Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dynamin-2B

Gene

DRP2B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative microtubule-associated force-producing protein, able to bind and hydrolyze GTP.By similarity

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 52GTPSequence analysis8
Nucleotide bindingi143 – 147GTPBy similarity5
Nucleotide bindingi204 – 207GTPBy similarity4

GO - Molecular functioni

  • clathrin binding Source: TAIR
  • GTPase activity Source: TAIR
  • GTP binding Source: UniProtKB-KW
  • microtubule binding Source: GO_Central

GO - Biological processi

  • clathrin-dependent endocytosis Source: TAIR
  • mitochondrial fission Source: GO_Central
  • regulation of establishment of cell polarity Source: TAIR
  • response to abscisic acid Source: TAIR
  • root hair initiation Source: TAIR

Keywordsi

Molecular functionHydrolase, Motor protein
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-169911 Regulation of Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-2B (EC:3.6.5.5)
Alternative name(s):
Dynamin-like protein 3
Dynamin-related protein 2B
Gene namesi
Name:DRP2B
Synonyms:ADL3, CF1
Ordered Locus Names:At1g59610
ORF Names:T30E16.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G59610
TAIRilocus:2202847 AT1G59610

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065831 – 920Dynamin-2BAdd BLAST920

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9LQ55
PRIDEiQ9LQ55

PTM databases

iPTMnetiQ9LQ55

Expressioni

Tissue specificityi

Ubiquitous. Preferentially expressed in siliques.1 Publication

Gene expression databases

ExpressionAtlasiQ9LQ55 baseline and differential
GenevisibleiQ9LQ55 AT

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DRP1AP426974EBI-2355848,EBI-994234

GO - Molecular functioni

  • clathrin binding Source: TAIR
  • microtubule binding Source: GO_Central

Protein-protein interaction databases

BioGridi27476, 9 interactors
DIPiDIP-53383N
IntActiQ9LQ55, 6 interactors
STRINGi3702.AT1G59610.1

Structurei

3D structure databases

ProteinModelPortaliQ9LQ55
SMRiQ9LQ55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 303Dynamin-type GPROSITE-ProRule annotationAdd BLAST269
Domaini579 – 703PHPROSITE-ProRule annotationAdd BLAST125
Domaini737 – 830GEDPROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 52G1 motifPROSITE-ProRule annotation8
Regioni71 – 73G2 motifPROSITE-ProRule annotation3
Regioni143 – 146G3 motifPROSITE-ProRule annotation4
Regioni204 – 207G4 motifPROSITE-ProRule annotation4
Regioni238 – 241G5 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili788 – 812Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi885 – 920Pro-richAdd BLAST36

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
HOGENOMiHOG000241772
InParanoidiQ9LQ55
KOiK01528
OMAiKIKEPCL
OrthoDBiEOG093604AX
PhylomeDBiQ9LQ55

Family and domain databases

CDDicd08771 DLP_1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LQ55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAIDELSQL SDSMRQAASL LADEDPDETS SSRRPATSLN VVALGNVGAG
60 70 80 90 100
KSAVLNSLIG HPVLPTGENG ATRAPIIIDL SREESLSSKA IILQIDNKNQ
110 120 130 140 150
QVSASALRHS LQDRLSKGAS GRGRDEIYLK LRTSTAPPLK LIDLPGLDQR
160 170 180 190 200
IVDDSMIGEH AQHNDAILLV VVPASQASEI SSSRALKIAK EYDPESTRTV
210 220 230 240 250
GIISKIDQAA ENPKSLAAVQ ALLSNQGPPK TTDIPWVALI GQSVSIASAQ
260 270 280 290 300
SGGSENSLET AWRAESESLK SILTGAPQSK LGRIALVDTL ASQIRSRMKL
310 320 330 340 350
RLPNILTGLQ GKSQIVQDEL ARLGEQLVSS AEGTRAIALE LCREFEDKFL
360 370 380 390 400
LHLAGGEGSG WKVVASFEGN FPNRIKKLPL DRHFDLNNVK RIVLEADGYQ
410 420 430 440 450
PYLISPEKGL RSLIKTVLEL AKDPARLCVD EVHRVLVDIV SASANATPGL
460 470 480 490 500
GRYPPFKREV VAIASAALDG FKNEAKKMVV ALVDMERAFV PPQHFIRLVQ
510 520 530 540 550
RRMERQRREE ELKGRSSKKG QDAEQSLLNR ATSPQPDGPS STGGSLKSLR
560 570 580 590 600
DKLMPQDKDK DKEKETPEVS GLKTAGPEGE ITAGYLMKKS AKTNGWSRRW
610 620 630 640 650
FVLNEKTGKL GYTKKQEERN FRGTVTLEEC SIEEISDDEG EKSKSSKDKK
660 670 680 690 700
SNGPDSKGPG LVFKITCRVP YKTVLKAHNA LVLKAESMVD KNEWINKLQK
710 720 730 740 750
VIQARGGQVG SASMRQSLSE GSLDKMVRKP VDPEEELRWM SQEVRGYVEA
760 770 780 790 800
VLNSLAANVP KAVVLCQVEK SKEDMLNQLY SSISAIGNER IESLIQEDQN
810 820 830 840 850
VKRRRDRYQK QSSLLSKLTR QLSIHDNRAA AASSWSDNSG TESSPRTNGG
860 870 880 890 900
SSGEDWMNAF NAAASGPDSL KRYGSGGHSR RYSDPAQNGE DSSGSGGSSR
910 920
RTTPNRLPPA PPQSGSSYRY
Length:920
Mass (Da):100,228
Last modified:February 1, 2005 - v2
Checksum:iD95964FE33B79AB2
GO

Sequence cautioni

The sequence AAF79753 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA77516 differs from that shown. Reason: Frameshift at position 832.Curated
The sequence BAA88113 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026987 mRNA Translation: BAA77516.1 Frameshift.
AB028467 mRNA Translation: BAA88111.1
AB028469 Genomic DNA Translation: BAA88113.1 Sequence problems.
AC009317 Genomic DNA Translation: AAF79753.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE33594.1
AY049230 mRNA Translation: AAK83573.1
BT000772 mRNA Translation: AAN31911.1
BT009695 mRNA Translation: AAP88329.1
PIRiH96619
T52426
RefSeqiNP_176170.1, NM_104654.5
UniGeneiAt.23927
At.67355

Genome annotation databases

EnsemblPlantsiAT1G59610.1; AT1G59610.1; AT1G59610
GeneIDi842251
GrameneiAT1G59610.1; AT1G59610.1; AT1G59610
KEGGiath:AT1G59610

Similar proteinsi

Entry informationi

Entry nameiDRP2B_ARATH
AccessioniPrimary (citable) accession number: Q9LQ55
Secondary accession number(s): Q9SLT3, Q9SLT4, Q9SXX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health