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Protein

Probable carboxylesterase 18

Gene

CXE18

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Carboxylesterase acting on esters with varying acyl chain length.By similarity

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei173 – 1731By similarity
Active sitei274 – 2741By similarity
Active sitei304 – 3041By similarity

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: TAIR

GO - Biological processi

  • metabolic process Source: InterPro
  • pollen tube growth Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

BioCyciARA:AT5G23530-MONOMER.

Protein family/group databases

ESTHERiarath-CXE18. Plant_carboxylesterase.
MEROPSiS09.A10.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable carboxylesterase 18
Alternative name(s):
AtCXE18 (EC:3.1.1.1)
Gene namesi
Name:CXE18
Ordered Locus Names:At5g23530
ORF Names:MQM1.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G23530.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 335334Probable carboxylesterase 18PRO_0000402562Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9LT10.
PRIDEiQ9LT10.

Expressioni

Tissue specificityi

Expressed in roots, flowers and siliques.1 Publication

Gene expression databases

GenevisibleiQ9LT10. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G23530.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LT10.
SMRiQ9LT10. Positions 13-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 963Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152323.
InParanoidiQ9LT10.
OMAiMRRTDCM.
OrthoDBiEOG09360EOQ.
PhylomeDBiQ9LT10.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LT10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDSQPNQK LTLPLKTRIA LTVISTMTDN AQRPDGTINR RFLRLFDFRA
60 70 80 90 100
PPNPKPVNIV STSDFVVDQS RDLWFRLYTP HVSGDKIPVV VFFHGGGFAF
110 120 130 140 150
LSPNAYPYDN VCRRFARKLP AYVISVNYRL APEHRYPAQY DDGFDALKYI
160 170 180 190 200
EENHGSILPA NADLSRCFFA GDSAGGNIAH NVAIRICREP RSSFTAVKLI
210 220 230 240 250
GLISIQPFFG GEERTEAEKQ LVGAPLVSPD RTDWCWKAMG LNRDHEAVNV
260 270 280 290 300
GGPNAVDISG LDYPETMVVV AGFDPLKDWQ RSYYEWLKLC GKKATLIEYP
310 320 330
NMFHAFYIFP ELPEAGQLIM RIKDFVDERV ASLSA
Length:335
Mass (Da):37,715
Last modified:October 1, 2000 - v1
Checksum:i6A265F9E310C676C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti300 – 3001P → S in AAM67089 (Ref. 5) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025633 Genomic DNA. Translation: BAA97248.1.
CP002688 Genomic DNA. Translation: AED93179.1.
AK226851 mRNA. Translation: BAE98944.1.
BT028935 mRNA. Translation: ABI49482.1.
AY088776 mRNA. Translation: AAM67089.1.
RefSeqiNP_197744.1. NM_122260.3.
UniGeneiAt.31003.

Genome annotation databases

EnsemblPlantsiAT5G23530.1; AT5G23530.1; AT5G23530.
GeneIDi832418.
GrameneiAT5G23530.1; AT5G23530.1; AT5G23530.
KEGGiath:AT5G23530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025633 Genomic DNA. Translation: BAA97248.1.
CP002688 Genomic DNA. Translation: AED93179.1.
AK226851 mRNA. Translation: BAE98944.1.
BT028935 mRNA. Translation: ABI49482.1.
AY088776 mRNA. Translation: AAM67089.1.
RefSeqiNP_197744.1. NM_122260.3.
UniGeneiAt.31003.

3D structure databases

ProteinModelPortaliQ9LT10.
SMRiQ9LT10. Positions 13-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G23530.1.

Protein family/group databases

ESTHERiarath-CXE18. Plant_carboxylesterase.
MEROPSiS09.A10.

Proteomic databases

PaxDbiQ9LT10.
PRIDEiQ9LT10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G23530.1; AT5G23530.1; AT5G23530.
GeneIDi832418.
GrameneiAT5G23530.1; AT5G23530.1; AT5G23530.
KEGGiath:AT5G23530.

Organism-specific databases

TAIRiAT5G23530.

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152323.
InParanoidiQ9LT10.
OMAiMRRTDCM.
OrthoDBiEOG09360EOQ.
PhylomeDBiQ9LT10.

Enzyme and pathway databases

BioCyciARA:AT5G23530-MONOMER.

Miscellaneous databases

PROiQ9LT10.

Gene expression databases

GenevisibleiQ9LT10. AT.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCXE18_ARATH
AccessioniPrimary (citable) accession number: Q9LT10
Secondary accession number(s): Q8L8W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.