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Q9LNR3

- LOX3_ARATH

UniProt

Q9LNR3 - LOX3_ARATH

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Protein

Lipoxygenase 3, chloroplastic

Gene
LOX3, At1g17420, F28G4.10
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

13S-lipoxygenase that can use linolenic acid as substrates. Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure By similarity.1 Publication

Catalytic activityi

Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.

Cofactori

Binds 1 iron ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi578 – 5781Iron; catalytic By similarity
Metal bindingi583 – 5831Iron; catalytic By similarity
Metal bindingi770 – 7701Iron; catalytic By similarity
Metal bindingi774 – 7741Iron; catalytic By similarity
Metal bindingi919 – 9191Iron; via carboxylate; catalytic By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. linoleate 13S-lipoxygenase activity Source: UniProtKB

GO - Biological processi

  1. anther dehiscence Source: TAIR
  2. anther development Source: TAIR
  3. lipid oxidation Source: TAIR
  4. oxylipin biosynthetic process Source: UniProtKB-UniPathway
  5. pollen development Source: TAIR
  6. response to fungus Source: TAIR
  7. response to high light intensity Source: UniProtKB
  8. response to jasmonic acid Source: UniProtKB
  9. response to wounding Source: UniProtKB
  10. stamen filament development Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00382.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoxygenase 3, chloroplastic (EC:1.13.11.12)
Short name:
AtLOX3
Gene namesi
Name:LOX3
Ordered Locus Names:At1g17420
ORF Names:F28G4.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G17420.

Subcellular locationi

Plastidchloroplast Reviewed prediction

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5252Chloroplast Reviewed predictionAdd
BLAST
Chaini53 – 919867Lipoxygenase 3, chloroplasticPRO_0000380592Add
BLAST

Proteomic databases

PaxDbiQ9LNR3.
PRIDEiQ9LNR3.

Expressioni

Tissue specificityi

Expressed in roots and leaves.1 Publication

Developmental stagei

First observed in lateral root primordia (LRP), from the first pericycle divisions. Later expressed in lateral roots. Expression is greatly increased in leaves during leaf senescence.2 Publications

Inductioni

Induced by methyl jasmonate (MeJA), bacterial pathogens (e.g. Pseudomonas syringae pv. tomato), high light and wounding.3 Publications

Gene expression databases

GenevestigatoriQ9LNR3.

Interactioni

Protein-protein interaction databases

BioGridi23554. 1 interaction.
IntActiQ9LNR3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9LNR3.
SMRiQ9LNR3. Positions 108-919.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 222137PLATAdd
BLAST
Domaini225 – 919695LipoxygenaseAdd
BLAST

Sequence similaritiesi

Belongs to the lipoxygenase family.
Contains 1 PLAT domain.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG69653.
HOGENOMiHOG000230469.
InParanoidiQ9LNR3.
KOiK00454.
OMAiLSKDKFA.
PhylomeDBiQ9LNR3.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProiIPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11771. PTHR11771. 1 hit.
PfamiPF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSiPR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEiPS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LNR3-1 [UniParc]FASTAAdd to Basket

« Hide

MALAKELMGY PLITERSSLV SSASHFKKRT QSTQFSINPF DRRPRKTKSG    50
VVAAISEDLV KTLRFSTTTG DRKSEEEEKA AVKFKVRAVV TVRNKNKEDL 100
KETLVKHLDA FADKIGRNIV LELISTQLDP KTKLPKKSNA AVLKDWSKKS 150
KTKAERVHYT AEFTVDAAFG SPGAITVMNK HQKEFFLESI TIEGFALGPV 200
HFPCNSWVQS QKDHPDKRIF FTNQPYLPNE TPSGLRVLRE KELKNLRGDG 250
SGVRKLSDRI YDFDVYNDLG NPDKSSELSR PKLGGKEVPY PRRCRTGRQS 300
TVSDKDAESR VEKPLPMYVP RDEQFEESKQ DTFAAGRLKA VLHHLIPSLK 350
ASIVAEDFAD FGEIDRLYKE GLLLKLGFQD DIFKKFPLPK VVVDTLQEST 400
KGLLKYDTPK ILSKDKNAWL RDDEFARQAI AGINPVNIER VKTFPPVSNL 450
DPKIYGPQHS ALTDDHIIGH LDGFSVQQAL EENRLYMLDY HDIFLPFLDR 500
INALDGRKAY ATRTIFFLTR LGTLKPVAIE LSLPPHGPKH RSKRVLTPPV 550
DATSNWMWQL AKAHVSSNDA GVHQLVNHWL RTHACLEPFI LAAHRQLSAM 600
HPIFKLLDPH MRYTLEINAL ARQSLISADG VIEGGFTAGA YGMEMSAAAY 650
KSSWRFDMEG LPADLIRRGM AIPDATQPHG LKLLIEDYPY ANDGLLLWSA 700
IQTWVRTYVE RYYPNPNLIK TDSELQSWYS ESINVGHADL RDADWWPELS 750
TVDDLVSILT TLIWLASAQH AALNFGQYPY GGYVPNRPPL MRRLIPDESD 800
PEYASFISHP EKYYFSSMPS LAQTSKFMAV VDTLSTHSPD EEYIGERQQP 850
SIWTGDAEIV EAFYGFAAEI GRIEKEIEKR NADPDRRNRC GAGVLPYELL 900
VPSSEPGVTC RGVPNSVSI 919
Length:919
Mass (Da):103,726
Last modified:October 1, 2000 - v1
Checksum:i194A0B150273E44C
GO

Sequence cautioni

The sequence AAF97315.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti374 – 3741L → P in CAB56692. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ249794 mRNA. Translation: CAB56692.1.
AC007843 Genomic DNA. Translation: AAF97315.1. Different initiation.
AC022492 Genomic DNA. Translation: AAF79461.1.
CP002684 Genomic DNA. Translation: AEE29585.1.
AY075625 mRNA. Translation: AAL91636.1.
BT006348 mRNA. Translation: AAP21156.1.
RefSeqiNP_564021.1. NM_101603.2.
UniGeneiAt.20467.
At.64244.
At.67022.

Genome annotation databases

EnsemblPlantsiAT1G17420.1; AT1G17420.1; AT1G17420.
GeneIDi838314.
KEGGiath:AT1G17420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ249794 mRNA. Translation: CAB56692.1 .
AC007843 Genomic DNA. Translation: AAF97315.1 . Different initiation.
AC022492 Genomic DNA. Translation: AAF79461.1 .
CP002684 Genomic DNA. Translation: AEE29585.1 .
AY075625 mRNA. Translation: AAL91636.1 .
BT006348 mRNA. Translation: AAP21156.1 .
RefSeqi NP_564021.1. NM_101603.2.
UniGenei At.20467.
At.64244.
At.67022.

3D structure databases

ProteinModelPortali Q9LNR3.
SMRi Q9LNR3. Positions 108-919.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 23554. 1 interaction.
IntActi Q9LNR3. 1 interaction.

Proteomic databases

PaxDbi Q9LNR3.
PRIDEi Q9LNR3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G17420.1 ; AT1G17420.1 ; AT1G17420 .
GeneIDi 838314.
KEGGi ath:AT1G17420.

Organism-specific databases

TAIRi AT1G17420.

Phylogenomic databases

eggNOGi NOG69653.
HOGENOMi HOG000230469.
InParanoidi Q9LNR3.
KOi K00454.
OMAi LSKDKFA.
PhylomeDBi Q9LNR3.

Enzyme and pathway databases

UniPathwayi UPA00382 .

Gene expression databases

Genevestigatori Q9LNR3.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProi IPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11771. PTHR11771. 1 hit.
Pfami PF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PRINTSi PR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEi PS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The second chloroplastic jasmonate-inducible 13-LOX from Arabidopsis leaves."
    Fritsche K., Feussner I.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Evidence supporting a role of jasmonic acid in Arabidopsis leaf senescence."
    He Y., Fukushige H., Hildebrand D.F., Gan S.
    Plant Physiol. 128:876-884(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  6. "Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade."
    Vellosillo T., Martinez M., Lopez M.A., Vicente J., Cascon T., Dolan L., Hamberg M., Castresana C.
    Plant Cell 19:831-846(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  7. "Systemic and intracellular responses to photooxidative stress in Arabidopsis."
    Rossel J.B., Wilson P.B., Hussain D., Woo N.S., Gordon M.J., Mewett O.P., Howell K.A., Whelan J., Kazan K., Pogson B.J.
    Plant Cell 19:4091-4110(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY HIGH LIGHT.
  8. "Identification and characterization of COI1-dependent transcription factor genes involved in JA-mediated response to wounding in Arabidopsis plants."
    Wang Z., Cao G., Wang X., Miao J., Liu X., Chen Z., Qu L.-J., Gu H.
    Plant Cell Rep. 27:125-135(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY WOUNDING.
  9. "Mapping methyl jasmonate-mediated transcriptional reprogramming of metabolism and cell cycle progression in cultured Arabidopsis cells."
    Pauwels L., Morreel K., De Witte E., Lammertyn F., Van Montagu M., Boerjan W., Inze D., Goossens A.
    Proc. Natl. Acad. Sci. U.S.A. 105:1380-1385(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY JASMONATE.
  10. "Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana."
    Bannenberg G., Martinez M., Hamberg M., Castresana C.
    Lipids 44:85-95(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiLOX3_ARATH
AccessioniPrimary (citable) accession number: Q9LNR3
Secondary accession number(s): Q9LQJ5, Q9SMW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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