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Q9LR65

- P2C01_ARATH

UniProt

Q9LR65 - P2C01_ARATH

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Protein

Probable protein phosphatase 2C 1

Gene

PPC6-6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May act as negative regulator of GCN5.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi95 – 951Manganese 1By similarity
Metal bindingi95 – 951Manganese 2By similarity
Metal bindingi96 – 961Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi307 – 3071Manganese 2By similarity
Metal bindingi353 – 3531Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G03590-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 1 (EC:3.1.3.16)
Short name:
AtPP2C01
Alternative name(s):
AtPPC6;6
Gene namesi
Name:PPC6-6
Ordered Locus Names:At1g03590
ORF Names:F21B7.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G03590.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Probable protein phosphatase 2C 1PRO_0000367935Add
BLAST

Proteomic databases

PaxDbiQ9LR65.
PRIDEiQ9LR65.

Expressioni

Gene expression databases

GenevestigatoriQ9LR65.

Interactioni

Subunit structurei

Interacts with GCN5.1 Publication

Protein-protein interaction databases

BioGridi24682. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9LR65.
SMRiQ9LR65. Positions 68-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 341252PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233897.
InParanoidiQ9LR65.
OMAiEQCFSSA.
PhylomeDBiQ9LR65.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9LR65-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGGCISKTSW SNEEPMHRPC LGMGCCGSKM GKRGFSDRMV SLHNLVSIPN
60 70 80 90 100
RIIGNGKSRS SCIFTQQGRK GINQDAMIVW EDFMSKDVTF CGVFDGHGPH
110 120 130 140 150
GHLVARKVRD SLPVKLLSLL NSIKSKQNGP IGTRASKSDS LEAEKEESTE
160 170 180 190 200
EDKLNFLWEE AFLKSFNAMD KELRSHPNLE CFCSGCTAVT IIKQGSNLYM
210 220 230 240 250
GNIGDSRAIL GSKDSNDSMI AVQLTVDLKP DLPREAERIK QCKGRVFALQ
260 270 280 290 300
DEPEVSRVWL PFDNAPGLAM ARAFGDFCLK DYGVISIPEF SHRVLTDRDQ
310 320 330 340 350
FIVLASDGVW DVLSNEEVVE VVASATSRAS AARLVVDSAV REWKLKYPTS
360 370 380 390 400
KMDDCAVVCL FLDGRMDSET SDNEEQCFSS ATNAVESDES QGAEPCLQRN
410 420 430 440 450
VTVRSLSTDQ ENNSYGKVIA EADNAEKEKT REGEQNWSGL EGVTRVNSLV
460
QLPRFPGEEP KT
Length:462
Mass (Da):50,975
Last modified:October 1, 2000 - v1
Checksum:iF264E7DA32C7E472
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002560 Genomic DNA. Translation: AAF86530.1.
CP002684 Genomic DNA. Translation: AEE27587.1.
AB079670 mRNA. Translation: BAB84699.1.
PIRiT00901.
RefSeqiNP_171856.4. NM_100239.7.
UniGeneiAt.42536.
At.44796.

Genome annotation databases

EnsemblPlantsiAT1G03590.1; AT1G03590.1; AT1G03590.
GeneIDi839447.
KEGGiath:AT1G03590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002560 Genomic DNA. Translation: AAF86530.1 .
CP002684 Genomic DNA. Translation: AEE27587.1 .
AB079670 mRNA. Translation: BAB84699.1 .
PIRi T00901.
RefSeqi NP_171856.4. NM_100239.7.
UniGenei At.42536.
At.44796.

3D structure databases

ProteinModelPortali Q9LR65.
SMRi Q9LR65. Positions 68-358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 24682. 1 interaction.

Proteomic databases

PaxDbi Q9LR65.
PRIDEi Q9LR65.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G03590.1 ; AT1G03590.1 ; AT1G03590 .
GeneIDi 839447.
KEGGi ath:AT1G03590.

Organism-specific databases

TAIRi AT1G03590.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233897.
InParanoidi Q9LR65.
OMAi EQCFSSA.
PhylomeDBi Q9LR65.

Enzyme and pathway databases

BioCyci ARA:AT1G03590-MONOMER.

Gene expression databases

Genevestigatori Q9LR65.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Substrate specificity of type 2C protein phosphatases (PP2C) in Arabidopsis thaliana."
    Izumi S., Yamada M., Ohsato H., Miyazaki S., Bohnert H.J., Fukuhara T.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-462.
  4. "Characterization of a phosphatase 2C protein as an interacting partner of the histone acetyltransferase GCN5 in Arabidopsis."
    Servet C., Benhamed M., Latrasse D., Kim W., Delarue M., Zhou D.-X.
    Biochim. Biophys. Acta 1779:376-382(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GCN5.
  5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C01_ARATH
AccessioniPrimary (citable) accession number: Q9LR65
Secondary accession number(s): Q8SBC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3