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Q9LR65

- P2C01_ARATH

UniProt

Q9LR65 - P2C01_ARATH

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Protein
Probable protein phosphatase 2C 1
Gene
PPC6-6, At1g03590, F21B7.20
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May act as negative regulator of GCN5.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi95 – 951Manganese 1 By similarity
Metal bindingi95 – 951Manganese 2 By similarity
Metal bindingi96 – 961Manganese 1; via carbonyl oxygen By similarity
Metal bindingi307 – 3071Manganese 2 By similarity
Metal bindingi353 – 3531Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G03590-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 1 (EC:3.1.3.16)
    Short name:
    AtPP2C01
    Alternative name(s):
    AtPPC6;6
    Gene namesi
    Name:PPC6-6
    Ordered Locus Names:At1g03590
    ORF Names:F21B7.20
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G03590.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: TAIR
    Complete GO annotation...

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 462462Probable protein phosphatase 2C 1
    PRO_0000367935Add
    BLAST

    Proteomic databases

    PaxDbiQ9LR65.
    PRIDEiQ9LR65.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9LR65.

    Interactioni

    Subunit structurei

    Interacts with GCN5.1 Publication

    Protein-protein interaction databases

    BioGridi24682. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LR65.
    SMRiQ9LR65. Positions 68-358.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini90 – 341252PP2C-like
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.
    Contains 1 PP2C-like domain.

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233897.
    InParanoidiQ9LR65.
    OMAiEQCFSSA.
    PhylomeDBiQ9LR65.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9LR65-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGCISKTSW SNEEPMHRPC LGMGCCGSKM GKRGFSDRMV SLHNLVSIPN    50
    RIIGNGKSRS SCIFTQQGRK GINQDAMIVW EDFMSKDVTF CGVFDGHGPH 100
    GHLVARKVRD SLPVKLLSLL NSIKSKQNGP IGTRASKSDS LEAEKEESTE 150
    EDKLNFLWEE AFLKSFNAMD KELRSHPNLE CFCSGCTAVT IIKQGSNLYM 200
    GNIGDSRAIL GSKDSNDSMI AVQLTVDLKP DLPREAERIK QCKGRVFALQ 250
    DEPEVSRVWL PFDNAPGLAM ARAFGDFCLK DYGVISIPEF SHRVLTDRDQ 300
    FIVLASDGVW DVLSNEEVVE VVASATSRAS AARLVVDSAV REWKLKYPTS 350
    KMDDCAVVCL FLDGRMDSET SDNEEQCFSS ATNAVESDES QGAEPCLQRN 400
    VTVRSLSTDQ ENNSYGKVIA EADNAEKEKT REGEQNWSGL EGVTRVNSLV 450
    QLPRFPGEEP KT 462
    Length:462
    Mass (Da):50,975
    Last modified:October 1, 2000 - v1
    Checksum:iF264E7DA32C7E472
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002560 Genomic DNA. Translation: AAF86530.1.
    CP002684 Genomic DNA. Translation: AEE27587.1.
    AB079670 mRNA. Translation: BAB84699.1.
    PIRiT00901.
    RefSeqiNP_171856.4. NM_100239.7.
    UniGeneiAt.42536.
    At.44796.

    Genome annotation databases

    EnsemblPlantsiAT1G03590.1; AT1G03590.1; AT1G03590.
    GeneIDi839447.
    KEGGiath:AT1G03590.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002560 Genomic DNA. Translation: AAF86530.1 .
    CP002684 Genomic DNA. Translation: AEE27587.1 .
    AB079670 mRNA. Translation: BAB84699.1 .
    PIRi T00901.
    RefSeqi NP_171856.4. NM_100239.7.
    UniGenei At.42536.
    At.44796.

    3D structure databases

    ProteinModelPortali Q9LR65.
    SMRi Q9LR65. Positions 68-358.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 24682. 1 interaction.

    Proteomic databases

    PaxDbi Q9LR65.
    PRIDEi Q9LR65.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G03590.1 ; AT1G03590.1 ; AT1G03590 .
    GeneIDi 839447.
    KEGGi ath:AT1G03590.

    Organism-specific databases

    TAIRi AT1G03590.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233897.
    InParanoidi Q9LR65.
    OMAi EQCFSSA.
    PhylomeDBi Q9LR65.

    Enzyme and pathway databases

    BioCyci ARA:AT1G03590-MONOMER.

    Gene expression databases

    Genevestigatori Q9LR65.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Substrate specificity of type 2C protein phosphatases (PP2C) in Arabidopsis thaliana."
      Izumi S., Yamada M., Ohsato H., Miyazaki S., Bohnert H.J., Fukuhara T.
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-462.
    4. "Characterization of a phosphatase 2C protein as an interacting partner of the histone acetyltransferase GCN5 in Arabidopsis."
      Servet C., Benhamed M., Latrasse D., Kim W., Delarue M., Zhou D.-X.
      Biochim. Biophys. Acta 1779:376-382(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GCN5.
    5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C01_ARATH
    AccessioniPrimary (citable) accession number: Q9LR65
    Secondary accession number(s): Q8SBC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: October 1, 2000
    Last modified: June 11, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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