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Protein

Proteasome subunit alpha type-5

Gene

PAE1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-OSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-OSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-OSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-OSA-5632684 Hedgehog 'on' state
R-OSA-5687128 MAPK6/MAPK4 signaling
R-OSA-5689603 UCH proteinases
R-OSA-5689880 Ub-specific processing proteases
R-OSA-6798695 Neutrophil degranulation
R-OSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-OSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-OSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-5 (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit E
20S proteasome subunit alpha-5
Gene namesi
Name:PAE1
Ordered Locus Names:Os11g0615700, LOC_Os11g40140
ORF Names:OsJ_34630Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241261 – 237Proteasome subunit alpha type-5Add BLAST237

Proteomic databases

PaxDbiQ9LSU1
PRIDEiQ9LSU1

Expressioni

Gene expression databases

ExpressionAtlasiQ9LSU1 differential
GenevisibleiQ9LSU1 OS

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os11g40140.1

Structurei

3D structure databases

ProteinModelPortaliQ9LSU1
SMRiQ9LSU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0176 Eukaryota
COG0638 LUCA
HOGENOMiHOG000091085
InParanoidiQ9LSU1
KOiK02729
OMAiFQVEYAR
OrthoDBiEOG09360K8Y

Family and domain databases

CDDicd03753 proteasome_alpha_type_5, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR033812 Proteasome_alpha_type_5
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LSU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLTRTEYDR GVNTFSPEGR LFQVEYAIEA IKLGSTAIGL KTKDGVVLAV
60 70 80 90 100
EKRVTSPLLE PSSVEKIMEI DEHIGCAMSG LIADARTLVE HARVETQNHR
110 120 130 140 150
FSYGEPMTVE STTQAICDLA LRFGEGDEES MSRPFGVSLL IAGHDENGPS
160 170 180 190 200
LYYTDPSGTF WQCNAKAIGS GSEGADSSLQ EQYNKELTLQ EAETIALSIL
210 220 230
KQVMEEKVTP NNVDIAKVSP NYHLYTPAEV EAVIARL
Length:237
Mass (Da):25,993
Last modified:October 1, 2000 - v1
Checksum:iE4EB5319CC409FA1
GO

Sequence cautioni

The sequence ABA94697 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026561 mRNA Translation: BAA96832.1
DP000010 Genomic DNA Translation: ABA94696.1
DP000010 Genomic DNA Translation: ABA94697.1 Sequence problems.
AP008217 Genomic DNA Translation: BAF28641.1
AP014967 Genomic DNA Translation: BAT14862.1
CM000148 Genomic DNA Translation: EEE52464.1
AK059521 mRNA Translation: BAG87018.1
AK103487 mRNA Translation: BAG96108.1
RefSeqiXP_015617773.1, XM_015762287.1
UniGeneiOs.3705

Genome annotation databases

EnsemblPlantsiOs11t0615700-01; Os11t0615700-01; Os11g0615700
Os11t0615700-02; Os11t0615700-02; Os11g0615700
GeneIDi4350922
GrameneiOs11t0615700-01; Os11t0615700-01; Os11g0615700
Os11t0615700-02; Os11t0615700-02; Os11g0615700
KEGGiosa:4350922

Similar proteinsi

Entry informationi

Entry nameiPSA5_ORYSJ
AccessioniPrimary (citable) accession number: Q9LSU1
Secondary accession number(s): Q0IRM4, Q2R171, Q2R172
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

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