Reviewed,
UniProtKB/Swiss-Prot Q9LRR9 (GOX2_ARATH)
Last modified
June 16, 2009.
Version 66.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Probable peroxisomal (S)-2-hydroxy-acid oxidase 2 EC=1.1.3.15 Alternative name(s): Glycolate oxidase 2 Short name=GOX 2 Short chain alpha-hydroxy acid oxidase 2 | ||||
| Gene names |
| ||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||
| Taxonomic identifier | 3702 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 367 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2. |
| Cofactor | FMN By similarity. |
| Pathway | Photosynthesis; photorespiration; glycine from 2-phosphoglycolic acid: step 2/3. |
| Subunit structure | Homotetramer or homooctamer By similarity. |
| Subcellular location | Peroxisome By similarity. |
| Sequence similarities | Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Contains 1 FMN hydroxy acid dehydrogenase domain. |
Ontologies
Alternative products
| This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms are produced. According to EST sequences. | ||||||
| Isoform 1 (identifier: Q9LRR9-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 367 | 367 | Probable peroxisomal (S)-2-hydroxy-acid oxidase 2 | PRO_0000206324 | |||||
Regions | |||||||||
| Domain | 1 – 359 | 359 | FMN hydroxy acid dehydrogenase | ||||||
| Nucleotide binding | 285 – 309 | 25 | FMN By similarity | ||||||
| Motif | 365 – 367 | 3 | Microbody targeting signal Potential | ||||||
Sites | |||||||||
| Active site | 254 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 24 | 1 | Substrate Potential | ||||||
| Binding site | 106 | 1 | FMN By similarity | ||||||
| Binding site | 127 | 1 | FMN By similarity | ||||||
| Binding site | 129 | 1 | Substrate By similarity | ||||||
| Binding site | 155 | 1 | FMN By similarity | ||||||
| Binding site | 164 | 1 | Substrate By similarity | ||||||
| Binding site | 230 | 1 | FMN By similarity | ||||||
| Binding site | 257 | 1 | Substrate Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 55 | 1 | V → A in AAL16258. Ref.2 | ||||||
| Sequence conflict | 363 | 1 | P → L in AAL38298. Ref.2 | ||||||
| Sequence conflict | 363 | 1 | P → L in AAM10128. Ref.2 | ||||||
Sequences
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References
| [1] | "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S. DNA Res. 7:131-135(2000) [PubMed: 10819329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [2] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: cv. Columbia. |
Cross-references
Sequence databases | |
|---|---|
| AB028617 Genomic DNA. Translation: BAB01334.1. AY053412 mRNA. Translation: AAK96642.1. AF428396 mRNA. Translation: AAL16164.1. AF428328 mRNA. Translation: AAL16258.1. AY065122 mRNA. Translation: AAL38298.1. Different initiation. AY074830 mRNA. Translation: AAL69528.1. AY081566 mRNA. Translation: AAM10128.1. | |
| IPI | IPI00528534. |
| RefSeq | NP_188060.1. NP_850584.1. |
| UniGene | At.21768 At.67007 At.71586 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AL8 based on UniProtKB P05414. |
| SMR | Q9LRR9. Positions 1-359. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9LRR9. 1 interaction. |
Proteomic databases | |
| PRIDE | Q9LRR9. |
| ProMEX | Q9LRR9. |
Genome annotation databases | |
| GeneID | 820665. |
| GenomeReviews | Gene locus AT3G14420 in contig BA000014_GR. |
| NMPDR | fig|3702.1.peg.13579. |
Organism-specific databases | |
| TAIR | At3g14420. |
Phylogenomic databases | |
| OMA | Q9LRR9. ADITRNH. |
Enzyme and pathway databases | |
| BRENDA | 1.1.3.15. 302. |
Family and domain databases | |
| InterPro | IPR012133. a-Hydoxy_acid_DH_FMN. IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR017934. FMN-dep_OHA_DH. IPR008259. FMN_hydac_DH_AS. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF01070. FMN_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF000138. Al-hdrx_acd_dh. 1 hit. |
| PROSITE | PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GOX2_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q9LRR9 Secondary accession number(s): Q8VZA4, Q944K6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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