Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9LR65 (P2C01_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein phosphatase 2C 1

Short name=AtPP2C01
EC=3.1.3.16
Alternative name(s):
AtPPC6;6
Gene names
Name:PPC6-6
Ordered Locus Names:At1g03590
ORF Names:F21B7.20
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as negative regulator of GCN5. Ref.4

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subunit structure

Interacts with GCN5. Ref.4

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Probable protein phosphatase 2C 1
PRO_0000367935

Regions

Domain90 – 341252PP2C-like

Sites

Metal binding951Manganese 1 By similarity
Metal binding951Manganese 2 By similarity
Metal binding961Manganese 1; via carbonyl oxygen By similarity
Metal binding3071Manganese 2 By similarity
Metal binding3531Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9LR65 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F264E7DA32C7E472

FASTA46250,975
        10         20         30         40         50         60 
MGGCISKTSW SNEEPMHRPC LGMGCCGSKM GKRGFSDRMV SLHNLVSIPN RIIGNGKSRS 

        70         80         90        100        110        120 
SCIFTQQGRK GINQDAMIVW EDFMSKDVTF CGVFDGHGPH GHLVARKVRD SLPVKLLSLL 

       130        140        150        160        170        180 
NSIKSKQNGP IGTRASKSDS LEAEKEESTE EDKLNFLWEE AFLKSFNAMD KELRSHPNLE 

       190        200        210        220        230        240 
CFCSGCTAVT IIKQGSNLYM GNIGDSRAIL GSKDSNDSMI AVQLTVDLKP DLPREAERIK 

       250        260        270        280        290        300 
QCKGRVFALQ DEPEVSRVWL PFDNAPGLAM ARAFGDFCLK DYGVISIPEF SHRVLTDRDQ 

       310        320        330        340        350        360 
FIVLASDGVW DVLSNEEVVE VVASATSRAS AARLVVDSAV REWKLKYPTS KMDDCAVVCL 

       370        380        390        400        410        420 
FLDGRMDSET SDNEEQCFSS ATNAVESDES QGAEPCLQRN VTVRSLSTDQ ENNSYGKVIA 

       430        440        450        460 
EADNAEKEKT REGEQNWSGL EGVTRVNSLV QLPRFPGEEP KT 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Substrate specificity of type 2C protein phosphatases (PP2C) in Arabidopsis thaliana."
Izumi S., Yamada M., Ohsato H., Miyazaki S., Bohnert H.J., Fukuhara T.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-462.
[4]"Characterization of a phosphatase 2C protein as an interacting partner of the histone acetyltransferase GCN5 in Arabidopsis."
Servet C., Benhamed M., Latrasse D., Kim W., Delarue M., Zhou D.-X.
Biochim. Biophys. Acta 1779:376-382(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH GCN5.
[5]"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC002560 Genomic DNA. Translation: AAF86530.1.
CP002684 Genomic DNA. Translation: AEE27587.1.
AB079670 mRNA. Translation: BAB84699.1.
PIRT00901.
RefSeqNP_171856.4. NM_100239.7.
UniGeneAt.42536.
At.44796.

3D structure databases

ProteinModelPortalQ9LR65.
SMRQ9LR65. Positions 63-365.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid24682. 1 interaction.

Proteomic databases

PaxDbQ9LR65.
PRIDEQ9LR65.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G03590.1; AT1G03590.1; AT1G03590.
GeneID839447.
KEGGath:AT1G03590.

Organism-specific databases

TAIRAT1G03590.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000233897.
InParanoidQ9LR65.
OMADYGVISI.
PhylomeDBQ9LR65.
ProtClustDBCLSN2719829.

Enzyme and pathway databases

BioCycARA:AT1G03590-MONOMER.

Gene expression databases

GenevestigatorQ9LR65.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 2 hits.
ProtoNetSearch...

Entry information

Entry nameP2C01_ARATH
AccessionPrimary (citable) accession number: Q9LR65
Secondary accession number(s): Q8SBC2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names