Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pumilio homolog 12

Gene

APUM12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pumilio homolog 12
Short name:
APUM-12
Short name:
AtPUM12
Gene namesi
Name:APUM12
Ordered Locus Names:At5g56510
ORF Names:MKN22.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G56510.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004013941 – 596Pumilio homolog 12Add BLAST596

Proteomic databases

PaxDbiQ9LVC3.
PRIDEiQ9LVC3.

Expressioni

Gene expression databases

GenevisibleiQ9LVC3. AT.

Interactioni

Protein-protein interaction databases

BioGridi20996. 1 interactor.
STRINGi3702.AT5G56510.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LVC3.
SMRiQ9LVC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini254 – 596PUM-HDPROSITE-ProRule annotationAdd BLAST343
Repeati277 – 312Pumilio 1Add BLAST36
Repeati313 – 348Pumilio 2Add BLAST36
Repeati349 – 388Pumilio 3Add BLAST40
Repeati389 – 424Pumilio 4Add BLAST36
Repeati425 – 460Pumilio 5Add BLAST36
Repeati461 – 496Pumilio 6Add BLAST36
Repeati497 – 532Pumilio 7Add BLAST36
Repeati533 – 570Pumilio 8Add BLAST38

Domaini

The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half doughnut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs (By similarity).By similarity

Sequence similaritiesi

Contains 1 PUM-HD domain.PROSITE-ProRule annotation
Contains 8 pumilio repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2049. Eukaryota.
COG5099. LUCA.
HOGENOMiHOG000176955.
InParanoidiQ9LVC3.
OMAiYRRAEQS.
OrthoDBiEOG093603UC.
PhylomeDBiQ9LVC3.

Family and domain databases

CDDicd07920. Pumilio. 1 hit.
Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR033133. PUM-HD.
IPR033712. Pumilio_RNA-bd.
IPR001313. Pumilio_RNA-bd_rpt.
[Graphical view]
PfamiPF00806. PUF. 6 hits.
[Graphical view]
SMARTiSM00025. Pumilio. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50302. PUM. 9 hits.
PS50303. PUM_HD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LVC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQRRGNELD EFEKLLGEIP KVTSGNDYNH FPICLSSSRS QSIKKVDQYL
60 70 80 90 100
PDDRAFTTSF SEANLHFGIP NHTPESPHPL FINPSYHSPS NSPCVYDKFD
110 120 130 140 150
SRKLDPVMFR KLQQVGYLPN LSSGISPAQR QHYLPHSQPL SHYQSPMTWR
160 170 180 190 200
DIEEENFQRL KLQEEQYLSI NPHFLHLQSM DTVPRQDHFD YRRAEQSNRN
210 220 230 240 250
LFWNGEDGNE SVRKMCYPEK ILMRSQMDLN TAKVIKYGAG DESQNGRLWL
260 270 280 290 300
QNQLNEDLTM SLNNLSLQPQ KYNSIAEARG KIYYLAKDQH GCRFLQRIFS
310 320 330 340 350
EKDGNDIEMI FNEIIDYISE LMMDPFGNYL VQKLLEVCNE DQRMQIVHSI
360 370 380 390 400
TRKPGLLIKI SCDMHGTRAV QKIVETAKRE EEISIIISAL KHGIVHLIKN
410 420 430 440 450
VNGNHVVQRC LQYLLPYCGK FLFEAAITHC VELATDRHGC CVLQKCLGYS
460 470 480 490 500
EGEQKQHLVS EIASNALLLS QDPFGNYVLQ YVFELQLQWA TFEILEQLEG
510 520 530 540 550
NYTELSMQKC SSNVVEKCLK LADDKHRARI IRELINYGRL DQVMLDPYGN
560 570 580 590
YVIQAALKQS KGNVHALLVD AIKLNISSLR TNPYGKKVLS ALSSKK
Length:596
Mass (Da):68,671
Last modified:November 30, 2010 - v2
Checksum:i3D8E134F7CF817ED
GO

Sequence cautioni

The sequence BAA97177 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019234 Genomic DNA. Translation: BAA97177.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED96775.1.
RefSeqiNP_200462.2. NM_125034.2.
UniGeneiAt.55587.

Genome annotation databases

EnsemblPlantsiAT5G56510.1; AT5G56510.1; AT5G56510.
GeneIDi835752.
GrameneiAT5G56510.1; AT5G56510.1; AT5G56510.
KEGGiath:AT5G56510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019234 Genomic DNA. Translation: BAA97177.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED96775.1.
RefSeqiNP_200462.2. NM_125034.2.
UniGeneiAt.55587.

3D structure databases

ProteinModelPortaliQ9LVC3.
SMRiQ9LVC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi20996. 1 interactor.
STRINGi3702.AT5G56510.1.

Proteomic databases

PaxDbiQ9LVC3.
PRIDEiQ9LVC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G56510.1; AT5G56510.1; AT5G56510.
GeneIDi835752.
GrameneiAT5G56510.1; AT5G56510.1; AT5G56510.
KEGGiath:AT5G56510.

Organism-specific databases

TAIRiAT5G56510.

Phylogenomic databases

eggNOGiKOG2049. Eukaryota.
COG5099. LUCA.
HOGENOMiHOG000176955.
InParanoidiQ9LVC3.
OMAiYRRAEQS.
OrthoDBiEOG093603UC.
PhylomeDBiQ9LVC3.

Miscellaneous databases

PROiQ9LVC3.

Gene expression databases

GenevisibleiQ9LVC3. AT.

Family and domain databases

CDDicd07920. Pumilio. 1 hit.
Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR033133. PUM-HD.
IPR033712. Pumilio_RNA-bd.
IPR001313. Pumilio_RNA-bd_rpt.
[Graphical view]
PfamiPF00806. PUF. 6 hits.
[Graphical view]
SMARTiSM00025. Pumilio. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50302. PUM. 9 hits.
PS50303. PUM_HD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPUM12_ARATH
AccessioniPrimary (citable) accession number: Q9LVC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.