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Protein

Superoxide dismutase [Fe] 2, chloroplastic

Gene

FSD2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems (By similarity). Plays important role in chloroplast development, particularly in the maintenance of thylakoids membranes. Seems to act as a heterodimer with FSD3.By similarity1 Publication

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity

Enzyme regulationi

Activated by cpn20/cpn21 (in vitro).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi77IronBy similarity1
Metal bindingi129IronBy similarity1
Metal bindingi228IronBy similarity1
Metal bindingi232IronBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • superoxide dismutase activity Source: UniProtKB

GO - Biological processi

  • oxidation-reduction process Source: UniProtKB
  • response to UV Source: TAIR

Keywordsi

Molecular functionOxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:AT5G51100-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Fe] 2, chloroplastic (EC:1.15.1.1)
Alternative name(s):
Protein ALBINO OR PALE GREEN 8
Protein FE SUPEROXIDE DISMUTASE 2
Gene namesi
Name:FSD2
Synonyms:APG8
Ordered Locus Names:At5g51100
ORF Names:MWD22.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G51100
TAIRilocus:2176167 AT5G51100

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid, Thylakoid

Pathology & Biotechi

Disruption phenotypei

Pale green phenotype. Abnormal plastids, highly vacuolated and without internal membrane structures like thylakoids.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46ChloroplastSequence analysisAdd BLAST46
ChainiPRO_000042126547 – 305Superoxide dismutase [Fe] 2, chloroplasticAdd BLAST259

Proteomic databases

PaxDbiQ9LU64

PTM databases

iPTMnetiQ9LU64

Expressioni

Inductioni

By UV-B treatment. Induced by salt stress.2 Publications

Gene expression databases

ExpressionAtlasiQ9LU64 baseline and differential
GenevisibleiQ9LU64 AT

Interactioni

Subunit structurei

Heterodimer with FSD3 (PubMed:18996978). Interacts with MRL7 and PRDA1 (PubMed:24132784).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FSD3Q9FMX07EBI-4424866,EBI-4430441

Protein-protein interaction databases

BioGridi20428, 9 interactors
IntActiQ9LU64, 8 interactors
STRINGi3702.AT5G51100.1

Structurei

3D structure databases

ProteinModelPortaliQ9LU64
SMRiQ9LU64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG0876 Eukaryota
COG0605 LUCA
HOGENOMiHOG000013584
InParanoidiQ9LU64
KOiK04564
OMAiFGTGWVW
OrthoDBiEOG09360IDF
PhylomeDBiQ9LU64

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LU64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNVAVTATP SSLLYSPLLL PSQGPNRRMQ WKRNGKRRLG TKVAVSGVIT
60 70 80 90 100
AGFELKPPPY PLDALEPHMS RETLDYHWGK HHKTYVENLN KQILGTDLDA
110 120 130 140 150
LSLEEVVLLS YNKGNMLPAF NNAAQAWNHE FFWESIQPGG GGKPTGELLR
160 170 180 190 200
LIERDFGSFE EFLERFKSAA ASNFGSGWTW LAYKANRLDV ANAVNPLPKE
210 220 230 240 250
EDKKLVIVKT PNAVNPLVWD YSPLLTIDTW EHAYYLDFEN RRAEYINTFM
260 270 280 290 300
EKLVSWETVS TRLESAIARA VQREQEGTET EDEENPDDEV PEVYLDSDID

VSEVD
Length:305
Mass (Da):34,664
Last modified:October 1, 2000 - v1
Checksum:i6A68EAF701EA5AC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023044 Genomic DNA Translation: BAA97372.1
CP002688 Genomic DNA Translation: AED96034.1
BT004073 mRNA Translation: AAO42100.1
BT005116 mRNA Translation: AAO50649.1
AK228538 mRNA Translation: BAF00460.1
AY085077 mRNA Translation: AAM61633.1
Y12641 mRNA Translation: CAA73188.1
RefSeqiNP_199923.1, NM_124489.3
UniGeneiAt.212

Genome annotation databases

EnsemblPlantsiAT5G51100.1; AT5G51100.1; AT5G51100
GeneIDi835183
GrameneiAT5G51100.1; AT5G51100.1; AT5G51100
KEGGiath:AT5G51100

Similar proteinsi

Entry informationi

Entry nameiSODF2_ARATH
AccessioniPrimary (citable) accession number: Q9LU64
Secondary accession number(s): O04879
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health