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Protein

Serine/threonine-protein kinase Nek6

Gene

NEK6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

May be involved in plant development processes.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei128 – 1281Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • cortical microtubule organization Source: CACAO
  • lateral root formation Source: CACAO
  • negative regulation of ethylene biosynthetic process Source: CACAO
  • protein phosphorylation Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G20860-MONOMER.
ReactomeiR-ATH-179409. APC-Cdc20 mediated degradation of Nek2A.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek6 (EC:2.7.11.1)
Alternative name(s):
NimA-related protein kinase 6
Short name:
AtNek6
Gene namesi
Name:NEK6
Ordered Locus Names:At3g20860
ORF Names:MOE17.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G20860.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Serine/threonine-protein kinase Nek6PRO_0000314042Add
BLAST

Proteomic databases

PaxDbiQ9LT35.
PRIDEiQ9LT35.

PTM databases

iPTMnetiQ9LT35.

Expressioni

Gene expression databases

GenevisibleiQ9LT35. AT.

Interactioni

Protein-protein interaction databases

BioGridi6966. 1 interaction.
STRINGi3702.AT3G20860.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LT35.
SMRiQ9LT35. Positions 2-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 257254Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0589. Eukaryota.
ENOG410Y7JF. LUCA.
HOGENOMiHOG000238503.
InParanoidiQ9LT35.
KOiK08857.
PhylomeDBiQ9LT35.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LT35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDYEVVEQI GRGAFGSAFL VIHKSERRKY VVKKIRLAKQ TERCKLAAIQ
60 70 80 90 100
EMSLISKLKS PYIVEYKDSW VEKDCVCIVT SYCEGGDMTQ MIKKSRGVFA
110 120 130 140 150
SEEKLCRWMV QLLLAIDYLH NNRVLHRDLK CSNIFLTKEN EVRLGDFGLA
160 170 180 190 200
KLLGKDDLAS SMVGTPNYMC PELLADIPYG YKSDIWSLGC CMFEVAAHQP
210 220 230 240 250
AFKAPDMAAL INKINRSSLS PLPVMYSSSL KRLIKSMLRK NPEHRPTAAE
260 270 280 290 300
LLRHPHLQPY LAQCQNLSPV FKPVVSKSEH NTNENRTGLP PKTKSAKTPI
310 320 330 340 350
KHNQESEETE KKNKDTSSSS KDKERPAKSQ EMSVISTLTL LREFQKKSPK
360 370 380 390 400
SEERAEALES LLELCAGLLR QEKFDELEGV LKPFGDETVS SRETAIWLTK
410
SLMNVKRKQN DDETNI
Length:416
Mass (Da):47,251
Last modified:October 1, 2000 - v1
Checksum:i917AA7B9000A3088
GO

Sequence cautioni

The sequence AEE76432.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025629 Genomic DNA. Translation: BAB02494.1.
CP002686 Genomic DNA. Translation: AEE76432.1. Different initiation.
RefSeqiNP_188722.1. NM_112977.1.
UniGeneiAt.53409.

Genome annotation databases

EnsemblPlantsiAT3G20860.1; AT3G20860.1; AT3G20860.
GeneIDi821634.
GrameneiAT3G20860.1; AT3G20860.1; AT3G20860.
KEGGiath:AT3G20860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025629 Genomic DNA. Translation: BAB02494.1.
CP002686 Genomic DNA. Translation: AEE76432.1. Different initiation.
RefSeqiNP_188722.1. NM_112977.1.
UniGeneiAt.53409.

3D structure databases

ProteinModelPortaliQ9LT35.
SMRiQ9LT35. Positions 2-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi6966. 1 interaction.
STRINGi3702.AT3G20860.1.

PTM databases

iPTMnetiQ9LT35.

Proteomic databases

PaxDbiQ9LT35.
PRIDEiQ9LT35.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G20860.1; AT3G20860.1; AT3G20860.
GeneIDi821634.
GrameneiAT3G20860.1; AT3G20860.1; AT3G20860.
KEGGiath:AT3G20860.

Organism-specific databases

TAIRiAT3G20860.

Phylogenomic databases

eggNOGiKOG0589. Eukaryota.
ENOG410Y7JF. LUCA.
HOGENOMiHOG000238503.
InParanoidiQ9LT35.
KOiK08857.
PhylomeDBiQ9LT35.

Enzyme and pathway databases

BioCyciARA:AT3G20860-MONOMER.
ReactomeiR-ATH-179409. APC-Cdc20 mediated degradation of Nek2A.

Miscellaneous databases

PROiQ9LT35.

Gene expression databases

GenevisibleiQ9LT35. AT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Members of the plant NIMA-related kinases are involved in organ development and vascularization in poplar, Arabidopsis and rice."
    Vigneault F., Lachance D., Cloutier M., Pelletier G., Levasseur C., Seguin A.
    Plant J. 51:575-588(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiNEK6_ARATH
AccessioniPrimary (citable) accession number: Q9LT35
Secondary accession number(s): F4JEU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.