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Protein

UDP-glucuronate 4-epimerase 2

Gene

GAE2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components.By similarity

Catalytic activityi

UDP-glucuronate = UDP-D-galacturonate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei243Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi93 – 124NADBy similarityAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandNAD

Enzyme and pathway databases

BRENDAi5.1.3.6 399

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronate 4-epimerase 2 (EC:5.1.3.6)
Alternative name(s):
UDP-glucuronic acid epimerase 2
Gene namesi
Name:GAE2
Ordered Locus Names:At1g02000
ORF Names:F22M8.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G02000
TAIRilocus:2025472 AT1G02000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002925971 – 434UDP-glucuronate 4-epimerase 2Add BLAST434

Proteomic databases

PaxDbiQ9LPC1

PTM databases

iPTMnetiQ9LPC1

Expressioni

Tissue specificityi

In roots, leaves, siliques, flowers, pollen and stems.2 Publications

Gene expression databases

ExpressionAtlasiQ9LPC1 baseline and differential
GenevisibleiQ9LPC1 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT1G02000.1

Structurei

3D structure databases

ProteinModelPortaliQ9LPC1
SMRiQ9LPC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi217 – 220Poly-Ser4
Compositional biasi431 – 434Poly-Ala4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IU3F Eukaryota
COG0451 LUCA
HOGENOMiHOG000168000
InParanoidiQ9LPC1
KOiK08679
OMAiMSRHLHR
OrthoDBiEOG09360AZR
PhylomeDBiQ9LPC1

Family and domain databases

InterProiView protein in InterPro
IPR001509 Epimerase_deHydtase
IPR036291 NAD(P)-bd_dom_sf
IPR008089 Nuc_sugar_epim
PfamiView protein in Pfam
PF01370 Epimerase, 1 hit
PRINTSiPR01713 NUCEPIMERASE
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LPC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLDDIPST PGKFKMMDKS PFFLHRTRWQ SSVAKLAFWS LVFFGLLFIF
60 70 80 90 100
FYRSPISNPD SSRRSLRTYS WGGPAWEKRV RSSARVRTRN GVSVLVTGAA
110 120 130 140 150
GFVGTHVSAA LKRRGDGVLG LDNFNDYYDT SLKRSRQALL ERSGVFIVEG
160 170 180 190 200
DINDLSLLKK LFEVVPFTHV MHLAAQAGVR YAMENPGSYV HSNIAGFVNL
210 220 230 240 250
LEVCKSANPQ PAIVWASSSS VYGLNTKVPF SEKDRTDQPA SLYAATKKAG
260 270 280 290 300
EEIAHTYNHI YGLSLTGLRF FTVYGPWGRP DMAYFFFTRD ILKGKAISIF
310 320 330 340 350
EGANHGTVAR DFTYIDDIVK GCLGALDTAE KSTGSGGKKR GAAQLRVFNL
360 370 380 390 400
GNTSPVPVTD LVSILERLLK VKAKRNMMKL PRNGDVPFTH ANISSAQREF
410 420 430
GYKPSTDLQT GLKKFVRWYL GYYKQGGKKV AAAA
Length:434
Mass (Da):48,133
Last modified:October 1, 2000 - v1
Checksum:i2B67F704D617FD6E
GO

Sequence cautioni

The sequence AAM61323 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020622 Genomic DNA Translation: AAF76478.1
CP002684 Genomic DNA Translation: AEE27364.1
AF334734 mRNA Translation: AAG50112.1
AY084754 mRNA Translation: AAM61323.1 Different initiation.
AK228396 mRNA Translation: BAF00333.1
PIRiA86152
RefSeqiNP_171702.1, NM_100080.4
UniGeneiAt.17005

Genome annotation databases

EnsemblPlantsiAT1G02000.1; AT1G02000.1; AT1G02000
GeneIDi839289
GrameneiAT1G02000.1; AT1G02000.1; AT1G02000
KEGGiath:AT1G02000

Similar proteinsi

Entry informationi

Entry nameiGAE2_ARATH
AccessioniPrimary (citable) accession number: Q9LPC1
Secondary accession number(s): Q0WRB6, Q8LFM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health