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Q9LR78

- BSU1_ARATH

UniProt

Q9LR78 - BSU1_ARATH

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Protein
Serine/threonine-protein phosphatase BSU1
Gene
BSU1, At1g03445, At1g03450, F21B7.7
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Phosphatase that acts as a positive regulator of brassinolide signaling. Dephosphorylates BES1, a transcription factor that regulates the expression of brassinolide-response genes, thereby playing an important role in the regulation of response to brassinosteroids.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi510 – 5101Manganese 1 By similarity
Metal bindingi512 – 5121Manganese 1 By similarity
Metal bindingi544 – 5441Manganese 1 By similarity
Metal bindingi544 – 5441Manganese 2 By similarity
Metal bindingi576 – 5761Manganese 2 By similarity
Active sitei577 – 5771Proton donor By similarity
Metal bindingi629 – 6291Manganese 2 By similarity
Metal bindingi707 – 7071Manganese 2 By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. manganese ion binding Source: InterPro
  3. protein binding Source: TAIR
  4. protein serine/threonine phosphatase activity Source: TAIR
Complete GO annotation...

GO - Biological processi

  1. brassinosteroid mediated signaling pathway Source: TAIR
  2. dephosphorylation Source: GOC
  3. regulation of protein localization Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G03445-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase BSU1 (EC:3.1.3.16)
Alternative name(s):
Bri1 suppressor protein 1
Gene namesi
Name:BSU1
Ordered Locus Names:At1g03445, At1g03450
ORF Names:F21B7.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G03445.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 793793Serine/threonine-protein phosphatase BSU1
PRO_0000058904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei444 – 4441Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9LR78.

Expressioni

Tissue specificityi

Mainly expressed in young, elongating tissues. In young seedlings, it is expressed at the base of the hypocotyl, at the tip and most peripheral cell layers of cotyledons, and in the vascular cylinder of roots, particularly in the elongation zone and at the point of emergence of lateral roots. In mature plants, it is still present in the root vasculature, but almost completely absent in fully expanded stems and leaves. In flowers, it is mainly expressed in sepal veins, anther filaments, and in the style, suggesting that BSU1 is expressed in actively growing regions and apparently enriched in vascular tissues.1 Publication

Gene expression databases

GenevestigatoriQ9LR78.

Interactioni

Protein-protein interaction databases

BioGridi24043. 1 interaction.
STRINGi3702.AT1G03445.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LR78.
SMRiQ9LR78. Positions 480-757.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati53 – 10957Kelch 1
Add
BLAST
Repeati110 – 16051Kelch 2
Add
BLAST
Repeati214 – 26249Kelch 3
Add
BLAST
Repeati264 – 31451Kelch 4
Add
BLAST
Repeati329 – 38860Kelch 5
Add
BLAST

Sequence similaritiesi

Contains 5 Kelch repeats.

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000246464.
InParanoidiQ9LR78.
KOiK14501.
OMAiEGDITHI.
PhylomeDBiQ9LR78.

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR015916. Gal_Oxidase_b-propeller.
IPR015915. Kelch-typ_b-propeller.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR012391. Ser/Thr_prot_Pase_BSU1.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF036363. PPP_BSU1. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LR78-1 [UniParc]FASTAAdd to Basket

« Hide

MAPDQSYQYP SPSYESIQTF YDTDEDWPGP RCGHTLTAVF VNNSHQLILF    50
GGSTTAVANH NSSLPEISLD GVTNSVHSFD VLTRKWTRLN PIGDVPSPRA 100
CHAAALYGTL ILIQGGIGPS GPSDGDVYML DMTNNKWIKF LVGGETPSPR 150
YGHVMDIAAQ RWLVIFSGNN GNEILDDTWA LDTRGPFSWD RLNPSGNQPS 200
GRMYASGSSR EDGIFLLCGG IDHSGVTLGD TYGLKMDSDN VWTPVPAVAP 250
SPRYQHTAVF GGSKLHVIGG ILNRARLIDG EAVVAVLDTE TGEWVDTNQP 300
ETSASGANRQ NQYQLMRRCH HAAASFGSHL YVHGGIREDV LLDDLLVAET 350
SQSSSPEPEE DNPDNYMLLD DYLMDEPKPL SSEPEASSFI MRSTSEIAMD 400
RLAEAHNLPT IENAFYDSAI EGYVPLQHGA ETVGNRGGLV RTASLDQSTQ 450
DLHKKVISTL LRPKTWTPPA NRDFFLSYLE VKHLCDEVEK IFMNEPTLLQ 500
LKVPIKVFGD IHGQYGDLMR LFHEYGHPSV EGDITHIDYL FLGDYVDRGQ 550
HSLEIIMLLF ALKIEYPKNI HLIRGNHESL AMNRIYGFLT ECEERMGESY 600
GFEAWLKINQ VFDYLPLAAL LEKKVLCVHG GIGRAVTIEE IENIERPAFP 650
DTGSMVLKDI LWSDPTMNDT VLGIVDNARG EGVVSFGPDI VKAFLERNGL 700
EMILRAHECV IDGFERFADG RLITVFSATN YCGTAQNAGA ILVIGRDMVI 750
YPKLIHPHPP PISSSEEDYT DKAWMQELNI EMPPTPARGE SSE 793
Length:793
Mass (Da):87,789
Last modified:March 15, 2004 - v2
Checksum:i07A083BD780EAA79
GO

Sequence cautioni

The sequence AAF86539.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY372269 mRNA. Translation: AAR19789.1.
AC002560 Genomic DNA. Translation: AAF86539.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE27572.1.
RefSeqiNP_171844.6. NM_100227.6.
UniGeneiAt.49845.

Genome annotation databases

EnsemblPlantsiAT1G03445.1; AT1G03445.1; AT1G03445.
GeneIDi838804.
KEGGiath:AT1G03445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY372269 mRNA. Translation: AAR19789.1 .
AC002560 Genomic DNA. Translation: AAF86539.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE27572.1 .
RefSeqi NP_171844.6. NM_100227.6.
UniGenei At.49845.

3D structure databases

ProteinModelPortali Q9LR78.
SMRi Q9LR78. Positions 480-757.
ModBasei Search...

Protein-protein interaction databases

BioGridi 24043. 1 interaction.
STRINGi 3702.AT1G03445.1-P.

Proteomic databases

PRIDEi Q9LR78.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G03445.1 ; AT1G03445.1 ; AT1G03445 .
GeneIDi 838804.
KEGGi ath:AT1G03445.

Organism-specific databases

TAIRi AT1G03445.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000246464.
InParanoidi Q9LR78.
KOi K14501.
OMAi EGDITHI.
PhylomeDBi Q9LR78.

Enzyme and pathway databases

BioCyci ARA:AT1G03445-MONOMER.

Miscellaneous databases

PROi Q9LR78.

Gene expression databases

Genevestigatori Q9LR78.

Family and domain databases

Gene3Di 2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR015916. Gal_Oxidase_b-propeller.
IPR015915. Kelch-typ_b-propeller.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR012391. Ser/Thr_prot_Pase_BSU1.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF036363. PPP_BSU1. 1 hit.
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nuclear protein phosphatases with Kelch-repeat domains modulate the response to brassinosteroids in Arabidopsis."
    Mora-Garcia S., Vert G., Yin Y., Cano-Delgado A., Cheong H., Chory J.
    Genes Dev. 18:448-460(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Arabidopsis PPP family of serine/threonine phosphatases."
    Farkas I., Dombradi V., Miskei M., Szabados L., Koncz C.
    Trends Plant Sci. 12:169-176(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiBSU1_ARATH
AccessioniPrimary (citable) accession number: Q9LR78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: June 11, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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