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Protein

Proteasome subunit alpha type-5

Gene

PAE1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-OSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-OSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-OSA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-OSA-4641258. Degradation of DVL.
R-OSA-5632684. Hedgehog 'on' state.
R-OSA-5668541. TNFR2 non-canonical NF-kB pathway.
R-OSA-5689603. UCH proteinases.
R-OSA-5689880. Ub-specific processing proteases.
R-OSA-6798695. Neutrophil degranulation.
R-OSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-OSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-5 (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit E
20S proteasome subunit alpha-5
Gene namesi
Name:PAE1
Ordered Locus Names:Os11g0615700, LOC_Os11g40140
ORF Names:OsJ_34630Imported
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241261 – 237Proteasome subunit alpha type-5Add BLAST237

Proteomic databases

PaxDbiQ9LSU1.
PRIDEiQ9LSU1.

Expressioni

Gene expression databases

GenevisibleiQ9LSU1. OS.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os11g40140.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LSU1.
SMRiQ9LSU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0176. Eukaryota.
COG0638. LUCA.
HOGENOMiHOG000091085.
InParanoidiQ9LSU1.
KOiK02729.
OMAiQMGYDRA.
OrthoDBiEOG09360K8Y.

Family and domain databases

CDDicd03753. proteasome_alpha_type_5. 1 hit.
Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR033812. Proteasome_alpha_type_5.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9LSU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLTRTEYDR GVNTFSPEGR LFQVEYAIEA IKLGSTAIGL KTKDGVVLAV
60 70 80 90 100
EKRVTSPLLE PSSVEKIMEI DEHIGCAMSG LIADARTLVE HARVETQNHR
110 120 130 140 150
FSYGEPMTVE STTQAICDLA LRFGEGDEES MSRPFGVSLL IAGHDENGPS
160 170 180 190 200
LYYTDPSGTF WQCNAKAIGS GSEGADSSLQ EQYNKELTLQ EAETIALSIL
210 220 230
KQVMEEKVTP NNVDIAKVSP NYHLYTPAEV EAVIARL
Length:237
Mass (Da):25,993
Last modified:October 1, 2000 - v1
Checksum:iE4EB5319CC409FA1
GO

Sequence cautioni

The sequence ABA94697 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026561 mRNA. Translation: BAA96832.1.
DP000010 Genomic DNA. Translation: ABA94696.1.
DP000010 Genomic DNA. Translation: ABA94697.1. Sequence problems.
AP008217 Genomic DNA. Translation: BAF28641.1.
AP014967 Genomic DNA. Translation: BAT14862.1.
CM000148 Genomic DNA. Translation: EEE52464.1.
AK059521 mRNA. Translation: BAG87018.1.
AK103487 mRNA. Translation: BAG96108.1.
RefSeqiXP_015617773.1. XM_015762287.1.
UniGeneiOs.3705.

Genome annotation databases

EnsemblPlantsiOS11T0615700-01; OS11T0615700-01; OS11G0615700.
OS11T0615700-02; OS11T0615700-02; OS11G0615700.
GeneIDi4350922.
GrameneiOS11T0615700-01; OS11T0615700-01; OS11G0615700.
OS11T0615700-02; OS11T0615700-02; OS11G0615700.
KEGGiosa:4350922.

Similar proteinsi

Entry informationi

Entry nameiPSA5_ORYSJ
AccessioniPrimary (citable) accession number: Q9LSU1
Secondary accession number(s): Q0IRM4, Q2R171, Q2R172
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families