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Q9LUC3

- MPK19_ARATH

UniProt

Q9LUC3 - MPK19_ARATH

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Protein
Mitogen-activated protein kinase 19
Gene
MPK19, At3g14720, MIE1.22
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541ATP By similarity
Active sitei151 – 1511Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 399ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: TAIR
Complete GO annotation...

GO - Biological processi

  1. MAPK cascade Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G14720-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 19 (EC:2.7.11.24)
Short name:
AtMPK19
Short name:
MAP kinase 19
Gene namesi
Name:MPK19
Ordered Locus Names:At3g14720
ORF Names:MIE1.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G14720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598Mitogen-activated protein kinase 19
PRO_0000245819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei187 – 1871Phosphothreonine By similarity
Modified residuei189 – 1891Phosphotyrosine By similarity
Modified residuei192 – 1921Phosphothreonine By similarity

Post-translational modificationi

Dually phosphorylated on Thr-187 and Tyr-189, which activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LUC3.
PRIDEiQ9LUC3.

Expressioni

Gene expression databases

GenevestigatoriQ9LUC3.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G14720.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LUC3.
SMRiQ9LUC3. Positions 1-362.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 316292Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi187 – 1893TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ9LUC3.
OMAiVPSTSAY.
PhylomeDBiQ9LUC3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LUC3-1 [UniParc]FASTAAdd to Basket

« Hide

MQKTQEKKNM KEMEFFTEYG DANRYRILEV IGKGSYGVVC AAIDTQTGEK    50
VAIKKINDVF EHVSDALRIL REVKLLRLLR HPDIVEIKSI MLPPSKREFK 100
DIYVVFELME SDLHQVIKAN DDLTREHHQF FLYQMLRALK YMHTANVYHR 150
DLKPKNILAN ANCKLKVCDF GLARVSFNDT PTTVFWTDYV ATRWYRAPEL 200
CGSFCSKYTP AIDIWSIGCI FAEVLTGKPL FPGKSVVHQL DLITDLLGTP 250
KSETIAGVRN EKARKYLNEM RKKNLVPFSQ KFPNADPLAL RLLQRLLAFD 300
PKDRPTAAEA LADPYFKCLA KVEREPSCQP ISKMEFEFER RRLTKDDIRE 350
LIYREILEYH PQLLKDYMNS EGSSFLYPSA IGHLRKQFAY LEENSGKSGP 400
VIPPDRKHAS LPRSAVHSSA VNSNAQPSLN ASDSRRVSIE PSRNGVVPST 450
SAYSTKPLGP PPRVPSGKPG RVVESSVTYE NDRNLKESSY DARTSYYRST 500
VLPPQTVSPN CYFLPNTMNQ EKRSGTEAAS QPKPQFVPTQ CNSAKPAELN 550
PNPYVQSQHK VGIDAKLLHA QSQYGPAGAA AVAVAAHRNI GAVGYGMS 598
Length:598
Mass (Da):67,408
Last modified:October 14, 2008 - v2
Checksum:i32C11D790A966F85
GO

Sequence cautioni

The sequence BAB02403.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023038 Genomic DNA. Translation: BAB02403.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75559.1.
BX824157 mRNA. No translation available.
RefSeqiNP_188090.2. NM_112333.3.
UniGeneiAt.8069.

Genome annotation databases

EnsemblPlantsiAT3G14720.1; AT3G14720.1; AT3G14720.
GeneIDi820700.
KEGGiath:AT3G14720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023038 Genomic DNA. Translation: BAB02403.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE75559.1 .
BX824157 mRNA. No translation available.
RefSeqi NP_188090.2. NM_112333.3.
UniGenei At.8069.

3D structure databases

ProteinModelPortali Q9LUC3.
SMRi Q9LUC3. Positions 1-362.
ModBasei Search...

Protein-protein interaction databases

STRINGi 3702.AT3G14720.1-P.

Proteomic databases

PaxDbi Q9LUC3.
PRIDEi Q9LUC3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G14720.1 ; AT3G14720.1 ; AT3G14720 .
GeneIDi 820700.
KEGGi ath:AT3G14720.

Organism-specific databases

GeneFarmi 834. 89.
TAIRi AT3G14720.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q9LUC3.
OMAi VPSTSAY.
PhylomeDBi Q9LUC3.

Enzyme and pathway databases

BioCyci ARA:AT3G14720-MONOMER.

Gene expression databases

Genevestigatori Q9LUC3.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
    Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
    Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 518-598.
    Strain: cv. Columbia.
  4. "Mitogen-activated protein kinase cascades in plants: a new nomenclature."
    MAPK group
    Trends Plant Sci. 7:301-308(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. Cited for: GENE FAMILY.

Entry informationi

Entry nameiMPK19_ARATH
AccessioniPrimary (citable) accession number: Q9LUC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 14, 2008
Last modified: June 11, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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