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Protein

Pyruvate kinase

Gene

At3g25960

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic (GAPC2), Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic (GAPC1)
  2. Phosphoglycerate kinase 3, cytosolic (PGK3)
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (At3g08590), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (PGM1)
  4. Enolase 1, chloroplastic (ENO1), Cytosolic enolase 3 (ENO3), Bifunctional enolase 2/transcriptional activator (ENO2)
  5. Pyruvate kinase (AXX17_At3g24740), Pyruvate kinase (AXX17_At5g51800), Pyruvate kinase (At5g63680), Pyruvate kinase (AXX17_At3g50280), Pyruvate kinase (AXX17_ATUG04870), Pyruvate kinase (MAH20.13), Pyruvate kinase (MCD7.8), Pyruvate kinase (At3g25960), Pyruvate kinase (F1I16_60), Pyruvate kinase (MBK5.16), Pyruvate kinase (AXX17_At3g50440), Plastidial pyruvate kinase 3, chloroplastic (PKP3), Pyruvate kinase (At5g08570), Pyruvate kinase (At3g52990), Pyruvate kinase (At5g56350), Pyruvate kinase (AXX17_At3g28070), Pyruvate kinase (AXX17_At3g47400), Pyruvate kinase (At2g36580), Pyruvate kinase, Probable pyruvate kinase, cytosolic isozyme (At4g26390), Pyruvate kinase (F8J2_160), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At3g03460), Plastidial pyruvate kinase 2 (PKP2), Pyruvate kinase (At2g36580), Pyruvate kinase (At3g04050), Pyruvate kinase (AXX17_At4g30430), Pyruvate kinase (F1I16_220), Plastidial pyruvate kinase 1, chloroplastic (PKP1), Pyruvate kinase (AXX17_At1g33230), Pyruvate kinase (At5g63680), Pyruvate kinase, Plastidial pyruvate kinase 4, chloroplastic (PKP4)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciARA:AT3G25960-MONOMER.
ReactomeiR-ATH-6798695. Neutrophil degranulation.
R-ATH-70171. Glycolysis.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Ordered Locus Names:At3g25960Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G25960.
TAIRilocus:2092085. AT3G25960.

Subcellular locationi

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G25960.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 357PKInterPro annotationAdd BLAST341
Domaini376 – 492PK_CInterPro annotationAdd BLAST117

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323. Eukaryota.
COG0469. LUCA.
HOGENOMiHOG000021559.
KOiK00873.
OrthoDBiEOG093607JW.

Family and domain databases

Gene3Di3.40.1380.20. 1 hit.
InterProiView protein in InterPro
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom_sf.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR036918. Pyrv_Knase_C_sf.
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiView protein in Pfam
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00110. PYRUVATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9LU95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMLLGGQAT NGALRSKTKI VCTLGPASRS VEMIEKLLKA GMNVARFNFS
60 70 80 90 100
HGSHSYHQET LDNLRTAMDN TGILCAVMLD TKSPVIRTGF LKEGKPIQLK
110 120 130 140 150
QGQEITISID YKIQGDSNTI SMSYKKLAED LKPGDVILCS DGTISLNVLS
160 170 180 190 200
CDKYLGLVRC RCENSALLGE RKNVNLPGIV VDLPTLTEKD KEDIMQWGVP
210 220 230 240 250
NKIDIIALSF VRKGSDLIQV RKLLGEHSKS IMLMSKVENQ EGVMNFDKIL
260 270 280 290 300
ENSDAFMVAR GDLGMEIPIE KMFLAQKTMI NKANAHGKPV VTATQMLESM
310 320 330 340 350
TVSPRPTRAE ATDVANAVLD GTDCVMLSGE TAAGAHPETA VLTMSRICKE
360 370 380 390 400
AEDFIDYDIL HKKTLGMVSL PLSPIESLAA SAVSTARSVF ASAIVVLTRG
410 420 430 440 450
GYTAELVAKY RPSVPILSVI MPEIAECSDS VAHVARRGLI YRGIIPVVGC
460 470 480 490
SARDSTEEMI RLAIGFAKTK GICKTGDSIV ALHKIDGSSI VRIVSVE
Length:497
Mass (Da):53,776
Last modified:October 1, 2000 - v1
Checksum:iA5D870163C31E8D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002686 Genomic DNA. Translation: AEE77095.1.
AB023041 Genomic DNA. Translation: BAB01059.1.
RefSeqiNP_189225.1. NM_113500.1.
UniGeneiAt.53498.

Genome annotation databases

EnsemblPlantsiAT3G25960.1; AT3G25960.1; AT3G25960.
GeneIDi822193.
GrameneiAT3G25960.1; AT3G25960.1; AT3G25960.
KEGGiath:AT3G25960.

Similar proteinsi

Entry informationi

Entry nameiQ9LU95_ARATH
AccessioniPrimary (citable) accession number: Q9LU95
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported