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Q9LR29

- TAR1_ARATH

UniProt

Q9LR29 - TAR1_ARATH

Protein

Tryptophan aminotransferase-related protein 1

Gene

TAR1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Probably involved in auxin production. TAA1, TAR1 and TAR2 are required for proper embryo patterning.1 Publication

    Catalytic activityi

    L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate.
    L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine.

    Cofactori

    Pyridoxal phosphate.By similarity

    Enzyme regulationi

    Inhibited by L-kynurenine.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei59 – 591Pyridoxal phosphateBy similarity
    Binding sitei169 – 1691Pyridoxal phosphateBy similarity
    Binding sitei190 – 1901Pyridoxal phosphateBy similarity
    Binding sitei224 – 2241Pyridoxal phosphateBy similarity

    GO - Molecular functioni

    1. carbon-sulfur lyase activity Source: InterPro
    2. L-tryptophan:2-oxoglutarate aminotransferase activity Source: TAIR
    3. L-tryptophan:pyruvate aminotransferase activity Source: TAIR
    4. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. auxin biosynthetic process Source: UniProtKB-UniPathway
    2. cotyledon development Source: TAIR
    3. cotyledon vascular tissue pattern formation Source: TAIR
    4. embryo development ending in seed dormancy Source: TAIR
    5. primary root development Source: TAIR

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Biological processi

    Auxin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan aminotransferase-related protein 1 (EC:2.6.1.27, EC:2.6.1.99)
    Gene namesi
    Name:TAR1
    Ordered Locus Names:At1g23320
    ORF Names:F26F24.17
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G23320.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Tryptophan aminotransferase-related protein 1PRO_0000411674Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei216 – 2161N6-(pyridoxal phosphate)lysineSequence Analysis

    Expressioni

    Tissue specificityi

    Very low expression in seedlings.1 Publication

    Inductioni

    Slightly up-regulated by ethylene.1 Publication

    Gene expression databases

    GenevestigatoriQ9LR29.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G23320.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LR29.
    SMRiQ9LR29. Positions 21-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni101 – 1022Pyridoxal phosphate bindingBy similarity
    Regioni190 – 1934Pyridoxal phosphate bindingBy similarity
    Regioni213 – 2164Pyridoxal phosphate bindingBy similarity

    Sequence similaritiesi

    Belongs to the alliinase family.Curated

    Phylogenomic databases

    eggNOGiNOG284125.
    HOGENOMiHOG000237549.
    InParanoidiQ9LR29.
    KOiK16903.
    OMAiCENSKKS.

    Family and domain databases

    Gene3Di2.10.25.30. 1 hit.
    3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR006948. Alliinase_C.
    IPR006947. EGF_alliinase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF04864. Alliinase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9LR29-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMVGCENSKK SDSGSNEDKS LSDDIINLDQ GDPTAFQEYW MKKKDRCTVV    50
    IPAWDLMSYF SDTKNVCWFL EPELEKAIKA LHGAIGNAAT EERYIVVGTG 100
    SSQLCQAALF ALSSLSEVKP VSIVAAVPYY STYVEEASYL QSTLYKWEGD 150
    ARTFDKKGPY IELVTSPNNP DGIMREPVVN RREGGKVIHD LAYYWPHYTP 200
    ITRRQDHDLM LFTFSKITGH AGSRIGWALV KDIEVAKKMV HYLTINSIGV 250
    SKESQTRATT ILNELTKTCR TQSESFFEYG YEKMKSRWER LREVVESGDA 300
    FTLPNYPQDF CNFFGKTLST SPAFAWLGYK EERDLGSLLK EKKVLTRGGD 350
    RCGCNKRYVR VSMLSRDDDF DVSLQRLATI KDLKCVEP 388
    Length:388
    Mass (Da):44,064
    Last modified:July 27, 2011 - v2
    Checksum:i4B5FEA35566BBD12
    GO

    Sequence cautioni

    The sequence AAF87014.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005292 Genomic DNA. Translation: AAF87014.1. Different initiation.
    CP002684 Genomic DNA. Translation: AEE30372.1.
    RefSeqiNP_173746.1. NM_102181.1.
    UniGeneiAt.51734.

    Genome annotation databases

    EnsemblPlantsiAT1G23320.1; AT1G23320.1; AT1G23320.
    GeneIDi838941.
    KEGGiath:AT1G23320.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005292 Genomic DNA. Translation: AAF87014.1 . Different initiation.
    CP002684 Genomic DNA. Translation: AEE30372.1 .
    RefSeqi NP_173746.1. NM_102181.1.
    UniGenei At.51734.

    3D structure databases

    ProteinModelPortali Q9LR29.
    SMRi Q9LR29. Positions 21-381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G23320.1-P.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G23320.1 ; AT1G23320.1 ; AT1G23320 .
    GeneIDi 838941.
    KEGGi ath:AT1G23320.

    Organism-specific databases

    TAIRi AT1G23320.

    Phylogenomic databases

    eggNOGi NOG284125.
    HOGENOMi HOG000237549.
    InParanoidi Q9LR29.
    KOi K16903.
    OMAi CENSKKS.

    Enzyme and pathway databases

    UniPathwayi UPA00151 .

    Gene expression databases

    Genevestigatori Q9LR29.

    Family and domain databases

    Gene3Di 2.10.25.30. 1 hit.
    3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR006948. Alliinase_C.
    IPR006947. EGF_alliinase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF04864. Alliinase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development."
      Stepanova A.N., Robertson-Hoyt J., Yun J., Benavente L.M., Xie D.Y., Dolezal K., Schlereth A., Juergens G., Alonso J.M.
      Cell 133:177-191(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, INDUCTION BY ETHYLENE, GENE FAMILY, NOMENCLATURE.
    4. "Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants."
      Tao Y., Ferrer J.L., Ljung K., Pojer F., Hong F., Long J.A., Li L., Moreno J.E., Bowman M.E., Ivans L.J., Cheng Y., Lim J., Zhao Y., Ballare C.L., Sandberg G., Noel J.P., Chory J.
      Cell 133:164-176(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    5. "A small-molecule screen identifies L-kynurenine as a competitive inhibitor of TAA1/TAR activity in ethylene-directed auxin biosynthesis and root growth in Arabidopsis."
      He W., Brumos J., Li H., Ji Y., Ke M., Gong X., Zeng Q., Li W., Zhang X., An F., Wen X., Li P., Chu J., Sun X., Yan C., Yan N., Xie D.Y., Raikhel N.
      , Yang Z., Stepanova A.N., Alonso J.M., Guo H.
      Plant Cell 23:3944-3960(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION.

    Entry informationi

    Entry nameiTAR1_ARATH
    AccessioniPrimary (citable) accession number: Q9LR29
    Secondary accession number(s): F4I655
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3