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Protein

ABC transporter B family member 18

Gene

ABCB18

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi382 – 389ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1015 – 1022ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G28390-MONOMER.
ReactomeiR-ATH-159418. Recycling of bile acids and salts.
R-ATH-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-ATH-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter B family member 18
Short name:
ABC transporter ABCB.18
Short name:
AtABCB18
Alternative name(s):
P-glycoprotein 18
Putative multidrug resistance protein 20
Gene namesi
Name:ABCB18
Synonyms:MDR20, PGP18
Ordered Locus Names:At3g28390
ORF Names:MFJ20.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G28390.
TAIRilocus:2088942. AT3G28390.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei70 – 90HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei146 – 168HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei172 – 194HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei252 – 272HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei284 – 304HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei657 – 677HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei699 – 719HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei780 – 800HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei804 – 824HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei880 – 900HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei919 – 939HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279311 – 1225ABC transporter B family member 18Add BLAST1225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi530N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi754N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi960N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1000N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1201N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9LSJ5.
PRIDEiQ9LSJ5.

Expressioni

Gene expression databases

GenevisibleiQ9LSJ5. AT.

Interactioni

Protein-protein interaction databases

BioGridi7797. 1 interactor.
MINTiMINT-8065261.
STRINGi3702.AT3G28390.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LSJ5.
SMRiQ9LSJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 312ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST290
Domaini347 – 583ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini657 – 945ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST289
Domaini980 – 1218ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9LSJ5.
KOiK05658.
OMAiFIIACSY.
OrthoDBiEOG093600PV.
PhylomeDBiQ9LSJ5.

Family and domain databases

Gene3Di1.20.1560.10. 2 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9LSJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSFGSIRS IFMHADGVDW MLMALGLIGA VGDGFITPII FFICSKLLNN
60 70 80 90 100
VGGSSFDDET FMQTVAKNAV ALVYVACASW VICFIEGYCW TRTGERQAAK
110 120 130 140 150
MREKYLKAVL RQDVGYFDLH VTSTSDVITS VSSDSLVIQD FLSEKLPNFL
160 170 180 190 200
MNTSAFVASY IVGFLLLWRL TIVGFPFIIL LLIPGLMYGR ALIRISMKIR
210 220 230 240 250
EEYNEAGSIA EQVISSVRTV YAFGSEKKMI EKFSTALQGS VKLGLRQGLA
260 270 280 290 300
KGIAIGSNGI TYAIWGFLTW YGSRMVMNHG SKGGTVSSVI VCVTFGGTSL
310 320 330 340 350
GQSLSNLKYF SEAFVVGERI MKVINRVPGI DSDNLEGQIL EKTRGEVEFN
360 370 380 390 400
HVKFTYPSRP ETPIFDDLCL RVPSGKTVAL VGGSGSGKST VISLLQRFYD
410 420 430 440 450
PIAGEILIDG LPINKLQVKW LRSQMGLVSQ EPVLFATSIK ENILFGKEDA
460 470 480 490 500
SMDEVVEAAK ASNAHSFISQ FPNSYQTQVG ERGVQLSGGQ KQRIAIARAI
510 520 530 540 550
IKSPIILLLD EATSALDSES ERVVQEALDN ASIGRTTIVI AHRLSTIRNA
560 570 580 590 600
DVICVVHNGR IIETGSHEEL LEKLDGQYTS LVRLQQVDNK ESDHISVEEG
610 620 630 640 650
QASSLSKDLK YSPKEFIHST SSNIVRDFPN LSPKDGKSLV PSFKRLMSMN
660 670 680 690 700
RPEWKHALYG CLGAALFGAV QPIYSYSSGS MVSVYFLASH DQIKEKTRIY
710 720 730 740 750
VLLFVGLALF TFLSNISQHY GFAYMGEYLT KRIRERMLGK ILTFEVNWFD
760 770 780 790 800
KDENSSGAIC SRLAKDANMV RSLVGDRMSL LVQTISAVSI TCAIGLVISW
810 820 830 840 850
RFSIVMMSVQ PVIVVCFYTQ RVLLKSMSRN AIKGQDESSK LAAEAVSNIR
860 870 880 890 900
TITAFSSQER IINLLKMVQE GPRKDSARQS WLAGIMLGTS QSLITCVSAL
910 920 930 940 950
NFWYGGKLIA DGKMMSKEFL EIFLIFASTG RVIAEAGTMT KDLVKGSDAV
960 970 980 990 1000
ASVFAVLDRN TTIEPENPDG YVPKKVKGQI SFSNVDFAYP TRPDVIIFQN
1010 1020 1030 1040 1050
FSIDIEDGKS TAIVGPSGSG KSTIISLIER FYDPLKGIVK IDGRDIRSCH
1060 1070 1080 1090 1100
LRSLRQHIAL VSQEPTLFAG TIRENIMYGG ASNKIDESEI IEAAKAANAH
1110 1120 1130 1140 1150
DFITSLSNGY DTCCGDRGVQ LSGGQKQRIA IARAVLKNPS VLLLDEATSA
1160 1170 1180 1190 1200
LDSQSESVVQ DALERLMVGR TSVVIAHRLS TIQKCDTIAV LENGAVVECG
1210 1220
NHSSLLAKGP KGAYFSLVSL QRTLF
Length:1,225
Mass (Da):134,303
Last modified:October 1, 2000 - v1
Checksum:iDCB4E5D590F4D782
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026644 Genomic DNA. Translation: BAB02855.1.
CP002686 Genomic DNA. Translation: AEE77440.1.
RefSeqiNP_189480.1. NM_113759.1.
UniGeneiAt.53538.

Genome annotation databases

EnsemblPlantsiAT3G28390.1; AT3G28390.1; AT3G28390.
GeneIDi822468.
GrameneiAT3G28390.1; AT3G28390.1; AT3G28390.
KEGGiath:AT3G28390.

Similar proteinsi

Entry informationi

Entry nameiAB18B_ARATH
AccessioniPrimary (citable) accession number: Q9LSJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families