Calcium-transporting ATPase 9, plasma membrane-type - Arabidopsis thaliana (Mouse-ear cress)

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Q9LU41 (ACA9_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Calcium-transporting ATPase 9, plasma membrane-type
EC=3.6.3.8

Alternative name(s):
Ca(2+)-ATPase isoform 9

Gene names

Name:	ACA9
Ordered Locus Names:	At3g21180
ORF Names:	MXL8.3

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	1086 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell or into organelles By similarity.
Catalytic activity	ATP + H₂O + Ca²⁺[side 1] = ADP + phosphate + Ca²⁺[side 2].
Enzyme regulation	Activated by calmodulin By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Domain	The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion By similarity.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]
Sequence caution	The sequence BAB01709.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Calcium Calmodulin-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro pollen development Inferred from mutant phenotype. Source: TAIR single fertilization Inferred from mutant phenotype. Source: TAIR
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay. Source: TAIR
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Inferred from direct assay. Source: TAIR calmodulin binding Inferred from direct assay. Source: TAIR metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1086

1086

Calcium-transporting ATPase 9, plasma membrane-type

PRO_0000046415

Regions

Topological domain

1 – 194

194

Cytoplasmic Potential

Transmembrane

195 – 215

Helical; Potential

Topological domain

216 – 233

Lumenal Potential

Transmembrane

234 – 254

Helical; Potential

Topological domain

255 – 382

128

Cytoplasmic Potential

Transmembrane

383 – 402

Helical; Potential

Topological domain

403 – 439

Lumenal Potential

Transmembrane

440 – 457

Helical; Potential

Topological domain

458 – 857

400

Cytoplasmic Potential

Transmembrane

858 – 876

Helical; Potential

Topological domain

877 – 887

Lumenal Potential

Transmembrane

888 – 908

Helical; Potential

Topological domain

909 – 928

Cytoplasmic Potential

Transmembrane

929 – 951

Helical; Potential

Topological domain

952 – 963

Lumenal Potential

Transmembrane

964 – 988

Helical; Potential

Topological domain

989 – 1006

Cytoplasmic Potential

Transmembrane

1007 – 1028

Helical; Potential

Topological domain

1029 – 1038

Lumenal Potential

Transmembrane

1039 – 1060

Helical; Potential

Topological domain

1061 – 1086

Cytoplasmic Potential

Region

57 – 68

Interaction with calmodulin By similarity

Sites

Active site

495

4-aspartylphosphate intermediate By similarity

Metal binding

802

Magnesium By similarity

Metal binding

806

Magnesium By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9LU41 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: EC317264EE1C3098
Show »

FASTA

1,086

118,768

        10         20         30         40         50         60 
MSTSSSNGLL LTSMSGRHDD MEAGSAKTEE HSDHEELQHD PDDPFDIDNT KNASVESLRR 

        70         80         90        100        110        120 
WRQAALVLNA SRRFRYTLDL NKEEHYDNRR RMIRAHAQVI RAALLFKLAG EQQIAFGSST 

       130        140        150        160        170        180 
PAASTGNFDI DLEKLVSMTR NQNMSNLQQY GGVKGVAEKL KSNMEQGINE DEKEVIDRKN 

       190        200        210        220        230        240 
AFGSNTYPKK KGKNFFMFLW EAWQDLTLII LIIAAVTSLA LGIKTEGLKE GWLDGGSIAF 

       250        260        270        280        290        300 
AVLLVIVVTA VSDYRQSLQF QNLNDEKRNI QLEVMRGGRT VKISIYDVVV GDVIPLRIGD 

       310        320        330        340        350        360 
QVPADGVLIS GHSLAIDESS MTGESKIVHK DQKSPFLMSG CKVADGVGNM LVTGVGINTE 

       370        380        390        400        410        420 
WGLLMASISE DTGEETPLQV RLNGLATFIG IVGLSVALVV LVALLVRYFT GTTQDTNGAT 

       430        440        450        460        470        480 
QFIKGTTSIS DIVDDCVKIF TIAVTIVVVA VPEGLPLAVT LTLAYSMRKM MADKALVRRL 

       490        500        510        520        530        540 
SACETMGSAT TICSDKTGTL TLNQMTVVET YAGGSKMDVA DNPSGLHPKL VALISEGVAQ 

       550        560        570        580        590        600 
NTTGNIFHPK DGGEVEISGS PTEKAILSWA YKLGMKFDTI RSESAIIHAF PFNSEKKRGG 

       610        620        630        640        650        660 
VAVLRGDSEV FIHWKGAAEI VLACCTQYMD SNGTLQSIES QKEFFRVAID SMAKNSLRCV 

       670        680        690        700        710        720 
AIACRTQELN QVPKEQEDLD KWALPEDELI LLAIVGIKDP CRPGVREAVR ICTSAGVKVR 

       730        740        750        760        770        780 
MVTGDNLQTA KAIALECGIL SSDTEAVEPT IIEGKVFREL SEKEREQVAK KITVMGRSSP 

       790        800        810        820        830        840 
NDKLLLVQAL RKNGDVVAVT GDGTNDAPAL HEADIGLSMG ISGTEVAKES SDIIILDDNF 

       850        860        870        880        890        900 
ASVVKVVRWG RSVYANIQKF IQFQLTVNVA ALIINVVAAM SSGDVPLKAV QLLWVNLIMD 

       910        920        930        940        950        960 
TLGALALATE PPTDHLMHRT PVGRREPLIT NIMWRNLLVQ SFYQVAVLLV LNFAGLSILG 

       970        980        990       1000       1010       1020 
LNHENHAHAV EVKNTMIFNA FVMCQIFNEF NARKPDEMNV FRGVNKNPLF VAIVGVTFIL 

      1030       1040       1050       1060       1070       1080 
QIIIVTFLGK FAHTVRLGWQ LWLASIIIGL VSWPLAIVGK LIPVPKTPMS VYFKKPFRKY 


KASRNA

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S. DNA Res. 7:131-135(2000) [PubMed: 10819329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. Shinozaki K. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB023045 Genomic DNA. Translation: BAB01709.1. Different initiation. CP002686 Genomic DNA. Translation: AEE76473.1. AK227228 mRNA. Translation: BAE99265.1.
IPI	IPI00548670.
RefSeq	NP_188755.2. NM_113013.4.
UniGene	At.38102.
3D structure databases
ProteinModelPortal	Q9LU41.
SMR	Q9LU41. Positions 152-1062.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9LU41.
Protein family/group databases
TCDB	3.A.3.2.14. P-type ATPase (P-ATPase) superfamily.
Proteomic databases
PRIDE	Q9LU41.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT3G21180.1; AT3G21180.1; AT3G21180.
GeneID	821671.
GenomeReviews	Gene locus AT3G21180 in contig BA000014_GR.
KEGG	ath:AT3G21180.
NMPDR	fig\|3702.1.peg.14351.
Organism-specific databases
TAIR	At3g21180.
Phylogenomic databases
eggNOG	KOG0204.
GeneTree	EPGT00050000008540.
HOGENOM	HBG456486.
InParanoid	Q9LU41.
OMA	LGSATEC.
PhylomeDB	Q9LU41.
ProtClustDB	CLSN2917947.
Gene expression databases
ArrayExpress	Q9LU41.
Genevestigator	Q9LU41.
GermOnline	AT3G21180. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006408. ATPase_P-typ_Ca-transp_PMCA. IPR006069. ATPase_P-typ_cation-exchng_asu. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR024750. Ca_ATPase_N_dom. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 1 hit.
KO	K01537.
Pfam	PF12515. CaATP_NAI. 1 hit. PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00121. NAKATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACA9_ARATH

Accession

Primary (citable) accession number: Q9LU41
Secondary accession number(s): Q0WUD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	June 26, 2007
Last modified:	January 25, 2012
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents