Geranylgeranyl pyrophosphate synthetase 3, chloroplastic precursor

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Reviewed, UniProtKB/Swiss-Prot Q9LUD9 (GGPP3_ARATH)

Last modified June 16, 2009. Version 48. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Geranylgeranyl pyrophosphate synthetase 3, chloroplastic
      Short name=GGPP synthetase 3
      Short name=GGPS3
Including the following 3 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10
    3- Recommended name:
            Farnesyltranstransferase
              EC=2.5.1.29

Gene names

Name:	GGPP3
Ordered Locus Names:	At3g14550
ORF Names:	MIE1.5

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

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Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.
Catalytic activity	Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate. Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Pathway	Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranylgeranyl-PP biosynthesis; geranylgeranyl-PP from farnesyl-PP and isopentenyl-PP: step 1/1.
Subunit structure	Monomer By similarity.
Subcellular location	Plastid › chloroplast. Ref.5
Tissue specificity	Mainly expressed in roots. Ref.5
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

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Ontologies

Keywords
Biological process	Carotenoid biosynthesis Isoprene biosynthesis
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Molecular function	Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	carotenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC farnesyltranstransferase activity Inferred from electronic annotation. Source: EC geranyltranstransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 39

Chloroplast Potential

Chain

40 – 360

321

Geranylgeranyl pyrophosphate synthetase 3, chloroplastic

PRO_0000045403

Experimental info

Sequence conflict

S → N in BAC42571. Ref.2

Sequence conflict

G → R in AAM64496. Ref.3

Sequence conflict

209

A → T in BAC42571. Ref.2

Sequence conflict

289

L → P in AAM64496. Ref.3

Sequence conflict

328

K → E in AAM64496. Ref.3

Sequence conflict

354

Y → H in AAB67731. Ref.4

Sequence conflict

357

C → F in AAB67731. Ref.4

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9LUD9-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: FDB5244FCBBB2742
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FASTA

360

38,844

        10         20         30         40         50         60 
MATTVHLSSF SLFIQSRGRR DNSISSVKSL KKRTGLSPSS ALTSQGGRDM IPPEGKCNDH 

        70         80         90        100        110        120 
NSAFDFKLYM IRKAESVNAA LDVSVPLREP LTVQEAVRYS LLAGGKRVRP LLCIAVCELV 

       130        140        150        160        170        180 
GGDEATAMSA ACAVEMIHTS SLIHDDLPCM DNADLRRGKP TNHKVYGEDM AVLAGDALLA 

       190        200        210        220        230        240 
LAFEHMTVVS SGLVAPERMI RAVVELARAI GTTGLVAGQM IDLASERLNP DKVGLEHLEF 

       250        260        270        280        290        300 
IHLHKTAALL EAAAVLGVIM GGGTEEEIEK LRKYARCIGL LFQVVDDILD VTKSTEELGK 

       310        320        330        340        350        360 
TAGKDVMAGK LTYPRLIGLE RSKEVAEKLR REAEEQLLGF DPSKAAPLVA LASYIACRHN

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S. DNA Res. 7:131-135(2000) [PubMed: 10819329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Functional annotation of a full-length Arabidopsis cDNA collection." Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K. Science 296:141-145(2002) [PubMed: 11910074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[3]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Two more members of an Arabidopsis geranylgeranyl pyrophosphate synthase gene family." Scolnik P.A., Bartley G.E. Plant Gene Register PGR96-014 Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 139-360. Strain: cv. Landsberg erecta. Tissue: Flower.
[5]	"Five geranylgeranyl diphosphate synthases expressed in different organs are localized into three subcellular compartments in Arabidopsis." Okada K., Saito T., Nakagawa T., Kawamukai M., Kamiya Y. Plant Physiol. 122:1045-1056(2000) [PubMed: 10759500] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

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Cross-references

Sequence databases
	AB023038 Genomic DNA. Translation: BAB02387.1. AK117933 mRNA. Translation: BAC42571.1. AY086932 mRNA. Translation: AAM64496.1. U44877 mRNA. Translation: AAB67731.1.
IPI	IPI00539630.
PIR	S71231.
3D structure databases
SMR	Q9LUD9. Positions 69-355.
ModBase	Search...
Proteomic databases
PRIDE	Q9LUD9.
Genome annotation databases
GenomeReviews	Gene locus AT3G14550 in contig BA000014_GR.
NMPDR	fig\|3702.1.peg.13594.
Organism-specific databases
TAIR	At3g14550.
Phylogenomic databases
OMA	Q9LUD9. EAIHRDK.
Enzyme and pathway databases
BRENDA	2.5.1.1. 302. 2.5.1.10. 302. 2.5.1.29. 302.
Gene expression databases
GermOnline	AT3G14550. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHER	PTHR12001. Polyprenyl_synt. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

GGPP3_ARATH

Accession

Primary (citable) accession number: Q9LUD9
Secondary accession number(s): Q38918, Q8GY09, Q8LBX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)

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Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents