Q9LTV6 (DECR2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisomal 2,4-dienoyl-CoA reductase
EC=1.3.1.34

Gene names

Ordered Locus Names:	At3g12800
ORF Names:	MBK21.23

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA By similarity.
Catalytic activity	Trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
Caution	Was originally assigned as At3g12790.

Ontologies

Keywords
Cellular component	Peroxisome
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	peroxisome Inferred from direct assay. Source: TAIR vacuolar membrane Inferred from direct assay. Source: TAIR
Molecular function	2,4-dienoyl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	Peroxisomal 2,4-dienoyl-CoA reductase		PRO_0000054564
Regions
	Nucleotide binding	17 – 41	25	NADP By similarity
	Motif	296 – 298	3	Microbody targeting signal Potential
Experimental info
	Sequence conflict	127	1	M → L in BAD44394. Ref.4
	Sequence conflict	238 – 239	2	MA → IT in BAD43663. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9LTV6 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 5606E22FC53D4F0A	FASTA	298	31,796
	10 20 30 40 50 60 MDSPFKPDVV RGQVALITGG GSGIGFEISS QFGKHGASIA IMGRRKQVLD DAVSALRSLG 70 80 90 100 110 120 IQAIGLEGDV RKQEDARRVV EATFQHFGKL DILVNAAAGN FLAAAEDLSP NGFRTVLDID 130 140 150 160 170 180 AVGTFNMCHA ALKYLKKGAP GRDSSSGGGS IINISATLHY TASWYQIHVS AAKAAVDATT 190 200 210 220 230 240 RNLALEWGTD YDIRVNGIAP GPIGGTPGMS KLVPEEIENK TREYMPLYKV GEKWDIAMAA 250 260 270 280 290 LYLSCDSGKY VSGLTMVVDG GLWLSKPRHL PKEAVKQLSR AVEKRSRAKP VGLPTSKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S. DNA Res. 7:131-135(2000) [PubMed: 10819329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB024033 Genomic DNA. Translation: BAB02424.1. CP002686 Genomic DNA. Translation: AEE75247.1. AY072396 mRNA. Translation: AAL62388.1. AY114700 mRNA. Translation: AAM48019.1. AK175259 mRNA. Translation: BAD43022.1. AK175900 mRNA. Translation: BAD43663.1. AK176181 mRNA. Translation: BAD43944.1. AK176305 mRNA. Translation: BAD44068.1. AK176508 mRNA. Translation: BAD44271.1. AK176631 mRNA. Translation: BAD44394.1. AK176892 mRNA. Translation: BAD44655.1. AK176909 mRNA. Translation: BAD44672.1. AK176776 mRNA. Translation: BAD44539.1. AK221326 mRNA. Translation: BAD94126.1.
IPI	IPI00548046.
RefSeq	NP_187886.2. NM_112116.3.
UniGene	At.47252.
3D structure databases
ProteinModelPortal	Q9LTV6.
SMR	Q9LTV6. Positions 9-273.
ModBase	Search...
Proteomic databases
PRIDE	Q9LTV6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT3G12800.1; AT3G12800.1; AT3G12800.
GeneID	820462.
GenomeReviews	Gene locus AT3G12800 in contig BA000014_GR.
KEGG	ath:AT3G12800.
NMPDR	fig|3702.1.peg.13360.
Organism-specific databases
TAIR	At3g12800.
Phylogenomic databases
GeneTree	EPGT00070000029949.
HOGENOM	HBG750976.
InParanoid	Q9LTV6.
OMA	FRDHGGV.
PhylomeDB	Q9LTV6.
ProtClustDB	CLSN2690890.
Gene expression databases
Genevestigator	Q9LTV6.
GermOnline	AT3G12800. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K13237.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DECR2_ARATH

Accession

Primary (citable) accession number: Q9LTV6
Secondary accession number(s): Q67Y37, Q680G7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2005
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program