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Protein

ABC transporter B family member 22

Gene

ABCB22

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi381 – 3888ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1019 – 10268ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G28415-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter B family member 22
Short name:
ABC transporter ABCB.22
Short name:
AtABCB22
Alternative name(s):
P-glycoprotein 22
Putative multidrug resistance protein 21
Gene namesi
Name:ABCB22
Synonyms:MDR21, PGP22
Ordered Locus Names:At3g28415
ORF Names:MFJ20.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G28415.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei69 – 8921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei145 – 16723HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei171 – 19323HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei251 – 27121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei274 – 29421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei661 – 68121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei703 – 72321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei782 – 80019HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei807 – 82317HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei885 – 90824HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei923 – 94321HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12291229ABC transporter B family member 22PRO_0000227932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi529 – 5291N-linked (GlcNAc...)Sequence analysis
Glycosylationi594 – 5941N-linked (GlcNAc...)Sequence analysis
Glycosylationi758 – 7581N-linked (GlcNAc...)Sequence analysis
Glycosylationi1004 – 10041N-linked (GlcNAc...)Sequence analysis
Glycosylationi1157 – 11571N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9LSJ2.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G28415.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LSJ2.
SMRiQ9LSJ2. Positions 6-584, 664-1226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 311290ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini346 – 582237ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini661 – 949289ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini984 – 1222239ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9LSJ2.
KOiK05658.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LSJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFGSVRSI FMHANSVDLV LMGLGLIGAV GDGFITPIIF FITGLLLNDI
60 70 80 90 100
GDSSFGDKTF MHAIMKNAVA LLYVAGASLV ICFVEGYCWT RTGERQASRM
110 120 130 140 150
REKYLRAVLR QDVGYFDLHV TSTSDVITSV SSDTLVIQDV LSEKLPNFLM
160 170 180 190 200
SASAFVASYI VGFIMLWRLT IVGFPFFILL LIPGLMCGRA LINISRKIRE
210 220 230 240 250
EYNEAGSIAE QAISLVRTVY AFGSERKMIS KFSAALEGSV KLGLRQGIAK
260 270 280 290 300
GIAIGSNGVT YAIWGFMTWY GSRMVMYHGA KGGTIFAVII CITYGGTSLG
310 320 330 340 350
RGLSNLKYFS EAVVAGERII EVIKRVPDID SDNPRGQVLE NIKGEVQFKH
360 370 380 390 400
VKFMYSSRPE TPIFDDLCLR IPSGKSVALV GGSGSGKSTV ISLLQRFYDP
410 420 430 440 450
IVGEILIDGV SIKKLQVKWL RSQMGLVSQE PALFATSIEE NILFGKEDAS
460 470 480 490 500
FDEVVEAAKS SNAHDFISQF PLGYKTQVGE RGVQMSGGQK QRISIARAII
510 520 530 540 550
KSPTLLLLDE ATSALDSESE RVVQEALDNA TIGRTTIVIA HRLSTIRNVD
560 570 580 590 600
VICVFKNGQI VETGSHEELM ENVDGQYTSL VRLQIMENEE SNDNVSVSMR
610 620 630 640 650
EGQFSNFNKD VKYSSRLSIQ SRSSLFATSS IDTNLAGSIP KDKKPSFKRL
660 670 680 690 700
MAMNKPEWKH ALYGCLSAVL YGALHPIYAY ASGSMVSVYF LTSHDEMKEK
710 720 730 740 750
TRIYVLLFVG LAVLCFLISI IQQYSFAYMG EYLTKRIREN ILSKLLTFEV
760 770 780 790 800
SWFDEDENSS GSICSRLAKD ANVVRSLVGE RVSLLVQTIS AVSVACTLGL
810 820 830 840 850
AISWKLSIVM IAIQPVVVGC FYTQRIVLKS ISKKAIKAQD ESSKLAAEAV
860 870 880 890 900
SNIRTITAFS SQERILKLLK MVQEGPQREN IRQSWLAGIV LATSRSLMTC
910 920 930 940 950
TSALNYWYGA RLIIDGKITS KAFFELFILF VSTGRVIADA GAMTMDLAKG
960 970 980 990 1000
SDAVGSVFAV LDRYTNIEPE KPDGFVPQNI KGQIKFVNVD FAYPTRPDVI
1010 1020 1030 1040 1050
IFKNFSIDID EGKSTAIVGP SGSGKSTIIG LIERFYDPLK GIVKIDGRDI
1060 1070 1080 1090 1100
RSYHLRSLRQ HIGLVSQEPI LFAGTIRENI MYGGASDKID ESEIIEAAKA
1110 1120 1130 1140 1150
ANAHDFIVTL SDGYDTYCGD RGVQLSGGQK QRIAIARAVL KNPSVLLLDE
1160 1170 1180 1190 1200
ATSALDNQSE RMVQDALGRL MVGRTSVVIA HRLSTIQNCD TITVLDKGKV
1210 1220
VECGTHSSLL AKGPTGVYFS LVSLQRTRY
Length:1,229
Mass (Da):134,940
Last modified:May 31, 2011 - v2
Checksum:iC5052E61E8A39EC3
GO

Sequence cautioni

The sequence AEE77442.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAB02858.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026644 Genomic DNA. Translation: BAB02858.1. Different initiation.
CP002686 Genomic DNA. Translation: AEE77442.1. Sequence problems.
RefSeqiNP_683599.1. NM_148757.1.
UniGeneiAt.53540.

Genome annotation databases

EnsemblPlantsiAT3G28415.1; AT3G28415.1; AT3G28415.
GeneIDi822471.
GrameneiAT3G28415.1; AT3G28415.1; AT3G28415.
KEGGiath:AT3G28415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026644 Genomic DNA. Translation: BAB02858.1. Different initiation.
CP002686 Genomic DNA. Translation: AEE77442.1. Sequence problems.
RefSeqiNP_683599.1. NM_148757.1.
UniGeneiAt.53540.

3D structure databases

ProteinModelPortaliQ9LSJ2.
SMRiQ9LSJ2. Positions 6-584, 664-1226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G28415.1.

Proteomic databases

PaxDbiQ9LSJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G28415.1; AT3G28415.1; AT3G28415.
GeneIDi822471.
GrameneiAT3G28415.1; AT3G28415.1; AT3G28415.
KEGGiath:AT3G28415.

Organism-specific databases

TAIRiAT3G28415.

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9LSJ2.
KOiK05658.

Enzyme and pathway databases

BioCyciARA:AT3G28415-MONOMER.

Miscellaneous databases

PROiQ9LSJ2.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "The Arabidopsis thaliana ABC protein superfamily, a complete inventory."
    Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.
    J. Biol. Chem. 276:30231-30244(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  4. Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiAB22B_ARATH
AccessioniPrimary (citable) accession number: Q9LSJ2
Secondary accession number(s): F4IZ32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: May 31, 2011
Last modified: February 17, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.