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Protein

Sugar transport protein 2

Gene

STP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, 3-O-methylglucose, xylose, mannose, fructose and galactose.1 Publication

Kineticsi

  1. KM=50 µM for galactose1 Publication
  2. KM=20 µM for 3-O-methylglucose1 Publication

    GO - Molecular functioni

    GO - Biological processi

    • glucose import Source: GO_Central
    • monosaccharide transmembrane transport Source: TAIR
    • pollen development Source: TAIR

    Keywordsi

    Biological processSugar transport, Symport, Transport

    Enzyme and pathway databases

    SABIO-RKQ9LNV3

    Protein family/group databases

    TCDBi2.A.1.1.48 the major facilitator superfamily (mfs)

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sugar transport protein 2
    Alternative name(s):
    Hexose transporter 2
    Gene namesi
    Name:STP2
    Ordered Locus Names:At1g07340
    ORF Names:F22G5.32
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    Proteomesi
    • UP000006548 Componenti: Chromosome 1

    Organism-specific databases

    AraportiAT1G07340
    TAIRilocus:2025102 AT1G07340

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
    Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
    Transmembranei80 – 100Helical; Name=2Sequence analysisAdd BLAST21
    Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
    Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
    Transmembranei167 – 187Helical; Name=5Sequence analysisAdd BLAST21
    Transmembranei200 – 220Helical; Name=6Sequence analysisAdd BLAST21
    Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
    Transmembranei320 – 340Helical; Name=8Sequence analysisAdd BLAST21
    Transmembranei348 – 368Helical; Name=9Sequence analysisAdd BLAST21
    Transmembranei381 – 401Helical; Name=10Sequence analysisAdd BLAST21
    Transmembranei421 – 441Helical; Name=11Sequence analysisAdd BLAST21
    Transmembranei450 – 470Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini471 – 498CytoplasmicSequence analysisAdd BLAST28

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000504321 – 498Sugar transport protein 2Add BLAST498

    Proteomic databases

    PaxDbiQ9LNV3
    PRIDEiQ9LNV3

    Expressioni

    Tissue specificityi

    Pollen specific (at protein level).1 Publication

    Developmental stagei

    Specifically expressed in pollen grains when the callose of microspores tetrads undergoes degradation, between early tetrad and late trinucleate stages (at protein level).1 Publication

    Gene expression databases

    ExpressionAtlasiQ9LNV3 baseline and differential
    GenevisibleiQ9LNV3 AT

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G07340.1

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LNV3
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Compositional biasi434 – 469Phe-richAdd BLAST36

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0254 Eukaryota
    ENOG410XNQK LUCA
    HOGENOMiHOG000202867
    InParanoidiQ9LNV3
    OMAiIFFAVMC
    OrthoDBiEOG093608DR
    PhylomeDBiQ9LNV3

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR020846 MFS_dom
    IPR005828 MFS_sugar_transport-like
    IPR036259 MFS_trans_sf
    IPR003663 Sugar/inositol_transpt
    IPR005829 Sugar_transporter_CS
    PfamiView protein in Pfam
    PF00083 Sugar_tr, 1 hit
    PRINTSiPR00171 SUGRTRNSPORT
    SUPFAMiSSF103473 SSF103473, 1 hit
    TIGRFAMsiTIGR00879 SP, 1 hit
    PROSITEiView protein in PROSITE
    PS50850 MFS, 1 hit
    PS00216 SUGAR_TRANSPORT_1, 1 hit
    PS00217 SUGAR_TRANSPORT_2, 1 hit

    Sequencei

    Sequence statusi: Complete.

    Q9LNV3-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MAVGSMNVEE GTKAFPAKLT GQVFLCCVIA AVGGLMFGYD IGISGGVTSM
    60 70 80 90 100
    DTFLLDFFPH VYEKKHRVHE NNYCKFDDQL LQLFTSSLYL AGIFASFISS
    110 120 130 140 150
    YVSRAFGRKP TIMLASIFFL VGAILNLSAQ ELGMLIGGRI LLGFGIGFGN
    160 170 180 190 200
    QTVPLFISEI APARYRGGLN VMFQFLITIG ILAASYVNYL TSTLKNGWRY
    210 220 230 240 250
    SLGGAAVPAL ILLIGSFFIH ETPASLIERG KDEKGKQVLR KIRGIEDIEL
    260 270 280 290 300
    EFNEIKYATE VATKVKSPFK ELFTKSENRP PLVCGTLLQF FQQFTGINVV
    310 320 330 340 350
    MFYAPVLFQT MGSGDNASLI STVVTNGVNA IATVISLLVV DFAGRRCLLM
    360 370 380 390 400
    EGALQMTATQ MTIGGILLAH LKLVGPITGH AVPLIVLILI CVYVSGFAWS
    410 420 430 440 450
    WGPLGWLVPS EIYPLEVRNA GYFCAVAMNM VCTFIIGQFF LSALCRFRSL
    460 470 480 490
    LFFFFGIMNI IMGLFVVFFL PETKGVPIEE MAEKRWKTHP RWKKYFKD
    Length:498
    Mass (Da):55,023
    Last modified:September 22, 2009 - v3
    Checksum:iCEA14ED417C93F93
    GO

    Sequence cautioni

    The sequence AAF79565 differs from that shown. Reason: Frameshift at position 383.Curated
    The sequence AAF79565 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence BX813610 differs from that shown. Sequencing errors.Curated

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AC022464 Genomic DNA Translation: AAF79565.1 Sequence problems.
    CP002684 Genomic DNA Translation: AEE28111.1
    BX813610 mRNA No translation available.
    AJ001362 Genomic DNA Translation: CAB59188.1
    PIRiE86208
    RefSeqiNP_172214.5, NM_100608.5
    UniGeneiAt.49862

    Genome annotation databases

    EnsemblPlantsiAT1G07340.1; AT1G07340.1; AT1G07340
    GeneIDi837245
    GrameneiAT1G07340.1; AT1G07340.1; AT1G07340
    KEGGiath:AT1G07340

    Similar proteinsi

    Entry informationi

    Entry nameiSTP2_ARATH
    AccessioniPrimary (citable) accession number: Q9LNV3
    Secondary accession number(s): Q9SMV5
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: September 22, 2009
    Last modified: May 23, 2018
    This is version 111 of the entry and version 3 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health