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Protein

UDP-glucuronate 4-epimerase 2

Gene

GAE2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components.By similarity

Catalytic activityi

UDP-glucuronate = UDP-D-galacturonate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei243Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi93 – 124NADBy similarityAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandNAD

Enzyme and pathway databases

BRENDAi5.1.3.6. 399.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronate 4-epimerase 2 (EC:5.1.3.6)
Alternative name(s):
UDP-glucuronic acid epimerase 2
Gene namesi
Name:GAE2
Ordered Locus Names:At1g02000
ORF Names:F22M8.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G02000.
TAIRilocus:2025472. AT1G02000.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002925971 – 434UDP-glucuronate 4-epimerase 2Add BLAST434

Proteomic databases

PaxDbiQ9LPC1.

PTM databases

iPTMnetiQ9LPC1.

Expressioni

Tissue specificityi

In roots, leaves, siliques, flowers, pollen and stems.2 Publications

Gene expression databases

ExpressionAtlasiQ9LPC1. baseline and differential.
GenevisibleiQ9LPC1. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT1G02000.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LPC1.
SMRiQ9LPC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi217 – 220Poly-Ser4
Compositional biasi431 – 434Poly-Ala4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IU3F. Eukaryota.
COG0451. LUCA.
HOGENOMiHOG000168000.
InParanoidiQ9LPC1.
KOiK08679.
OMAiMHIDNIP.
OrthoDBiEOG09360AZR.
PhylomeDBiQ9LPC1.

Family and domain databases

InterProiView protein in InterPro
IPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
IPR008089. Nuc_sugar_epim.
PfamiView protein in Pfam
PF01370. Epimerase. 1 hit.
PRINTSiPR01713. NUCEPIMERASE.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9LPC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLDDIPST PGKFKMMDKS PFFLHRTRWQ SSVAKLAFWS LVFFGLLFIF
60 70 80 90 100
FYRSPISNPD SSRRSLRTYS WGGPAWEKRV RSSARVRTRN GVSVLVTGAA
110 120 130 140 150
GFVGTHVSAA LKRRGDGVLG LDNFNDYYDT SLKRSRQALL ERSGVFIVEG
160 170 180 190 200
DINDLSLLKK LFEVVPFTHV MHLAAQAGVR YAMENPGSYV HSNIAGFVNL
210 220 230 240 250
LEVCKSANPQ PAIVWASSSS VYGLNTKVPF SEKDRTDQPA SLYAATKKAG
260 270 280 290 300
EEIAHTYNHI YGLSLTGLRF FTVYGPWGRP DMAYFFFTRD ILKGKAISIF
310 320 330 340 350
EGANHGTVAR DFTYIDDIVK GCLGALDTAE KSTGSGGKKR GAAQLRVFNL
360 370 380 390 400
GNTSPVPVTD LVSILERLLK VKAKRNMMKL PRNGDVPFTH ANISSAQREF
410 420 430
GYKPSTDLQT GLKKFVRWYL GYYKQGGKKV AAAA
Length:434
Mass (Da):48,133
Last modified:October 1, 2000 - v1
Checksum:i2B67F704D617FD6E
GO

Sequence cautioni

The sequence AAM61323 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020622 Genomic DNA. Translation: AAF76478.1.
CP002684 Genomic DNA. Translation: AEE27364.1.
AF334734 mRNA. Translation: AAG50112.1.
AY084754 mRNA. Translation: AAM61323.1. Different initiation.
AK228396 mRNA. Translation: BAF00333.1.
PIRiA86152.
RefSeqiNP_171702.1. NM_100080.4.
UniGeneiAt.17005.

Genome annotation databases

EnsemblPlantsiAT1G02000.1; AT1G02000.1; AT1G02000.
GeneIDi839289.
GrameneiAT1G02000.1; AT1G02000.1; AT1G02000.
KEGGiath:AT1G02000.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGAE2_ARATH
AccessioniPrimary (citable) accession number: Q9LPC1
Secondary accession number(s): Q0WRB6, Q8LFM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families