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Q9LUC3

- MPK19_ARATH

UniProt

Q9LUC3 - MPK19_ARATH

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Protein

Mitogen-activated protein kinase 19

Gene

MPK19

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541ATPPROSITE-ProRule annotation
Active sitei151 – 1511Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 399ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: TAIR

GO - Biological processi

  1. MAPK cascade Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G14720-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 19 (EC:2.7.11.24)
Short name:
AtMPK19
Short name:
MAP kinase 19
Gene namesi
Name:MPK19
Ordered Locus Names:At3g14720
ORF Names:MIE1.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G14720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598Mitogen-activated protein kinase 19PRO_0000245819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei187 – 1871PhosphothreonineBy similarity
Modified residuei189 – 1891PhosphotyrosineBy similarity
Modified residuei192 – 1921PhosphothreonineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-187 and Tyr-189, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LUC3.
PRIDEiQ9LUC3.

Expressioni

Gene expression databases

GenevestigatoriQ9LUC3.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G14720.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LUC3.
SMRiQ9LUC3. Positions 1-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 316292Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi187 – 1893TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ9LUC3.
OMAiVPSTSAY.
PhylomeDBiQ9LUC3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LUC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKTQEKKNM KEMEFFTEYG DANRYRILEV IGKGSYGVVC AAIDTQTGEK
60 70 80 90 100
VAIKKINDVF EHVSDALRIL REVKLLRLLR HPDIVEIKSI MLPPSKREFK
110 120 130 140 150
DIYVVFELME SDLHQVIKAN DDLTREHHQF FLYQMLRALK YMHTANVYHR
160 170 180 190 200
DLKPKNILAN ANCKLKVCDF GLARVSFNDT PTTVFWTDYV ATRWYRAPEL
210 220 230 240 250
CGSFCSKYTP AIDIWSIGCI FAEVLTGKPL FPGKSVVHQL DLITDLLGTP
260 270 280 290 300
KSETIAGVRN EKARKYLNEM RKKNLVPFSQ KFPNADPLAL RLLQRLLAFD
310 320 330 340 350
PKDRPTAAEA LADPYFKCLA KVEREPSCQP ISKMEFEFER RRLTKDDIRE
360 370 380 390 400
LIYREILEYH PQLLKDYMNS EGSSFLYPSA IGHLRKQFAY LEENSGKSGP
410 420 430 440 450
VIPPDRKHAS LPRSAVHSSA VNSNAQPSLN ASDSRRVSIE PSRNGVVPST
460 470 480 490 500
SAYSTKPLGP PPRVPSGKPG RVVESSVTYE NDRNLKESSY DARTSYYRST
510 520 530 540 550
VLPPQTVSPN CYFLPNTMNQ EKRSGTEAAS QPKPQFVPTQ CNSAKPAELN
560 570 580 590
PNPYVQSQHK VGIDAKLLHA QSQYGPAGAA AVAVAAHRNI GAVGYGMS
Length:598
Mass (Da):67,408
Last modified:October 14, 2008 - v2
Checksum:i32C11D790A966F85
GO

Sequence cautioni

The sequence BAB02403.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023038 Genomic DNA. Translation: BAB02403.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE75559.1.
BX824157 mRNA. No translation available.
RefSeqiNP_188090.2. NM_112333.3.
UniGeneiAt.8069.

Genome annotation databases

EnsemblPlantsiAT3G14720.1; AT3G14720.1; AT3G14720.
GeneIDi820700.
KEGGiath:AT3G14720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB023038 Genomic DNA. Translation: BAB02403.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE75559.1 .
BX824157 mRNA. No translation available.
RefSeqi NP_188090.2. NM_112333.3.
UniGenei At.8069.

3D structure databases

ProteinModelPortali Q9LUC3.
SMRi Q9LUC3. Positions 1-361.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT3G14720.1-P.

Proteomic databases

PaxDbi Q9LUC3.
PRIDEi Q9LUC3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G14720.1 ; AT3G14720.1 ; AT3G14720 .
GeneIDi 820700.
KEGGi ath:AT3G14720.

Organism-specific databases

GeneFarmi 834. 89.
TAIRi AT3G14720.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q9LUC3.
OMAi VPSTSAY.
PhylomeDBi Q9LUC3.

Enzyme and pathway databases

BioCyci ARA:AT3G14720-MONOMER.

Gene expression databases

Genevestigatori Q9LUC3.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
    Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
    Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 518-598.
    Strain: cv. Columbia.
  4. "Mitogen-activated protein kinase cascades in plants: a new nomenclature."
    MAPK group
    Trends Plant Sci. 7:301-308(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. Cited for: GENE FAMILY.

Entry informationi

Entry nameiMPK19_ARATH
AccessioniPrimary (citable) accession number: Q9LUC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3