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Q9LSD0

- RIR2C_ARATH

UniProt

Q9LSD0 - RIR2C_ARATH

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Protein
Ribonucleoside-diphosphate reductase small chain C
Gene
TSO2, At3g27060, MOJ10.13
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.1 Publication

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Iron 1 By similarity
Metal bindingi107 – 1071Iron 1 By similarity
Metal bindingi107 – 1071Iron 2 By similarity
Metal bindingi110 – 1101Iron 1 By similarity
Active sitei114 – 1141 By similarity
Metal bindingi169 – 1691Iron 2 By similarity
Metal bindingi203 – 2031Iron 2 By similarity
Metal bindingi206 – 2061Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA repair Source: TAIR
  2. DNA replication Source: TAIR
  3. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  4. multicellular organismal development Source: TAIR
  5. programmed cell death Source: TAIR
  6. regulation of cell cycle Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G27060-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain C (EC:1.17.4.1)
Alternative name(s):
Ribonucleoside-diphosphate reductase TSO2 subunit
Ribonucleotide reductase small subunit C
Gene namesi
Name:TSO2
Ordered Locus Names:At3g27060
ORF Names:MOJ10.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G27060.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 332332Ribonucleoside-diphosphate reductase small chain C
PRO_0000254195Add
BLAST

Proteomic databases

PRIDEiQ9LSD0.

Expressioni

Tissue specificityi

Expressed in roots, cauline leaves, stems and flowers.1 Publication

Gene expression databases

ArrayExpressiQ9LSD0.
GenevestigatoriQ9LSD0.

Interactioni

Subunit structurei

Heterodimer of a large and a small chain By similarity.

Protein-protein interaction databases

BioGridi7654. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9LSD0.
SMRiQ9LSD0. Positions 6-287.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ9LSD0.
KOiK10808.
OMAiGVMNSTK.
PhylomeDBiQ9LSD0.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LSD0-1 [UniParc]FASTAAdd to Basket

« Hide

MPSMPEEPLL TPTPDRFCMF PIHYPQIWEM YKKAEASFWT AEEVDLSQDN    50
RDWENSLNDG ERHFIKHVLA FFAASDGIVL ENLASRFMSD VQVSEARAFY 100
GFQIAIENIH SEMYSLLLDT YIKDNKERDH LFRAIETIPC VAKKAQWAMK 150
WIDGSQTFAE RIIAFACVEG IFFSGSFCSI FWLKKRGLMP GLTFSNELIS 200
RDEGLHCDFA CLLYTLLKTK LSEERVKSIV CDAVEIEREF VCDALPCALV 250
GMNRDLMSQY IEFVADRLLG ALGYGKVYGV TNPFDWMELI SLQGKTNFFE 300
KRVGDYQKAS VMSSVNGNGA FDNHVFSLDE DF 332
Length:332
Mass (Da):38,034
Last modified:October 1, 2000 - v1
Checksum:i9EADC6E82B4DFCE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026649 Genomic DNA. Translation: BAB01087.1.
CP002686 Genomic DNA. Translation: AEE77261.1.
AY063837 mRNA. Translation: AAL36193.1.
AY117212 mRNA. Translation: AAM51287.1.
RefSeqiNP_189342.1. NM_113620.3.
UniGeneiAt.24911.
At.74191.

Genome annotation databases

EnsemblPlantsiAT3G27060.1; AT3G27060.1; AT3G27060.
GeneIDi822324.
KEGGiath:AT3G27060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026649 Genomic DNA. Translation: BAB01087.1 .
CP002686 Genomic DNA. Translation: AEE77261.1 .
AY063837 mRNA. Translation: AAL36193.1 .
AY117212 mRNA. Translation: AAM51287.1 .
RefSeqi NP_189342.1. NM_113620.3.
UniGenei At.24911.
At.74191.

3D structure databases

ProteinModelPortali Q9LSD0.
SMRi Q9LSD0. Positions 6-287.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 7654. 1 interaction.

Proteomic databases

PRIDEi Q9LSD0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G27060.1 ; AT3G27060.1 ; AT3G27060 .
GeneIDi 822324.
KEGGi ath:AT3G27060.

Organism-specific databases

GeneFarmi 2091. 386.
TAIRi AT3G27060.

Phylogenomic databases

InParanoidi Q9LSD0.
KOi K10808.
OMAi GVMNSTK.
PhylomeDBi Q9LSD0.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci ARA:AT3G27060-MONOMER.

Gene expression databases

ArrayExpressi Q9LSD0.
Genevestigatori Q9LSD0.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Arabidopsis ribonucleotide reductases are critical for cell cycle progression, DNA damage repair, and plant development."
    Wang C., Liu Z.
    Plant Cell 18:350-365(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.

Entry informationi

Entry nameiRIR2C_ARATH
AccessioniPrimary (citable) accession number: Q9LSD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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