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Q9LQN6

- P2C04_ARATH

UniProt

Q9LQN6 - P2C04_ARATH

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Protein

Probable protein phosphatase 2C 4

Gene
PLL5, At1g07630, F24B9.25, F24B9.31
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in leaf development regulation.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi286 – 2861Manganese 1 By similarity
Metal bindingi286 – 2861Manganese 2 By similarity
Metal bindingi287 – 2871Manganese 1; via carbonyl oxygen By similarity
Metal bindingi581 – 5811Manganese 2 By similarity
Metal bindingi644 – 6441Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. leaf development Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G07630-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 4 (EC:3.1.3.16)
Short name:
AtPP2C04
Alternative name(s):
Protein POLTERGEIST-LIKE 5
Protein phosphatase 2C PLL5
Short name:
PP2C PLL5
Gene namesi
Name:PLL5
Ordered Locus Names:At1g07630
ORF Names:F24B9.25, F24B9.31
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G07630.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Plants show abnormal leaves altered in shape and curling.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 662662Probable protein phosphatase 2C 4PRO_0000301263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei153 – 1531Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9LQN6.

Expressioni

Tissue specificityi

Expressed in seedlings, roots, leaves, stems, young inflorescences, flowers and siliques.1 Publication

Gene expression databases

GenevestigatoriQ9LQN6.

Structurei

3D structure databases

ProteinModelPortaliQ9LQN6.
SMRiQ9LQN6. Positions 281-656.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini269 – 629361PP2C-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 174Poly-Gly
Compositional biasi62 – 665Poly-Thr

Domaini

The conserved PP2C phosphatase domain (250-651) is interrupted by an insertion of approximately 100 amino acids.

Sequence similaritiesi

Belongs to the PP2C family.
Contains 1 PP2C-like domain.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000239375.
InParanoidiQ9LQN6.
OMAiINEETMM.
PhylomeDBiQ9LQN6.

Family and domain databases

Gene3Di3.60.40.10. 3 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9LQN6-1 [UniParc]FASTAAdd to Basket

« Hide

MGNGVTKLSI CFTGGGGERL RPKDISVLLP DPLDEGLGHS FCYVRPDPTL    50
ISSSKVHSEE DTTTTTFRTI SGASVSANTA TPLSTSLYDP YGHIDRAAAF 100
ESTTSFSSIP LQPIPKSSGP IVLGSGPIER GFLSGPIERG FMSGPLDRVG 150
LFSGPLDKPN SDHHHQFQRS FSHGLALRVG SRKRSLVRIL RRAISKTMSR 200
GQNSIVAPIK SVKDSDNWGI RSEKSRNLHN ENLTVNSLNF SSEVSLDDDV 250
SLENQNLQWA QGKAGEDRVH VVVSEEHGWL FVGIYDGFNG PDAPDYLLSH 300
LYPVVHRELK GLLWDDSNVE SKSQDLERSN GDESCSNQEK DETCERWWRC 350
EWDRESQDLD RRLKEQISRR SGSDRLTNHS EVLEALSQAL RKTEEAYLDT 400
ADKMLDENPE LALMGSCVLV MLMKGEDIYV MNVGDSRAVL GQKSEPDYWL 450
AKIRQDLERI NEETMMNDLE GCEGDQSSLV PNLSAFQLTV DHSTNIEEEV 500
ERIRNEHPDD VTAVTNERVK GSLKVTRAFG AGFLKQPKWN NALLEMFQID 550
YVGKSPYINC LPSLYHHRLG SKDRFLILSS DGLYQYFTNE EAVSEVELFI 600
TLQPEGDPAQ HLVQELLFRA AKKAGMDFHE LLEIPQGERR RYHDDVSIVV 650
ISLEGRMWKS CV 662
Length:662
Mass (Da):74,274
Last modified:October 1, 2000 - v1
Checksum:iB1A3670D06B1B94E
GO

Sequence cautioni

The sequence AAK32783.1 differs from that shown. Reason: Frameshift at position 491.
The sequence AAM91433.1 differs from that shown. Reason: Frameshift at position 491.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti368 – 3681S → G in AAM61450. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007583 Genomic DNA. Translation: AAF75095.1.
CP002684 Genomic DNA. Translation: AEE28151.1.
AF361615 mRNA. Translation: AAK32783.1. Frameshift.
AY133603 mRNA. Translation: AAM91433.1. Frameshift.
AY084887 mRNA. Translation: AAM61450.1.
PIRiG86210.
RefSeqiNP_563791.1. NM_100636.2.
UniGeneiAt.43724.
At.72523.

Genome annotation databases

EnsemblPlantsiAT1G07630.1; AT1G07630.1; AT1G07630.
GeneIDi837276.
KEGGiath:AT1G07630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007583 Genomic DNA. Translation: AAF75095.1 .
CP002684 Genomic DNA. Translation: AEE28151.1 .
AF361615 mRNA. Translation: AAK32783.1 . Frameshift.
AY133603 mRNA. Translation: AAM91433.1 . Frameshift.
AY084887 mRNA. Translation: AAM61450.1 .
PIRi G86210.
RefSeqi NP_563791.1. NM_100636.2.
UniGenei At.43724.
At.72523.

3D structure databases

ProteinModelPortali Q9LQN6.
SMRi Q9LQN6. Positions 281-656.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9LQN6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G07630.1 ; AT1G07630.1 ; AT1G07630 .
GeneIDi 837276.
KEGGi ath:AT1G07630.

Organism-specific databases

TAIRi AT1G07630.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000239375.
InParanoidi Q9LQN6.
OMAi INEETMM.
PhylomeDBi Q9LQN6.

Enzyme and pathway databases

BioCyci ARA:AT1G07630-MONOMER.

Gene expression databases

Genevestigatori Q9LQN6.

Family and domain databases

Gene3Di 3.60.40.10. 3 hits.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "POL and related phosphatases are dosage-sensitive regulators of meristem and organ development in Arabidopsis."
    Song S.-K., Clark S.E.
    Dev. Biol. 285:272-284(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE, DISRUPTION PHENOTYPE.
  6. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C04_ARATH
AccessioniPrimary (citable) accession number: Q9LQN6
Secondary accession number(s): Q8LFF0, Q9ASX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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