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Q9LR29

- TAR1_ARATH

UniProt

Q9LR29 - TAR1_ARATH

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Protein

Tryptophan aminotransferase-related protein 1

Gene
TAR1, At1g23320, F26F24.17
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably involved in auxin production. TAA1, TAR1 and TAR2 are required for proper embryo patterning.1 Publication

Catalytic activityi

L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate.
L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine.

Cofactori

Pyridoxal phosphate By similarity.

Enzyme regulationi

Inhibited by L-kynurenine.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei59 – 591Pyridoxal phosphate By similarity
Binding sitei169 – 1691Pyridoxal phosphate By similarity
Binding sitei190 – 1901Pyridoxal phosphate By similarity
Binding sitei224 – 2241Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. carbon-sulfur lyase activity Source: InterPro
  2. L-tryptophan:2-oxoglutarate aminotransferase activity Source: TAIR
  3. L-tryptophan:pyruvate aminotransferase activity Source: TAIR
  4. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. auxin biosynthetic process Source: UniProtKB-UniPathway
  2. cotyledon development Source: TAIR
  3. cotyledon vascular tissue pattern formation Source: TAIR
  4. embryo development ending in seed dormancy Source: TAIR
  5. primary root development Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Biological processi

Auxin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00151.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan aminotransferase-related protein 1 (EC:2.6.1.27, EC:2.6.1.99)
Gene namesi
Name:TAR1
Ordered Locus Names:At1g23320
ORF Names:F26F24.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G23320.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No visible phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Tryptophan aminotransferase-related protein 1PRO_0000411674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei216 – 2161N6-(pyridoxal phosphate)lysine Reviewed prediction

Expressioni

Tissue specificityi

Very low expression in seedlings.1 Publication

Inductioni

Slightly up-regulated by ethylene.2 Publications

Gene expression databases

GenevestigatoriQ9LR29.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G23320.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LR29.
SMRiQ9LR29. Positions 21-381.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni101 – 1022Pyridoxal phosphate binding By similarity
Regioni190 – 1934Pyridoxal phosphate binding By similarity
Regioni213 – 2164Pyridoxal phosphate binding By similarity

Sequence similaritiesi

Belongs to the alliinase family.

Phylogenomic databases

eggNOGiNOG284125.
HOGENOMiHOG000237549.
InParanoidiQ9LR29.
KOiK16903.
OMAiCENSKKS.

Family and domain databases

Gene3Di2.10.25.30. 1 hit.
3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR006948. Alliinase_C.
IPR006947. EGF_alliinase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF04864. Alliinase_C. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9LR29-1 [UniParc]FASTAAdd to Basket

« Hide

MMVGCENSKK SDSGSNEDKS LSDDIINLDQ GDPTAFQEYW MKKKDRCTVV    50
IPAWDLMSYF SDTKNVCWFL EPELEKAIKA LHGAIGNAAT EERYIVVGTG 100
SSQLCQAALF ALSSLSEVKP VSIVAAVPYY STYVEEASYL QSTLYKWEGD 150
ARTFDKKGPY IELVTSPNNP DGIMREPVVN RREGGKVIHD LAYYWPHYTP 200
ITRRQDHDLM LFTFSKITGH AGSRIGWALV KDIEVAKKMV HYLTINSIGV 250
SKESQTRATT ILNELTKTCR TQSESFFEYG YEKMKSRWER LREVVESGDA 300
FTLPNYPQDF CNFFGKTLST SPAFAWLGYK EERDLGSLLK EKKVLTRGGD 350
RCGCNKRYVR VSMLSRDDDF DVSLQRLATI KDLKCVEP 388
Length:388
Mass (Da):44,064
Last modified:July 27, 2011 - v2
Checksum:i4B5FEA35566BBD12
GO

Sequence cautioni

The sequence AAF87014.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC005292 Genomic DNA. Translation: AAF87014.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE30372.1.
RefSeqiNP_173746.1. NM_102181.1.
UniGeneiAt.51734.

Genome annotation databases

EnsemblPlantsiAT1G23320.1; AT1G23320.1; AT1G23320.
GeneIDi838941.
KEGGiath:AT1G23320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC005292 Genomic DNA. Translation: AAF87014.1 . Different initiation.
CP002684 Genomic DNA. Translation: AEE30372.1 .
RefSeqi NP_173746.1. NM_102181.1.
UniGenei At.51734.

3D structure databases

ProteinModelPortali Q9LR29.
SMRi Q9LR29. Positions 21-381.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G23320.1-P.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G23320.1 ; AT1G23320.1 ; AT1G23320 .
GeneIDi 838941.
KEGGi ath:AT1G23320.

Organism-specific databases

TAIRi AT1G23320.

Phylogenomic databases

eggNOGi NOG284125.
HOGENOMi HOG000237549.
InParanoidi Q9LR29.
KOi K16903.
OMAi CENSKKS.

Enzyme and pathway databases

UniPathwayi UPA00151 .

Gene expression databases

Genevestigatori Q9LR29.

Family and domain databases

Gene3Di 2.10.25.30. 1 hit.
3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR006948. Alliinase_C.
IPR006947. EGF_alliinase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF04864. Alliinase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "TAA1-mediated auxin biosynthesis is essential for hormone crosstalk and plant development."
    Stepanova A.N., Robertson-Hoyt J., Yun J., Benavente L.M., Xie D.Y., Dolezal K., Schlereth A., Juergens G., Alonso J.M.
    Cell 133:177-191(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, INDUCTION BY ETHYLENE, GENE FAMILY, NOMENCLATURE.
  4. "Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants."
    Tao Y., Ferrer J.L., Ljung K., Pojer F., Hong F., Long J.A., Li L., Moreno J.E., Bowman M.E., Ivans L.J., Cheng Y., Lim J., Zhao Y., Ballare C.L., Sandberg G., Noel J.P., Chory J.
    Cell 133:164-176(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. "A small-molecule screen identifies L-kynurenine as a competitive inhibitor of TAA1/TAR activity in ethylene-directed auxin biosynthesis and root growth in Arabidopsis."
    He W., Brumos J., Li H., Ji Y., Ke M., Gong X., Zeng Q., Li W., Zhang X., An F., Wen X., Li P., Chu J., Sun X., Yan C., Yan N., Xie D.Y., Raikhel N.
    , Yang Z., Stepanova A.N., Alonso J.M., Guo H.
    Plant Cell 23:3944-3960(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION.

Entry informationi

Entry nameiTAR1_ARATH
AccessioniPrimary (citable) accession number: Q9LR29
Secondary accession number(s): F4I655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: May 14, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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