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Protein

Mitogen-activated protein kinase 19

Gene

MPK19

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541ATPPROSITE-ProRule annotation
Active sitei151 – 1511Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 399ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase activity Source: TAIR

GO - Biological processi

  • MAPK cascade Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G14720-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 19 (EC:2.7.11.24)
Short name:
AtMPK19
Short name:
MAP kinase 19
Gene namesi
Name:MPK19
Ordered Locus Names:At3g14720
ORF Names:MIE1.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G14720.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: GOC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598Mitogen-activated protein kinase 19PRO_0000245819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei187 – 1871PhosphothreonineBy similarity
Modified residuei189 – 1891PhosphotyrosineBy similarity
Modified residuei192 – 1921PhosphothreonineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-187 and Tyr-189, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LUC3.
PRIDEiQ9LUC3.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G14720.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LUC3.
SMRiQ9LUC3. Positions 1-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 316292Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi187 – 1893TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ9LUC3.
OMAiEPSRNGV.
PhylomeDBiQ9LUC3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LUC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKTQEKKNM KEMEFFTEYG DANRYRILEV IGKGSYGVVC AAIDTQTGEK
60 70 80 90 100
VAIKKINDVF EHVSDALRIL REVKLLRLLR HPDIVEIKSI MLPPSKREFK
110 120 130 140 150
DIYVVFELME SDLHQVIKAN DDLTREHHQF FLYQMLRALK YMHTANVYHR
160 170 180 190 200
DLKPKNILAN ANCKLKVCDF GLARVSFNDT PTTVFWTDYV ATRWYRAPEL
210 220 230 240 250
CGSFCSKYTP AIDIWSIGCI FAEVLTGKPL FPGKSVVHQL DLITDLLGTP
260 270 280 290 300
KSETIAGVRN EKARKYLNEM RKKNLVPFSQ KFPNADPLAL RLLQRLLAFD
310 320 330 340 350
PKDRPTAAEA LADPYFKCLA KVEREPSCQP ISKMEFEFER RRLTKDDIRE
360 370 380 390 400
LIYREILEYH PQLLKDYMNS EGSSFLYPSA IGHLRKQFAY LEENSGKSGP
410 420 430 440 450
VIPPDRKHAS LPRSAVHSSA VNSNAQPSLN ASDSRRVSIE PSRNGVVPST
460 470 480 490 500
SAYSTKPLGP PPRVPSGKPG RVVESSVTYE NDRNLKESSY DARTSYYRST
510 520 530 540 550
VLPPQTVSPN CYFLPNTMNQ EKRSGTEAAS QPKPQFVPTQ CNSAKPAELN
560 570 580 590
PNPYVQSQHK VGIDAKLLHA QSQYGPAGAA AVAVAAHRNI GAVGYGMS
Length:598
Mass (Da):67,408
Last modified:October 14, 2008 - v2
Checksum:i32C11D790A966F85
GO

Sequence cautioni

The sequence BAB02403.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023038 Genomic DNA. Translation: BAB02403.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75559.1.
BX824157 mRNA. No translation available.
RefSeqiNP_188090.2. NM_112333.3.
UniGeneiAt.8069.

Genome annotation databases

EnsemblPlantsiAT3G14720.1; AT3G14720.1; AT3G14720.
GeneIDi820700.
KEGGiath:AT3G14720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023038 Genomic DNA. Translation: BAB02403.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75559.1.
BX824157 mRNA. No translation available.
RefSeqiNP_188090.2. NM_112333.3.
UniGeneiAt.8069.

3D structure databases

ProteinModelPortaliQ9LUC3.
SMRiQ9LUC3. Positions 1-362.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G14720.1.

Proteomic databases

PaxDbiQ9LUC3.
PRIDEiQ9LUC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G14720.1; AT3G14720.1; AT3G14720.
GeneIDi820700.
KEGGiath:AT3G14720.

Organism-specific databases

GeneFarmi834. 89.
TAIRiAT3G14720.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ9LUC3.
OMAiEPSRNGV.
PhylomeDBiQ9LUC3.

Enzyme and pathway databases

BioCyciARA:AT3G14720-MONOMER.

Miscellaneous databases

PROiQ9LUC3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
    Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
    Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 518-598.
    Strain: cv. Columbia.
  4. "Mitogen-activated protein kinase cascades in plants: a new nomenclature."
    MAPK group
    Trends Plant Sci. 7:301-308(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. Cited for: GENE FAMILY.

Entry informationi

Entry nameiMPK19_ARATH
AccessioniPrimary (citable) accession number: Q9LUC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 14, 2008
Last modified: July 22, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.