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Q9LSU1

- PSA5_ORYSJ

UniProt

Q9LSU1 - PSA5_ORYSJ

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Protein
Proteasome subunit alpha type-5
Gene
PAE1, Os11g0615700, LOC_Os11g40140
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

  1. ribonuclease activity Source: EnsemblPlants/Gramene
  2. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. response to cadmium ion Source: EnsemblPlants/Gramene
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
REACT_212204. Separation of Sister Chromatids.
REACT_214064. ER-Phagosome pathway.
REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-5 (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit E
20S proteasome subunit alpha-5
Gene namesi
Name:PAE1
Ordered Locus Names:Os11g0615700, LOC_Os11g40140
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 11

Organism-specific databases

GrameneiQ9LSU1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytosolic ribosome Source: EnsemblPlants/Gramene
  2. nucleus Source: UniProtKB-SubCell
  3. plasma membrane Source: EnsemblPlants/Gramene
  4. proteasome core complex, alpha-subunit complex Source: InterPro
  5. vacuolar membrane Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Proteasome subunit alpha type-5
PRO_0000124126Add
BLAST

Proteomic databases

PaxDbiQ9LSU1.
PRIDEiQ9LSU1.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Protein-protein interaction databases

STRINGi39947.LOC_Os11g40140.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LSU1.
SMRiQ9LSU1. Positions 8-234.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.

Phylogenomic databases

eggNOGiCOG0638.
HOGENOMiHOG000091085.
KOiK02729.
OMAiCAMSGLT.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LSU1-1 [UniParc]FASTAAdd to Basket

« Hide

MFLTRTEYDR GVNTFSPEGR LFQVEYAIEA IKLGSTAIGL KTKDGVVLAV    50
EKRVTSPLLE PSSVEKIMEI DEHIGCAMSG LIADARTLVE HARVETQNHR 100
FSYGEPMTVE STTQAICDLA LRFGEGDEES MSRPFGVSLL IAGHDENGPS 150
LYYTDPSGTF WQCNAKAIGS GSEGADSSLQ EQYNKELTLQ EAETIALSIL 200
KQVMEEKVTP NNVDIAKVSP NYHLYTPAEV EAVIARL 237
Length:237
Mass (Da):25,993
Last modified:October 1, 2000 - v1
Checksum:iE4EB5319CC409FA1
GO

Sequence cautioni

The sequence ABA94697.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026561 mRNA. Translation: BAA96832.1.
DP000010 Genomic DNA. Translation: ABA94696.1.
DP000010 Genomic DNA. Translation: ABA94697.1. Sequence problems.
AP008217 Genomic DNA. No translation available.
RefSeqiNP_001068278.1. NM_001074810.1.
UniGeneiOs.3705.

Genome annotation databases

EnsemblPlantsiOS11T0615700-01; OS11T0615700-01; OS11G0615700.
OS11T0615700-02; OS11T0615700-02; OS11G0615700.
GeneIDi4350922.
KEGGiosa:4350922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026561 mRNA. Translation: BAA96832.1 .
DP000010 Genomic DNA. Translation: ABA94696.1 .
DP000010 Genomic DNA. Translation: ABA94697.1 . Sequence problems.
AP008217 Genomic DNA. No translation available.
RefSeqi NP_001068278.1. NM_001074810.1.
UniGenei Os.3705.

3D structure databases

ProteinModelPortali Q9LSU1.
SMRi Q9LSU1. Positions 8-234.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 39947.LOC_Os11g40140.1.

Proteomic databases

PaxDbi Q9LSU1.
PRIDEi Q9LSU1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS11T0615700-01 ; OS11T0615700-01 ; OS11G0615700 .
OS11T0615700-02 ; OS11T0615700-02 ; OS11G0615700 .
GeneIDi 4350922.
KEGGi osa:4350922.

Organism-specific databases

Gramenei Q9LSU1.

Phylogenomic databases

eggNOGi COG0638.
HOGENOMi HOG000091085.
KOi K02729.
OMAi CAMSGLT.

Enzyme and pathway databases

Reactomei REACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
REACT_212204. Separation of Sister Chromatids.
REACT_214064. ER-Phagosome pathway.
REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structural features of the 20S proteasome subunits of rice (Oryza sativa)."
    Sassa H., Oguchi S., Inoue T., Hirano H.
    Gene 250:61-66(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Nipponbare.
  2. "The sequence of rice chromosomes 11 and 12, rich in disease resistance genes and recent gene duplications."
    The rice chromosomes 11 and 12 sequencing consortia
    BMC Biol. 3:20-20(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiPSA5_ORYSJ
AccessioniPrimary (citable) accession number: Q9LSU1
Secondary accession number(s): Q2R171, Q2R172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi