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Protein

Hexokinase-3

Gene

At1g50460

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity).By similarity

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi101 – 106ATPSequence analysis6

GO - Molecular functioni

GO - Biological processi

  • cellular glucose homeostasis Source: GO_Central
  • glycolytic process Source: GO_Central
  • response to cold Source: TAIR
  • response to osmotic stress Source: TAIR
  • response to salt stress Source: TAIR
  • root hair cell development Source: TAIR

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G50460-MONOMER.
ReactomeiR-ATH-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-ATH-6798695. Neutrophil degranulation.
R-ATH-70171. Glycolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-3 (EC:2.7.1.1)
Gene namesi
Ordered Locus Names:At1g50460
ORF Names:F11F12.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G50460.
TAIRilocus:2008031. AT1G50460.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002596311 – 498Hexokinase-3Add BLAST498

Proteomic databases

PaxDbiQ9LPS1.
PRIDEiQ9LPS1.

PTM databases

iPTMnetiQ9LPS1.

Expressioni

Gene expression databases

GenevisibleiQ9LPS1. AT.

Interactioni

Protein-protein interaction databases

BioGridi26693. 5 interactors.
MINTiMINT-8059306.
STRINGi3702.AT1G50460.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LPS1.
SMRiQ9LPS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 494HexokinasePROSITE-ProRule annotationAdd BLAST460

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni90 – 227Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST138
Regioni170 – 196Glucose-bindingSequence analysisAdd BLAST27
Regioni228 – 483Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST256

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
HOGENOMiHOG000162670.
InParanoidiQ9LPS1.
KOiK00844.
OMAiERQFFRA.
OrthoDBiEOG09360B3Y.
PhylomeDBiQ9LPS1.

Family and domain databases

InterProiView protein in InterPro
IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiView protein in Pfam
PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
PROSITEiView protein in PROSITE
PS51748. HEXOKINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9LPS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKVAVAFAA VAVVAACSVA AVMVGRRMKS RRKWRTVVEI LKELEDDCDT
60 70 80 90 100
PVGRLRQVVD AMAVEMHAGL ASEGGSKLKM LLTFVDDLPT GREKGTYYAL
110 120 130 140 150
HLGGTYFRIL RVLLGDQRSY LDVQDVERHP IPSHLMNSTS EVLFNFLAFS
160 170 180 190 200
LERFIEKEEN GSDSQGVRRE LAFTFSFPVK HTSISSGVLI KWTKGFEISE
210 220 230 240 250
MVGQDIAECL QGALNRRGLD MHVAALVNDT VGALSLGYYH DPDTVVAVVF
260 270 280 290 300
GTGSNACYLE RTDAIIKCQG LLTTSGSMVV NMEWGNFWSS HLPRTSYDID
310 320 330 340 350
LDAESSNAND MGFEKMISGM YLGDIVRRVI LRMSEDSDIF GPISPVLSEP
360 370 380 390 400
YVLRTNSVSA IHEDDTPELQ EVARILKDIG VSDVPLKVRK LVVKICDVVT
410 420 430 440 450
RRAGRLAAAG IAGILKKIGR DGSGGITSGR SRSEIQMQKR TVVAVEGGLY
460 470 480 490
MNYTMFREYM EEALVEILGE EVSQYVVVKA MEDGSSIGSA LLVASLQS
Length:498
Mass (Da):54,591
Last modified:October 1, 2000 - v1
Checksum:i1818AD18A17063D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012561 Genomic DNA. Translation: AAF87885.1.
CP002684 Genomic DNA. Translation: AEE32553.1.
AY074314 mRNA. Translation: AAL67011.1.
AY096416 mRNA. Translation: AAM20056.1.
PIRiA96541.
RefSeqiNP_175463.1. NM_103929.4.
UniGeneiAt.27557.

Genome annotation databases

EnsemblPlantsiAT1G50460.1; AT1G50460.1; AT1G50460.
GeneIDi841468.
GrameneiAT1G50460.1; AT1G50460.1; AT1G50460.
KEGGiath:AT1G50460.

Similar proteinsi

Entry informationi

Entry nameiHXK3_ARATH
AccessioniPrimary (citable) accession number: Q9LPS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families