Reviewed, UniProtKB/Swiss-Prot Q9LQ89 (ROGF2_ARATH)

Names and origin

Protein names

Recommended name:
    Rop guanine nucleotide exchange factor 2
      Short name=RopGEF2

Gene names

Name:	ROPGEF2
Ordered Locus Names:	At1g01700
ORF Names:	T1N6.8

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts as an activator of Rop GTPases by exchanging GDP with GTP. Ref.2
Domain	The PRONE domain is responsible for the GEF activity By similarity.
Sequence similarities	Contains 1 PRONE domain.
Sequence caution	The sequence AAF78400.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Molecular function	Guanine-nucleotide releasing factor
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Rop guanine nucleotide exchange factor 2		PRO_0000234059
Regions
	Domain	107 – 485	379	PRONE

Sequences

	Sequence		Length	Mass (Da)
	Q9LQ89-1 [UniParc]. Last modified March 24, 2009. Version 2. Checksum: E7C2574C8810E4EA	FASTA	485	54,699
	10 20 30 40 50 60 MENLPNHEEN DDVGYHQSPG PIDPNDHSAS ETPVYSTMST DSFAYHRTCS ETSGGGFSDQ 70 80 90 100 110 120 IDETSSFCTE ASPSDWPVLT ESNNSASSNF PTVFDLKHNQ IETDEHLAVQ EISEPELETM 130 140 150 160 170 180 KERFSKLLLG EDMSGSGKGV CTAVTISNAI TNLYATVFGQ NLRLEPLEIE QKTTWKREMN 190 200 210 220 230 240 CLLSVCDYIF EFIPKSQNLS NGATVEVMES RPRADIYINL PALRKLDSML MEALDSFQKT 250 260 270 280 290 300 EFWYAEEGSL SMKSTRSATG SFRKVIVQRK EEKWWLPIPL VPLQGLSEKA RKQLKSKRES 310 320 330 340 350 360 TNQIHKAAMA INSSILGEMD IPDSYMATLP KSGKASTGDA IYRHMTSSGR FSPEKLLDRL 370 380 390 400 410 420 KIVSEHEALQ LADRVEASMY TWRRKACLNN SKSSWNMVKD LMSITERSDK NYVLAERAES 430 440 450 460 470 480 LLFCLKQRYP ELSQTSLDIC KIHCNKDVGK AVLESYSRVL EGLAFNIVAW IDDVLYVDKT MRGEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"A new family of RhoGEFs activates the Rop molecular switch in plants." Berken A., Thomas C., Wittinghofer A. Nature 436:1176-1180(2005) [PubMed: 15980860] [Abstract] Cited for: CHARACTERIZATION, FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC009273 Genomic DNA. Translation: AAF78400.1. Sequence problems.
IPI	IPI00543460.
PIR	A86148.
RefSeq	NP_171676.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	839250.
GenomeReviews	Gene locus AT1G01700 in contig CT485782_GR.
Organism-specific databases
TAIR	At1g01700.
Phylogenomic databases
OMA	ICEYIVE
Gene expression databases
Genevestigator	Q9LQ89.
GermOnline	AT1G01700. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR005512. Rop_nucl_exchang_PRONE. [Graphical view]
PROSITE	PS51334. PRONE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ROGF2_ARATH

Accession

Primary (citable) accession number: Q9LQ89

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	March 24, 2009
Last modified:	November 3, 2009
This is version 34 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)