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Q9LV37

- MPK9_ARATH

UniProt

Q9LV37 - MPK9_ARATH

Protein

Mitogen-activated protein kinase 9

Gene

MPK9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei52 – 521ATPPROSITE-ProRule annotation
    Active sitei149 – 1491Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 379ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: TAIR

    GO - Biological processi

    1. abscisic acid-activated signaling pathway Source: TAIR
    2. MAPK cascade Source: GOC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT3G18040-MONOMER.
    ARA:GQT-1685-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 9 (EC:2.7.11.24)
    Short name:
    AtMPK9
    Short name:
    MAP kinase 9
    Gene namesi
    Name:MPK9
    Ordered Locus Names:At3g18040
    ORF Names:MRC8.2, MRC8.4
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G18040.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: TAIR
    2. mitochondrion Source: TAIR
    3. nucleus Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 510510Mitogen-activated protein kinase 9PRO_0000245809Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei185 – 1851PhosphothreonineBy similarity
    Modified residuei187 – 1871PhosphotyrosineBy similarity
    Modified residuei190 – 1901PhosphothreonineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9LV37.
    PRIDEiQ9LV37.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9LV37.
    GenevestigatoriQ9LV37.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-8060599.
    STRINGi3702.AT3G18040.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LV37.
    SMRiQ9LV37. Positions 23-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 314292Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi185 – 1873TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    InParanoidiQ9LV37.
    OMAiKENGSHN.
    PhylomeDBiQ9LV37.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: Q9LV37-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPHKKVALE TEFFTEYGEA SRYQIQEVIG KGSYGVVASA IDTHSGEKVA    50
    IKKINDVFEH VSDATRILRE IKLLRLLRHP DIVEIKHVML PPSRREFRDI 100
    YVVFELMESD LHQVIKANDD LTPEHYQFFL YQLLRGLKFI HTANVFHRDL 150
    KPKNILANSD CKLKICDFGL ARVSFNDAPS AIFWTDYVAT RWYRAPELCG 200
    SFFSKYTPAI DIWSIGCIFA EMLTGKPLFP GKNVVHQLDI MTDLLGTPPP 250
    EAIARIRNEK ARRYLGNMRR KPPVPFTHKF PHVDPLALRL LHRLLAFDPK 300
    DRPSAEEALA DPYFYGLANV DREPSTQPIP KLEFEFERRK ITKEDVRELI 350
    YREILEYHPQ MLQEYLRGGE QTSFMYPSGV DRFKRQFAHL EENYGKGEKG 400
    SPLQRQHASL PRERVPAPKK ENGSHNHDIE NRSIASLVTT LESPPTSQHE 450
    GSDYRNGTSQ TGYSARSLLK SASISASKCI GMKPRNKSEY GESNNDTVDA 500
    LSQKVAALHT 510
    Length:510
    Mass (Da):58,395
    Last modified:July 11, 2006 - v2
    Checksum:i6E41FB646C3C7F12
    GO

    Sequence cautioni

    The sequence BAB02016.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461G → C in BAA92223. 1 PublicationCurated
    Sequence conflicti54 – 541I → S in BAA92223. 1 PublicationCurated
    Sequence conflicti96 – 961E → D in BAA92223. 1 PublicationCurated
    Sequence conflicti190 – 1901T → N in BAA92223. 1 PublicationCurated
    Sequence conflicti341 – 3411I → L in BAA92223. 1 PublicationCurated
    Sequence conflicti461 – 4611T → Q in BAA92223. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038694 mRNA. Translation: BAA92223.1.
    AB020749 Genomic DNA. Translation: BAB02016.1. Different initiation.
    CP002686 Genomic DNA. Translation: AEE76038.1.
    RefSeqiNP_566595.1. NM_112686.4. [Q9LV37-1]
    UniGeneiAt.471.

    Genome annotation databases

    EnsemblPlantsiAT3G18040.1; AT3G18040.1; AT3G18040. [Q9LV37-1]
    GeneIDi821329.
    KEGGiath:AT3G18040.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB038694 mRNA. Translation: BAA92223.1 .
    AB020749 Genomic DNA. Translation: BAB02016.1 . Different initiation.
    CP002686 Genomic DNA. Translation: AEE76038.1 .
    RefSeqi NP_566595.1. NM_112686.4. [Q9LV37-1 ]
    UniGenei At.471.

    3D structure databases

    ProteinModelPortali Q9LV37.
    SMRi Q9LV37. Positions 23-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8060599.
    STRINGi 3702.AT3G18040.1-P.

    Proteomic databases

    PaxDbi Q9LV37.
    PRIDEi Q9LV37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G18040.1 ; AT3G18040.1 ; AT3G18040 . [Q9LV37-1 ]
    GeneIDi 821329.
    KEGGi ath:AT3G18040.

    Organism-specific databases

    GeneFarmi 865. 89.
    TAIRi AT3G18040.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    InParanoidi Q9LV37.
    OMAi KENGSHN.
    PhylomeDBi Q9LV37.

    Enzyme and pathway databases

    BioCyci ARA:AT3G18040-MONOMER.
    ARA:GQT-1685-MONOMER.

    Gene expression databases

    ArrayExpressi Q9LV37.
    Genevestigatori Q9LV37.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Arabidopsis thaliana mRNA for MAP kinase."
      Mizoguchi T., Ichimura K., Shinozaki K.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    2. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
      Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
      DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Mitogen-activated protein kinase cascades in plants: a new nomenclature."
      MAPK group
      Trends Plant Sci. 7:301-308(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    5. Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiMPK9_ARATH
    AccessioniPrimary (citable) accession number: Q9LV37
    Secondary accession number(s): Q9MB22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3