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Protein

Glutamate decarboxylase 5

Gene

GAD5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis (By similarity).By similarity

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Decarboxylase, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT3G17760-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase 5 (EC:4.1.1.15)
Short name:
GAD 5
Gene namesi
Name:GAD5
Ordered Locus Names:At3g17760
ORF Names:MIG5.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G17760
TAIRilocus:2089779 AT3G17760

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004169561 – 494Glutamate decarboxylase 5Add BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei276N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ9LSH2
PRIDEiQ9LSH2

PTM databases

iPTMnetiQ9LSH2

Expressioni

Tissue specificityi

Expressed in flowers.1 Publication

Gene expression databases

ExpressionAtlasiQ9LSH2 baseline and differential
GenevisibleiQ9LSH2 AT

Interactioni

Subunit structurei

Homohexamer. Interacts with clamodulin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9LSH2, 1 interactor
STRINGi3702.AT3G17760.1

Structurei

3D structure databases

ProteinModelPortaliQ9LSH2
SMRiQ9LSH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1383 Eukaryota
COG0076 LUCA
InParanoidiQ9LSH2
KOiK01580
OMAiNAETGWE
OrthoDBiEOG093607ZR
PhylomeDBiQ9LSH2

Family and domain databases

Gene3Di3.40.640.10, 1 hit
InterProiView protein in InterPro
IPR010107 Glutamate_decarboxylase
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43321 PTHR43321, 1 hit
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01788 Glu-decarb-GAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LSH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLATNSDSD EHLHSTFASR YVRAVVPRFK MPDHCMPKDA AYQVINDELM
60 70 80 90 100
LDGNPRLNLA SFVTTWMEPE CDKLIMDSVN KNYVDMDEYP VTTELQNRCV
110 120 130 140 150
NMIANLFHAP VGEDEAAIGC GTVGSSEAIM LAGLAFKRKW QHRRKAQGLP
160 170 180 190 200
IDKPNIVTGA NVQVCWEKFA RYFEVELKEV KLSEDYYVMD PAKAVEMVDE
210 220 230 240 250
NTICVAAILG STLTGEFEDV KQLNDLLAEK NAETGWETPI HVDAASGGFI
260 270 280 290 300
APFLYPDLEW DFRLPWVKSI NVSGHKYGLV YAGVGWVVWR TKDDLPEELV
310 320 330 340 350
FHINYLGADQ PTFTLNFSKG SSQIIAQYYQ FIRLGFEGYK NIMENCMDNA
360 370 380 390 400
RRLREGIEMT GKFNIVSKDI GVPLVAFSLK DSSKHTVFEI AESLRKFGWI
410 420 430 440 450
IPAYTMPADA QHIAVLRVVI REDFSRGLAD RLITHIIQVL KEIEGLPSRI
460 470 480 490
AHLAAAAAVS GDDEEVKVKT AKMSLEDITK YWKRLVEHKR NIVC
Length:494
Mass (Da):55,770
Last modified:October 1, 2000 - v1
Checksum:i7985F175E54DF262
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026646 Genomic DNA Translation: BAB02870.1
CP002686 Genomic DNA Translation: AEE76003.1
CP002686 Genomic DNA Translation: AEE76004.1
RefSeqiNP_001154621.1, NM_001161149.1
NP_188403.1, NM_112657.2
UniGeneiAt.38660

Genome annotation databases

EnsemblPlantsiAT3G17760.1; AT3G17760.1; AT3G17760
AT3G17760.2; AT3G17760.2; AT3G17760
GeneIDi821044
GrameneiAT3G17760.1; AT3G17760.1; AT3G17760
AT3G17760.2; AT3G17760.2; AT3G17760
KEGGiath:AT3G17760

Similar proteinsi

Entry informationi

Entry nameiDCE5_ARATH
AccessioniPrimary (citable) accession number: Q9LSH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health