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Protein

Receptor-like protein kinase HERK 1

Gene

HERK1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor-like protein kinase required for cell elongation during vegetative growth, mostly in a brassinosteroid-(BR-) independent manner.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei513ATPCurated1
Active sitei609Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi491 – 499ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: TAIR
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  • response to brassinosteroid Source: TAIR
  • unidimensional cell growth Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-like protein kinase HERK 1 (EC:2.7.11.-)
Alternative name(s):
Protein HERCULES RECEPTOR KINASE 1
Gene namesi
Name:HERK1
Ordered Locus Names:At3g46290
ORF Names:F12M12.260, F18L15.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G46290.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 405ExtracellularSequence analysisAdd BLAST381
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 830CytoplasmicSequence analysisAdd BLAST404

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype; due to redundancy with THE1. Herk1 and the1 double mutants are stunted. In herk1-1, shorter hypocotyls without brassinolide (BL) treatment than with BL treatment.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi513K → R: Loss of kinase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000031202925 – 830Receptor-like protein kinase HERK 1Add BLAST806

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Glycosylationi217N-linked (GlcNAc...)Sequence analysis1
Glycosylationi280N-linked (GlcNAc...)Sequence analysis1
Glycosylationi381N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9LX66.
PRIDEiQ9LX66.

PTM databases

iPTMnetiQ9LX66.

Expressioni

Tissue specificityi

Expressed in most vegetative tissues, including leaves, stems and roots, especially in cell elongation regions.1 Publication

Inductioni

By brassinosteroids (BR).1 Publication

Gene expression databases

GenevisibleiQ9LX66. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G46290.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LX66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini485 – 758Protein kinasePROSITE-ProRule annotationAdd BLAST274

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi396 – 402Poly-Ser7

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000238317.
InParanoidiQ9LX66.
OMAiCICHGFT.
OrthoDBiEOG093602FA.
PhylomeDBiQ9LX66.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR024788. Malectin-like_Carb-bd_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12819. Malectin_like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LX66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIEKFETFI LISTISILLC ICHGFTPVDN YLINCGSPTN GTLMGRIFLS
60 70 80 90 100
DKLSSKLLTS SKEILASVGG NSGSDIYHTA RVFTEVSSYK FSVTRGRHWV
110 120 130 140 150
RLYFNPFDYQ NFKMGSAKFA VSSQSHVLLS DFTVTSSKVV KEYSLNVTTN
160 170 180 190 200
DLVLTFTPSS GSFAFVNAIE VISIPDTLIT GSPRFVGNPA QFPDMSMQGL
210 220 230 240 250
ETIHRVNMGG PLVASNNDTL TRTWVPDSEF LLEKNLAKSM SKFSTVNFVP
260 270 280 290 300
GYATEDSAPR TVYGSCTEMN SADNPNSIFN VTWEFDVDPG FQYYFRFHFC
310 320 330 340 350
DIVSLSLNQL YFNLYVDSMV AATDIDLSTL VDNTLAGAYS MDFVTQTPKG
360 370 380 390 400
SNKVRVSIGP STVHTDYPNA IVNGLEIMKM NNSKGQLSTG TFVPGSSSSS
410 420 430 440 450
KSNLGLIVGS AIGSLLAVVF LGSCFVLYKK RKRGQDGHSK TWMPFSINGT
460 470 480 490 500
SMGSKYSNGT TLTSITTNAN YRIPFAAVKD ATNNFDESRN IGVGGFGKVY
510 520 530 540 550
KGELNDGTKV AVKRGNPKSQ QGLAEFRTEI EMLSQFRHRH LVSLIGYCDE
560 570 580 590 600
NNEMILIYEY MENGTVKSHL YGSGLPSLTW KQRLEICIGA ARGLHYLHTG
610 620 630 640 650
DSKPVIHRDV KSANILLDEN FMAKVADFGL SKTGPELDQT HVSTAVKGSF
660 670 680 690 700
GYLDPEYFRR QQLTDKSDVY SFGVVLFEVL CARPVIDPTL PREMVNLAEW
710 720 730 740 750
AMKWQKKGQL DQIIDQSLRG NIRPDSLRKF AETGEKCLAD YGVDRPSMGD
760 770 780 790 800
VLWNLEYALQ LQEAVIDGEP EDNSTNMIGE LPPQINNFSQ GDTSVNVPGT
810 820 830
AGRFEESSID DLSGVSMSKV FSQLVKSEGR
Length:830
Mass (Da):91,468
Last modified:October 1, 2000 - v1
Checksum:i9767A13857FE36BF
GO

Sequence cautioni

The sequence CAB62020 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133298 Genomic DNA. Translation: CAB62020.1. Sequence problems.
AL355775 Genomic DNA. Translation: CAB90956.1.
CP002686 Genomic DNA. Translation: AEE78143.1.
PIRiT45686.
T49270.
RefSeqiNP_190214.1. NM_114497.4.
UniGeneiAt.546.
At.69879.

Genome annotation databases

EnsemblPlantsiAT3G46290.1; AT3G46290.1; AT3G46290.
GeneIDi823774.
GrameneiAT3G46290.1; AT3G46290.1; AT3G46290.
KEGGiath:AT3G46290.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133298 Genomic DNA. Translation: CAB62020.1. Sequence problems.
AL355775 Genomic DNA. Translation: CAB90956.1.
CP002686 Genomic DNA. Translation: AEE78143.1.
PIRiT45686.
T49270.
RefSeqiNP_190214.1. NM_114497.4.
UniGeneiAt.546.
At.69879.

3D structure databases

ProteinModelPortaliQ9LX66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G46290.1.

PTM databases

iPTMnetiQ9LX66.

Proteomic databases

PaxDbiQ9LX66.
PRIDEiQ9LX66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G46290.1; AT3G46290.1; AT3G46290.
GeneIDi823774.
GrameneiAT3G46290.1; AT3G46290.1; AT3G46290.
KEGGiath:AT3G46290.

Organism-specific databases

TAIRiAT3G46290.

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000238317.
InParanoidiQ9LX66.
OMAiCICHGFT.
OrthoDBiEOG093602FA.
PhylomeDBiQ9LX66.

Miscellaneous databases

PROiQ9LX66.

Gene expression databases

GenevisibleiQ9LX66. AT.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR024788. Malectin-like_Carb-bd_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12819. Malectin_like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHERK_ARATH
AccessioniPrimary (citable) accession number: Q9LX66
Secondary accession number(s): Q9SNA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.