHGIITSIT
210 220 230
HGVMSVDDYF LCVENGRAAT ASLSAFFRKN FQQSSSKAG
Length:239
Mass (Da):25,810
Last modified:October 1, 2000 - v1
Checksum:i8E22AE4B0899FECE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355775 Genomic DNA. Translation: CAB90948.1.
CP002686 Genomic DNA. Translation: AEE78129.1.
CP002686 Genomic DNA. Translation: AEE78130.1.
CP002686 Genomic DNA. Translation: AEE78131.1.
CP002686 Genomic DNA. Translation: AEE78132.1.
CP002686 Genomic DNA. Translation: AEE78133.1.
CP002686 Genomic DNA. Translation: AEE78134.1.
BT003125 mRNA. Translation: AAO24557.1.
AK317261 mRNA. Translation: BAH19939.1.
AK317537 mRNA. Translation: BAH20201.1.
AK228171 mRNA. Translation: BAF00127.1.
PIRiT49262.
RefSeqiNP_001030817.1. NM_001035740.2.
NP_001030818.1. NM_001035741.2.
NP_001030819.1. NM_001035742.2.
NP_001078250.1. NM_001084781.1.
NP_001190019.1. NM_001203090.1.
NP_190207.1. NM_114490.3.
UniGeneiAt.43331.

Genome annotation databases

EnsemblPlantsiAT3G46210.1; AT3G46210.1; AT3G46210.
AT3G46210.2; AT3G46210.2; AT3G46210.
AT3G46210.3; AT3G46210.3; AT3G46210.
AT3G46210.4; AT3G46210.4; AT3G46210.
AT3G46210.5; AT3G46210.5; AT3G46210.
AT3G46210.6; AT3G46210.6; AT3G46210.
GeneIDi823766.
KEGGiath:AT3G46210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355775 Genomic DNA. Translation: CAB90948.1.
CP002686 Genomic DNA. Translation: AEE78129.1.
CP002686 Genomic DNA. Translation: AEE78130.1.
CP002686 Genomic DNA. Translation: AEE78131.1.
CP002686 Genomic DNA. Translation: AEE78132.1.
CP002686 Genomic DNA. Translation: AEE78133.1.
CP002686 Genomic DNA. Translation: AEE78134.1.
BT003125 mRNA. Translation: AAO24557.1.
AK317261 mRNA. Translation: BAH19939.1.
AK317537 mRNA. Translation: BAH20201.1.
AK228171 mRNA. Translation: BAF00127.1.
PIRiT49262.
RefSeqiNP_001030817.1. NM_001035740.2.
NP_001030818.1. NM_001035741.2.
NP_001030819.1. NM_001035742.2.
NP_001078250.1. NM_001084781.1.
NP_001190019.1. NM_001203090.1.
NP_190207.1. NM_114490.3.
UniGeneiAt.43331.

3D structure databases

SMRiQ9LX74. Positions 5-233.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9LX74. 2 interactions.
STRINGi3702.AT3G46210.1.

PTM databases

iPTMnetiQ9LX74.

Proteomic databases

PaxDbiQ9LX74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G46210.1; AT3G46210.1; AT3G46210.
AT3G46210.2; AT3G46210.2; AT3G46210.
AT3G46210.3; AT3G46210.3; AT3G46210.
AT3G46210.4; AT3G46210.4; AT3G46210.
AT3G46210.5; AT3G46210.5; AT3G46210.
AT3G46210.6; AT3G46210.6; AT3G46210.
GeneIDi823766.
KEGGiath:AT3G46210.

Organism-specific databases

TAIRiAT3G46210.

Phylogenomic databases

eggNOGiKOG1069. Eukaryota.
COG0689. LUCA.
HOGENOMiHOG000229515.
KOiK12590.
OMAiICCCLTE.

Enzyme and pathway databases

ReactomeiR-ATH-429958. mRNA decay by 3' to 5' exoribonuclease.
R-ATH-450604. KSRP (KHSRP) binds and destabilizes mRNA.

Miscellaneous databases

PROiQ9LX74.

Family and domain databases

Gene3Di3.30.230.70. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
    Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
    DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiEXOS5_ARATH
AccessioniPrimary (citable) accession number: Q9LX74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2016
Last sequence update: October 1, 2000
Last modified: January 20, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.