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Q9LUD9 (GGPP3_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Geranylgeranyl pyrophosphate synthase 3, chloroplastic
Short name=GGPP synthase 3
Short name=GGPS3
Alternative name(s):
(2E,6E)-farnesyl diphosphate synthase 3
Dimethylallyltranstransferase 3
EC=2.5.1.1
Farnesyl diphosphate synthase 3
Farnesyltranstransferase 3
EC=2.5.1.29
Geranyltranstransferase 3
EC=2.5.1.10
Gene names
Name:GGPP3
Ordered Locus Names:At3g14550
ORF Names:MIE1.5
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.

Catalytic activity

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.

(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Pathway

Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.

Subunit structure

Monomer By similarity.

Subcellular location

Plastid › chloroplast Ref.5.

Tissue specificity

Mainly expressed in roots. Ref.5

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3939Chloroplast Potential
Chain40 – 360321Geranylgeranyl pyrophosphate synthase 3, chloroplastic
PRO_0000045403

Sites

Metal binding1451Magnesium 1 By similarity
Metal binding1451Magnesium 2 By similarity
Metal binding1511Magnesium 1 By similarity
Metal binding1511Magnesium 2 By similarity
Metal binding2861Magnesium 3 By similarity
Binding site1061Isopentenyl diphosphate By similarity
Binding site1091Isopentenyl diphosphate By similarity
Binding site1381Isopentenyl diphosphate By similarity
Binding site1561Dimethylallyl diphosphate By similarity
Binding site1571Isopentenyl diphosphate By similarity
Binding site2451Dimethylallyl diphosphate By similarity
Binding site2461Dimethylallyl diphosphate By similarity
Binding site2831Dimethylallyl diphosphate By similarity
Binding site3001Dimethylallyl diphosphate By similarity
Binding site3101Dimethylallyl diphosphate By similarity

Experimental info

Sequence conflict81S → N in BAC42571. Ref.2
Sequence conflict551G → R in AAM64496. Ref.3
Sequence conflict2091A → T in BAC42571. Ref.2
Sequence conflict2891L → P in AAM64496. Ref.3
Sequence conflict3281K → E in AAM64496. Ref.3
Sequence conflict3541Y → H in AAB67731. Ref.4
Sequence conflict3571C → F in AAB67731. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9LUD9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: FDB5244FCBBB2742

FASTA36038,844
        10         20         30         40         50         60 
MATTVHLSSF SLFIQSRGRR DNSISSVKSL KKRTGLSPSS ALTSQGGRDM IPPEGKCNDH 

        70         80         90        100        110        120 
NSAFDFKLYM IRKAESVNAA LDVSVPLREP LTVQEAVRYS LLAGGKRVRP LLCIAVCELV 

       130        140        150        160        170        180 
GGDEATAMSA ACAVEMIHTS SLIHDDLPCM DNADLRRGKP TNHKVYGEDM AVLAGDALLA 

       190        200        210        220        230        240 
LAFEHMTVVS SGLVAPERMI RAVVELARAI GTTGLVAGQM IDLASERLNP DKVGLEHLEF 

       250        260        270        280        290        300 
IHLHKTAALL EAAAVLGVIM GGGTEEEIEK LRKYARCIGL LFQVVDDILD VTKSTEELGK 

       310        320        330        340        350        360 
TAGKDVMAGK LTYPRLIGLE RSKEVAEKLR REAEEQLLGF DPSKAAPLVA LASYIACRHN

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
DNA Res. 7:131-135(2000) [PubMed: 10819329] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]"Functional annotation of a full-length Arabidopsis cDNA collection."
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K.
Science 296:141-145(2002) [PubMed: 11910074] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[3]"Full-length cDNA from Arabidopsis thaliana."
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Two more members of an Arabidopsis geranylgeranyl pyrophosphate synthase gene family."
Scolnik P.A., Bartley G.E.
Plant Gene Register PGR96-014
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 139-360.
Strain: cv. Landsberg erecta.
Tissue: Flower.
[5]"Five geranylgeranyl diphosphate synthases expressed in different organs are localized into three subcellular compartments in Arabidopsis."
Okada K., Saito T., Nakagawa T., Kawamukai M., Kamiya Y.
Plant Physiol. 122:1045-1056(2000) [PubMed: 10759500] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB023038 Genomic DNA. Translation: BAB02387.1.
AK117933 mRNA. Translation: BAC42571.1.
AY086932 mRNA. Translation: AAM64496.1.
U44877 mRNA. Translation: AAB67731.1.
IPIIPI00539630.
PIRS71231.

3D structure databases

ProteinModelPortalQ9LUD9.
SMRQ9LUD9. Positions 69-355.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9LUD9.

Proteomic databases

PRIDEQ9LUD9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GenomeReviewsGene locus AT3G14550 in contig BA000014_GR.
NMPDRfig|3702.1.peg.13594.

Organism-specific databases

TAIRAt3g14550.

Phylogenomic databases

eggNOGKOG0776.
GeneTreeEPGT00070000028421.
HOGENOMHBG732667.
InParanoidQ9LUD9.
OMAANTETHG.
PhylomeDBQ9LUD9.

Gene expression databases

GenevestigatorQ9LUD9.
GermOnlineAT3G14550. Arabidopsis thaliana.

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. Terpenoid_synth. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGGPP3_ARATH
AccessionPrimary (citable) accession number: Q9LUD9
Secondary accession number(s): Q38918, Q8GY09, Q8LBX9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2000
Last modified: November 16, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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