Reviewed,
UniProtKB/Swiss-Prot Q9LUD9 (GGPP3_ARATH)
Last modified
February 9, 2010.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Geranylgeranyl pyrophosphate synthetase 3, chloroplastic Short name=GGPP synthetase 3 Short name=GGPS3 Including the following 3 domains: 1- Recommended name: Dimethylallyltranstransferase EC=2.5.1.1 2- Recommended name: Geranyltranstransferase EC=2.5.1.10 3- Recommended name: Farnesyltranstransferase EC=2.5.1.29 | ||||||
| Gene names |
| ||||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 360 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. |
| Catalytic activity | Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate. Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. |
| Cofactor | Binds 3 magnesium ions per subunit By similarity. |
| Pathway | |
| Subunit structure | Monomer By similarity. |
| Subcellular location | |
| Tissue specificity | Mainly expressed in roots. Ref.5 |
| Sequence similarities | Belongs to the FPP/GGPP synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Carotenoid biosynthesis Isoprene biosynthesis |
| Cellular component | Chloroplast Plastid |
| Domain | Transit peptide |
| Ligand | Magnesium Metal-binding |
| Molecular function | Transferase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | carotenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | chloroplast Ref.5 Inferred from direct assay. Source: TAIR etioplast Ref.5Inferred from direct assay. Source: TAIR |
| Molecular function | dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC farnesyltranstransferase activity Ref.5Inferred from direct assay. Source: TAIR geranyltranstransferase activityInferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 39 | 39 | Chloroplast Potential | ||||||
| Chain | 40 – 360 | 321 | Geranylgeranyl pyrophosphate synthetase 3, chloroplastic | PRO_0000045403 | |||||
Sites | |||||||||
| Metal binding | 145 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 145 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 151 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 151 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 286 | 1 | Magnesium 3 By similarity | ||||||
| Binding site | 106 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 109 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 138 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 156 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 157 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 245 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 246 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 283 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 300 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 310 | 1 | Dimethylallyl diphosphate By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 8 | 1 | S → N in BAC42571. Ref.2 | ||||||
| Sequence conflict | 55 | 1 | G → R in AAM64496. Ref.3 | ||||||
| Sequence conflict | 209 | 1 | A → T in BAC42571. Ref.2 | ||||||
| Sequence conflict | 289 | 1 | L → P in AAM64496. Ref.3 | ||||||
| Sequence conflict | 328 | 1 | K → E in AAM64496. Ref.3 | ||||||
| Sequence conflict | 354 | 1 | Y → H in AAB67731. Ref.4 | ||||||
| Sequence conflict | 357 | 1 | C → F in AAB67731. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S. DNA Res. 7:131-135(2000) [PubMed: 10819329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [2] | "Functional annotation of a full-length Arabidopsis cDNA collection." Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K. Science 296:141-145(2002) [PubMed: 11910074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [3] | "Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Two more members of an Arabidopsis geranylgeranyl pyrophosphate synthase gene family." Scolnik P.A., Bartley G.E. Plant Gene Register PGR96-014 Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 139-360. Strain: cv. Landsberg erecta. Tissue: Flower. |
| [5] | "Five geranylgeranyl diphosphate synthases expressed in different organs are localized into three subcellular compartments in Arabidopsis." Okada K., Saito T., Nakagawa T., Kawamukai M., Kamiya Y. Plant Physiol. 122:1045-1056(2000) [PubMed: 10759500] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB023038 Genomic DNA. Translation: BAB02387.1. AK117933 mRNA. Translation: BAC42571.1. AY086932 mRNA. Translation: AAM64496.1. U44877 mRNA. Translation: AAB67731.1. |
| IPI | IPI00539630. |
| PIR | S71231. |
3D structure databases | |
| SMR | Q9LUD9. Positions 69-355. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9LUD9. |
Proteomic databases | |
| PRIDE | Q9LUD9. |
Genome annotation databases | |
| GenomeReviews | Gene locus AT3G14550 in contig BA000014_GR. |
| NMPDR | fig|3702.1.peg.13594. |
Organism-specific databases | |
| TAIR | At3g14550. |
Phylogenomic databases | |
| eggNOG | KOG0776. |
| HOGENOM | HBG732667. |
| InParanoid | Q9LUD9. |
| OMA | EAIHRDK. |
| PhylomeDB | Q9LUD9. |
Enzyme and pathway databases | |
| BRENDA | 2.5.1.1. 302. 2.5.1.10. 302. 2.5.1.29. 302. |
Gene expression databases | |
| Genevestigator | Q9LUD9. |
| GermOnline | AT3G14550. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view] |
| Gene3D | G3DSA:1.10.600.10. Terpenoid_synth. 1 hit. |
| PANTHER | PTHR12001. Polyprenyl_synt. 1 hit. |
| Pfam | PF00348. polyprenyl_synt. 1 hit. [Graphical view] |
| PROSITE | PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GGPP3_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q9LUD9 Secondary accession number(s): Q38918, Q8GY09, Q8LBX9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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