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Q9LV87 (PEP1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elicitor peptide 1
Gene names
Name:PEP1
Synonyms:PROPEP1
Ordered Locus Names:At5g64900
ORF Names:MXK3.13
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Elicitor of plant defense. Induces the production of plant defensin (PDF1.2) and of H2O2. Promotes resistance to the root fungal pathogen P.irregulare. Ref.5

Subunit structure

Interacts with its receptor PEPR1. Ref.6 Ref.7

Induction

By wounding, methyl jasmonate (MeJA), ethylene. The expression of the peptide PEP1 precursor is induced by the mature peptide PEP1.

Sequence similarities

Belongs to the brassicaceae elicitor peptide family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 6969
PRO_0000249079
Peptide70 – 9223Elicitor peptide 1 Ref.5
PRO_0000249080

Sites

Site861Required for ligand-receptor interaction

Experimental info

Mutagenesis781R → A: No effect. Ref.7
Mutagenesis791G → A: No effect. Ref.7
Mutagenesis801K → A: No effect. Ref.7
Mutagenesis811E → A: No effect. Ref.7
Mutagenesis821K → A: No effect. Ref.7
Mutagenesis831V → A: No effect. Ref.7
Mutagenesis841S → A: Loss of binding to PEPR1 and of subsequent signaling. Ref.7
Mutagenesis851S → A: No effect. Ref.7
Mutagenesis861G → A or P: Loss of binding to PEPR1 and of subsequent signaling. Ref.7
Mutagenesis871R → A: No effect. Ref.7
Mutagenesis881P → A: No effect. Ref.7
Mutagenesis891G → A: No effect. Ref.7
Mutagenesis901Q → A: No effect. Ref.7
Mutagenesis911H → A: No effect. Ref.7
Mutagenesis921N → A: No effect. Ref.7
Sequence conflict101E → G in AAM63605. Ref.4
Sequence conflict481K → E in AAM63605. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9LV87 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: A21FA1697B8FDA65

FASTA9210,389
        10         20         30         40         50         60 
MEKSDRRSEE SHLWIPLQCL DQTLRAILKC LGLFHQDSPT TSSPGTSKQP KEEKEDVTME 

        70         80         90 
KEEVVVTSRA TKVKAKQRGK EKVSSGRPGQ HN 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Full-length cDNA from Arabidopsis thaliana."
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"An endogenous peptide signal in Arabidopsis activates components of the innate immune response."
Huffaker A., Pearce G., Ryan C.A.
Proc. Natl. Acad. Sci. U.S.A. 103:10098-10103(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 70-92, FUNCTION, PROTEOLYTIC PROCESSING, IDENTIFICATION BY MASS SPECTROMETRY, GENE FAMILY, NOMENCLATURE.
[6]"The cell surface leucine-rich repeat receptor for AtPep1, an endogenous peptide elicitor in Arabidopsis, is functional in transgenic tobacco cells."
Yamaguchi Y., Pearce G., Ryan C.A.
Proc. Natl. Acad. Sci. U.S.A. 103:10104-10109(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PEPR1.
[7]"Structure-activity studies of AtPep1, a plant peptide signal involved in the innate immune response."
Pearce G., Yamaguchi Y., Munske G., Ryan C.A.
Peptides 29:2083-2089(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PEPR1, MUTAGENESIS OF ARG-78; GLY-79; LYS-80; GLU-81; LYS-82; VAL-83; SER-84; SER-85; GLY-86; ARG-87; PRO-88; GLY-89; GLN-90; HIS-91 AND ASN-92.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB019236 Genomic DNA. Translation: BAA97302.1.
CP002688 Genomic DNA. Translation: AED97966.1.
AY062830 mRNA. Translation: AAL32908.1.
AY081662 mRNA. Translation: AAM10224.1.
AY086540 mRNA. Translation: AAM63605.1.
RefSeqNP_569001.1. NM_125888.3.
UniGeneAt.27218.

3D structure databases

ProteinModelPortalQ9LV87.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G64900.1; AT5G64900.1; AT5G64900.
GeneID836613.
KEGGath:AT5G64900.

Organism-specific databases

TAIRAT5G64900.

Phylogenomic databases

HOGENOMHOG000115496.
OMASEESHLW.
PhylomeDBQ9LV87.
ProtClustDBCLSN2690083.

Gene expression databases

GenevestigatorQ9LV87.

Family and domain databases

ProtoNetSearch...

Entry information

Entry namePEP1_ARATH
AccessionPrimary (citable) accession number: Q9LV87
Secondary accession number(s): Q8LCK9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names