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Protein

Probable protein phosphatase 2C 80

Gene

At5g66720

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi204Manganese 1By similarity1
Metal bindingi204Manganese 2By similarity1
Metal bindingi205Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi336Manganese 2By similarity1
Metal bindingi402Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 80 (EC:3.1.3.16)
Short name:
AtPP2C80
Gene namesi
Ordered Locus Names:At5g66720
ORF Names:MSN2.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G66720
TAIRilocus:2173679 AT5G66720

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003679991 – 414Probable protein phosphatase 2C 80Add BLAST414

Proteomic databases

PaxDbiQ9LVQ8
PRIDEiQ9LVQ8

Expressioni

Gene expression databases

ExpressionAtlasiQ9LVQ8 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi22047, 12 interactors
IntActiQ9LVQ8, 12 interactors
STRINGi3702.AT5G66720.1

Structurei

3D structure databases

ProteinModelPortaliQ9LVQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 411PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG1379 Eukaryota
COG0631 LUCA
HOGENOMiHOG000239282
InParanoidiQ9LVQ8
KOiK17508
OMAiFTAASMR
OrthoDBiEOG09360IX6
PhylomeDBiQ9LVQ8

Family and domain databases

Gene3Di3.60.40.10, 2 hits
InterProiView protein in InterPro
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
SMARTiView protein in SMART
SM00331 PP2C_SIG, 1 hit
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9LVQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSATALSRLN PVSQFGFQRI VAGKSKSFFS NSGQRRLFSD SSRFRQAMAA
60 70 80 90 100
SGSLPVFGDA CLDDLVTTCS NGLDFTKKRS SGGSFTINCP VASMRLGKRG
110 120 130 140 150
GMMKNRLVCH YSVVDPLEKS RALFGTLSKS VHTSPMACFS VGPAHELSSL
160 170 180 190 200
NGGSQESPPT TTTSLKSLRL VSGSCYLPHP EKEATGGEDA HFICDEEQAI
210 220 230 240 250
GVADGVGGWA EVGVNAGLFS RELMSYSVSA IQEQHKGSSI DPLVVLEKAH
260 270 280 290 300
SQTKAKGSST ACIIVLKDKG LHAINLGDSG FTVVREGTTV FQSPVQQHGF
310 320 330 340 350
NFTYQLESGN SADVPSSGQV FTIDVQSGDV IVAGTDGVYD NLYNEEITGV
360 370 380 390 400
VVSSVRAGLD PKGTAQKIAE LARQRAVDKK RQSPFATAAQ EAGYRYYGGK
410
LDDITAVVSY VTSS
Length:414
Mass (Da):43,873
Last modified:October 1, 2000 - v1
Checksum:i795E4D79381D5789
GO
Isoform 2 (identifier: Q9LVQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-169: Missing.

Note: May be due to a competing acceptor splice site. No experimental confirmation available.
Show »
Length:411
Mass (Da):43,517
Checksum:iFF894EE7D74F49E3
GO

Sequence cautioni

The sequence BX833253 differs from that shown. Sequencing errors.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036777167 – 169Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018119 Genomic DNA Translation: BAA97278.1
CP002688 Genomic DNA Translation: AED98255.1
CP002688 Genomic DNA Translation: AED98256.1
AK117127 mRNA Translation: BAC41805.1
AY136405 mRNA Translation: AAM97071.1
BT000228 mRNA Translation: AAN15547.1
BX833253 mRNA No translation available.
RefSeqiNP_201473.1, NM_126070.4 [Q9LVQ8-1]
NP_975004.1, NM_203275.1 [Q9LVQ8-2]
UniGeneiAt.28853

Genome annotation databases

EnsemblPlantsiAT5G66720.1; AT5G66720.1; AT5G66720 [Q9LVQ8-1]
AT5G66720.2; AT5G66720.2; AT5G66720 [Q9LVQ8-2]
GeneIDi836805
GrameneiAT5G66720.1; AT5G66720.1; AT5G66720 [Q9LVQ8-1]
AT5G66720.2; AT5G66720.2; AT5G66720 [Q9LVQ8-2]
KEGGiath:AT5G66720

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiP2C80_ARATH
AccessioniPrimary (citable) accession number: Q9LVQ8
Secondary accession number(s): Q3E849
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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