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Protein

Sugar transport protein 2

Gene

STP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, 3-O-methylglucose, xylose, mannose, fructose and galactose.1 Publication

Kineticsi

  1. KM=50 µM for galactose1 Publication
  2. KM=20 µM for 3-O-methylglucose1 Publication

    GO - Molecular functioni

    GO - Biological processi

    • glucose import Source: GO_Central
    • hexose transmembrane transport Source: GO_Central
    • monosaccharide transport Source: TAIR
    • pollen development Source: TAIR
    Complete GO annotation...

    Keywords - Biological processi

    Sugar transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.1.1.48. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sugar transport protein 2
    Alternative name(s):
    Hexose transporter 2
    Gene namesi
    Name:STP2
    Ordered Locus Names:At1g07340
    ORF Names:F22G5.32
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 1

    Organism-specific databases

    TAIRiAT1G07340.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2222CytoplasmicSequence analysisAdd
    BLAST
    Transmembranei23 – 4321Helical; Name=1Sequence analysisAdd
    BLAST
    Transmembranei80 – 10021Helical; Name=2Sequence analysisAdd
    BLAST
    Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
    BLAST
    Transmembranei167 – 18721Helical; Name=5Sequence analysisAdd
    BLAST
    Transmembranei200 – 22021Helical; Name=6Sequence analysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=7Sequence analysisAdd
    BLAST
    Transmembranei320 – 34021Helical; Name=8Sequence analysisAdd
    BLAST
    Transmembranei348 – 36821Helical; Name=9Sequence analysisAdd
    BLAST
    Transmembranei381 – 40121Helical; Name=10Sequence analysisAdd
    BLAST
    Transmembranei421 – 44121Helical; Name=11Sequence analysisAdd
    BLAST
    Transmembranei450 – 47021Helical; Name=12Sequence analysisAdd
    BLAST
    Topological domaini471 – 49828CytoplasmicSequence analysisAdd
    BLAST

    GO - Cellular componenti

    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Sugar transport protein 2PRO_0000050432Add
    BLAST

    Proteomic databases

    PaxDbiQ9LNV3.
    PRIDEiQ9LNV3.

    Expressioni

    Tissue specificityi

    Pollen specific (at protein level).1 Publication

    Developmental stagei

    Specifically expressed in pollen grains when the callose of microspores tetrads undergoes degradation, between early tetrad and late trinucleate stages (at protein level).1 Publication

    Gene expression databases

    GenevisibleiQ9LNV3. AT.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G07340.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LNV3.
    SMRiQ9LNV3. Positions 23-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi434 – 46936Phe-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    HOGENOMiHOG000202867.
    InParanoidiQ9LNV3.
    OMAiKNGWRYS.
    PhylomeDBiQ9LNV3.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport_like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9LNV3-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MAVGSMNVEE GTKAFPAKLT GQVFLCCVIA AVGGLMFGYD IGISGGVTSM
    60 70 80 90 100
    DTFLLDFFPH VYEKKHRVHE NNYCKFDDQL LQLFTSSLYL AGIFASFISS
    110 120 130 140 150
    YVSRAFGRKP TIMLASIFFL VGAILNLSAQ ELGMLIGGRI LLGFGIGFGN
    160 170 180 190 200
    QTVPLFISEI APARYRGGLN VMFQFLITIG ILAASYVNYL TSTLKNGWRY
    210 220 230 240 250
    SLGGAAVPAL ILLIGSFFIH ETPASLIERG KDEKGKQVLR KIRGIEDIEL
    260 270 280 290 300
    EFNEIKYATE VATKVKSPFK ELFTKSENRP PLVCGTLLQF FQQFTGINVV
    310 320 330 340 350
    MFYAPVLFQT MGSGDNASLI STVVTNGVNA IATVISLLVV DFAGRRCLLM
    360 370 380 390 400
    EGALQMTATQ MTIGGILLAH LKLVGPITGH AVPLIVLILI CVYVSGFAWS
    410 420 430 440 450
    WGPLGWLVPS EIYPLEVRNA GYFCAVAMNM VCTFIIGQFF LSALCRFRSL
    460 470 480 490
    LFFFFGIMNI IMGLFVVFFL PETKGVPIEE MAEKRWKTHP RWKKYFKD
    Length:498
    Mass (Da):55,023
    Last modified:September 22, 2009 - v3
    Checksum:iCEA14ED417C93F93
    GO

    Sequence cautioni

    The sequence AAF79565.1 differs from that shown. Reason: Frameshift at position 383. Curated
    The sequence AAF79565.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
    The sequence BX813610 differs from that shown.Sequencing errors.Curated

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC022464 Genomic DNA. Translation: AAF79565.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE28111.1.
    BX813610 mRNA. No translation available.
    AJ001362 Genomic DNA. Translation: CAB59188.1.
    PIRiE86208.
    RefSeqiNP_172214.5. NM_100608.5.
    UniGeneiAt.49862.

    Genome annotation databases

    EnsemblPlantsiAT1G07340.1; AT1G07340.1; AT1G07340.
    GeneIDi837245.
    GrameneiAT1G07340.1; AT1G07340.1; AT1G07340.
    KEGGiath:AT1G07340.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC022464 Genomic DNA. Translation: AAF79565.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE28111.1.
    BX813610 mRNA. No translation available.
    AJ001362 Genomic DNA. Translation: CAB59188.1.
    PIRiE86208.
    RefSeqiNP_172214.5. NM_100608.5.
    UniGeneiAt.49862.

    3D structure databases

    ProteinModelPortaliQ9LNV3.
    SMRiQ9LNV3. Positions 23-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi3702.AT1G07340.1.

    Protein family/group databases

    TCDBi2.A.1.1.48. the major facilitator superfamily (mfs).

    Proteomic databases

    PaxDbiQ9LNV3.
    PRIDEiQ9LNV3.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblPlantsiAT1G07340.1; AT1G07340.1; AT1G07340.
    GeneIDi837245.
    GrameneiAT1G07340.1; AT1G07340.1; AT1G07340.
    KEGGiath:AT1G07340.

    Organism-specific databases

    TAIRiAT1G07340.

    Phylogenomic databases

    eggNOGiKOG0254. Eukaryota.
    ENOG410XNQK. LUCA.
    HOGENOMiHOG000202867.
    InParanoidiQ9LNV3.
    OMAiKNGWRYS.
    PhylomeDBiQ9LNV3.

    Miscellaneous databases

    PROiQ9LNV3.

    Gene expression databases

    GenevisibleiQ9LNV3. AT.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR005828. MFS_sugar_transport_like.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
      Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
      Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "A male gametophyte-specific monosaccharide transporter in Arabidopsis."
      Truernit E., Stadler R., Baier K., Sauer N.
      Plant J. 17:191-201(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14, FUNCTION, TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, DEVELOPMENTAL STAGE.
      Strain: cv. Columbia.
    5. "The monosaccharide transporter gene family in land plants is ancient and shows differential subfamily expression and expansion across lineages."
      Johnson D.A., Hill J.P., Thomas M.A.
      BMC Evol. Biol. 6:64-64(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiSTP2_ARATH
    AccessioniPrimary (citable) accession number: Q9LNV3
    Secondary accession number(s): Q9SMV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: September 22, 2009
    Last modified: July 6, 2016
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.