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Q9LUC3 (MPK19_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase 19

Short name=AtMPK19
Short name=MAP kinase 19
EC=2.7.11.24
Gene names
Name:MPK19
Ordered Locus Names:At3g14720
ORF Names:MIE1.22
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length598 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Activated by threonine and tyrosine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-187 and Tyr-189, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAB02403.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 598598Mitogen-activated protein kinase 19
PRO_0000245819

Regions

Domain25 – 316292Protein kinase
Nucleotide binding31 – 399ATP By similarity
Motif187 – 1893TXY

Sites

Active site1511Proton acceptor By similarity
Binding site541ATP By similarity

Amino acid modifications

Modified residue1871Phosphothreonine By similarity
Modified residue1891Phosphotyrosine By similarity
Modified residue1921Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9LUC3 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: 32C11D790A966F85

FASTA59867,408
        10         20         30         40         50         60 
MQKTQEKKNM KEMEFFTEYG DANRYRILEV IGKGSYGVVC AAIDTQTGEK VAIKKINDVF 

        70         80         90        100        110        120 
EHVSDALRIL REVKLLRLLR HPDIVEIKSI MLPPSKREFK DIYVVFELME SDLHQVIKAN 

       130        140        150        160        170        180 
DDLTREHHQF FLYQMLRALK YMHTANVYHR DLKPKNILAN ANCKLKVCDF GLARVSFNDT 

       190        200        210        220        230        240 
PTTVFWTDYV ATRWYRAPEL CGSFCSKYTP AIDIWSIGCI FAEVLTGKPL FPGKSVVHQL 

       250        260        270        280        290        300 
DLITDLLGTP KSETIAGVRN EKARKYLNEM RKKNLVPFSQ KFPNADPLAL RLLQRLLAFD 

       310        320        330        340        350        360 
PKDRPTAAEA LADPYFKCLA KVEREPSCQP ISKMEFEFER RRLTKDDIRE LIYREILEYH 

       370        380        390        400        410        420 
PQLLKDYMNS EGSSFLYPSA IGHLRKQFAY LEENSGKSGP VIPPDRKHAS LPRSAVHSSA 

       430        440        450        460        470        480 
VNSNAQPSLN ASDSRRVSIE PSRNGVVPST SAYSTKPLGP PPRVPSGKPG RVVESSVTYE 

       490        500        510        520        530        540 
NDRNLKESSY DARTSYYRST VLPPQTVSPN CYFLPNTMNQ EKRSGTEAAS QPKPQFVPTQ 

       550        560        570        580        590 
CNSAKPAELN PNPYVQSQHK VGIDAKLLHA QSQYGPAGAA AVAVAAHRNI GAVGYGMS 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 518-598.
Strain: cv. Columbia.
[4]"Mitogen-activated protein kinase cascades in plants: a new nomenclature."
MAPK group
Trends Plant Sci. 7:301-308(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[5]"Ancient signals: comparative genomics of plant MAPK and MAPKK gene families."
Hamel L.P., Nicole M.C., Sritubtim S., Morency M.J., Ellis M., Ehlting J., Beaudoin N., Barbazuk B., Klessig D., Lee J., Martin G., Mundy J., Ohashi Y., Scheel D., Sheen J., Xing T., Zhang S., Seguin A., Ellis B.E.
Trends Plant Sci. 11:192-198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB023038 Genomic DNA. Translation: BAB02403.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75559.1.
BX824157 mRNA. No translation available.
RefSeqNP_188090.2. NM_112333.3.
UniGeneAt.8069.

3D structure databases

ProteinModelPortalQ9LUC3.
SMRQ9LUC3. Positions 1-362.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT3G14720.1-P.

Proteomic databases

PaxDbQ9LUC3.
PRIDEQ9LUC3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G14720.1; AT3G14720.1; AT3G14720.
GeneID820700.
KEGGath:AT3G14720.

Organism-specific databases

GeneFarm834. 89.
TAIRAT3G14720.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
InParanoidQ9LUC3.
OMAVPSTSAY.
PhylomeDBQ9LUC3.

Enzyme and pathway databases

BioCycARA:AT3G14720-MONOMER.

Gene expression databases

GenevestigatorQ9LUC3.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPK19_ARATH
AccessionPrimary (citable) accession number: Q9LUC3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 14, 2008
Last modified: June 11, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names