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Q9LRZ4

- P2C41_ARATH

UniProt

Q9LRZ4 - P2C41_ARATH

Protein

Probable protein phosphatase 2C 41

Gene

At3g16800

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi98 – 981Manganese 1By similarity
    Metal bindingi98 – 981Manganese 2By similarity
    Metal bindingi99 – 991Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi293 – 2931Manganese 2By similarity
    Metal bindingi339 – 3391Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT3G16800-MONOMER.
    ARA:GQT-1053-MONOMER.
    ARA:GQT-1054-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 41 (EC:3.1.3.16)
    Short name:
    AtPP2C41
    Gene namesi
    Ordered Locus Names:At3g16800
    ORF Names:K20I9.2
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G16800.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: TAIR
    2. nucleus Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Probable protein phosphatase 2C 41PRO_0000367965Add
    BLAST

    Proteomic databases

    PRIDEiQ9LRZ4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9LRZ4.
    GenevestigatoriQ9LRZ4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LRZ4.
    SMRiQ9LRZ4. Positions 62-348.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini169 – 309141PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233897.
    InParanoidiQ9LRZ4.
    OMAiRSIAMDD.
    PhylomeDBiQ9LRZ4.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9LRZ4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVLLPAFLDG LARTVSTKKG KKLSEDEDGG REIAKSMIKD SKKNSTLLGT    50
    SGFVSSESSK RFTSICSNRG EKGINQDRAI VWEGFGCQED ITFCGMFDGH 100
    GPWGHVIAKR VKKSFPSSLL CQWQQTLASL SSSPECSSPF DLWKQACLKT 150
    FSIIDLDLKI SPSIDSYCSG CTALTAVLQG DHLVIANAGD SRAVIATTSD 200
    DGNGLVPVQL SVDFKPNIPE EAERIKQSDG RLFCLDDEPG VYRVGMPNGG 250
    SLGLAVSRAF GDYCLKDFGL VSEPEVTYRK ITDKDQFLIL ATDGMWDVMT 300
    NNEAVEIVRG VKERRKSAKR LVERAVTLWR RKRRSIAMDD ISVLCLFFRP 350
    S 351
    Length:351
    Mass (Da):38,601
    Last modified:October 1, 2000 - v1
    Checksum:i5161F2EA4314BFD6
    GO
    Isoform 2 (identifier: Q9LRZ4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-95: Missing.
         295-315: MWDVMTNNEAVEIVRGVKERR → VIYQTYSAFKSKSRLINHIIV
         316-351: Missing.

    Note: May be due to intron retention. No experimental confirmation available.

    Show »
    Length:220
    Mass (Da):23,983
    Checksum:i8581675EA34F603A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9595Missing in isoform 2. 1 PublicationVSP_036767Add
    BLAST
    Alternative sequencei295 – 31521MWDVM…VKERR → VIYQTYSAFKSKSRLINHII V in isoform 2. 1 PublicationVSP_036768Add
    BLAST
    Alternative sequencei316 – 35136Missing in isoform 2. 1 PublicationVSP_036769Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028608 Genomic DNA. Translation: BAA95773.1.
    CP002686 Genomic DNA. Translation: AEE75866.1.
    CP002686 Genomic DNA. Translation: AEE75867.1.
    AY099831 mRNA. Translation: AAM20682.1.
    BT000321 mRNA. Translation: AAN15640.1.
    AK317121 mRNA. Translation: BAH19809.1.
    AY088376 mRNA. Translation: AAM65915.1.
    RefSeqiNP_188303.1. NM_112554.2. [Q9LRZ4-1]
    NP_850599.2. NM_180268.3. [Q9LRZ4-1]
    UniGeneiAt.38836.

    Genome annotation databases

    EnsemblPlantsiAT3G16800.1; AT3G16800.1; AT3G16800. [Q9LRZ4-1]
    AT3G16800.2; AT3G16800.2; AT3G16800. [Q9LRZ4-1]
    GeneIDi820933.
    KEGGiath:AT3G16800.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028608 Genomic DNA. Translation: BAA95773.1 .
    CP002686 Genomic DNA. Translation: AEE75866.1 .
    CP002686 Genomic DNA. Translation: AEE75867.1 .
    AY099831 mRNA. Translation: AAM20682.1 .
    BT000321 mRNA. Translation: AAN15640.1 .
    AK317121 mRNA. Translation: BAH19809.1 .
    AY088376 mRNA. Translation: AAM65915.1 .
    RefSeqi NP_188303.1. NM_112554.2. [Q9LRZ4-1 ]
    NP_850599.2. NM_180268.3. [Q9LRZ4-1 ]
    UniGenei At.38836.

    3D structure databases

    ProteinModelPortali Q9LRZ4.
    SMRi Q9LRZ4. Positions 62-348.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9LRZ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G16800.1 ; AT3G16800.1 ; AT3G16800 . [Q9LRZ4-1 ]
    AT3G16800.2 ; AT3G16800.2 ; AT3G16800 . [Q9LRZ4-1 ]
    GeneIDi 820933.
    KEGGi ath:AT3G16800.

    Organism-specific databases

    TAIRi AT3G16800.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233897.
    InParanoidi Q9LRZ4.
    OMAi RSIAMDD.
    PhylomeDBi Q9LRZ4.

    Enzyme and pathway databases

    BioCyci ARA:AT3G16800-MONOMER.
    ARA:GQT-1053-MONOMER.
    ARA:GQT-1054-MONOMER.

    Gene expression databases

    ArrayExpressi Q9LRZ4.
    Genevestigatori Q9LRZ4.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
      DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: cv. Columbia.
    4. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
      Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
      DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C41_ARATH
    AccessioniPrimary (citable) accession number: Q9LRZ4
    Secondary accession number(s): Q8LPG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3