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Protein

V-type proton ATPase subunit H

Gene

VHA-H

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-ATH-1222556 ROS, RNS production in phagocytes
R-ATH-77387 Insulin receptor recycling
R-ATH-917977 Transferrin endocytosis and recycling

Protein family/group databases

TCDBi3.A.2.2.5 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit H
Short name:
V-ATPase subunit H
Alternative name(s):
Vacuolar H(+)-ATPase subunit H
Vacuolar proton pump subunit H
Gene namesi
Name:VHA-H
Ordered Locus Names:At3g42050
ORF Names:F4M19_10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G42050
TAIRilocus:2083881 AT3G42050

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001242001 – 441V-type proton ATPase subunit HAdd BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9LX65
PRIDEiQ9LX65

PTM databases

iPTMnetiQ9LX65
SwissPalmiQ9LX65

Expressioni

Gene expression databases

ExpressionAtlasiQ9LX65 baseline and differential
GenevisibleiQ9LX65 AT

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c'', d and e).

Protein-protein interaction databases

BioGridi8496, 2 interactors
STRINGi3702.AT3G42050.1

Structurei

3D structure databases

ProteinModelPortaliQ9LX65
SMRiQ9LX65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase H subunit family.Curated

Phylogenomic databases

eggNOGiKOG2759 Eukaryota
COG5231 LUCA
HOGENOMiHOG000012406
InParanoidiQ9LX65
KOiK02144
OMAiRPIPWDG
OrthoDBiEOG093609FJ
PhylomeDBiQ9LX65

Family and domain databases

Gene3Di1.25.10.10, 1 hit
1.25.40.150, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR004908 ATPase_V1-cplx_hsu
IPR011987 ATPase_V1-cplx_hsu_C
IPR038497 ATPase_V1-cplx_hsu_C_sf
PANTHERiPTHR10698 PTHR10698, 1 hit
PfamiView protein in Pfam
PF11698 V-ATPase_H_C, 1 hit
PIRSFiPIRSF032184 ATPase_V1_H, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LX65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQAELSIEQ VLKRDIPWET YMNTKLVSAK GLQLLRRYDK KPESARAQLL
60 70 80 90 100
DEDGPAYVHL FVSILRDIFK EETVEYVLAL IYEMLSANPT RARLFHDESL
110 120 130 140 150
ANEDTYEPFL RLLWKGNWFI QEKSCKILAW IISARPKAGN AVIGNGIDDV
160 170 180 190 200
LKGLVEWLCA QLKQPSHPTR GVPIAISCLS SLLKEPVVRS SFVQADGVKL
210 220 230 240 250
LVPLISPAST QQSIQLLYET CLCIWLLSYY EPAIEYLATS RTMQRLTEVV
260 270 280 290 300
KHSTKEKVVR VVILTFRNLL PKGTFGAQMV DLGLPHIIHS LKTQAWSDED
310 320 330 340 350
LLDALNQLEE GLKDKIKKLS SFDKYKQEVL LGHLDWNPMH KETNFWRENV
360 370 380 390 400
TCFEENDFQI LRVLLTILDT SSDPRSLAVA CFDISQFIQY HAAGRVIVAD
410 420 430 440
LKAKERVMKL INHENAEVTK NAILCIQRLL LGAKYASFLQ A
Length:441
Mass (Da):50,284
Last modified:October 1, 2000 - v1
Checksum:iE0D57EB194158528
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356013 Genomic DNA Translation: CAB91576.1
CP002686 Genomic DNA Translation: AEE77718.1
AY091685 mRNA Translation: AAM10284.1
PIRiT48960
RefSeqiNP_189791.1, NM_114072.4
UniGeneiAt.19846

Genome annotation databases

EnsemblPlantsiAT3G42050.1; AT3G42050.1; AT3G42050
GeneIDi823170
GrameneiAT3G42050.1; AT3G42050.1; AT3G42050
KEGGiath:AT3G42050

Similar proteinsi

Entry informationi

Entry nameiVATH_ARATH
AccessioniPrimary (citable) accession number: Q9LX65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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