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Protein

Dynamin-2B

Gene

DRP2B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative microtubule-associated force-producing protein, able to bind and hydrolyze GTP.By similarity

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 528GTPSequence analysis
Nucleotide bindingi143 – 1475GTPBy similarity
Nucleotide bindingi204 – 2074GTPBy similarity

GO - Molecular functioni

  • clathrin binding Source: TAIR
  • GTPase activity Source: TAIR
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • clathrin-mediated endocytosis Source: TAIR
  • response to abscisic acid Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G59610-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-2B (EC:3.6.5.5)
Alternative name(s):
Dynamin-like protein 3
Dynamin-related protein 2B
Gene namesi
Name:DRP2B
Synonyms:ADL3, CF1
Ordered Locus Names:At1g59610
ORF Names:T30E16.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G59610.

Subcellular locationi

GO - Cellular componenti

  • cell plate Source: TAIR
  • clathrin-coated endocytic vesicle Source: TAIR
  • cytosol Source: TAIR
  • microtubule Source: UniProtKB-KW
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
  • vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 920920Dynamin-2BPRO_0000206583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9LQ55.
PRIDEiQ9LQ55.

PTM databases

iPTMnetiQ9LQ55.

Expressioni

Tissue specificityi

Ubiquitous. Preferentially expressed in siliques.1 Publication

Gene expression databases

ExpressionAtlasiQ9LQ55. baseline and differential.
GenevisibleiQ9LQ55. AT.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DRP1AP426974EBI-2355848,EBI-994234

GO - Molecular functioni

  • clathrin binding Source: TAIR

Protein-protein interaction databases

BioGridi27476. 9 interactions.
DIPiDIP-53383N.
IntActiQ9LQ55. 6 interactions.
STRINGi3702.AT1G59610.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LQ55.
SMRiQ9LQ55. Positions 7-494, 574-642.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 303269Dynamin-type GAdd
BLAST
Domaini579 – 703125PHPROSITE-ProRule annotationAdd
BLAST
Domaini737 – 83094GEDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili788 – 81225Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi885 – 92036Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
HOGENOMiHOG000241772.
InParanoidiQ9LQ55.
KOiK01528.
OMAiHKRERYQ.
PhylomeDBiQ9LQ55.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 2 hits.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LQ55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAIDELSQL SDSMRQAASL LADEDPDETS SSRRPATSLN VVALGNVGAG
60 70 80 90 100
KSAVLNSLIG HPVLPTGENG ATRAPIIIDL SREESLSSKA IILQIDNKNQ
110 120 130 140 150
QVSASALRHS LQDRLSKGAS GRGRDEIYLK LRTSTAPPLK LIDLPGLDQR
160 170 180 190 200
IVDDSMIGEH AQHNDAILLV VVPASQASEI SSSRALKIAK EYDPESTRTV
210 220 230 240 250
GIISKIDQAA ENPKSLAAVQ ALLSNQGPPK TTDIPWVALI GQSVSIASAQ
260 270 280 290 300
SGGSENSLET AWRAESESLK SILTGAPQSK LGRIALVDTL ASQIRSRMKL
310 320 330 340 350
RLPNILTGLQ GKSQIVQDEL ARLGEQLVSS AEGTRAIALE LCREFEDKFL
360 370 380 390 400
LHLAGGEGSG WKVVASFEGN FPNRIKKLPL DRHFDLNNVK RIVLEADGYQ
410 420 430 440 450
PYLISPEKGL RSLIKTVLEL AKDPARLCVD EVHRVLVDIV SASANATPGL
460 470 480 490 500
GRYPPFKREV VAIASAALDG FKNEAKKMVV ALVDMERAFV PPQHFIRLVQ
510 520 530 540 550
RRMERQRREE ELKGRSSKKG QDAEQSLLNR ATSPQPDGPS STGGSLKSLR
560 570 580 590 600
DKLMPQDKDK DKEKETPEVS GLKTAGPEGE ITAGYLMKKS AKTNGWSRRW
610 620 630 640 650
FVLNEKTGKL GYTKKQEERN FRGTVTLEEC SIEEISDDEG EKSKSSKDKK
660 670 680 690 700
SNGPDSKGPG LVFKITCRVP YKTVLKAHNA LVLKAESMVD KNEWINKLQK
710 720 730 740 750
VIQARGGQVG SASMRQSLSE GSLDKMVRKP VDPEEELRWM SQEVRGYVEA
760 770 780 790 800
VLNSLAANVP KAVVLCQVEK SKEDMLNQLY SSISAIGNER IESLIQEDQN
810 820 830 840 850
VKRRRDRYQK QSSLLSKLTR QLSIHDNRAA AASSWSDNSG TESSPRTNGG
860 870 880 890 900
SSGEDWMNAF NAAASGPDSL KRYGSGGHSR RYSDPAQNGE DSSGSGGSSR
910 920
RTTPNRLPPA PPQSGSSYRY
Length:920
Mass (Da):100,228
Last modified:February 1, 2005 - v2
Checksum:iD95964FE33B79AB2
GO

Sequence cautioni

The sequence AAF79753.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAA77516.1 differs from that shown. Reason: Frameshift at position 832. Curated
The sequence BAA88113.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026987 mRNA. Translation: BAA77516.1. Frameshift.
AB028467 mRNA. Translation: BAA88111.1.
AB028469 Genomic DNA. Translation: BAA88113.1. Sequence problems.
AC009317 Genomic DNA. Translation: AAF79753.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33594.1.
AY049230 mRNA. Translation: AAK83573.1.
BT000772 mRNA. Translation: AAN31911.1.
BT009695 mRNA. Translation: AAP88329.1.
PIRiH96619.
T52426.
RefSeqiNP_176170.1. NM_104654.4.
UniGeneiAt.23927.
At.67355.

Genome annotation databases

EnsemblPlantsiAT1G59610.1; AT1G59610.1; AT1G59610.
GeneIDi842251.
GrameneiAT1G59610.1; AT1G59610.1; AT1G59610.
KEGGiath:AT1G59610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026987 mRNA. Translation: BAA77516.1. Frameshift.
AB028467 mRNA. Translation: BAA88111.1.
AB028469 Genomic DNA. Translation: BAA88113.1. Sequence problems.
AC009317 Genomic DNA. Translation: AAF79753.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33594.1.
AY049230 mRNA. Translation: AAK83573.1.
BT000772 mRNA. Translation: AAN31911.1.
BT009695 mRNA. Translation: AAP88329.1.
PIRiH96619.
T52426.
RefSeqiNP_176170.1. NM_104654.4.
UniGeneiAt.23927.
At.67355.

3D structure databases

ProteinModelPortaliQ9LQ55.
SMRiQ9LQ55. Positions 7-494, 574-642.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi27476. 9 interactions.
DIPiDIP-53383N.
IntActiQ9LQ55. 6 interactions.
STRINGi3702.AT1G59610.1.

PTM databases

iPTMnetiQ9LQ55.

Proteomic databases

PaxDbiQ9LQ55.
PRIDEiQ9LQ55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G59610.1; AT1G59610.1; AT1G59610.
GeneIDi842251.
GrameneiAT1G59610.1; AT1G59610.1; AT1G59610.
KEGGiath:AT1G59610.

Organism-specific databases

TAIRiAT1G59610.

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
HOGENOMiHOG000241772.
InParanoidiQ9LQ55.
KOiK01528.
OMAiHKRERYQ.
PhylomeDBiQ9LQ55.

Enzyme and pathway databases

BioCyciARA:AT1G59610-MONOMER.

Miscellaneous databases

PROiQ9LQ55.

Gene expression databases

ExpressionAtlasiQ9LQ55. baseline and differential.
GenevisibleiQ9LQ55. AT.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 2 hits.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel Arabidopsis thaliana dynamin-like protein containing the pleckstrin homology domain."
    Mikami K., Iuchi S., Yamaguchi-Shinozaki K., Shinozaki K.
    J. Exp. Bot. 51:317-318(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Isolation and analysis of cDNA within a 300 kb Arabidopsis thaliana genomic region located around the 100 map unit of chromosome 1."
    Kato A., Suzuki M., Kuwahara A., Ooe H., Higano-Inaba K., Komeda Y.
    Gene 239:309-316(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: cv. Columbia.
  3. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "A unified nomenclature for Arabidopsis dynamin-related large GTPases based on homology and possible functions."
    Hong Z., Bednarek S.Y., Blumwald E., Hwang I., Jurgens G., Menzel D., Osteryoung K.W., Raikhel N.V., Shinozaki K., Tsutsumi N., Verma D.P.S.
    Plant Mol. Biol. 53:261-265(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  7. "Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
    Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
    Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDRP2B_ARATH
AccessioniPrimary (citable) accession number: Q9LQ55
Secondary accession number(s): Q9SLT3, Q9SLT4, Q9SXX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: February 17, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.