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Q9LQN6 (P2C04_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein phosphatase 2C 4

Short name=AtPP2C04
EC=3.1.3.16
Alternative name(s):
Protein POLTERGEIST-LIKE 5
Protein phosphatase 2C PLL5
Short name=PP2C PLL5
Gene names
Name:PLL5
Ordered Locus Names:At1g07630
ORF Names:F24B9.25, F24B9.31
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length662 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in leaf development regulation. Ref.5

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subcellular location

Nucleus Probable.

Tissue specificity

Expressed in seedlings, roots, leaves, stems, young inflorescences, flowers and siliques. Ref.5

Domain

The conserved PP2C phosphatase domain (250-651) is interrupted by an insertion of approximately 100 amino acids.

Disruption phenotype

Plants show abnormal leaves altered in shape and curling. Ref.5

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Sequence caution

The sequence AAK32783.1 differs from that shown. Reason: Frameshift at position 491.

The sequence AAM91433.1 differs from that shown. Reason: Frameshift at position 491.

Ontologies

Keywords
   Cellular componentNucleus
   LigandMagnesium
Manganese
Metal-binding
   Molecular functionDevelopmental protein
Hydrolase
Protein phosphatase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processleaf development

Inferred from mutant phenotype Ref.5. Source: TAIR

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from direct assay PubMed 17317660. Source: TAIR

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 662662Probable protein phosphatase 2C 4
PRO_0000301263

Regions

Domain269 – 629361PP2C-like
Compositional bias14 – 174Poly-Gly
Compositional bias62 – 665Poly-Thr

Sites

Metal binding2861Manganese 1 By similarity
Metal binding2861Manganese 2 By similarity
Metal binding2871Manganese 1; via carbonyl oxygen By similarity
Metal binding5811Manganese 2 By similarity
Metal binding6441Manganese 2 By similarity

Amino acid modifications

Modified residue1531Phosphoserine By similarity

Experimental info

Sequence conflict3681S → G in AAM61450. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9LQN6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: B1A3670D06B1B94E

FASTA66274,274
        10         20         30         40         50         60 
MGNGVTKLSI CFTGGGGERL RPKDISVLLP DPLDEGLGHS FCYVRPDPTL ISSSKVHSEE 

        70         80         90        100        110        120 
DTTTTTFRTI SGASVSANTA TPLSTSLYDP YGHIDRAAAF ESTTSFSSIP LQPIPKSSGP 

       130        140        150        160        170        180 
IVLGSGPIER GFLSGPIERG FMSGPLDRVG LFSGPLDKPN SDHHHQFQRS FSHGLALRVG 

       190        200        210        220        230        240 
SRKRSLVRIL RRAISKTMSR GQNSIVAPIK SVKDSDNWGI RSEKSRNLHN ENLTVNSLNF 

       250        260        270        280        290        300 
SSEVSLDDDV SLENQNLQWA QGKAGEDRVH VVVSEEHGWL FVGIYDGFNG PDAPDYLLSH 

       310        320        330        340        350        360 
LYPVVHRELK GLLWDDSNVE SKSQDLERSN GDESCSNQEK DETCERWWRC EWDRESQDLD 

       370        380        390        400        410        420 
RRLKEQISRR SGSDRLTNHS EVLEALSQAL RKTEEAYLDT ADKMLDENPE LALMGSCVLV 

       430        440        450        460        470        480 
MLMKGEDIYV MNVGDSRAVL GQKSEPDYWL AKIRQDLERI NEETMMNDLE GCEGDQSSLV 

       490        500        510        520        530        540 
PNLSAFQLTV DHSTNIEEEV ERIRNEHPDD VTAVTNERVK GSLKVTRAFG AGFLKQPKWN 

       550        560        570        580        590        600 
NALLEMFQID YVGKSPYINC LPSLYHHRLG SKDRFLILSS DGLYQYFTNE EAVSEVELFI 

       610        620        630        640        650        660 
TLQPEGDPAQ HLVQELLFRA AKKAGMDFHE LLEIPQGERR RYHDDVSIVV ISLEGRMWKS 


CV 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Full-length cDNA from Arabidopsis thaliana."
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"POL and related phosphatases are dosage-sensitive regulators of meristem and organ development in Arabidopsis."
Song S.-K., Clark S.E.
Dev. Biol. 285:272-284(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE, DISRUPTION PHENOTYPE.
[6]"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC007583 Genomic DNA. Translation: AAF75095.1.
CP002684 Genomic DNA. Translation: AEE28151.1.
AF361615 mRNA. Translation: AAK32783.1. Frameshift.
AY133603 mRNA. Translation: AAM91433.1. Frameshift.
AY084887 mRNA. Translation: AAM61450.1.
PIRG86210.
RefSeqNP_563791.1. NM_100636.2.
UniGeneAt.43724.
At.72523.

3D structure databases

ProteinModelPortalQ9LQN6.
SMRQ9LQN6. Positions 281-656.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9LQN6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G07630.1; AT1G07630.1; AT1G07630.
GeneID837276.
KEGGath:AT1G07630.

Organism-specific databases

TAIRAT1G07630.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000239375.
InParanoidQ9LQN6.
OMAINEETMM.
PhylomeDBQ9LQN6.
ProtClustDBCLSN2683691.

Enzyme and pathway databases

BioCycARA:AT1G07630-MONOMER.

Gene expression databases

GenevestigatorQ9LQN6.

Family and domain databases

Gene3D3.60.40.10. 3 hits.
InterProIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 3 hits.
ProtoNetSearch...

Entry information

Entry nameP2C04_ARATH
AccessionPrimary (citable) accession number: Q9LQN6
Secondary accession number(s): Q8LFF0, Q9ASX4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names