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Protein

Probable protein phosphatase 2C 4

Gene

PLL5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in leaf development regulation.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi286 – 2861Manganese 1By similarity
Metal bindingi286 – 2861Manganese 2By similarity
Metal bindingi287 – 2871Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi581 – 5811Manganese 2By similarity
Metal bindingi644 – 6441Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. leaf development Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G07630-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 4 (EC:3.1.3.16)
Short name:
AtPP2C04
Alternative name(s):
Protein POLTERGEIST-LIKE 5
Protein phosphatase 2C PLL5
Short name:
PP2C PLL5
Gene namesi
Name:PLL5
Ordered Locus Names:At1g07630
ORF Names:F24B9.25, F24B9.31
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G07630.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Plants show abnormal leaves altered in shape and curling.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 662662Probable protein phosphatase 2C 4PRO_0000301263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei153 – 1531PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9LQN6.

Expressioni

Tissue specificityi

Expressed in seedlings, roots, leaves, stems, young inflorescences, flowers and siliques.1 Publication

Gene expression databases

GenevestigatoriQ9LQN6.

Structurei

3D structure databases

ProteinModelPortaliQ9LQN6.
SMRiQ9LQN6. Positions 281-656.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini269 – 629361PP2C-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 174Poly-Gly
Compositional biasi62 – 665Poly-Thr

Domaini

The conserved PP2C phosphatase domain (250-651) is interrupted by an insertion of approximately 100 amino acids.

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000239375.
InParanoidiQ9LQN6.
OMAiDQTRISS.
PhylomeDBiQ9LQN6.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9LQN6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNGVTKLSI CFTGGGGERL RPKDISVLLP DPLDEGLGHS FCYVRPDPTL
60 70 80 90 100
ISSSKVHSEE DTTTTTFRTI SGASVSANTA TPLSTSLYDP YGHIDRAAAF
110 120 130 140 150
ESTTSFSSIP LQPIPKSSGP IVLGSGPIER GFLSGPIERG FMSGPLDRVG
160 170 180 190 200
LFSGPLDKPN SDHHHQFQRS FSHGLALRVG SRKRSLVRIL RRAISKTMSR
210 220 230 240 250
GQNSIVAPIK SVKDSDNWGI RSEKSRNLHN ENLTVNSLNF SSEVSLDDDV
260 270 280 290 300
SLENQNLQWA QGKAGEDRVH VVVSEEHGWL FVGIYDGFNG PDAPDYLLSH
310 320 330 340 350
LYPVVHRELK GLLWDDSNVE SKSQDLERSN GDESCSNQEK DETCERWWRC
360 370 380 390 400
EWDRESQDLD RRLKEQISRR SGSDRLTNHS EVLEALSQAL RKTEEAYLDT
410 420 430 440 450
ADKMLDENPE LALMGSCVLV MLMKGEDIYV MNVGDSRAVL GQKSEPDYWL
460 470 480 490 500
AKIRQDLERI NEETMMNDLE GCEGDQSSLV PNLSAFQLTV DHSTNIEEEV
510 520 530 540 550
ERIRNEHPDD VTAVTNERVK GSLKVTRAFG AGFLKQPKWN NALLEMFQID
560 570 580 590 600
YVGKSPYINC LPSLYHHRLG SKDRFLILSS DGLYQYFTNE EAVSEVELFI
610 620 630 640 650
TLQPEGDPAQ HLVQELLFRA AKKAGMDFHE LLEIPQGERR RYHDDVSIVV
660
ISLEGRMWKS CV
Length:662
Mass (Da):74,274
Last modified:October 1, 2000 - v1
Checksum:iB1A3670D06B1B94E
GO

Sequence cautioni

The sequence AAK32783.1 differs from that shown. Reason: Frameshift at position 491. Curated
The sequence AAM91433.1 differs from that shown. Reason: Frameshift at position 491. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti368 – 3681S → G in AAM61450. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007583 Genomic DNA. Translation: AAF75095.1.
CP002684 Genomic DNA. Translation: AEE28151.1.
AF361615 mRNA. Translation: AAK32783.1. Frameshift.
AY133603 mRNA. Translation: AAM91433.1. Frameshift.
AY084887 mRNA. Translation: AAM61450.1.
PIRiG86210.
RefSeqiNP_563791.1. NM_100636.2.
UniGeneiAt.43724.
At.72523.

Genome annotation databases

EnsemblPlantsiAT1G07630.1; AT1G07630.1; AT1G07630.
GeneIDi837276.
KEGGiath:AT1G07630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007583 Genomic DNA. Translation: AAF75095.1.
CP002684 Genomic DNA. Translation: AEE28151.1.
AF361615 mRNA. Translation: AAK32783.1. Frameshift.
AY133603 mRNA. Translation: AAM91433.1. Frameshift.
AY084887 mRNA. Translation: AAM61450.1.
PIRiG86210.
RefSeqiNP_563791.1. NM_100636.2.
UniGeneiAt.43724.
At.72523.

3D structure databases

ProteinModelPortaliQ9LQN6.
SMRiQ9LQN6. Positions 281-656.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9LQN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G07630.1; AT1G07630.1; AT1G07630.
GeneIDi837276.
KEGGiath:AT1G07630.

Organism-specific databases

TAIRiAT1G07630.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000239375.
InParanoidiQ9LQN6.
OMAiDQTRISS.
PhylomeDBiQ9LQN6.

Enzyme and pathway databases

BioCyciARA:AT1G07630-MONOMER.

Gene expression databases

GenevestigatoriQ9LQN6.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "POL and related phosphatases are dosage-sensitive regulators of meristem and organ development in Arabidopsis."
    Song S.-K., Clark S.E.
    Dev. Biol. 285:272-284(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE, DISRUPTION PHENOTYPE.
  6. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C04_ARATH
AccessioniPrimary (citable) accession number: Q9LQN6
Secondary accession number(s): Q8LFF0, Q9ASX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.