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Q9LQ48

- GSTUF_ARATH

UniProt

Q9LQ48 - GSTUF_ARATH

Protein

Glutathione S-transferase U15

Gene

GSTU15

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to toxic substance Source: UniProtKB-KW
    2. toxin catabolic process Source: TAIR

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Detoxification

    Enzyme and pathway databases

    BioCyciARA:AT1G59670-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase U15 (EC:2.5.1.18)
    Short name:
    AtGSTU15
    Alternative name(s):
    GST class-tau member 15
    Gene namesi
    Name:GSTU15
    Ordered Locus Names:At1g59670
    ORF Names:T30E16.25
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G59670.

    Subcellular locationi

    Cytoplasmcytosol Curated

    GO - Cellular componenti

    1. cytoplasm Source: TAIR
    2. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233Glutathione S-transferase U15PRO_0000413561Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei158 – 1581PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9LQ48.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9LQ48.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G59670.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LQ48.
    SMRiQ9LQ48. Positions 5-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 8581GST N-terminalAdd
    BLAST
    Domaini92 – 219128GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni15 – 162Glutathione bindingBy similarity
    Regioni42 – 432Glutathione bindingBy similarity
    Regioni56 – 572Glutathione bindingBy similarity
    Regioni69 – 702Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Tau family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG287605.
    HOGENOMiHOG000125749.
    InParanoidiQ9LQ48.
    KOiK00799.
    OMAiDETWASS.
    PhylomeDBiQ9LQ48.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9LQ48-1 [UniParc]FASTAAdd to Basket

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    MGEREEVKLL GTWYSPVVIR AKIALRLKSV DYDYVEEDLF GSKSELLLKS    50
    NPIFKKVPVL IHNTKPVCVS LNIVEYIDET WNSSGSSILP SHPYDRALAR 100
    FWSVFVDDKW LPTLMAAVVA KSEEAKAKGM EEVEEGLLQL EAAFIALSKG 150
    KSFFGGETIG FIDICLGSFL VLLKAREKLK NEKILDELKT PSLYRWANQF 200
    LSNEMVKNVV PDIDKVAKFI EEFEDRAQYI RCF 233
    Length:233
    Mass (Da):26,535
    Last modified:October 1, 2000 - v1
    Checksum:i8722CA2CE7AEC09D
    GO

    Sequence cautioni

    The sequence ABK28444.1 differs from that shown. Reason: Erroneous termination at position 234. Translated as stop.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61E → Q in AAM61551. 1 PublicationCurated
    Sequence conflicti24 – 241A → D in AAM61551. 1 PublicationCurated
    Sequence conflicti38 – 381D → N in AAM61551. 1 PublicationCurated
    Sequence conflicti53 – 542IF → VY in AAM61551. 1 PublicationCurated
    Sequence conflicti141 – 1411E → D in AAM61551. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009317 Genomic DNA. Translation: AAF79758.1.
    CP002684 Genomic DNA. Translation: AEE33601.1.
    DQ446376 mRNA. Translation: ABE65725.1.
    DQ652904 mRNA. Translation: ABK28444.1. Sequence problems.
    AY084992 mRNA. Translation: AAM61551.1.
    PIRiD96620.
    RefSeqiNP_176176.1. NM_104660.2.
    UniGeneiAt.36811.

    Genome annotation databases

    EnsemblPlantsiAT1G59670.1; AT1G59670.1; AT1G59670.
    GeneIDi842257.
    KEGGiath:AT1G59670.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009317 Genomic DNA. Translation: AAF79758.1 .
    CP002684 Genomic DNA. Translation: AEE33601.1 .
    DQ446376 mRNA. Translation: ABE65725.1 .
    DQ652904 mRNA. Translation: ABK28444.1 . Sequence problems.
    AY084992 mRNA. Translation: AAM61551.1 .
    PIRi D96620.
    RefSeqi NP_176176.1. NM_104660.2.
    UniGenei At.36811.

    3D structure databases

    ProteinModelPortali Q9LQ48.
    SMRi Q9LQ48. Positions 5-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G59670.1-P.

    Proteomic databases

    PRIDEi Q9LQ48.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G59670.1 ; AT1G59670.1 ; AT1G59670 .
    GeneIDi 842257.
    KEGGi ath:AT1G59670.

    Organism-specific databases

    TAIRi AT1G59670.

    Phylogenomic databases

    eggNOGi NOG287605.
    HOGENOMi HOG000125749.
    InParanoidi Q9LQ48.
    KOi K00799.
    OMAi DETWASS.
    PhylomeDBi Q9LQ48.

    Enzyme and pathway databases

    BioCyci ARA:AT1G59670-MONOMER.

    Gene expression databases

    Genevestigatori Q9LQ48.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
      Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
      Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
      Wagner U., Edwards R., Dixon D.P., Mauch F.
      Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiGSTUF_ARATH
    AccessioniPrimary (citable) accession number: Q9LQ48
    Secondary accession number(s): A0MED4, Q8LF83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3