Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9LUC3

- MPK19_ARATH

UniProt

Q9LUC3 - MPK19_ARATH

Protein

Mitogen-activated protein kinase 19

Gene

MPK19

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei54 – 541ATPPROSITE-ProRule annotation
    Active sitei151 – 1511Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi31 – 399ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: TAIR

    GO - Biological processi

    1. MAPK cascade Source: GOC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT3G14720-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 19 (EC:2.7.11.24)
    Short name:
    AtMPK19
    Short name:
    MAP kinase 19
    Gene namesi
    Name:MPK19
    Ordered Locus Names:At3g14720
    ORF Names:MIE1.22
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G14720.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 598598Mitogen-activated protein kinase 19PRO_0000245819Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei187 – 1871PhosphothreonineBy similarity
    Modified residuei189 – 1891PhosphotyrosineBy similarity
    Modified residuei192 – 1921PhosphothreonineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-187 and Tyr-189, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9LUC3.
    PRIDEiQ9LUC3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9LUC3.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT3G14720.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LUC3.
    SMRiQ9LUC3. Positions 1-362.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 316292Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi187 – 1893TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    InParanoidiQ9LUC3.
    OMAiVPSTSAY.
    PhylomeDBiQ9LUC3.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9LUC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKTQEKKNM KEMEFFTEYG DANRYRILEV IGKGSYGVVC AAIDTQTGEK    50
    VAIKKINDVF EHVSDALRIL REVKLLRLLR HPDIVEIKSI MLPPSKREFK 100
    DIYVVFELME SDLHQVIKAN DDLTREHHQF FLYQMLRALK YMHTANVYHR 150
    DLKPKNILAN ANCKLKVCDF GLARVSFNDT PTTVFWTDYV ATRWYRAPEL 200
    CGSFCSKYTP AIDIWSIGCI FAEVLTGKPL FPGKSVVHQL DLITDLLGTP 250
    KSETIAGVRN EKARKYLNEM RKKNLVPFSQ KFPNADPLAL RLLQRLLAFD 300
    PKDRPTAAEA LADPYFKCLA KVEREPSCQP ISKMEFEFER RRLTKDDIRE 350
    LIYREILEYH PQLLKDYMNS EGSSFLYPSA IGHLRKQFAY LEENSGKSGP 400
    VIPPDRKHAS LPRSAVHSSA VNSNAQPSLN ASDSRRVSIE PSRNGVVPST 450
    SAYSTKPLGP PPRVPSGKPG RVVESSVTYE NDRNLKESSY DARTSYYRST 500
    VLPPQTVSPN CYFLPNTMNQ EKRSGTEAAS QPKPQFVPTQ CNSAKPAELN 550
    PNPYVQSQHK VGIDAKLLHA QSQYGPAGAA AVAVAAHRNI GAVGYGMS 598
    Length:598
    Mass (Da):67,408
    Last modified:October 14, 2008 - v2
    Checksum:i32C11D790A966F85
    GO

    Sequence cautioni

    The sequence BAB02403.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023038 Genomic DNA. Translation: BAB02403.1. Sequence problems.
    CP002686 Genomic DNA. Translation: AEE75559.1.
    BX824157 mRNA. No translation available.
    RefSeqiNP_188090.2. NM_112333.3.
    UniGeneiAt.8069.

    Genome annotation databases

    EnsemblPlantsiAT3G14720.1; AT3G14720.1; AT3G14720.
    GeneIDi820700.
    KEGGiath:AT3G14720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023038 Genomic DNA. Translation: BAB02403.1 . Sequence problems.
    CP002686 Genomic DNA. Translation: AEE75559.1 .
    BX824157 mRNA. No translation available.
    RefSeqi NP_188090.2. NM_112333.3.
    UniGenei At.8069.

    3D structure databases

    ProteinModelPortali Q9LUC3.
    SMRi Q9LUC3. Positions 1-362.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT3G14720.1-P.

    Proteomic databases

    PaxDbi Q9LUC3.
    PRIDEi Q9LUC3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G14720.1 ; AT3G14720.1 ; AT3G14720 .
    GeneIDi 820700.
    KEGGi ath:AT3G14720.

    Organism-specific databases

    GeneFarmi 834. 89.
    TAIRi AT3G14720.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    InParanoidi Q9LUC3.
    OMAi VPSTSAY.
    PhylomeDBi Q9LUC3.

    Enzyme and pathway databases

    BioCyci ARA:AT3G14720-MONOMER.

    Gene expression databases

    Genevestigatori Q9LUC3.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
      DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
      Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
      Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 518-598.
      Strain: cv. Columbia.
    4. "Mitogen-activated protein kinase cascades in plants: a new nomenclature."
      MAPK group
      Trends Plant Sci. 7:301-308(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    5. Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiMPK19_ARATH
    AccessioniPrimary (citable) accession number: Q9LUC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3