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Protein

Mitogen-activated protein kinase 19

Gene

MPK19

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPPROSITE-ProRule annotation1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 39ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase activity Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 19 (EC:2.7.11.24)
Short name:
AtMPK19
Short name:
MAP kinase 19
Gene namesi
Name:MPK19
Ordered Locus Names:At3g14720
ORF Names:MIE1.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G14720.
TAIRilocus:2089576. AT3G14720.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002458191 – 598Mitogen-activated protein kinase 19Add BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei187PhosphothreonineBy similarity1
Modified residuei189PhosphotyrosineBy similarity1
Modified residuei192PhosphothreonineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-187 and Tyr-189, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LUC3.

Expressioni

Gene expression databases

ExpressionAtlasiQ9LUC3. baseline and differential.
GenevisibleiQ9LUC3. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G14720.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LUC3.
SMRiQ9LUC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 316Protein kinasePROSITE-ProRule annotationAdd BLAST292

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi187 – 189TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660. Eukaryota.
ENOG410XNY0. LUCA.
HOGENOMiHOG000233024.
InParanoidiQ9LUC3.
OMAiQTVSPNC.
OrthoDBiEOG093605CF.
PhylomeDBiQ9LUC3.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9LUC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKTQEKKNM KEMEFFTEYG DANRYRILEV IGKGSYGVVC AAIDTQTGEK
60 70 80 90 100
VAIKKINDVF EHVSDALRIL REVKLLRLLR HPDIVEIKSI MLPPSKREFK
110 120 130 140 150
DIYVVFELME SDLHQVIKAN DDLTREHHQF FLYQMLRALK YMHTANVYHR
160 170 180 190 200
DLKPKNILAN ANCKLKVCDF GLARVSFNDT PTTVFWTDYV ATRWYRAPEL
210 220 230 240 250
CGSFCSKYTP AIDIWSIGCI FAEVLTGKPL FPGKSVVHQL DLITDLLGTP
260 270 280 290 300
KSETIAGVRN EKARKYLNEM RKKNLVPFSQ KFPNADPLAL RLLQRLLAFD
310 320 330 340 350
PKDRPTAAEA LADPYFKCLA KVEREPSCQP ISKMEFEFER RRLTKDDIRE
360 370 380 390 400
LIYREILEYH PQLLKDYMNS EGSSFLYPSA IGHLRKQFAY LEENSGKSGP
410 420 430 440 450
VIPPDRKHAS LPRSAVHSSA VNSNAQPSLN ASDSRRVSIE PSRNGVVPST
460 470 480 490 500
SAYSTKPLGP PPRVPSGKPG RVVESSVTYE NDRNLKESSY DARTSYYRST
510 520 530 540 550
VLPPQTVSPN CYFLPNTMNQ EKRSGTEAAS QPKPQFVPTQ CNSAKPAELN
560 570 580 590
PNPYVQSQHK VGIDAKLLHA QSQYGPAGAA AVAVAAHRNI GAVGYGMS
Length:598
Mass (Da):67,408
Last modified:October 14, 2008 - v2
Checksum:i32C11D790A966F85
GO

Sequence cautioni

The sequence BAB02403 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023038 Genomic DNA. Translation: BAB02403.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75559.1.
BX824157 mRNA. No translation available.
RefSeqiNP_188090.2. NM_112333.3.
UniGeneiAt.8069.

Genome annotation databases

EnsemblPlantsiAT3G14720.1; AT3G14720.1; AT3G14720.
GeneIDi820700.
GrameneiAT3G14720.1; AT3G14720.1; AT3G14720.
KEGGiath:AT3G14720.

Similar proteinsi

Entry informationi

Entry nameiMPK19_ARATH
AccessioniPrimary (citable) accession number: Q9LUC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 14, 2008
Last modified: September 27, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families