Q9LUU7 (P2C43_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable protein phosphatase 2C 43
Short name=AtPP2C43
EC=3.1.3.16

Gene names

Ordered Locus Names:	At3g17250
ORF Names:	MGD8.13, MGD8.8

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 2 magnesium or manganese ions per subunit By similarity.
Sequence similarities	Belongs to the PP2C family. Contains 1 PP2C-like domain.

Ontologies

Keywords
Ligand	Magnesium Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from electronic annotation. Source: InterPro
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Probable protein phosphatase 2C 43		PRO_0000367967
Regions
	Domain	117 – 386	270	PP2C-like
Sites
	Metal binding	163	1	Manganese 1 By similarity
	Metal binding	163	1	Manganese 2 By similarity
	Metal binding	164	1	Manganese 1; via carbonyl oxygen By similarity
	Metal binding	341	1	Manganese 2 By similarity
	Metal binding	384	1	Manganese 2 By similarity
Experimental info
	Sequence conflict	303	1	W → S in BAD94223. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9LUU7 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 63B7B3E7DD69FCE4	FASTA	422	47,599
	10 20 30 40 50 60 MRTSKASVTQ TWLLYTQLCL WKDLIIRYVR QIIRRAKSML FSQNMVADSA EISVIDVKSH 70 80 90 100 110 120 LSVAKDPSNF QIAEIRIHDS ICIDIPSSEE TPLLESIKSC SATTIEEHVT EFVPNISSGS 130 140 150 160 170 180 YADKGDYREY MEDEHICIDD LSDHLGSSFY RFPVPMAFYG VFDGHGGSDA SQYIKENAMS 190 200 210 220 230 240 LFFEDAVFRQ SPSVVDSLFL KELETSHREA YRLADLAMED ERIVSSSCGT TALTALVIGR 250 260 270 280 290 300 HLMVANVGDC RAVLCRKGKA VDMSFDHKST FEPERRRVED LGGYFEGEYL YGDLAVTRAL 310 320 330 340 350 360 GDWSIKRFSP LGESLSPLIS DPDIQQMILT EEDEFLIMGC DGVWDVMTSQ YAVTFVRQGL 370 380 390 400 410 420 RRHGDPRRCA MELGREALRL DSSDNVTVVV ICFSSSPAPQ RRRIRFCVSD EARARLQTML EG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S. DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis." Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y. BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB022216 Genomic DNA. Translation: BAB02728.1. CP002686 Genomic DNA. Translation: AEE75928.1. AK220861 mRNA. Translation: BAD94223.1. AK228860 mRNA. Translation: BAF00754.1.
IPI	IPI00542203.
RefSeq	NP_188351.2. NM_112603.2.
UniGene	At.38757.
3D structure databases
ProteinModelPortal	Q9LUU7.
SMR	Q9LUU7. Positions 95-393.
ModBase	Search...
Proteomic databases
PaxDb	Q9LUU7.
PRIDE	Q9LUU7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT3G17250.1; AT3G17250.1; AT3G17250.
GeneID	820986.
KEGG	ath:AT3G17250.
Organism-specific databases
TAIR	At3g17250.
Phylogenomic databases
eggNOG	COG0631.
HOGENOM	HOG000233896.
InParanoid	Q9LUU7.
KO	K14803.
OMA	NAMRLFF.
PhylomeDB	Q9LUU7.
ProtClustDB	CLSN2690996.
Gene expression databases
Genevestigator	Q9LUU7.
Family and domain databases
Gene3D	3.60.40.10. 1 hit.
InterPro	IPR001932. PP2C-like. IPR000222. PP2C_Mn2_Asp60_BS. IPR015655. Protein_Pase_2C. [Graphical view]
PANTHER	PTHR13832. PTHR13832. 1 hit.
Pfam	PF00481. PP2C. 1 hit. [Graphical view]
SMART	SM00331. PP2C_SIG. 1 hit. SM00332. PP2Cc. 1 hit. [Graphical view]
SUPFAM	SSF81606. PP2C-related. 1 hit.
PROSITE	PS01032. PP2C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P2C43_ARATH

Accession

Primary (citable) accession number: Q9LUU7
Secondary accession number(s): Q56ZV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program