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Protein

Probable protein phosphatase 2C 40

Gene

At3g16560

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi180 – 1801Manganese 1By similarity
Metal bindingi180 – 1801Manganese 2By similarity
Metal bindingi181 – 1811Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi408 – 4081Manganese 2By similarity
Metal bindingi471 – 4711Manganese 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G16560-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 40 (EC:3.1.3.16)
Short name:
AtPP2C40
Alternative name(s):
Protein phosphatase 2C homolog 1
Gene namesi
Ordered Locus Names:At3g16560
ORF Names:MDC8.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G16560.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Probable protein phosphatase 2C 40PRO_0000301257Add
BLAST

Proteomic databases

PRIDEiQ9LUS8.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G16560.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LUS8.
SMRiQ9LUS8. Positions 131-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 480336PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi80 – 13960Ser-richAdd
BLAST
Compositional biasi465 – 4684Poly-Arg

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000240776.
InParanoidiQ9LUS8.
OMAiTIMVITL.
PhylomeDBiQ9LUS8.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LUS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQEGTDPYGE IEISFGYQCN NKKIGIPEDK IADGREVLGG FRLQKTSSFS
60 70 80 90 100
CLSGAALSGN PTLANTNICN GVIGSEILPS LDSPKSFRKV PSSPALSKLD
110 120 130 140 150
ILSPSLHGSM VSLSCSSSTS PSPPEPESCY LTSMSSPSSV NEGFLLSAME
160 170 180 190 200
VQVAGGAAGE DRVQAVCSEE NGWLFCAIYD GFNGRDAADF LACTLYESIV
210 220 230 240 250
FHLQLLDRQM KQTKSDDDGE KLELLSNISN VDYSSTDLFR QGVLDCLNRA
260 270 280 290 300
LFQAETDFLR MVEQEMEERP DLVSVGSCVL VTLLVGKDLY VLNLGDSRAV
310 320 330 340 350
LATYNGNKKL QAVQLTEDHT VDNEVEEARL LSEHLDDPKI VIGGKIKGKL
360 370 380 390 400
KVTRALGVGY LKKEKLNDAL MGILRVRNLL SPPYVSVEPS MRVHKITESD
410 420 430 440 450
HFVIVASDGL FDFFSNEEAI GLVHSFVSSN PSGDPAKFLL ERLVAKAAAR
460 470 480 490
AGFTLEELTN VPAGRRRRYH DDVTIMVITL GTDQRTSKAS TFV
Length:493
Mass (Da):53,614
Last modified:October 1, 2000 - v1
Checksum:i613ED80B06B8C844
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti372 – 3721G → E in AAM64473 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022217 Genomic DNA. Translation: BAB02747.1.
CP002686 Genomic DNA. Translation: AEE75836.1.
AY136458 mRNA. Translation: AAM97123.1.
BT008864 mRNA. Translation: AAP68303.1.
AY086406 mRNA. Translation: AAM64473.1.
RefSeqiNP_566554.1. NM_112529.2.
UniGeneiAt.38878.

Genome annotation databases

EnsemblPlantsiAT3G16560.1; AT3G16560.1; AT3G16560.
GeneIDi820905.
KEGGiath:AT3G16560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022217 Genomic DNA. Translation: BAB02747.1.
CP002686 Genomic DNA. Translation: AEE75836.1.
AY136458 mRNA. Translation: AAM97123.1.
BT008864 mRNA. Translation: AAP68303.1.
AY086406 mRNA. Translation: AAM64473.1.
RefSeqiNP_566554.1. NM_112529.2.
UniGeneiAt.38878.

3D structure databases

ProteinModelPortaliQ9LUS8.
SMRiQ9LUS8. Positions 131-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G16560.1.

Proteomic databases

PRIDEiQ9LUS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G16560.1; AT3G16560.1; AT3G16560.
GeneIDi820905.
KEGGiath:AT3G16560.

Organism-specific databases

TAIRiAT3G16560.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000240776.
InParanoidiQ9LUS8.
OMAiTIMVITL.
PhylomeDBiQ9LUS8.

Enzyme and pathway databases

BioCyciARA:AT3G16560-MONOMER.

Miscellaneous databases

PROiQ9LUS8.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C40_ARATH
AccessioniPrimary (citable) accession number: Q9LUS8
Secondary accession number(s): Q8LCU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.