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Protein

Serine/threonine-protein kinase AGC1-5

Gene

AGC1-5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions redudantly with AGC1-7 as signaling component in the pollen tube. Required for polarized growth of pollen tubes.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Enzyme regulationi

Activated by PDPK1/PDK1.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei214 – 2141ATPPROSITE-ProRule annotation
Active sitei310 – 3101Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi191 – 1999ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: TAIR
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • pollen tube growth Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G12690-MONOMER.
ARA:GQT-996-MONOMER.
ARA:GQT-997-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase AGC1-5Curated (EC:2.7.11.11 Publication)
Alternative name(s):
AGC serine/threonine-protein kinase subfamily 1 member 51 Publication
Gene namesi
Name:AGC1-51 Publication
Synonyms:AGC1.51 Publication
Ordered Locus Names:At3g12690Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G12690.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth conditions, but pollen of the double mutants agc1.5 and agc1.7 is impaired in polarized growth of pollen tube.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577Serine/threonine-protein kinase AGC1-5PRO_0000431358Add
BLAST

Post-translational modificationi

Autophosphorylated and phosphorylated by PDPK1/PDK1.1 Publication

Proteomic databases

PaxDbiQ9LTW5.
PRIDEiQ9LTW5.

Expressioni

Tissue specificityi

Specifically expressed in pollen grains.1 Publication

Gene expression databases

GenevisibleiQ9LTW5. AT.

Interactioni

Subunit structurei

Interacts with PDPK1/PDK1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PDPK1Q9XF673EBI-1103747,EBI-1103587

Protein-protein interaction databases

BioGridi5784. 1 interaction.
IntActiQ9LTW5. 1 interaction.
STRINGi3702.AT3G12690.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LTW5.
SMRiQ9LTW5. Positions 183-542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini185 – 509325Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini510 – 57768AGC-kinase C-terminalCuratedAdd
BLAST

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0610. Eukaryota.
ENOG410XQ0C. LUCA.
HOGENOMiHOG000233027.
InParanoidiQ9LTW5.
OMAiKRAPRHN.
PhylomeDBiQ9LTW5.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LTW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLASKKNTA NVGSKEIDPI KPKSPRSSLS PFSLKLGDNV PRNPHFDPKK
60 70 80 90 100
MDPLVKHQPP KSLEPPPSTR GTNSEGDLKH NTYSSDGDSL AMRKNAPKNL
110 120 130 140 150
HYDPKKIVPL TTSETYSPSA RNHHHHRTKS PDKKRAPRHN GDYAYGDNLV
160 170 180 190 200
GPSAQPFKPH TGGDVRWDAI NSIASKGPQI GLDNFRLLKR LGYGDIGSVY
210 220 230 240 250
LADLRGTNAV FAMKVMDKAS LASRNKLLRA QTEREILSLL DHPFLPTLYS
260 270 280 290 300
YFETDKFYCL VMEFCSGGNL HSLRQKQPSR RFTEEAARFY ASEVLLALEY
310 320 330 340 350
LHMLGVVYRD LKPENILVRD EGHIMLSDFD LSLRCTFNPT LVKSSSVCSG
360 370 380 390 400
GGAILNEEFA VNGCMHPSAF LPRLLPSKKT RKAKSDSGLG GLSMPELMAE
410 420 430 440 450
PTDVRSMSFV GTHEYLAPEI IRGEGHGSAV DWWTFGIFLY ELLHGTTPFK
460 470 480 490 500
GQGNRATLHN VVGQPLKFPD TPHVSSAARD LIRGLLVKDP HRRIAYTRGA
510 520 530 540 550
TEIKQHPFFE GVNWALVRSA APPHIPDPVD LGPYAAARGK TKSHGGGDHC
560 570
NSMKPEPLVA CAAGPTDDTA YIDFEYF
Length:577
Mass (Da):63,768
Last modified:October 1, 2000 - v1
Checksum:i2CD2C7C30FAFA9A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024033 Genomic DNA. Translation: BAB02413.1.
CP002686 Genomic DNA. Translation: AEE75233.1.
CP002686 Genomic DNA. Translation: AEE75234.1.
CP002686 Genomic DNA. Translation: AEE75235.1.
BT011689 mRNA. Translation: AAS49052.1.
BT020332 mRNA. Translation: AAV85687.1.
AK229198 mRNA. Translation: BAF01068.1.
RefSeqiNP_187875.1. NM_112105.4.
NP_974295.1. NM_202566.1.
NP_974296.1. NM_202567.1.
UniGeneiAt.39562.

Genome annotation databases

EnsemblPlantsiAT3G12690.1; AT3G12690.1; AT3G12690.
AT3G12690.2; AT3G12690.2; AT3G12690.
AT3G12690.3; AT3G12690.3; AT3G12690.
GeneIDi820450.
GrameneiAT3G12690.1; AT3G12690.1; AT3G12690.
AT3G12690.2; AT3G12690.2; AT3G12690.
AT3G12690.3; AT3G12690.3; AT3G12690.
KEGGiath:AT3G12690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024033 Genomic DNA. Translation: BAB02413.1.
CP002686 Genomic DNA. Translation: AEE75233.1.
CP002686 Genomic DNA. Translation: AEE75234.1.
CP002686 Genomic DNA. Translation: AEE75235.1.
BT011689 mRNA. Translation: AAS49052.1.
BT020332 mRNA. Translation: AAV85687.1.
AK229198 mRNA. Translation: BAF01068.1.
RefSeqiNP_187875.1. NM_112105.4.
NP_974295.1. NM_202566.1.
NP_974296.1. NM_202567.1.
UniGeneiAt.39562.

3D structure databases

ProteinModelPortaliQ9LTW5.
SMRiQ9LTW5. Positions 183-542.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5784. 1 interaction.
IntActiQ9LTW5. 1 interaction.
STRINGi3702.AT3G12690.1.

Proteomic databases

PaxDbiQ9LTW5.
PRIDEiQ9LTW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G12690.1; AT3G12690.1; AT3G12690.
AT3G12690.2; AT3G12690.2; AT3G12690.
AT3G12690.3; AT3G12690.3; AT3G12690.
GeneIDi820450.
GrameneiAT3G12690.1; AT3G12690.1; AT3G12690.
AT3G12690.2; AT3G12690.2; AT3G12690.
AT3G12690.3; AT3G12690.3; AT3G12690.
KEGGiath:AT3G12690.

Organism-specific databases

TAIRiAT3G12690.

Phylogenomic databases

eggNOGiKOG0610. Eukaryota.
ENOG410XQ0C. LUCA.
HOGENOMiHOG000233027.
InParanoidiQ9LTW5.
OMAiKRAPRHN.
PhylomeDBiQ9LTW5.

Enzyme and pathway databases

BioCyciARA:AT3G12690-MONOMER.
ARA:GQT-996-MONOMER.
ARA:GQT-997-MONOMER.

Miscellaneous databases

PROiQ9LTW5.

Gene expression databases

GenevisibleiQ9LTW5. AT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Growth signalling pathways in Arabidopsis and the AGC protein kinases."
    Boegre L., Okresz L., Henriques R., Anthony R.G.
    Trends Plant Sci. 8:424-431(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  6. "Structural and functional insights into the regulation of Arabidopsis AGC VIIIa kinases."
    Zegzouti H., Li W., Lorenz T.C., Xie M., Payne C.T., Smith K., Glenny S., Payne G.S., Christensen S.K.
    J. Biol. Chem. 281:35520-35530(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY, ENZYME REGULATION, INTERACTION WITH PDPK1/PDK1, AUTOPHOSPHORYLATION, PHOSPHORYLATION BY PDPK1/PDK1.
  7. "Two Arabidopsis AGC kinases are critical for the polarized growth of pollen tubes."
    Zhang Y., He J., McCormick S.
    Plant J. 58:474-484(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiAGC15_ARATH
AccessioniPrimary (citable) accession number: Q9LTW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 26, 2014
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.