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Protein

Proteasome subunit beta type-2

Gene

PBD1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-OSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-OSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-OSA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-OSA-5632684. Hedgehog 'on' state.
R-OSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-OSA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-OSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.984.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-2 (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit D
20S proteasome subunit beta-4
Gene namesi
Name:PBD1
Ordered Locus Names:Os03g0695600, LOC_Os03g48930
ORF Names:OsJ_12208Imported, OSJNBb0021P10.3
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 3

Subcellular locationi

  • Cytoplasm PROSITE-ProRule annotation
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Proteasome subunit beta type-2PRO_0000148051Add
BLAST

Proteomic databases

PaxDbiQ9LST6.

Expressioni

Gene expression databases

ExpressionAtlasiQ9LST6. baseline and differential.
GenevisibleiQ9LST6. OS.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os03g48930.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LST6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0177. Eukaryota.
COG0638. LUCA.
HOGENOMiHOG000188743.
InParanoidiQ9LST6.
OMAiCIGEAKR.
OrthoDBiEOG09360MSV.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LST6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECVIGVVGR DFAVVAADTS AVQSILVHKT DEDKVMVLDS HKLMGASGEP
60 70 80 90 100
GDRVQFTEFI QKNLHLYQFR NNIPLSTAAT ANFTRGELAT ALRKNPYYVN
110 120 130 140 150
VLLAGYDSDV GASLYYIDYI ATFHKIEKGA FGYGSYFCLS LMDKLYRPDM
160 170 180 190 200
SVEEAVDLVD KCIKEIRLRL VVAPQNFIIK IVDKEGAREY ARRAYTDSPP
210
EAATSEAATV AA
Length:212
Mass (Da):23,478
Last modified:June 27, 2006 - v2
Checksum:i0673DC260C8CDCF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121F → I in BAA96837 (PubMed:10854779).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026566 mRNA. Translation: BAA96837.1.
AC123974 Genomic DNA. Translation: AAO19369.1.
DP000009 Genomic DNA. Translation: ABF98343.1.
AP008209 Genomic DNA. Translation: BAF12890.1.
AP014959 Genomic DNA. Translation: BAS85882.1.
CM000140 Genomic DNA. Translation: EAZ28234.1.
AK061228 mRNA. Translation: BAG87805.1.
AK099128 mRNA. Translation: BAG93942.1.
RefSeqiXP_015632007.1. XM_015776521.1.
UniGeneiOs.9323.

Genome annotation databases

EnsemblPlantsiOS03T0695600-01; OS03T0695600-01; OS03G0695600.
OS03T0695600-03; OS03T0695600-03; OS03G0695600.
GeneIDi4333803.
GrameneiOS03T0695600-01; OS03T0695600-01; OS03G0695600.
OS03T0695600-03; OS03T0695600-03; OS03G0695600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026566 mRNA. Translation: BAA96837.1.
AC123974 Genomic DNA. Translation: AAO19369.1.
DP000009 Genomic DNA. Translation: ABF98343.1.
AP008209 Genomic DNA. Translation: BAF12890.1.
AP014959 Genomic DNA. Translation: BAS85882.1.
CM000140 Genomic DNA. Translation: EAZ28234.1.
AK061228 mRNA. Translation: BAG87805.1.
AK099128 mRNA. Translation: BAG93942.1.
RefSeqiXP_015632007.1. XM_015776521.1.
UniGeneiOs.9323.

3D structure databases

ProteinModelPortaliQ9LST6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os03g48930.1.

Protein family/group databases

MEROPSiT01.984.

Proteomic databases

PaxDbiQ9LST6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS03T0695600-01; OS03T0695600-01; OS03G0695600.
OS03T0695600-03; OS03T0695600-03; OS03G0695600.
GeneIDi4333803.
GrameneiOS03T0695600-01; OS03T0695600-01; OS03G0695600.
OS03T0695600-03; OS03T0695600-03; OS03G0695600.

Phylogenomic databases

eggNOGiKOG0177. Eukaryota.
COG0638. LUCA.
HOGENOMiHOG000188743.
InParanoidiQ9LST6.
OMAiCIGEAKR.
OrthoDBiEOG09360MSV.

Enzyme and pathway databases

ReactomeiR-OSA-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-OSA-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-OSA-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-OSA-5632684. Hedgehog 'on' state.
R-OSA-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-OSA-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-OSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Gene expression databases

ExpressionAtlasiQ9LST6. baseline and differential.
GenevisibleiQ9LST6. OS.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSB2_ORYSJ
AccessioniPrimary (citable) accession number: Q9LST6
Secondary accession number(s): Q10ER6, Q851D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 27, 2006
Last modified: September 7, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.