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Protein

Proteasome subunit alpha type-6

Gene

PAA1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-OSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-OSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-OSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-OSA-5632684 Hedgehog 'on' state
R-OSA-5687128 MAPK6/MAPK4 signaling
R-OSA-5689603 UCH proteinases
R-OSA-5689880 Ub-specific processing proteases
R-OSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-OSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-OSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.971

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-6 (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit A
20S proteasome subunit alpha-1
Gene namesi
Name:PAA1
Ordered Locus Names:Os03g0180400, LOC_Os03g08280
ORF Names:OsJ_09653Imported, OSJNBa0050H14.19, OSJNBb0076N15.5
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241371 – 246Proteasome subunit alpha type-6Add BLAST246

Proteomic databases

PRIDEiQ9LSU3

Expressioni

Gene expression databases

ExpressionAtlasiQ9LSU3 differential
GenevisibleiQ9LSU3 OS

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9LSU3
SMRiQ9LSU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000091084
InParanoidiQ9LSU3
KOiK02730
OMAiYGYEITP
OrthoDBiEOG09360JM8

Family and domain databases

CDDicd03754 proteasome_alpha_type_6, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
IPR034642 Proteasome_subunit_alpha6
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LSU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRGTGAGYD RHITIFSPEG RLYQVEYAFK AVKSAGVTSI GVRGKDSVCV
60 70 80 90 100
VTQKKVPDKL LDHTSVTHLF PITKYIGLLA TGLTADARSL VYQARNEAAE
110 120 130 140 150
FRFKWGYEMP VDVLAKWIAD KAQVYTQHAY MRPLGVVAMV LGYDEEKNAQ
160 170 180 190 200
LFKCDPAGHF FGHKATSAGL KEQEAINFLE KKMKDDPQFS YEETVQIAIS
210 220 230 240
ALQSVLQEDF KATEIEVGVV RKDDRVFRAL TTEEIDQHLT AISERD
Length:246
Mass (Da):27,573
Last modified:October 1, 2000 - v1
Checksum:iB4D9158DEA8FEDD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026558 mRNA Translation: BAA96829.1
AC125472 Genomic DNA Translation: AAO13479.1
AC126223 Genomic DNA Translation: AAN65435.1
DP000009 Genomic DNA Translation: ABF94305.1
AP008209 Genomic DNA Translation: BAF11076.1
AP014959 Genomic DNA Translation: BAS82617.1
CM000140 Genomic DNA Translation: EAZ25813.1
AK059929 mRNA Translation: BAG87220.1
AK060026 mRNA Translation: BAG87278.1
AK101031 mRNA Translation: BAG94887.1
RefSeqiXP_015630351.1, XM_015774865.1
UniGeneiOs.3704

Genome annotation databases

EnsemblPlantsiOs03t0180400-01; Os03t0180400-01; Os03g0180400
GeneIDi4331828
GrameneiOs03t0180400-01; Os03t0180400-01; Os03g0180400
KEGGiosa:4331828

Similar proteinsi

Entry informationi

Entry nameiPSA6_ORYSJ
AccessioniPrimary (citable) accession number: Q9LSU3
Secondary accession number(s): Q10QW9, Q7G665
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

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