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Q9LUI3

- TSO1_ARATH

UniProt

Q9LUI3 - TSO1_ARATH

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Protein

CRC domain-containing protein TSO1

Gene

TSO1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Probable floral-specific cell division component, required for proper organ formation in flowers. Regulates the floral meristem cell division and the inflorescence meristem organization. Plays a role in development of both male and female reproductive tissues.4 Publications

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: TAIR

GO - Biological processi

  1. floral organ morphogenesis Source: UniProtKB
  2. regulation of cell division Source: UniProtKB
  3. regulation of meristem structural organization Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
CRC domain-containing protein TSO1
Gene namesi
Name:TSO1
Ordered Locus Names:At3g22780
ORF Names:MWI23.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G22780.

Subcellular locationi

Nucleus 2 Publications

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Despite a wild-type flower phenotype, the null mutant presents defects in pollen, carpel and ovule development, including a failure in megasporogenesis. Small siliques.3 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi403 – 4031C → Y: Abnormalities in floral meristems and sepals including increased cell size, decreased cell number, disorganized layer structure, increased DNA content per cell, and partially formed cell walls. Resulting phenotype is callus-like tissues in place of floral organs. 1 Publication
Mutagenesisi501 – 5011C → Y: Abnormalities in floral meristems and sepals including increased cell size, decreased cell number, disorganized layer structure, increased DNA content per cell, and partially formed cell walls. Resulting phenotype is callus-like tissues in place of floral organs. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695CRC domain-containing protein TSO1PRO_0000418166Add
BLAST

Proteomic databases

PRIDEiQ9LUI3.

Expressioni

Tissue specificityi

Ubiquitous but expressed mostly in flowers with highest levels in developing ovules and microspores.3 Publications

Developmental stagei

Expressed at the first stage of pollen development in uninucleate microspores and bicellular pollen but not in tricellular and mature pollen.1 Publication

Gene expression databases

GenevestigatoriQ9LUI3.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G22780.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LUI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini399 – 524126CRCPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi269 – 28315Nuclear localization signalSequence AnalysisAdd
BLAST

Domaini

The cysteine-rich domain CRC binds zinc in vitro.

Sequence similaritiesi

Belongs to the lin-54 family.Curated
Contains 1 CRC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG258818.
HOGENOMiHOG000084455.
InParanoidiQ9LUI3.
OMAiLVIMESK.
PhylomeDBiQ9LUI3.

Family and domain databases

InterProiIPR005172. CRC.
IPR028307. Lin-54_fam.
[Graphical view]
PANTHERiPTHR12446. PTHR12446. 1 hit.
PfamiPF03638. TCR. 2 hits.
[Graphical view]
PROSITEiPS51634. CRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LUI3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDKSQKNPTS QIGTSTPKSK FEDSPVFNYI SNLSPIESVK SISTAQTFSS
60 70 80 90 100
LSFTSPPPVF TSPHVISHRE SRFFRCHNSV DRSKHLESLD GSAVKGEVVV
110 120 130 140 150
PLVEDLNKEA SLEDEEETSV ETSSELPQIM KFDSQTSEHS DSPCTEDVVI
160 170 180 190 200
EASSDPPRGD NGSSSEDVTM GLQNMLVVRE GNDTPGCGRL ISDATELLVF
210 220 230 240 250
RSPNDSEAFR CLVDKISSSE RRFCAGVKST KRPDINKDIP ANGSSNENQP
260 270 280 290 300
LAVLPTNESV FNLHRGGMRR RCLDFEMPGK RKKDIVDDQQ SVCDNNVAGE
310 320 330 340 350
SSSSCVVPGI GLHLNAVAMS AKDSNISVIH GYSISGEIQK SFSGSTTPIQ
360 370 380 390 400
SQDTVQETSD QAENEPVEEV PKALVFPELN LGSLKKKMRK SEQAGEGESC
410 420 430 440 450
KRCNCKKSKC LKLYCECFAA GVYCIEPCSC IDCFNKPIHE ETVLATRKQI
460 470 480 490 500
ESRNPLAFAP KVIRNADSIM EASDDASKTP ASARHKRGCN CKKSNCMKKY
510 520 530 540 550
CECYQGGVGC SMNCRCEGCT NVFGRKDGSL LVIMESKLEE NQETYEKRIA
560 570 580 590 600
KIQHNVEVSK EVEQNPSSDQ PSTPLPPYRH LVVHQPFLSK NRLPPTQFFL
610 620 630 640 650
GTGSSSFRKP NSDLAQSQNE KKPLETVTED KTEIMPEILL NSPIANIKAI
660 670 680 690
SPNSKRVSPP QPGSSESGSI LRRRGNGRKL ILRSIPAFPS LNPNQ
Length:695
Mass (Da):76,277
Last modified:October 1, 2000 - v1
Checksum:i34BBA0E450F6BCE1
GO

Sequence cautioni

The sequence AAK76693.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301M → L in AAF27433. (PubMed:10769244)Curated
Sequence conflicti130 – 1301M → L in AAF69124. (PubMed:10769245)Curated
Sequence conflicti375 – 3751V → M in AAK76693. (PubMed:14593172)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF206324 mRNA. Translation: AAF27433.1.
AF204059 mRNA. Translation: AAF69124.1.
AB022223 Genomic DNA. Translation: BAB01253.1.
CP002686 Genomic DNA. Translation: AEE76676.1.
AY046019 mRNA. Translation: AAK76693.1. Different initiation.
AY142642 mRNA. Translation: AAN13100.1.
RefSeqiNP_566718.2. NM_113177.3.
UniGeneiAt.24953.
At.68193.

Genome annotation databases

EnsemblPlantsiAT3G22780.1; AT3G22780.1; AT3G22780.
GeneIDi821849.
KEGGiath:AT3G22780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF206324 mRNA. Translation: AAF27433.1 .
AF204059 mRNA. Translation: AAF69124.1 .
AB022223 Genomic DNA. Translation: BAB01253.1 .
CP002686 Genomic DNA. Translation: AEE76676.1 .
AY046019 mRNA. Translation: AAK76693.1 . Different initiation.
AY142642 mRNA. Translation: AAN13100.1 .
RefSeqi NP_566718.2. NM_113177.3.
UniGenei At.24953.
At.68193.

3D structure databases

ProteinModelPortali Q9LUI3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT3G22780.1-P.

Proteomic databases

PRIDEi Q9LUI3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G22780.1 ; AT3G22780.1 ; AT3G22780 .
GeneIDi 821849.
KEGGi ath:AT3G22780.

Organism-specific databases

TAIRi AT3G22780.

Phylogenomic databases

eggNOGi NOG258818.
HOGENOMi HOG000084455.
InParanoidi Q9LUI3.
OMAi LVIMESK.
PhylomeDBi Q9LUI3.

Gene expression databases

Genevestigatori Q9LUI3.

Family and domain databases

InterProi IPR005172. CRC.
IPR028307. Lin-54_fam.
[Graphical view ]
PANTHERi PTHR12446. PTHR12446. 1 hit.
Pfami PF03638. TCR. 2 hits.
[Graphical view ]
PROSITEi PS51634. CRC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of meristem organization and cell division by TSO1, an Arabidopsis gene with cysteine-rich repeats."
    Song J.Y., Leung T., Ehler L.K., Wang C., Liu Z.
    Development 127:2207-2217(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF CYS-403, SUBCELLULAR LOCATION.
    Strain: cv. Landsberg erecta.
    Tissue: Flower.
  2. "TSO1 is a novel protein that modulates cytokinesis and cell expansion in Arabidopsis."
    Hauser B.A., He J.Q., Park S.O., Gasser C.S.
    Development 127:2219-2226(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF CYS-501, SUBCELLULAR LOCATION.
    Strain: cv. Landsberg erecta.
  3. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 160-695.
    Strain: cv. Columbia.
  6. "TSO1 functions in cell division during Arabidopsis flower development."
    Liu Z., Running M.P., Meyerowitz E.M.
    Development 124:665-672(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Arabidopsis TSO1 regulates directional processes in cells during floral organogenesis."
    Hauser B.A., Villanueva J.M., Gasser C.S.
    Genetics 150:411-423(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  8. "The conserved cysteine-rich domain of a tesmin/TSO1-like protein binds zinc in vitro and TSO1 is required for both male and female fertility in Arabidopsis thaliana."
    Andersen S.U., Algreen-Petersen R.G., Hoedl M., Jurkiewicz A., Cvitanich C., Braunschweig U., Schauser L., Oh S.A., Twell D., Jensen E.O.
    J. Exp. Bot. 58:3657-3670(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE, ZINC-BINDING, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  9. "Recessive antimorphic alleles overcome functionally redundant loci to reveal TSO1 function in Arabidopsis flowers and meristems."
    Sijacic P., Wang W., Liu Z.
    PLoS Genet. 7:E1002352-E1002352(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTSO1_ARATH
AccessioniPrimary (citable) accession number: Q9LUI3
Secondary accession number(s): Q8H1Q0, Q94AI2, Q9LE32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3