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Q9LQC0

- HMOX4_ARATH

UniProt

Q9LQC0 - HMOX4_ARATH

Protein

Heme oxygenase 4, chloroplastic

Gene

HO4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the opening of the heme ring to form the open-chain tetrapyrrole biliverdin IX with the release of iron and carbon monoxide (CO). Produces specifically the biliverdin IX-alpha isomer. Plays a minor role in phytochrome assembly and photomorphogenesis.2 Publications

    Catalytic activityi

    Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

    pH dependencei

    Optimum pH is 7.2.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi91 – 911Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: TAIR
    2. heme oxygenase (decyclizing) activity Source: TAIR
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. heme oxidation Source: InterPro
    2. photosynthesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Photosynthesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G58300-MONOMER.
    MetaCyc:AT1G58300-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme oxygenase 4, chloroplastic (EC:1.14.99.3)
    Gene namesi
    Name:HO4
    Ordered Locus Names:At1g58300
    ORF Names:F19C14.8
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G58300.

    Subcellular locationi

    Plastidchloroplast 1 Publication

    GO - Cellular componenti

    1. chloroplast Source: TAIR

    Keywords - Cellular componenti

    Chloroplast, Plastid

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype under normal growth conditions.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 283Heme oxygenase 4, chloroplasticPRO_0000412188
    Transit peptidei1 – ?ChloroplastSequence Analysis

    Expressioni

    Tissue specificityi

    Widely expressed at low levels.1 Publication

    Gene expression databases

    GenevestigatoriQ9LQC0.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G58300.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LQC0.
    SMRiQ9LQC0. Positions 78-281.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heme oxygenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG255302.
    HOGENOMiHOG000265822.
    InParanoidiQ9LQC0.
    KOiK00510.
    OMAiYNINFAH.
    PhylomeDBiQ9LQC0.

    Family and domain databases

    Gene3Di1.20.910.10. 1 hit.
    InterProiIPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR016951. Haem_Oase_decyc_pln.
    [Graphical view]
    PfamiPF01126. Heme_oxygenase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF030219. Heme_Oase_decyc_pln. 1 hit.
    SUPFAMiSSF48613. SSF48613. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9LQC0-1 [UniParc]FASTAAdd to Basket

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    MATSRLNASC RFPASRRLDC ESYVSLRAKT VTIRYVRTIA APRRHLVRRA    50
    NEDQTLVVNV VAAAGEKPER RYPREPNGFV EEMRFVVMKI HPRDQVKEGK 100
    SDSNDLVSTW NFTIEGYLKF LVDSKLVFET LERIINESAI QAYAGLKNTG 150
    LERAENLSRD LEWFKEQGYE IPESMVPGKA YSQYLKNIAE KDPPAFICHF 200
    YNINFAHSAG GRMIGTKVAE KILDNKELEF YKWDGQLSEL LQNVSEELNK 250
    VAELWTREEK NHCLEETEKS FKFYWEIFRY LLS 283
    Length:283
    Mass (Da):32,953
    Last modified:October 1, 2000 - v1
    Checksum:iAB44816340D77DF5
    GO

    Sequence cautioni

    The sequence ABK28442.1 differs from that shown. Reason: Erroneous termination at position 284. Translated as stop.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 943PRD → QEI in AAK63007. (PubMed:11402195)Curated
    Sequence conflicti102 – 1021D → V in AAK63007. (PubMed:11402195)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF320023 Genomic DNA. Translation: AAK63007.1.
    AC008051 Genomic DNA. Translation: AAF82257.1.
    CP002684 Genomic DNA. Translation: AEE33533.1.
    DQ446372 mRNA. Translation: ABE65721.1.
    DQ652902 mRNA. Translation: ABK28442.1. Sequence problems.
    AF295364 Genomic DNA. Translation: AAG30207.1.
    PIRiF96616.
    RefSeqiNP_176126.1. NM_104610.1.
    UniGeneiAt.52255.

    Genome annotation databases

    EnsemblPlantsiAT1G58300.1; AT1G58300.1; AT1G58300.
    GeneIDi842199.
    KEGGiath:AT1G58300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF320023 Genomic DNA. Translation: AAK63007.1 .
    AC008051 Genomic DNA. Translation: AAF82257.1 .
    CP002684 Genomic DNA. Translation: AEE33533.1 .
    DQ446372 mRNA. Translation: ABE65721.1 .
    DQ652902 mRNA. Translation: ABK28442.1 . Sequence problems.
    AF295364 Genomic DNA. Translation: AAG30207.1 .
    PIRi F96616.
    RefSeqi NP_176126.1. NM_104610.1.
    UniGenei At.52255.

    3D structure databases

    ProteinModelPortali Q9LQC0.
    SMRi Q9LQC0. Positions 78-281.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G58300.1-P.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G58300.1 ; AT1G58300.1 ; AT1G58300 .
    GeneIDi 842199.
    KEGGi ath:AT1G58300.

    Organism-specific databases

    TAIRi AT1G58300.

    Phylogenomic databases

    eggNOGi NOG255302.
    HOGENOMi HOG000265822.
    InParanoidi Q9LQC0.
    KOi K00510.
    OMAi YNINFAH.
    PhylomeDBi Q9LQC0.

    Enzyme and pathway databases

    BioCyci ARA:AT1G58300-MONOMER.
    MetaCyc:AT1G58300-MONOMER.

    Gene expression databases

    Genevestigatori Q9LQC0.

    Family and domain databases

    Gene3Di 1.20.910.10. 1 hit.
    InterProi IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR016951. Haem_Oase_decyc_pln.
    [Graphical view ]
    Pfami PF01126. Heme_oxygenase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF030219. Heme_Oase_decyc_pln. 1 hit.
    SUPFAMi SSF48613. SSF48613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The heme-oxygenase family required for phytochrome chromophore biosynthesis is necessary for proper photomorphogenesis in higher plants."
      Davis S.J., Bhoo S.H., Durski A.M., Walker J.M., Vierstra R.D.
      Plant Physiol. 126:656-669(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
      Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
      Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Regulation of HEMA1 expression by phytochrome and a plastid signal during de-etiolation in Arabidopsis thaliana."
      McCormac A.C., Fischer A., Kumar A.M., Soll D., Terry M.J.
      Plant J. 25:549-561(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 144-283.
    6. "Multiple heme oxygenase family members contribute to the biosynthesis of the phytochrome chromophore in Arabidopsis."
      Emborg T.J., Walker J.M., Noh B., Vierstra R.D.
      Plant Physiol. 140:856-868(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    7. "Characterization of the haem oxygenase protein family in Arabidopsis thaliana reveals a diversity of functions."
      Gisk B., Yasui Y., Kohchi T., Frankenberg-Dinkel N.
      Biochem. J. 425:425-434(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES.

    Entry informationi

    Entry nameiHMOX4_ARATH
    AccessioniPrimary (citable) accession number: Q9LQC0
    Secondary accession number(s): A0MED2, Q94FX2, Q9FUN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3