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Protein

Electron transfer flavoprotein subunit beta, mitochondrial

Gene

ETFB

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Involved in leucine catabolism and in phytol degradation.By similarity1 Publication

Cofactori

Protein has several cofactor binding sites:
  • FADBy similarityNote: Binds 1 FAD per dimer.By similarity
  • AMPBy similarityNote: Binds 1 AMP per subunit.By similarity

GO - Molecular functioni

GO - Biological processi

  • chlorophyll catabolic process Source: TAIR
  • leucine catabolic process Source: TAIR
  • oxidation-reduction process Source: GO_Central

Keywordsi

Biological processElectron transport, Transport
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-ATH-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transfer flavoprotein subunit beta, mitochondrial
Short name:
Beta-ETF
Gene namesi
Name:ETFB
Ordered Locus Names:At5g43430
ORF Names:MWF20.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G43430
TAIRilocus:2176446 AT5G43430

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Reduced plant viability on extended exposure to darkness and a reduced reproductive performance under normal growth conditions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000324180? – 251Electron transfer flavoprotein subunit beta, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ9LSW8
PRIDEiQ9LSW8

PTM databases

iPTMnetiQ9LSW8

Expressioni

Inductioni

Expressed constitutively. Not induced by dark treatment or sucrose starvation.1 Publication

Gene expression databases

ExpressionAtlasiQ9LSW8 baseline and differential
GenevisibleiQ9LSW8 AT

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

Protein-protein interaction databases

IntActiQ9LSW8, 1 interactor
STRINGi3702.AT5G43430.1

Structurei

3D structure databases

ProteinModelPortaliQ9LSW8
SMRiQ9LSW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETF beta-subunit/FixA family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3180 Eukaryota
COG2086 LUCA
HOGENOMiHOG000247877
InParanoidiQ9LSW8
KOiK03521
OMAiRIPNMRG
OrthoDBiEOG09360JWS
PhylomeDBiQ9LSW8

Family and domain databases

CDDicd01714 ETF_beta, 1 hit
Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR000049 ET-Flavoprotein_bsu_CS
IPR014730 ETF_a/b_N
IPR012255 ETF_b
IPR033948 ETF_beta_N
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21294 PTHR21294, 1 hit
PfamiView protein in Pfam
PF01012 ETF, 1 hit
PIRSFiPIRSF000090 Beta-ETF, 1 hit
SMARTiView protein in SMART
SM00893 ETF, 1 hit
PROSITEiView protein in PROSITE
PS01065 ETF_BETA, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9LSW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKILVAVKRV VDYAVKIRVK PDKTGVETQN VKMSMNPFCE IALEEALRIK
60 70 80 90 100
EAGFAKEVIA VSIGPSQCVD TLRTGLAMGA DRGIHVETNS IFLPLTIAKI
110 120 130 140 150
LKSLADVENP GLIFLGKQAI DDDCNQTGQM VAALLGWPQA TFASKVVLDK
160 170 180 190 200
DKNVATVDRE VDGGLETLNV DLPAVITTDL RLNQPRYASL PNIMKAKSKP
210 220 230 240 250
IKKMTVQDLK VDIKSDIEIL EVTEPPKRKS GVMVSSVDEL IDKLKNEAHV

V
Length:251
Mass (Da):27,400
Last modified:October 1, 2000 - v1
Checksum:i5C5B8146CA02AF7F
GO
Isoform 2 (identifier: Q9LSW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-178: T → S
     179-251: Missing.

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:178
Mass (Da):19,134
Checksum:i0FA666D9F8565449
GO
Isoform 3 (identifier: Q9LSW8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:219
Mass (Da):23,792
Checksum:i3CC7A09A21B4C790
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91I → S in AAM61464 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0321731 – 32Missing in isoform 3. CuratedAdd BLAST32
Alternative sequenceiVSP_032174178T → S in isoform 2. Curated1
Alternative sequenceiVSP_032175179 – 251Missing in isoform 2. CuratedAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025638 Genomic DNA Translation: BAA97422.1
CP002688 Genomic DNA Translation: AED94960.1
CP002688 Genomic DNA Translation: AED94961.1
CP002688 Genomic DNA Translation: AED94962.1
AY045657 mRNA Translation: AAK74015.1
AF446867 mRNA Translation: AAL38600.1
AY084901 mRNA Translation: AAM61464.1
RefSeqiNP_001032002.1, NM_001036925.2 [Q9LSW8-2]
NP_001078699.1, NM_001085230.2 [Q9LSW8-3]
NP_199156.1, NM_123709.4 [Q9LSW8-1]
UniGeneiAt.66670
At.7156

Genome annotation databases

EnsemblPlantsiAT5G43430.1; AT5G43430.1; AT5G43430 [Q9LSW8-1]
AT5G43430.2; AT5G43430.2; AT5G43430 [Q9LSW8-2]
AT5G43430.3; AT5G43430.3; AT5G43430 [Q9LSW8-3]
GeneIDi834363
GrameneiAT5G43430.1; AT5G43430.1; AT5G43430 [Q9LSW8-1]
AT5G43430.2; AT5G43430.2; AT5G43430 [Q9LSW8-2]
AT5G43430.3; AT5G43430.3; AT5G43430 [Q9LSW8-3]
KEGGiath:AT5G43430

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiETFB_ARATH
AccessioniPrimary (citable) accession number: Q9LSW8
Secondary accession number(s): A8MRD3, Q2V317, Q8LFE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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