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Protein

Glutathione S-transferase U15

Gene

GSTU15

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • response to toxic substance Source: UniProtKB-KW
  • toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification

Enzyme and pathway databases

BioCyciARA:AT1G59670-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U15 (EC:2.5.1.18)
Short name:
AtGSTU15
Alternative name(s):
GST class-tau member 15
Gene namesi
Name:GSTU15
Ordered Locus Names:At1g59670
ORF Names:T30E16.25
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G59670.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135611 – 233Glutathione S-transferase U15Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LQ48.

Expressioni

Gene expression databases

GenevisibleiQ9LQ48. AT.

Interactioni

Protein-protein interaction databases

BioGridi27482. 1 interactor.
STRINGi3702.AT1G59670.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LQ48.
SMRiQ9LQ48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 85GST N-terminalAdd BLAST81
Domaini92 – 219GST C-terminalAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 16Glutathione bindingBy similarity2
Regioni42 – 43Glutathione bindingBy similarity2
Regioni56 – 57Glutathione bindingBy similarity2
Regioni69 – 70Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
HOGENOMiHOG000125749.
InParanoidiQ9LQ48.
KOiK00799.
OMAiGTWYSPV.
OrthoDBiEOG09360N01.
PhylomeDBiQ9LQ48.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LQ48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEREEVKLL GTWYSPVVIR AKIALRLKSV DYDYVEEDLF GSKSELLLKS
60 70 80 90 100
NPIFKKVPVL IHNTKPVCVS LNIVEYIDET WNSSGSSILP SHPYDRALAR
110 120 130 140 150
FWSVFVDDKW LPTLMAAVVA KSEEAKAKGM EEVEEGLLQL EAAFIALSKG
160 170 180 190 200
KSFFGGETIG FIDICLGSFL VLLKAREKLK NEKILDELKT PSLYRWANQF
210 220 230
LSNEMVKNVV PDIDKVAKFI EEFEDRAQYI RCF
Length:233
Mass (Da):26,535
Last modified:October 1, 2000 - v1
Checksum:i8722CA2CE7AEC09D
GO

Sequence cautioni

The sequence ABK28444 differs from that shown. Reason: Erroneous termination at position 234. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6E → Q in AAM61551 (Ref. 4) Curated1
Sequence conflicti24A → D in AAM61551 (Ref. 4) Curated1
Sequence conflicti38D → N in AAM61551 (Ref. 4) Curated1
Sequence conflicti53 – 54IF → VY in AAM61551 (Ref. 4) Curated2
Sequence conflicti141E → D in AAM61551 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009317 Genomic DNA. Translation: AAF79758.1.
CP002684 Genomic DNA. Translation: AEE33601.1.
DQ446376 mRNA. Translation: ABE65725.1.
DQ652904 mRNA. Translation: ABK28444.1. Sequence problems.
AY084992 mRNA. Translation: AAM61551.1.
PIRiD96620.
RefSeqiNP_176176.1. NM_104660.2.
UniGeneiAt.36811.

Genome annotation databases

EnsemblPlantsiAT1G59670.1; AT1G59670.1; AT1G59670.
GeneIDi842257.
GrameneiAT1G59670.1; AT1G59670.1; AT1G59670.
KEGGiath:AT1G59670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009317 Genomic DNA. Translation: AAF79758.1.
CP002684 Genomic DNA. Translation: AEE33601.1.
DQ446376 mRNA. Translation: ABE65725.1.
DQ652904 mRNA. Translation: ABK28444.1. Sequence problems.
AY084992 mRNA. Translation: AAM61551.1.
PIRiD96620.
RefSeqiNP_176176.1. NM_104660.2.
UniGeneiAt.36811.

3D structure databases

ProteinModelPortaliQ9LQ48.
SMRiQ9LQ48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi27482. 1 interactor.
STRINGi3702.AT1G59670.1.

Proteomic databases

PaxDbiQ9LQ48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G59670.1; AT1G59670.1; AT1G59670.
GeneIDi842257.
GrameneiAT1G59670.1; AT1G59670.1; AT1G59670.
KEGGiath:AT1G59670.

Organism-specific databases

TAIRiAT1G59670.

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
HOGENOMiHOG000125749.
InParanoidiQ9LQ48.
KOiK00799.
OMAiGTWYSPV.
OrthoDBiEOG09360N01.
PhylomeDBiQ9LQ48.

Enzyme and pathway databases

BioCyciARA:AT1G59670-MONOMER.

Miscellaneous databases

PROiQ9LQ48.

Gene expression databases

GenevisibleiQ9LQ48. AT.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTUF_ARATH
AccessioniPrimary (citable) accession number: Q9LQ48
Secondary accession number(s): A0MED4, Q8LF83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.