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Q9LPS1

- HXK3_ARATH

UniProt

Q9LPS1 - HXK3_ARATH

Protein

Hexokinase-3

Gene

At1g50460

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol By similarity.By similarity

    Catalytic activityi

    ATP + D-hexose = ADP + D-hexose 6-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi101 – 1066ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hexokinase activity Source: UniProtKB-EC
    3. protein binding Source: TAIR

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. response to cold Source: TAIR
    3. response to osmotic stress Source: TAIR
    4. response to salt stress Source: TAIR
    5. root hair cell development Source: TAIR

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G50460-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hexokinase-3 (EC:2.7.1.1)
    Gene namesi
    Ordered Locus Names:At1g50460
    ORF Names:F11F12.18
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G50460.

    Subcellular locationi

    Mitochondrion outer membrane 2 Publications; Single-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of mitochondrial outer membrane Source: TAIR
    2. mitochondrion Source: TAIR
    3. plastid Source: TAIR

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Hexokinase-3PRO_0000259631Add
    BLAST

    Proteomic databases

    PaxDbiQ9LPS1.
    PRIDEiQ9LPS1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9LPS1.

    Interactioni

    Protein-protein interaction databases

    BioGridi26693. 1 interaction.
    MINTiMINT-8059306.
    STRINGi3702.AT1G50460.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LPS1.
    SMRiQ9LPS1. Positions 55-494.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 239202Hexokinase type-1Add
    BLAST
    Domaini244 – 494251Hexokinase type-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni170 – 19627Glucose-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated
    Contains 1 hexokinase type-1 domain.Curated
    Contains 1 hexokinase type-2 domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5026.
    HOGENOMiHOG000162670.
    InParanoidiQ9LPS1.
    KOiK00844.
    OMAiYTMFREY.
    PhylomeDBiQ9LPS1.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.

    Sequencei

    Sequence statusi: Complete.

    Q9LPS1-1 [UniParc]FASTAAdd to Basket

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    MGKVAVAFAA VAVVAACSVA AVMVGRRMKS RRKWRTVVEI LKELEDDCDT    50
    PVGRLRQVVD AMAVEMHAGL ASEGGSKLKM LLTFVDDLPT GREKGTYYAL 100
    HLGGTYFRIL RVLLGDQRSY LDVQDVERHP IPSHLMNSTS EVLFNFLAFS 150
    LERFIEKEEN GSDSQGVRRE LAFTFSFPVK HTSISSGVLI KWTKGFEISE 200
    MVGQDIAECL QGALNRRGLD MHVAALVNDT VGALSLGYYH DPDTVVAVVF 250
    GTGSNACYLE RTDAIIKCQG LLTTSGSMVV NMEWGNFWSS HLPRTSYDID 300
    LDAESSNAND MGFEKMISGM YLGDIVRRVI LRMSEDSDIF GPISPVLSEP 350
    YVLRTNSVSA IHEDDTPELQ EVARILKDIG VSDVPLKVRK LVVKICDVVT 400
    RRAGRLAAAG IAGILKKIGR DGSGGITSGR SRSEIQMQKR TVVAVEGGLY 450
    MNYTMFREYM EEALVEILGE EVSQYVVVKA MEDGSSIGSA LLVASLQS 498
    Length:498
    Mass (Da):54,591
    Last modified:October 1, 2000 - v1
    Checksum:i1818AD18A17063D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC012561 Genomic DNA. Translation: AAF87885.1.
    CP002684 Genomic DNA. Translation: AEE32553.1.
    AY074314 mRNA. Translation: AAL67011.1.
    AY096416 mRNA. Translation: AAM20056.1.
    PIRiA96541.
    RefSeqiNP_175463.1. NM_103929.3.
    UniGeneiAt.27557.

    Genome annotation databases

    EnsemblPlantsiAT1G50460.1; AT1G50460.1; AT1G50460.
    GeneIDi841468.
    KEGGiath:AT1G50460.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC012561 Genomic DNA. Translation: AAF87885.1 .
    CP002684 Genomic DNA. Translation: AEE32553.1 .
    AY074314 mRNA. Translation: AAL67011.1 .
    AY096416 mRNA. Translation: AAM20056.1 .
    PIRi A96541.
    RefSeqi NP_175463.1. NM_103929.3.
    UniGenei At.27557.

    3D structure databases

    ProteinModelPortali Q9LPS1.
    SMRi Q9LPS1. Positions 55-494.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 26693. 1 interaction.
    MINTi MINT-8059306.
    STRINGi 3702.AT1G50460.1-P.

    Proteomic databases

    PaxDbi Q9LPS1.
    PRIDEi Q9LPS1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G50460.1 ; AT1G50460.1 ; AT1G50460 .
    GeneIDi 841468.
    KEGGi ath:AT1G50460.

    Organism-specific databases

    GeneFarmi 4245. 430.
    TAIRi AT1G50460.

    Phylogenomic databases

    eggNOGi COG5026.
    HOGENOMi HOG000162670.
    InParanoidi Q9LPS1.
    KOi K00844.
    OMAi YTMFREY.
    PhylomeDBi Q9LPS1.

    Enzyme and pathway databases

    BioCyci ARA:AT1G50460-MONOMER.

    Gene expression databases

    Genevestigatori Q9LPS1.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Enzymes of glycolysis are functionally associated with the mitochondrion in Arabidopsis cells."
      Giege P., Heazlewood J.L., Roessner-Tunali U., Millar A.H., Fernie A.R., Leaver C.J., Sweetlove L.J.
      Plant Cell 15:2140-2151(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
      Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
      Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
      Strain: cv. Landsberg erecta.

    Entry informationi

    Entry nameiHXK3_ARATH
    AccessioniPrimary (citable) accession number: Q9LPS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3