Q9LNV3 (STP2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sugar transport protein 2

Alternative name(s):
Hexose transporter 2

Gene names

Name:	STP2
Ordered Locus Names:	At1g07340
ORF Names:	F22G5.32

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, 3-O-methylglucose, xylose, mannose, fructose and galactose. Ref.4
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Pollen specific (at protein level). Ref.4
Developmental stage	Specifically expressed in pollen grains when the callose of microspores tetrads undergoes degradation, between early tetrad and late trinucleate stages (at protein level). Ref.4
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]
Biophysicochemical properties	Kinetic parameters: KM=50 µM for galactose Ref.4 KM=20 µM for 3-O-methylglucose
Sequence caution	The sequence AAF79565.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAF79565.1 differs from that shown. Reason: Frameshift at position 383. The sequence BX813610 differs from that shown. Reason: Sequencing errors.

Ontologies

Keywords
Biological process	Sugar transport Symport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pollen development Traceable author statement Ref.4. Source: TAIR
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	monosaccharide transmembrane transporter activity Inferred from direct assay Ref.4. Source: TAIR symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 498	498	Sugar transport protein 2		PRO_0000050432
Regions
	Topological domain	1 – 22	22	Cytoplasmic Potential
	Transmembrane	23 – 43	21	Helical; Name=1; Potential
	Transmembrane	80 – 100	21	Helical; Name=2; Potential
	Transmembrane	117 – 137	21	Helical; Name=3; Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Transmembrane	167 – 187	21	Helical; Name=5; Potential
	Transmembrane	200 – 220	21	Helical; Name=6; Potential
	Transmembrane	288 – 308	21	Helical; Name=7; Potential
	Transmembrane	320 – 340	21	Helical; Name=8; Potential
	Transmembrane	348 – 368	21	Helical; Name=9; Potential
	Transmembrane	381 – 401	21	Helical; Name=10; Potential
	Transmembrane	421 – 441	21	Helical; Name=11; Potential
	Transmembrane	450 – 470	21	Helical; Name=12; Potential
	Topological domain	471 – 498	28	Cytoplasmic Potential
	Compositional bias	434 – 469	36	Phe-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9LNV3 [UniParc]. Last modified September 22, 2009. Version 3. Checksum: CEA14ED417C93F93	FASTA	498	55,023
	10 20 30 40 50 60 MAVGSMNVEE GTKAFPAKLT GQVFLCCVIA AVGGLMFGYD IGISGGVTSM DTFLLDFFPH 70 80 90 100 110 120 VYEKKHRVHE NNYCKFDDQL LQLFTSSLYL AGIFASFISS YVSRAFGRKP TIMLASIFFL 130 140 150 160 170 180 VGAILNLSAQ ELGMLIGGRI LLGFGIGFGN QTVPLFISEI APARYRGGLN VMFQFLITIG 190 200 210 220 230 240 ILAASYVNYL TSTLKNGWRY SLGGAAVPAL ILLIGSFFIH ETPASLIERG KDEKGKQVLR 250 260 270 280 290 300 KIRGIEDIEL EFNEIKYATE VATKVKSPFK ELFTKSENRP PLVCGTLLQF FQQFTGINVV 310 320 330 340 350 360 MFYAPVLFQT MGSGDNASLI STVVTNGVNA IATVISLLVV DFAGRRCLLM EGALQMTATQ 370 380 390 400 410 420 MTIGGILLAH LKLVGPITGH AVPLIVLILI CVYVSGFAWS WGPLGWLVPS EIYPLEVRNA 430 440 450 460 470 480 GYFCAVAMNM VCTFIIGQFF LSALCRFRSL LFFFFGIMNI IMGLFVVFFL PETKGVPIEE 490 MAEKRWKTHP RWKKYFKD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation." Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M. Genome Res. 14:406-413(2004) [PubMed: 14993207] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"A male gametophyte-specific monosaccharide transporter in Arabidopsis." Truernit E., Stadler R., Baier K., Sauer N. Plant J. 17:191-201(1999) [PubMed: 10074716] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-14, FUNCTION, TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, DEVELOPMENTAL STAGE. Strain: cv. Columbia.
[5]	"The monosaccharide transporter gene family in land plants is ancient and shows differential subfamily expression and expansion across lineages." Johnson D.A., Hill J.P., Thomas M.A. BMC Evol. Biol. 6:64-64(2006) [PubMed: 16923188] [Abstract] Cited for: GENE FAMILY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC022464 Genomic DNA. Translation: AAF79565.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE28111.1. BX813610 mRNA. No translation available. AJ001362 Genomic DNA. Translation: CAB59188.1.
IPI	IPI00533527.
PIR	E86208.
RefSeq	NP_172214.5. NM_100608.5.
UniGene	At.49862.
3D structure databases
ProteinModelPortal	Q9LNV3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9LNV3.
Protein family/group databases
TCDB	2.A.1.1.48. major facilitator superfamily (MFS).
Proteomic databases
PRIDE	Q9LNV3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G07340.1; AT1G07340.1; AT1G07340.
GeneID	837245.
GenomeReviews	Gene locus AT1G07340 in contig CT485782_GR.
KEGG	ath:AT1G07340.
Organism-specific databases
TAIR	At1g07340.
Phylogenomic databases
eggNOG	KOG0254.
GeneTree	EPGT00070000028469.
HOGENOM	HBG744444.
InParanoid	Q9LNV3.
ProtClustDB	CLSN2927326.
Gene expression databases
Genevestigator	Q9LNV3.
GermOnline	AT1G07340. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR00171. SUGRTRNSPORT.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

STP2_ARATH

Accession

Primary (citable) accession number: Q9LNV3
Secondary accession number(s): Q9SMV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	September 22, 2009
Last modified:	December 14, 2011
This is version 74 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program