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Protein

Eukaryotic peptide chain release factor subunit 1-2

Gene

ERF1-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (PubMed:15474304). Modulates plant growth and development (PubMed:16113224).1 Publication1 Publication

GO - Molecular functioni

  • translation release factor activity Source: TAIR

GO - Biological processi

  • regulation of growth Source: UniProtKB-KW
  • translational termination Source: TAIR

Keywordsi

Biological processGrowth regulation, Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-ATH-72764 Eukaryotic Translation Termination
R-ATH-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-ATH-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic peptide chain release factor subunit 1-2
Short name:
Eukaryotic release factor 1-2
Short name:
eRF1-2
Alternative name(s):
Omnipotent suppressor protein 1 homolog 2
Short name:
SUP1 homolog 2
Gene namesi
Name:ERF1-2
Ordered Locus Names:At1g12920
ORF Names:F13K23.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G12920
TAIRilocus:2010341 AT1G12920

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi180G → A: Loss of peptidyl-tRNA hydrolytic activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001431632 – 434Eukaryotic peptide chain release factor subunit 1-2Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9LPV8
PRIDEiQ9LPV8

PTM databases

iPTMnetiQ9LPV8

Expressioni

Gene expression databases

ExpressionAtlasiQ9LPV8 baseline and differential
GenevisibleiQ9LPV8 AT

Interactioni

Subunit structurei

Heterodimer of two subunits, one of which binds GTP.

Protein-protein interaction databases

BioGridi23090, 3 interactors
IntActiQ9LPV8, 2 interactors
STRINGi3702.AT1G12920.1

Structurei

3D structure databases

ProteinModelPortaliQ9LPV8
SMRiQ9LPV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic release factor 1 family.Curated

Phylogenomic databases

eggNOGiKOG0688 Eukaryota
COG1503 LUCA
HOGENOMiHOG000224681
InParanoidiQ9LPV8
KOiK03265
OMAiGPGTEKM
OrthoDBiEOG093609S9
PhylomeDBiQ9LPV8

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
3.30.960.10, 1 hit
InterProiView protein in InterPro
IPR005140 eRF1_1_Pelota
IPR005141 eRF1_2
IPR005142 eRF1_3
IPR029064 L30e-like
IPR004403 Peptide_chain-rel_eRF1/aRF1
IPR024049 Release_factor_eRF1/aRF1_N
PANTHERiPTHR10113 PTHR10113, 1 hit
PfamiView protein in Pfam
PF03463 eRF1_1, 1 hit
PF03464 eRF1_2, 1 hit
PF03465 eRF1_3, 1 hit
SMARTiView protein in SMART
SM01194 eRF1_1, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit
SSF55481 SSF55481, 1 hit
TIGRFAMsiTIGR03676 aRF1/eRF1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LPV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEADTNIE IWKIKKLIKG LESARGNGTS MISLIMPPRD QVSRVTKMLG
60 70 80 90 100
DEYGTASNIK SRVNRQSVLS AITSAQQRLK LYNKVPTNGL VLYTGTIVND
110 120 130 140 150
DGKEKKVTFD FEPFRPINAS LYLCDNKFHT EALNELLESD DKFGFIVMDG
160 170 180 190 200
NGTLFGTLSG NTREVLHKFT VDLPKKHGRG GQSALRFARL RMEKRHNYVR
210 220 230 240 250
KTAELATQFY INPATSQPNV SGLILAGSAD FKTELSQSEL FDPRLQAKIL
260 270 280 290 300
NVVDVSYGGE NGFNQAIELS AEILSNVKFI QEKKLIGKYF EEISQDTGKY
310 320 330 340 350
VFGVEDTLKA LEMGAIETLI VWENLDINRY ELKNSTTGEM VVKHFGKDQE
360 370 380 390 400
SDTSNFHDSE TNAELEVQEK MPLLEWFANE YKRFGCTLEF VTNKSQEGSQ
410 420 430
FCRGFGGIGG MLRYQLDMRT FDELSDTEVY EDSD
Length:434
Mass (Da):48,941
Last modified:October 1, 2000 - v1
Checksum:i63454371B158D851
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012187 Genomic DNA Translation: AAF78496.1
CP002684 Genomic DNA Translation: AEE28949.1
AY034963 mRNA Translation: AAK59469.1
BT026125 mRNA Translation: ABG48481.1
AY086623 mRNA Translation: AAM63682.1
X69374 mRNA Translation: CAA49171.1
U40218 mRNA Translation: AAA91170.1
Z18188 mRNA Translation: CAA79125.1
PIRiH86262
S31445
RefSeqiNP_172752.1, NM_101163.2
UniGeneiAt.23958

Genome annotation databases

EnsemblPlantsiAT1G12920.1; AT1G12920.1; AT1G12920
GeneIDi837850
GrameneiAT1G12920.1; AT1G12920.1; AT1G12920
KEGGiath:AT1G12920

Similar proteinsi

Entry informationi

Entry nameiERF1Y_ARATH
AccessioniPrimary (citable) accession number: Q9LPV8
Secondary accession number(s): Q147G8
, Q39098, Q39223, Q41987
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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