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Protein

Tirucalladienol synthase

Gene

PEN3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts oxidosqualene to tirucalladienol.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = tirucalla-7,24-dien-3-beta-ol.1 Publication

GO - Molecular functioni

  • lupeol synthase activity Source: TAIR

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BioCyciARA:AT5G36150-MONOMER
MetaCyc:AT5G36150-MONOMER
ReactomeiR-ATH-191273 Cholesterol biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tirucalladienol synthase (EC:5.4.99.56)
Alternative name(s):
Pentacyclic triterpene synthase 3
Short name:
AtPEN3
Gene namesi
Name:PEN3
Ordered Locus Names:At5g36150
ORF Names:MAB16.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G36150
TAIRilocus:2158921 AT5G36150

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003661381 – 760Tirucalladienol synthaseAdd BLAST760

Proteomic databases

PaxDbiQ9LVY2
PRIDEiQ9LVY2

PTM databases

iPTMnetiQ9LVY2

Expressioni

Gene expression databases

ExpressionAtlasiQ9LVY2 baseline and differential
GenevisibleiQ9LVY2 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G36150.1

Structurei

3D structure databases

ProteinModelPortaliQ9LVY2
SMRiQ9LVY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati149 – 190PFTB 1Add BLAST42
Repeati641 – 682PFTB 2Add BLAST42

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0497 Eukaryota
COG1657 LUCA
HOGENOMiHOG000234317
InParanoidiQ9LVY2
KOiK16205
OMAiESHSFMF
OrthoDBiEOG0936031Q
PhylomeDBiQ9LVY2

Family and domain databases

CDDicd02892 SQCY_1, 1 hit
InterProiView protein in InterPro
IPR032696 SQ_cyclase_C
IPR032697 SQ_cyclase_N
IPR018333 Squalene_cyclase
IPR002365 Terpene_synthase_CS
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF13243 SQHop_cyclase_C, 1 hit
PF13249 SQHop_cyclase_N, 1 hit
SUPFAMiSSF48239 SSF48239, 2 hits
TIGRFAMsiTIGR01787 squalene_cyclas, 1 hit
PROSITEiView protein in PROSITE
PS01074 TERPENE_SYNTHASES, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LVY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLRIGAKA GDDPHLCTTN NFLGRQIWEF DANAGSPAEL SEVDQARQNF
60 70 80 90 100
SNNRSQYKAC ADLLWRMQFL REKNFEQKIP RVRIEDAKKI TFEDAKNTLR
110 120 130 140 150
RGIHYMAALQ SDDGHWPSEN AGCIFFNAPF VICLYITGHL DKVFSEEHRK
160 170 180 190 200
EMLRYMYNHQ NDDGGWGIDV ESHSFMFCTV INYICLRIFG VDPDHDGESA
210 220 230 240 250
CARARKWIID HGGATYTPLF GKAWLSVLGV YEWSGCKPIP PEFWFFPSYF
260 270 280 290 300
PINGGTLWIY LRDTFMAMSY LYGKKFVAKP TPLILQLREE LYPQPYAEIV
310 320 330 340 350
WSQARSRCAK EDLYYPQSLV QDLFWKLVHM FSENILNRWP FNKLIREKAI
360 370 380 390 400
RTAMELIHYH DEATRYITGG AVPKVFHMLA CWVEDPESDY FKKHLARVSH
410 420 430 440 450
FIWIAEDGLK IQTFGSQIWD TAFVLQVMLA ADVDDEIRPT LIKGYSYLRK
460 470 480 490 500
SQFTENPPGD YINMFRDISK GGWGYSDKDQ GWPVSDCISE SLECCLIFES
510 520 530 540 550
MSSEFIGEKM EVERLYDAVN MLLYMQSRNG GISIWEAASG KKWLEWLSPI
560 570 580 590 600
EFIEDTILEH EYLECTGSAI VVLARFMKQF PGHRTEEVKK FITKGVKYIE
610 620 630 640 650
SLQIADGSWY GNWGICFIYG TFFAVRGLVA AGNTYDNCEA IRRAVRFLLD
660 670 680 690 700
IQNGEGGWGE SFLSCPNKNY IPLEGNKTDV VNTGQALMVL IMGGQMDRDP
710 720 730 740 750
LPVHRAAKVL INSQMDNGDF PQQEIRGVYK MNVMLNFPTF RNSFTLWALT
760
HYTKAIRLLL
Length:760
Mass (Da):87,804
Last modified:September 22, 2009 - v2
Checksum:iD30F08C6501FCE4B
GO

Sequence cautioni

The sequence BAA96890 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018112 Genomic DNA Translation: BAA96890.1 Sequence problems.
CP002688 Genomic DNA Translation: AED94049.1
CP002688 Genomic DNA Translation: ANM70931.1
RefSeqiNP_001318680.1, NM_001344127.1
NP_198464.4, NM_123006.4
UniGeneiAt.55157

Genome annotation databases

EnsemblPlantsiAT5G36150.1; AT5G36150.1; AT5G36150
AT5G36150.2; AT5G36150.2; AT5G36150
GeneIDi833612
GrameneiAT5G36150.1; AT5G36150.1; AT5G36150
AT5G36150.2; AT5G36150.2; AT5G36150
KEGGiath:AT5G36150

Similar proteinsi

Entry informationi

Entry nameiPEN3_ARATH
AccessioniPrimary (citable) accession number: Q9LVY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 22, 2009
Last modified: May 23, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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