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Protein

Pumilio homolog 12

Gene

APUM12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Pumilio homolog 12
Short name:
APUM-12
Short name:
AtPUM12
Gene namesi
Name:APUM12
Ordered Locus Names:At5g56510
ORF Names:MKN22.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G56510
TAIRilocus:2167111 AT5G56510

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004013941 – 596Pumilio homolog 12Add BLAST596

Proteomic databases

PaxDbiQ9LVC3
PRIDEiQ9LVC3

Expressioni

Gene expression databases

ExpressionAtlasiQ9LVC3 baseline and differential
GenevisibleiQ9LVC3 AT

Interactioni

Protein-protein interaction databases

BioGridi20996, 1 interactor
STRINGi3702.AT5G56510.1

Structurei

3D structure databases

ProteinModelPortaliQ9LVC3
SMRiQ9LVC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini254 – 596PUM-HDPROSITE-ProRule annotationAdd BLAST343
Repeati277 – 312Pumilio 1Add BLAST36
Repeati313 – 348Pumilio 2Add BLAST36
Repeati349 – 388Pumilio 3Add BLAST40
Repeati389 – 424Pumilio 4Add BLAST36
Repeati425 – 460Pumilio 5Add BLAST36
Repeati461 – 496Pumilio 6Add BLAST36
Repeati497 – 532Pumilio 7Add BLAST36
Repeati533 – 570Pumilio 8Add BLAST38

Domaini

The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs (By similarity).By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2049 Eukaryota
COG5099 LUCA
HOGENOMiHOG000176955
InParanoidiQ9LVC3
OMAiEAAITHC
OrthoDBiEOG093603UC
PhylomeDBiQ9LVC3

Family and domain databases

CDDicd07920 Pumilio, 1 hit
Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR033133 PUM-HD
IPR033712 Pumilio_RNA-bd
IPR001313 Pumilio_RNA-bd_rpt
PfamiView protein in Pfam
PF00806 PUF, 6 hits
SMARTiView protein in SMART
SM00025 Pumilio, 8 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50302 PUM, 9 hits
PS50303 PUM_HD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LVC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQRRGNELD EFEKLLGEIP KVTSGNDYNH FPICLSSSRS QSIKKVDQYL
60 70 80 90 100
PDDRAFTTSF SEANLHFGIP NHTPESPHPL FINPSYHSPS NSPCVYDKFD
110 120 130 140 150
SRKLDPVMFR KLQQVGYLPN LSSGISPAQR QHYLPHSQPL SHYQSPMTWR
160 170 180 190 200
DIEEENFQRL KLQEEQYLSI NPHFLHLQSM DTVPRQDHFD YRRAEQSNRN
210 220 230 240 250
LFWNGEDGNE SVRKMCYPEK ILMRSQMDLN TAKVIKYGAG DESQNGRLWL
260 270 280 290 300
QNQLNEDLTM SLNNLSLQPQ KYNSIAEARG KIYYLAKDQH GCRFLQRIFS
310 320 330 340 350
EKDGNDIEMI FNEIIDYISE LMMDPFGNYL VQKLLEVCNE DQRMQIVHSI
360 370 380 390 400
TRKPGLLIKI SCDMHGTRAV QKIVETAKRE EEISIIISAL KHGIVHLIKN
410 420 430 440 450
VNGNHVVQRC LQYLLPYCGK FLFEAAITHC VELATDRHGC CVLQKCLGYS
460 470 480 490 500
EGEQKQHLVS EIASNALLLS QDPFGNYVLQ YVFELQLQWA TFEILEQLEG
510 520 530 540 550
NYTELSMQKC SSNVVEKCLK LADDKHRARI IRELINYGRL DQVMLDPYGN
560 570 580 590
YVIQAALKQS KGNVHALLVD AIKLNISSLR TNPYGKKVLS ALSSKK
Length:596
Mass (Da):68,671
Last modified:November 30, 2010 - v2
Checksum:i3D8E134F7CF817ED
GO

Sequence cautioni

The sequence BAA97177 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019234 Genomic DNA Translation: BAA97177.1 Sequence problems.
CP002688 Genomic DNA Translation: AED96775.1
CP002688 Genomic DNA Translation: ANM71040.1
CP002688 Genomic DNA Translation: ANM71041.1
CP002688 Genomic DNA Translation: ANM71042.1
CP002688 Genomic DNA Translation: ANM71043.1
RefSeqiNP_001318812.1, NM_001345201.1
NP_001332599.1, NM_001345204.1
NP_001332600.1, NM_001345203.1
NP_001332601.1, NM_001345202.1
NP_200462.2, NM_125034.2
UniGeneiAt.55587

Genome annotation databases

EnsemblPlantsiAT5G56510.1; AT5G56510.1; AT5G56510
AT5G56510.2; AT5G56510.2; AT5G56510
AT5G56510.3; AT5G56510.3; AT5G56510
AT5G56510.4; AT5G56510.4; AT5G56510
AT5G56510.6; AT5G56510.6; AT5G56510
GeneIDi835752
GrameneiAT5G56510.1; AT5G56510.1; AT5G56510
AT5G56510.2; AT5G56510.2; AT5G56510
AT5G56510.3; AT5G56510.3; AT5G56510
AT5G56510.4; AT5G56510.4; AT5G56510
AT5G56510.6; AT5G56510.6; AT5G56510
KEGGiath:AT5G56510

Similar proteinsi

Entry informationi

Entry nameiPUM12_ARATH
AccessioniPrimary (citable) accession number: Q9LVC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 30, 2010
Last modified: April 25, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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