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Protein

Serine/threonine-protein kinase AGC1-5

Gene

AGC1-5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions redudantly with AGC1-7 as signaling component in the pollen tube. Required for polarized growth of pollen tubes.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Enzyme regulationi

Activated by PDPK1/PDK1.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei214ATPPROSITE-ProRule annotation1
Active sitei310Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi191 – 199ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: TAIR
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • pollen tube growth Source: TAIR

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase AGC1-5Curated (EC:2.7.11.11 Publication)
Alternative name(s):
AGC serine/threonine-protein kinase subfamily 1 member 51 Publication
Gene namesi
Name:AGC1-51 Publication
Synonyms:AGC1.51 Publication
Ordered Locus Names:At3g12690Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G12690
TAIRilocus:2087785 AT3G12690

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth conditions, but pollen of the double mutants agc1.5 and agc1.7 is impaired in polarized growth of pollen tube.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004313581 – 577Serine/threonine-protein kinase AGC1-5Add BLAST577

Post-translational modificationi

Autophosphorylated and phosphorylated by PDPK1/PDK1.1 Publication

Proteomic databases

PaxDbiQ9LTW5

PTM databases

iPTMnetiQ9LTW5

Expressioni

Tissue specificityi

Specifically expressed in pollen grains.1 Publication

Gene expression databases

ExpressionAtlasiQ9LTW5 baseline and differential
GenevisibleiQ9LTW5 AT

Interactioni

Subunit structurei

Interacts with PDPK1/PDK1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PDPK1Q9XF673EBI-1103747,EBI-1103587

Protein-protein interaction databases

BioGridi5784, 1 interactor
IntActiQ9LTW5, 1 interactor
STRINGi3702.AT3G12690.1

Structurei

3D structure databases

ProteinModelPortaliQ9LTW5
SMRiQ9LTW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 509Protein kinasePROSITE-ProRule annotationAdd BLAST325
Domaini510 – 577AGC-kinase C-terminalCuratedAdd BLAST68

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0610 Eukaryota
ENOG410XQ0C LUCA
HOGENOMiHOG000233027
InParanoidiQ9LTW5
OMAiGVGCMQP
OrthoDBiEOG093608MB
PhylomeDBiQ9LTW5

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LTW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLASKKNTA NVGSKEIDPI KPKSPRSSLS PFSLKLGDNV PRNPHFDPKK
60 70 80 90 100
MDPLVKHQPP KSLEPPPSTR GTNSEGDLKH NTYSSDGDSL AMRKNAPKNL
110 120 130 140 150
HYDPKKIVPL TTSETYSPSA RNHHHHRTKS PDKKRAPRHN GDYAYGDNLV
160 170 180 190 200
GPSAQPFKPH TGGDVRWDAI NSIASKGPQI GLDNFRLLKR LGYGDIGSVY
210 220 230 240 250
LADLRGTNAV FAMKVMDKAS LASRNKLLRA QTEREILSLL DHPFLPTLYS
260 270 280 290 300
YFETDKFYCL VMEFCSGGNL HSLRQKQPSR RFTEEAARFY ASEVLLALEY
310 320 330 340 350
LHMLGVVYRD LKPENILVRD EGHIMLSDFD LSLRCTFNPT LVKSSSVCSG
360 370 380 390 400
GGAILNEEFA VNGCMHPSAF LPRLLPSKKT RKAKSDSGLG GLSMPELMAE
410 420 430 440 450
PTDVRSMSFV GTHEYLAPEI IRGEGHGSAV DWWTFGIFLY ELLHGTTPFK
460 470 480 490 500
GQGNRATLHN VVGQPLKFPD TPHVSSAARD LIRGLLVKDP HRRIAYTRGA
510 520 530 540 550
TEIKQHPFFE GVNWALVRSA APPHIPDPVD LGPYAAARGK TKSHGGGDHC
560 570
NSMKPEPLVA CAAGPTDDTA YIDFEYF
Length:577
Mass (Da):63,768
Last modified:October 1, 2000 - v1
Checksum:i2CD2C7C30FAFA9A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024033 Genomic DNA Translation: BAB02413.1
CP002686 Genomic DNA Translation: AEE75233.1
CP002686 Genomic DNA Translation: AEE75234.1
CP002686 Genomic DNA Translation: AEE75235.1
BT011689 mRNA Translation: AAS49052.1
BT020332 mRNA Translation: AAV85687.1
AK229198 mRNA Translation: BAF01068.1
RefSeqiNP_187875.1, NM_112105.5
NP_974295.1, NM_202566.2
NP_974296.1, NM_202567.2
UniGeneiAt.39562

Genome annotation databases

EnsemblPlantsiAT3G12690.1; AT3G12690.1; AT3G12690
AT3G12690.2; AT3G12690.2; AT3G12690
AT3G12690.3; AT3G12690.3; AT3G12690
GeneIDi820450
GrameneiAT3G12690.1; AT3G12690.1; AT3G12690
AT3G12690.2; AT3G12690.2; AT3G12690
AT3G12690.3; AT3G12690.3; AT3G12690
KEGGiath:AT3G12690

Similar proteinsi

Entry informationi

Entry nameiAGC15_ARATH
AccessioniPrimary (citable) accession number: Q9LTW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 26, 2014
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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