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Protein

Probable protein phosphatase 2C 40

Gene

At3g16560

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi180Manganese 1By similarity1
Metal bindingi180Manganese 2By similarity1
Metal bindingi181Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi408Manganese 2By similarity1
Metal bindingi471Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 40 (EC:3.1.3.16)
Short name:
AtPP2C40
Alternative name(s):
Protein phosphatase 2C homolog 1
Gene namesi
Ordered Locus Names:At3g16560
ORF Names:MDC8.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G16560.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003012571 – 493Probable protein phosphatase 2C 40Add BLAST493

Proteomic databases

PaxDbiQ9LUS8.
PRIDEiQ9LUS8.

PTM databases

iPTMnetiQ9LUS8.

Expressioni

Gene expression databases

GenevisibleiQ9LUS8. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G16560.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LUS8.
SMRiQ9LUS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 480PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST336

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi80 – 139Ser-richAdd BLAST60
Compositional biasi465 – 468Poly-Arg4

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0700. Eukaryota.
COG0631. LUCA.
HOGENOMiHOG000240776.
InParanoidiQ9LUS8.
OMAiTIMVITL.
OrthoDBiEOG09360EX3.
PhylomeDBiQ9LUS8.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LUS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEGTDPYGE IEISFGYQCN NKKIGIPEDK IADGREVLGG FRLQKTSSFS
60 70 80 90 100
CLSGAALSGN PTLANTNICN GVIGSEILPS LDSPKSFRKV PSSPALSKLD
110 120 130 140 150
ILSPSLHGSM VSLSCSSSTS PSPPEPESCY LTSMSSPSSV NEGFLLSAME
160 170 180 190 200
VQVAGGAAGE DRVQAVCSEE NGWLFCAIYD GFNGRDAADF LACTLYESIV
210 220 230 240 250
FHLQLLDRQM KQTKSDDDGE KLELLSNISN VDYSSTDLFR QGVLDCLNRA
260 270 280 290 300
LFQAETDFLR MVEQEMEERP DLVSVGSCVL VTLLVGKDLY VLNLGDSRAV
310 320 330 340 350
LATYNGNKKL QAVQLTEDHT VDNEVEEARL LSEHLDDPKI VIGGKIKGKL
360 370 380 390 400
KVTRALGVGY LKKEKLNDAL MGILRVRNLL SPPYVSVEPS MRVHKITESD
410 420 430 440 450
HFVIVASDGL FDFFSNEEAI GLVHSFVSSN PSGDPAKFLL ERLVAKAAAR
460 470 480 490
AGFTLEELTN VPAGRRRRYH DDVTIMVITL GTDQRTSKAS TFV
Length:493
Mass (Da):53,614
Last modified:October 1, 2000 - v1
Checksum:i613ED80B06B8C844
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti372G → E in AAM64473 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022217 Genomic DNA. Translation: BAB02747.1.
CP002686 Genomic DNA. Translation: AEE75836.1.
AY136458 mRNA. Translation: AAM97123.1.
BT008864 mRNA. Translation: AAP68303.1.
AY086406 mRNA. Translation: AAM64473.1.
RefSeqiNP_566554.1. NM_112529.3.
UniGeneiAt.38878.

Genome annotation databases

EnsemblPlantsiAT3G16560.1; AT3G16560.1; AT3G16560.
GeneIDi820905.
GrameneiAT3G16560.1; AT3G16560.1; AT3G16560.
KEGGiath:AT3G16560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022217 Genomic DNA. Translation: BAB02747.1.
CP002686 Genomic DNA. Translation: AEE75836.1.
AY136458 mRNA. Translation: AAM97123.1.
BT008864 mRNA. Translation: AAP68303.1.
AY086406 mRNA. Translation: AAM64473.1.
RefSeqiNP_566554.1. NM_112529.3.
UniGeneiAt.38878.

3D structure databases

ProteinModelPortaliQ9LUS8.
SMRiQ9LUS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G16560.1.

PTM databases

iPTMnetiQ9LUS8.

Proteomic databases

PaxDbiQ9LUS8.
PRIDEiQ9LUS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G16560.1; AT3G16560.1; AT3G16560.
GeneIDi820905.
GrameneiAT3G16560.1; AT3G16560.1; AT3G16560.
KEGGiath:AT3G16560.

Organism-specific databases

TAIRiAT3G16560.

Phylogenomic databases

eggNOGiKOG0700. Eukaryota.
COG0631. LUCA.
HOGENOMiHOG000240776.
InParanoidiQ9LUS8.
OMAiTIMVITL.
OrthoDBiEOG09360EX3.
PhylomeDBiQ9LUS8.

Miscellaneous databases

PROiQ9LUS8.

Gene expression databases

GenevisibleiQ9LUS8. AT.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2C40_ARATH
AccessioniPrimary (citable) accession number: Q9LUS8
Secondary accession number(s): Q8LCU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.