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Q9LQN6

- P2C04_ARATH

UniProt

Q9LQN6 - P2C04_ARATH

Protein

Probable protein phosphatase 2C 4

Gene

PLL5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Involved in leaf development regulation.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi286 – 2861Manganese 1By similarity
    Metal bindingi286 – 2861Manganese 2By similarity
    Metal bindingi287 – 2871Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi581 – 5811Manganese 2By similarity
    Metal bindingi644 – 6441Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. leaf development Source: TAIR

    Keywords - Molecular functioni

    Developmental protein, Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G07630-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 4 (EC:3.1.3.16)
    Short name:
    AtPP2C04
    Alternative name(s):
    Protein POLTERGEIST-LIKE 5
    Protein phosphatase 2C PLL5
    Short name:
    PP2C PLL5
    Gene namesi
    Name:PLL5
    Ordered Locus Names:At1g07630
    ORF Names:F24B9.25, F24B9.31
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G07630.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Plants show abnormal leaves altered in shape and curling.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 662662Probable protein phosphatase 2C 4PRO_0000301263Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei153 – 1531PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9LQN6.

    Expressioni

    Tissue specificityi

    Expressed in seedlings, roots, leaves, stems, young inflorescences, flowers and siliques.1 Publication

    Gene expression databases

    GenevestigatoriQ9LQN6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LQN6.
    SMRiQ9LQN6. Positions 281-656.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini269 – 629361PP2C-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi14 – 174Poly-Gly
    Compositional biasi62 – 665Poly-Thr

    Domaini

    The conserved PP2C phosphatase domain (250-651) is interrupted by an insertion of approximately 100 amino acids.

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000239375.
    InParanoidiQ9LQN6.
    OMAiINEETMM.
    PhylomeDBiQ9LQN6.

    Family and domain databases

    Gene3Di3.60.40.10. 3 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9LQN6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNGVTKLSI CFTGGGGERL RPKDISVLLP DPLDEGLGHS FCYVRPDPTL    50
    ISSSKVHSEE DTTTTTFRTI SGASVSANTA TPLSTSLYDP YGHIDRAAAF 100
    ESTTSFSSIP LQPIPKSSGP IVLGSGPIER GFLSGPIERG FMSGPLDRVG 150
    LFSGPLDKPN SDHHHQFQRS FSHGLALRVG SRKRSLVRIL RRAISKTMSR 200
    GQNSIVAPIK SVKDSDNWGI RSEKSRNLHN ENLTVNSLNF SSEVSLDDDV 250
    SLENQNLQWA QGKAGEDRVH VVVSEEHGWL FVGIYDGFNG PDAPDYLLSH 300
    LYPVVHRELK GLLWDDSNVE SKSQDLERSN GDESCSNQEK DETCERWWRC 350
    EWDRESQDLD RRLKEQISRR SGSDRLTNHS EVLEALSQAL RKTEEAYLDT 400
    ADKMLDENPE LALMGSCVLV MLMKGEDIYV MNVGDSRAVL GQKSEPDYWL 450
    AKIRQDLERI NEETMMNDLE GCEGDQSSLV PNLSAFQLTV DHSTNIEEEV 500
    ERIRNEHPDD VTAVTNERVK GSLKVTRAFG AGFLKQPKWN NALLEMFQID 550
    YVGKSPYINC LPSLYHHRLG SKDRFLILSS DGLYQYFTNE EAVSEVELFI 600
    TLQPEGDPAQ HLVQELLFRA AKKAGMDFHE LLEIPQGERR RYHDDVSIVV 650
    ISLEGRMWKS CV 662
    Length:662
    Mass (Da):74,274
    Last modified:October 1, 2000 - v1
    Checksum:iB1A3670D06B1B94E
    GO

    Sequence cautioni

    The sequence AAK32783.1 differs from that shown. Reason: Frameshift at position 491.
    The sequence AAM91433.1 differs from that shown. Reason: Frameshift at position 491.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti368 – 3681S → G in AAM61450. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007583 Genomic DNA. Translation: AAF75095.1.
    CP002684 Genomic DNA. Translation: AEE28151.1.
    AF361615 mRNA. Translation: AAK32783.1. Frameshift.
    AY133603 mRNA. Translation: AAM91433.1. Frameshift.
    AY084887 mRNA. Translation: AAM61450.1.
    PIRiG86210.
    RefSeqiNP_563791.1. NM_100636.2.
    UniGeneiAt.43724.
    At.72523.

    Genome annotation databases

    EnsemblPlantsiAT1G07630.1; AT1G07630.1; AT1G07630.
    GeneIDi837276.
    KEGGiath:AT1G07630.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007583 Genomic DNA. Translation: AAF75095.1 .
    CP002684 Genomic DNA. Translation: AEE28151.1 .
    AF361615 mRNA. Translation: AAK32783.1 . Frameshift.
    AY133603 mRNA. Translation: AAM91433.1 . Frameshift.
    AY084887 mRNA. Translation: AAM61450.1 .
    PIRi G86210.
    RefSeqi NP_563791.1. NM_100636.2.
    UniGenei At.43724.
    At.72523.

    3D structure databases

    ProteinModelPortali Q9LQN6.
    SMRi Q9LQN6. Positions 281-656.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9LQN6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G07630.1 ; AT1G07630.1 ; AT1G07630 .
    GeneIDi 837276.
    KEGGi ath:AT1G07630.

    Organism-specific databases

    TAIRi AT1G07630.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000239375.
    InParanoidi Q9LQN6.
    OMAi INEETMM.
    PhylomeDBi Q9LQN6.

    Enzyme and pathway databases

    BioCyci ARA:AT1G07630-MONOMER.

    Gene expression databases

    Genevestigatori Q9LQN6.

    Family and domain databases

    Gene3Di 3.60.40.10. 3 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "POL and related phosphatases are dosage-sensitive regulators of meristem and organ development in Arabidopsis."
      Song S.-K., Clark S.E.
      Dev. Biol. 285:272-284(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE, DISRUPTION PHENOTYPE.
    6. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C04_ARATH
    AccessioniPrimary (citable) accession number: Q9LQN6
    Secondary accession number(s): Q8LFF0, Q9ASX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3