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Protein

3-ketoacyl-CoA synthase 3

Gene

KCS3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.Curated

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168By similarity1
Active sitei247By similarity1
Active sitei345By similarity1
Active sitei349By similarity1
Active sitei378By similarity1
Active sitei382By similarity1

GO - Molecular functioni

GO - Biological processi

  • fatty acid biosynthetic process Source: UniProtKB-UniPathway
  • response to cold Source: TAIR
  • response to light stimulus Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciARA:AT1G07720-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA synthase 31 Publication (EC:2.3.1.199Curated)
Short name:
KCS-31 Publication
Alternative name(s):
Very long-chain fatty acid condensing enzyme 31 Publication
Short name:
VLCFA condensing enzyme 31 Publication
Gene namesi
Name:KCS31 Publication
Ordered Locus Names:At1g07720Imported
ORF Names:F24B9.18Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G07720.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: TAIR
  • membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000024909526 – 4783-ketoacyl-CoA synthase 3Add BLAST453

Proteomic databases

PaxDbiQ9LQP8.

Expressioni

Tissue specificityi

Expressed in siliques, leaves, stems and seedlings.1 Publication

Inductioni

Repressed by herbicides such as flufenacet and benfuresate (PubMed:12916765). Down-regulated by darkness and low temperature, and up-regulated by salt, drought and osmotic stress (PubMed:18465198).2 Publications

Gene expression databases

GenevisibleiQ9LQP8. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G07720.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LQP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 313FAESequence analysisAdd BLAST288

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated
Contains 1 FAE (fatty acid elongase) domain.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH8S. Eukaryota.
ENOG410Y9JS. LUCA.
HOGENOMiHOG000238893.
InParanoidiQ9LQP8.
KOiK15397.
OMAiHLRLNEY.
OrthoDBiEOG093608SJ.

Family and domain databases

Gene3Di3.40.47.10. 3 hits.
InterProiIPR012392. 3-ktacl-CoA_syn.
IPR013747. ACP_syn_III_C.
IPR013601. FAE1_typ3_polyketide_synth.
IPR016039. Thiolase-like.
[Graphical view]
PANTHERiPTHR31561. PTHR31561. 1 hit.
PfamiPF08541. ACP_syn_III_C. 1 hit.
PF08392. FAE1_CUT1_RppA. 1 hit.
[Graphical view]
PIRSFiPIRSF036417. 3-ktacl-CoA_syn. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LQP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLVMLLSL LVSYLIFKIW KRIDSKRDQN CYILDYQCHK PSDDRMVNTQ
60 70 80 90 100
FSGDIILRNK HLRLNEYKFL LKAIVSSGIG EQTYAPRLFF EGREQRPTLQ
110 120 130 140 150
DGLSEMEEFY IDTIEKVLKR NKISPSEIDI LVVNVSMLNS TPSLSARIIN
160 170 180 190 200
HYKMREDIKV FNLTAMGCSA SVISIDIVKN IFKTYKNKLA LVVTSESLSP
210 220 230 240 250
NWYSGNNRSM ILANCLFRSG GCAVLLTNKR SLSRRAMFKL RCLVRTHHGA
260 270 280 290 300
RDDSFNACVQ KEDELGHIGV HLDKTLPKAA TRAFIDNLKV ITPKILPVTE
310 320 330 340 350
LLRFMLCLLL KKLRSSPSKG STNVTQAAPK AGVKAGINFK TGIDHFCIHT
360 370 380 390 400
GGKAVIDAIG YSLDLNEYDL EPARMTLHRF GNTSASSLWY VLGYMEAKKR
410 420 430 440 450
LKRGDRVFMI SFGAGFKCNS CVWEVVRDLN VGEAVGNVWN HCINQYPPKS
460 470
ILNPFFEKYG WIHEEEDPDT FKMPEGFM
Length:478
Mass (Da):54,335
Last modified:May 31, 2011 - v3
Checksum:iA6EB0BE5C305D809
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007583 Genomic DNA. Translation: AAF75082.1.
CP002684 Genomic DNA. Translation: AEE28169.1.
AF428349 mRNA. Translation: AAL16279.1.
AY062700 mRNA. Translation: AAL32778.1.
AY128794 mRNA. Translation: AAM91194.1.
PIRiD86212.
RefSeqiNP_172251.1. NM_100646.3.
UniGeneiAt.14838.

Genome annotation databases

EnsemblPlantsiAT1G07720.1; AT1G07720.1; AT1G07720.
GeneIDi837286.
GrameneiAT1G07720.1; AT1G07720.1; AT1G07720.
KEGGiath:AT1G07720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007583 Genomic DNA. Translation: AAF75082.1.
CP002684 Genomic DNA. Translation: AEE28169.1.
AF428349 mRNA. Translation: AAL16279.1.
AY062700 mRNA. Translation: AAL32778.1.
AY128794 mRNA. Translation: AAM91194.1.
PIRiD86212.
RefSeqiNP_172251.1. NM_100646.3.
UniGeneiAt.14838.

3D structure databases

ProteinModelPortaliQ9LQP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G07720.1.

Proteomic databases

PaxDbiQ9LQP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G07720.1; AT1G07720.1; AT1G07720.
GeneIDi837286.
GrameneiAT1G07720.1; AT1G07720.1; AT1G07720.
KEGGiath:AT1G07720.

Organism-specific databases

TAIRiAT1G07720.

Phylogenomic databases

eggNOGiENOG410IH8S. Eukaryota.
ENOG410Y9JS. LUCA.
HOGENOMiHOG000238893.
InParanoidiQ9LQP8.
KOiK15397.
OMAiHLRLNEY.
OrthoDBiEOG093608SJ.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciARA:AT1G07720-MONOMER.

Miscellaneous databases

PROiQ9LQP8.

Gene expression databases

GenevisibleiQ9LQP8. AT.

Family and domain databases

Gene3Di3.40.47.10. 3 hits.
InterProiIPR012392. 3-ktacl-CoA_syn.
IPR013747. ACP_syn_III_C.
IPR013601. FAE1_typ3_polyketide_synth.
IPR016039. Thiolase-like.
[Graphical view]
PANTHERiPTHR31561. PTHR31561. 1 hit.
PfamiPF08541. ACP_syn_III_C. 1 hit.
PF08392. FAE1_CUT1_RppA. 1 hit.
[Graphical view]
PIRSFiPIRSF036417. 3-ktacl-CoA_syn. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKCS3_ARATH
AccessioniPrimary (citable) accession number: Q9LQP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: May 31, 2011
Last modified: November 30, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.