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Q9LSH2

- DCE5_ARATH

UniProt

Q9LSH2 - DCE5_ARATH

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Protein

Glutamate decarboxylase 5

Gene

GAD5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis (By similarity).By similarity

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

Pyridoxal phosphate.By similarity

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Calmodulin-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT3G17760-MONOMER.
ARA:GQT-2607-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase 5 (EC:4.1.1.15)
Short name:
GAD 5
Gene namesi
Name:GAD5
Ordered Locus Names:At3g17760
ORF Names:MIG5.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G17760.

Subcellular locationi

GO - Cellular componenti

  1. plasmodesma Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Glutamate decarboxylase 5PRO_0000416956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei276 – 2761N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PRIDEiQ9LSH2.

Expressioni

Tissue specificityi

Expressed in flowers.1 Publication

Gene expression databases

GenevestigatoriQ9LSH2.

Interactioni

Subunit structurei

Homohexamer. Interacts with clamodulin (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9LSH2. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9LSH2.
SMRiQ9LSH2. Positions 13-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

InParanoidiQ9LSH2.
KOiK01580.
OMAiPTFQINF.
PhylomeDBiQ9LSH2.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9LSH2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLATNSDSD EHLHSTFASR YVRAVVPRFK MPDHCMPKDA AYQVINDELM
60 70 80 90 100
LDGNPRLNLA SFVTTWMEPE CDKLIMDSVN KNYVDMDEYP VTTELQNRCV
110 120 130 140 150
NMIANLFHAP VGEDEAAIGC GTVGSSEAIM LAGLAFKRKW QHRRKAQGLP
160 170 180 190 200
IDKPNIVTGA NVQVCWEKFA RYFEVELKEV KLSEDYYVMD PAKAVEMVDE
210 220 230 240 250
NTICVAAILG STLTGEFEDV KQLNDLLAEK NAETGWETPI HVDAASGGFI
260 270 280 290 300
APFLYPDLEW DFRLPWVKSI NVSGHKYGLV YAGVGWVVWR TKDDLPEELV
310 320 330 340 350
FHINYLGADQ PTFTLNFSKG SSQIIAQYYQ FIRLGFEGYK NIMENCMDNA
360 370 380 390 400
RRLREGIEMT GKFNIVSKDI GVPLVAFSLK DSSKHTVFEI AESLRKFGWI
410 420 430 440 450
IPAYTMPADA QHIAVLRVVI REDFSRGLAD RLITHIIQVL KEIEGLPSRI
460 470 480 490
AHLAAAAAVS GDDEEVKVKT AKMSLEDITK YWKRLVEHKR NIVC
Length:494
Mass (Da):55,770
Last modified:October 1, 2000 - v1
Checksum:i7985F175E54DF262
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026646 Genomic DNA. Translation: BAB02870.1.
CP002686 Genomic DNA. Translation: AEE76003.1.
CP002686 Genomic DNA. Translation: AEE76004.1.
RefSeqiNP_001154621.1. NM_001161149.1.
NP_188403.1. NM_112657.1.
UniGeneiAt.38660.

Genome annotation databases

EnsemblPlantsiAT3G17760.1; AT3G17760.1; AT3G17760.
AT3G17760.2; AT3G17760.2; AT3G17760.
GeneIDi821044.
KEGGiath:AT3G17760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026646 Genomic DNA. Translation: BAB02870.1 .
CP002686 Genomic DNA. Translation: AEE76003.1 .
CP002686 Genomic DNA. Translation: AEE76004.1 .
RefSeqi NP_001154621.1. NM_001161149.1.
NP_188403.1. NM_112657.1.
UniGenei At.38660.

3D structure databases

ProteinModelPortali Q9LSH2.
SMRi Q9LSH2. Positions 13-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9LSH2. 1 interaction.

Proteomic databases

PRIDEi Q9LSH2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G17760.1 ; AT3G17760.1 ; AT3G17760 .
AT3G17760.2 ; AT3G17760.2 ; AT3G17760 .
GeneIDi 821044.
KEGGi ath:AT3G17760.

Organism-specific databases

TAIRi AT3G17760.

Phylogenomic databases

InParanoidi Q9LSH2.
KOi K01580.
OMAi PTFQINF.
PhylomeDBi Q9LSH2.

Enzyme and pathway databases

BioCyci ARA:AT3G17760-MONOMER.
ARA:GQT-2607-MONOMER.

Gene expression databases

Genevestigatori Q9LSH2.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Metabolism and functions of gamma-aminobutyric acid."
    Shelp B.J., Bown A.W., McLean M.D.
    Trends Plant Sci. 4:446-452(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "Contribution of the GABA shunt to hypoxia-induced alanine accumulation in roots of Arabidopsis thaliana."
    Miyashita Y., Good A.G.
    Plant Cell Physiol. 49:92-102(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiDCE5_ARATH
AccessioniPrimary (citable) accession number: Q9LSH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3