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Protein

Probable phospholipid-transporting ATPase 7

Gene

ALA7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in transport of phospholipids and in regulation of pollen plasma membrane lipid asymmetry.1 Publication

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4254-aspartylphosphate intermediateBy similarity1
Metal bindingi886MagnesiumBy similarity1
Metal bindingi890MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • Golgi vesicle budding Source: GO_Central
  • pollen tube growth Source: TAIR
  • regulation of membrane lipid metabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G13900-MONOMER.
ReactomeiR-ATH-6798695. Neutrophil degranulation.
R-ATH-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase 71 Publication (EC:3.6.3.11 Publication)
Short name:
AtALA71 Publication
Alternative name(s):
Aminophospholipid flippase 71 Publication
Gene namesi
Name:ALA71 Publication
Ordered Locus Names:At3g13900Imported
ORF Names:MDC16.2Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G13900.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74CytoplasmicSequence analysisAdd BLAST74
Transmembranei75 – 96HelicalSequence analysisAdd BLAST22
Topological domaini97 – 100ExtracellularSequence analysis4
Transmembranei101 – 123HelicalSequence analysisAdd BLAST23
Topological domaini124 – 305CytoplasmicSequence analysisAdd BLAST182
Transmembranei306 – 327HelicalSequence analysisAdd BLAST22
Topological domaini328 – 359ExtracellularSequence analysisAdd BLAST32
Transmembranei360 – 377HelicalSequence analysisAdd BLAST18
Topological domaini378 – 941CytoplasmicSequence analysisAdd BLAST564
Transmembranei942 – 961HelicalSequence analysisAdd BLAST20
Topological domaini962 – 975ExtracellularSequence analysisAdd BLAST14
Transmembranei976 – 995HelicalSequence analysisAdd BLAST20
Topological domaini996 – 1025CytoplasmicSequence analysisAdd BLAST30
Transmembranei1026 – 1048HelicalSequence analysisAdd BLAST23
Topological domaini1049 – 1061ExtracellularSequence analysisAdd BLAST13
Transmembranei1062 – 1084HelicalSequence analysisAdd BLAST23
Topological domaini1085 – 1090CytoplasmicSequence analysis6
Transmembranei1091 – 1111HelicalSequence analysisAdd BLAST21
Topological domaini1112 – 1128ExtracellularSequence analysisAdd BLAST17
Transmembranei1129 – 1153HelicalSequence analysisAdd BLAST25
Topological domaini1154 – 1243CytoplasmicSequence analysisAdd BLAST90

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Ala6 and ala7 double mutants are hypersensitive to temperature stress and are impaired in pollen fitness with an altered lipid composition and short and slow pollen tubes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463911 – 1243Probable phospholipid-transporting ATPase 7Add BLAST1243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki623Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9LVK9.

Expressioni

Gene expression databases

GenevisibleiQ9LVK9. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G13900.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LVK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiQ9LVK9.
KOiK01530.
OMAiRKVAVHK.
OrthoDBiEOG0936012H.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 2 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LVK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRRIRSRI RKSHFYTFKC LRPKTLEDQG PHIINGPGYT RIVHCNQPHL
60 70 80 90 100
HLAKVLRYTS NYVSTTRYNL ITFLPKCLYE QFHRVANFYF LVAAILSVFP
110 120 130 140 150
LSPFNKWSMI APLIFVVGLS MGKEALEDWR RFMQDVKVNS RKATVHRGDG
160 170 180 190 200
DFGRRKWKKL RVGDVVKVEK DQFFPADLLL LSSSYEDGIC YVETMNLDGE
210 220 230 240 250
TNLKVKRCLD VTLPLERDDT FQSFSGTIKC EDPNPNLYTF VGNLEYDGQV
260 270 280 290 300
YPLDPSQILL RDSKLRNTSY VYGVVVFTGH DTKVMQNSTK SPSKRSRIEK
310 320 330 340 350
RMDYIIYTLF ALLVLVSFIS SLGFAVMTKM HMGDWWYLRP DKPERLTNPR
360 370 380 390 400
NPFHAWVVHL ITAVLLYGYL IPISLYVSIE LVKVLQATFI NQDLQMYDSE
410 420 430 440 450
SGTPAQARTS NLNEELGQVD TILSDKTGTL TCNQMDFLKC SIAGTSYGVR
460 470 480 490 500
ASEVELAAAK QMAIDLDEEQ GEEVTHLPRT RGRMHGYAKM PSKTSSDIEL
510 520 530 540 550
ETVITATDEG DQTQSTGIKG FSFEDQRLMG GNWLNEPNSD DILMFLRILA
560 570 580 590 600
VCHTAIPEVD EDTGKCTYEA ESPDEVAFLV AAGEFGFEFT KRTQSSVFIS
610 620 630 640 650
ERHSGQPVER EYKVLNVLDF TSKRKRMSVI VRDEKGQILL LCKGADSIIF
660 670 680 690 700
ERLSKNGKNY LEATSKHLNG YGEAGLRTLA LSYRKLDETE YSIWNSEFHK
710 720 730 740 750
AKTSVGADRD EMLEKVSDMM EKELILVGAT AVEDKLQKGV PQCIDKLAQA
760 770 780 790 800
GLKIWVLTGD KMETAINIGY ACSLLRQGMK QIYIALRNEE GSSQDPEAAA
810 820 830 840 850
RENILMQIIN ASQMIKLEKD PHAAFALIID GKTLTYALED DIKYQFLALA
860 870 880 890 900
VDCASVICCR VSPKQKALVT RLAKEGTGKT TLAIGDGAND VGMIQEADIG
910 920 930 940 950
VGISGVEGMQ AVMASDFSIA QFRFLERLLV VHGHWCYKRI AQMICYFFYK
960 970 980 990 1000
NITFGLTLFY FEAFTGFSGQ AIYNDSYLLL FNVILTSLPV IALGVFEQDV
1010 1020 1030 1040 1050
SSEVCLQFPA LYQQGPKNLF FDWYRIIGWM ANGVYASVVI FSLNIGIFHV
1060 1070 1080 1090 1100
QSFCSGGQTA DMDAMGTAMF TCIIWAVNVQ IALTMSHFTW IQHVLIWGSI
1110 1120 1130 1140 1150
VTWYIFLALF GMLPPKVSGN IFHMLSETLA PAPIFWLTSL LVIAATTLPY
1160 1170 1180 1190 1200
LAYISFQRSL NPLDHHIIQE IKHFRIDVQD ECMWTRERSK AREKTKIGVT
1210 1220 1230 1240
ARVDAKIRQL RGRLQRKHSI LSVMSGLSGV SASTDTTSTT QHS
Length:1,243
Mass (Da):140,301
Last modified:January 25, 2012 - v3
Checksum:iC6BCC3D8BD909E08
GO

Sequence cautioni

The sequence BAB02320 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti614V → F in BAB02320 (PubMed:10819329).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019229 Genomic DNA. Translation: BAB02320.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75436.1.
RefSeqiNP_188006.4. NM_112244.5.

Genome annotation databases

EnsemblPlantsiAT3G13900.1; AT3G13900.1; AT3G13900.
GeneIDi820603.
GrameneiAT3G13900.1; AT3G13900.1; AT3G13900.
KEGGiath:AT3G13900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019229 Genomic DNA. Translation: BAB02320.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75436.1.
RefSeqiNP_188006.4. NM_112244.5.

3D structure databases

ProteinModelPortaliQ9LVK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G13900.1.

Proteomic databases

PaxDbiQ9LVK9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G13900.1; AT3G13900.1; AT3G13900.
GeneIDi820603.
GrameneiAT3G13900.1; AT3G13900.1; AT3G13900.
KEGGiath:AT3G13900.

Organism-specific databases

TAIRiAT3G13900.

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiQ9LVK9.
KOiK01530.
OMAiRKVAVHK.
OrthoDBiEOG0936012H.

Enzyme and pathway databases

BioCyciARA:AT3G13900-MONOMER.
ReactomeiR-ATH-6798695. Neutrophil degranulation.
R-ATH-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiQ9LVK9.

Gene expression databases

GenevisibleiQ9LVK9. AT.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 2 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALA7_ARATH
AccessioniPrimary (citable) accession number: Q9LVK9
Secondary accession number(s): F4JEL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 25, 2012
Last modified: November 30, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.