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Q9LSU0

- PSA3_ORYSJ

UniProt

Q9LSU0 - PSA3_ORYSJ

Protein

Proteasome subunit alpha type-3

Gene

PAG1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. response to cadmium ion Source: EnsemblPlants/Gramene
    2. response to cold Source: EnsemblPlants/Gramene
    3. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    ReactomeiREACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
    REACT_212204. Separation of Sister Chromatids.
    REACT_214064. ER-Phagosome pathway.
    REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit alpha type-3 (EC:3.4.25.1)
    Alternative name(s):
    20S proteasome alpha subunit G
    20S proteasome subunit alpha-7
    Gene namesi
    Name:PAG1
    Ordered Locus Names:Os01g0811100, LOC_Os01g59600
    ORF Names:P0425G02.8, P0468B07.45
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 1

    Organism-specific databases

    GrameneiQ9LSU0.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. apoplast Source: EnsemblPlants/Gramene
    2. cytosol Source: EnsemblPlants/Gramene
    3. nucleus Source: UniProtKB-SubCell
    4. proteasome core complex, alpha-subunit complex Source: InterPro
    5. vacuolar membrane Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 249249Proteasome subunit alpha type-3PRO_0000124099Add
    BLAST

    Proteomic databases

    PaxDbiQ9LSU0.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LSU0.
    SMRiQ9LSU0. Positions 2-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1A family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    HOGENOMiHOG000091086.
    KOiK02727.
    OMAiCRQGVIE.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view]
    SMARTiSM00948. Proteasome_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9LSU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSIGTGYDL SVTTFSPDGR VFQVEYATKA VDNSGTVVGI KCKDGIVLGV    50
    EKLVTSKMML EGSNRRIHSV HWHSGLAVAG LAADGRQIVS RAKSEAASYE 100
    KVYGEPISVK ELADRVASYV HLCTLYWWLR PFGCGVILGG YDRDGPQLYM 150
    IEPSGVSYKY FGAALGKGRQ AAKTEIEKLK LSELTCREGI VEVAKIIYGV 200
    HDEAKDKAFE LELSWICDES NRQHQKVPAD LLEQAKVAAQ AALEEMDAD 249
    Length:249
    Mass (Da):27,238
    Last modified:October 1, 2000 - v1
    Checksum:iE6D37062AC03E31E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026562 mRNA. Translation: BAA96833.1.
    AP003247 Genomic DNA. Translation: BAD68202.1.
    AP003260 Genomic DNA. Translation: BAD68244.1.
    RefSeqiNP_001044588.1. NM_001051123.1.
    UniGeneiOs.3706.

    Genome annotation databases

    EnsemblPlantsiOS01T0811100-01; OS01T0811100-01; OS01G0811100.
    OS01T0811100-02; OS01T0811100-02; OS01G0811100.
    GeneIDi4327357.
    KEGGiosa:4327357.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026562 mRNA. Translation: BAA96833.1 .
    AP003247 Genomic DNA. Translation: BAD68202.1 .
    AP003260 Genomic DNA. Translation: BAD68244.1 .
    RefSeqi NP_001044588.1. NM_001051123.1.
    UniGenei Os.3706.

    3D structure databases

    ProteinModelPortali Q9LSU0.
    SMRi Q9LSU0. Positions 2-245.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9LSU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS01T0811100-01 ; OS01T0811100-01 ; OS01G0811100 .
    OS01T0811100-02 ; OS01T0811100-02 ; OS01G0811100 .
    GeneIDi 4327357.
    KEGGi osa:4327357.

    Organism-specific databases

    Gramenei Q9LSU0.

    Phylogenomic databases

    eggNOGi COG0638.
    HOGENOMi HOG000091086.
    KOi K02727.
    OMAi CRQGVIE.

    Enzyme and pathway databases

    Reactomei REACT_205610. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_205939. Autodegradation of the E3 ubiquitin ligase COP1.
    REACT_207219. APC/C:Cdc20 mediated degradation of Securin.
    REACT_212204. Separation of Sister Chromatids.
    REACT_214064. ER-Phagosome pathway.
    REACT_219834. AUF1 (hnRNP D0) destabilizes mRNA.
    REACT_223172. Antigen processing: Ubiquitination & Proteasome degradation.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR000426. Proteasome_asu_N.
    IPR023332. Proteasome_suA-type.
    IPR001353. Proteasome_sua/b.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    PF10584. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SMARTi SM00948. Proteasome_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
    PS51475. PROTEASOME_ALPHA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structural features of the 20S proteasome subunits of rice (Oryza sativa)."
      Sassa H., Oguchi S., Inoue T., Hirano H.
      Gene 250:61-66(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Nipponbare.
    2. "The genome sequence and structure of rice chromosome 1."
      Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
      , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
      Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiPSA3_ORYSJ
    AccessioniPrimary (citable) accession number: Q9LSU0
    Secondary accession number(s): Q5VQP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 8, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3