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Protein

Probable phospholipid-transporting ATPase 4

Gene

ALA4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in transport of phospholipids.1 Publication

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4254-aspartylphosphate intermediateBy similarity1
Metal bindingi867MagnesiumBy similarity1
Metal bindingi871MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G17500-MONOMER.
ReactomeiR-ATH-6798695. Neutrophil degranulation.
R-ATH-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase 41 Publication (EC:3.6.3.11 Publication)
Short name:
AtALA41 Publication
Alternative name(s):
Aminophospholipid flippase 41 Publication
Gene namesi
Name:ALA41 Publication
Ordered Locus Names:At1g17500Imported
ORF Names:F1L3.21Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G17500.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74CytoplasmicSequence analysisAdd BLAST74
Transmembranei75 – 96HelicalSequence analysisAdd BLAST22
Topological domaini97 – 100ExtracellularSequence analysis4
Transmembranei101 – 123HelicalSequence analysisAdd BLAST23
Topological domaini124 – 305CytoplasmicSequence analysisAdd BLAST182
Transmembranei306 – 327HelicalSequence analysisAdd BLAST22
Topological domaini328 – 359ExtracellularSequence analysisAdd BLAST32
Transmembranei360 – 377HelicalSequence analysisAdd BLAST18
Topological domaini378 – 922CytoplasmicSequence analysisAdd BLAST545
Transmembranei923 – 942HelicalSequence analysisAdd BLAST20
Topological domaini943 – 956ExtracellularSequence analysisAdd BLAST14
Transmembranei957 – 976HelicalSequence analysisAdd BLAST20
Topological domaini977 – 1006CytoplasmicSequence analysisAdd BLAST30
Transmembranei1007 – 1029HelicalSequence analysisAdd BLAST23
Topological domaini1030 – 1042ExtracellularSequence analysisAdd BLAST13
Transmembranei1043 – 1065HelicalSequence analysisAdd BLAST23
Topological domaini1066 – 1071CytoplasmicSequence analysis6
Transmembranei1072 – 1092HelicalSequence analysisAdd BLAST21
Topological domaini1093 – 1109ExtracellularSequence analysisAdd BLAST17
Transmembranei1110 – 1134HelicalSequence analysisAdd BLAST25
Topological domaini1135 – 1216CytoplasmicSequence analysisAdd BLAST82

GO - Cellular componenti

  • Golgi membrane Source: GOC
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR
  • trans-Golgi network Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463881 – 1216Probable phospholipid-transporting ATPase 4Add BLAST1216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki605Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9LNQ4.
PRIDEiQ9LNQ4.

PTM databases

iPTMnetiQ9LNQ4.
SwissPalmiQ9LNQ4.

Expressioni

Gene expression databases

GenevisibleiQ9LNQ4. AT.

Interactioni

Protein-protein interaction databases

BioGridi23564. 1 interactor.
STRINGi3702.AT1G17500.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LNQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiQ9LNQ4.
KOiK01530.
OMAiMPKWWYL.
OrthoDBiEOG0936012H.
PhylomeDBiQ9LNQ4.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LNQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGRIRSKL RLSHIYTFGC LRPSADEGQD PHPIQGPGFS RTVYCNQPHM
60 70 80 90 100
HKKKPLKYRS NYVSTTRYNL ITFFPKCLYE QFHRAANFYF LVAAILSVFP
110 120 130 140 150
LSPFNKWSMI APLVFVVGLS MLKEALEDWS RFMQDVKINA SKVYVHKSDG
160 170 180 190 200
EFRRRKWKKI SVGDIVKVEK DGFFPADLLL LSSSYEDGIC YVETMNLDGE
210 220 230 240 250
TNLKVKRSLE VTLSLDDYDS FKDFTGIIRC EDPNPSLYTF VGNLEYERQI
260 270 280 290 300
FPLDPSQILL RDSKLRNTPY VYGVVVFTGH DTKVMQNSTK SPSKRSRIEK
310 320 330 340 350
TMDYIIYTLL VLLILISCIS SSGFAWETKF HMPKWWYLRP EEPENLTNPS
360 370 380 390 400
NPVYAGFVHL ITALLLYGYL IPISLYVSIE VVKVLQASFI NKDLHMYDSE
410 420 430 440 450
SGVPAHARTS NLNEELGQVD TILSDKTGTL TCNQMDFLKC SIAGTSYGVR
460 470 480 490 500
SSEVEVAAAQ QMAVDLDEHG EVSSRTSTPR AQARDIEVES SITPRIPIKG
510 520 530 540 550
FGFEDIRLMD GNWLREPHTD DILLFFRILA ICHTAIPELN EETGKYTYEA
560 570 580 590 600
ESPDEASFLT AASEFGFVFF KRTQSSVYVH ERLSHSGQTI EREYKVLNLL
610 620 630 640 650
DFTSKRKRMS VVVRDEEGQI LLLCKGADSI IFERLAKNGK VYLGPTTKHL
660 670 680 690 700
NEYGEAGLRT LALSYRKLDE EEYSAWNAEF HKAKTSIGSD RDELLERISD
710 720 730 740 750
MIEKDLILVG ATAVEDKLQK GVPQCIDKLA QAGLKLWVLT GDKMETAINI
760 770 780 790 800
GYSCSLLRQG MKQICITVVN SEGASQDAKA VKDNILNQIT KAVQMVKLEK
810 820 830 840 850
DPHAAFALII DGKTLTYALE DEMKYQFLAL AVDCASVICC RVSPKQKALV
860 870 880 890 900
TRLVKEGTGK ITLAIGDGAN DVGMIQEADI GVGISGVEGM QAVMASDFSI
910 920 930 940 950
AQFRFLERLL VVHGHWCYKR IAQMICYFFY KNIAFGLTLF YFEAFTGFSG
960 970 980 990 1000
QSVYNDYYLL LFNVVLTSLP VIALGVFEQD VSSEICLQFP ALYQQGKKNL
1010 1020 1030 1040 1050
FFDWYRILGW MGNGVYSSLV IFFLNIGIIY EQAFRVSGQT ADMDAVGTTM
1060 1070 1080 1090 1100
FTCIIWAVNV QIALTVSHFT WIQHVLIWGS IGLWYLFVAL YGMMPPSLSG
1110 1120 1130 1140 1150
NIYRILVEIL APAPIYWIAT FLVTVTTVLP YFAHISFQRF LHPLDHHIIQ
1160 1170 1180 1190 1200
EIKYYKRDVE DRRMWTRERT KAREKTKIGF TARVDAKIRH LRSKLNKKQS
1210
NMSQFSTQDT MSPRSV
Length:1,216
Mass (Da):138,189
Last modified:January 11, 2001 - v2
Checksum:iFC9B0CD7F96D21E1
GO

Sequence cautioni

The sequence AAF79467 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022492 Genomic DNA. Translation: AAF79467.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29599.1.
RefSeqiNP_173193.2. NM_101612.3.
UniGeneiAt.27975.

Genome annotation databases

EnsemblPlantsiAT1G17500.1; AT1G17500.1; AT1G17500.
GeneIDi838324.
GrameneiAT1G17500.1; AT1G17500.1; AT1G17500.
KEGGiath:AT1G17500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022492 Genomic DNA. Translation: AAF79467.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29599.1.
RefSeqiNP_173193.2. NM_101612.3.
UniGeneiAt.27975.

3D structure databases

ProteinModelPortaliQ9LNQ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23564. 1 interactor.
STRINGi3702.AT1G17500.1.

PTM databases

iPTMnetiQ9LNQ4.
SwissPalmiQ9LNQ4.

Proteomic databases

PaxDbiQ9LNQ4.
PRIDEiQ9LNQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G17500.1; AT1G17500.1; AT1G17500.
GeneIDi838324.
GrameneiAT1G17500.1; AT1G17500.1; AT1G17500.
KEGGiath:AT1G17500.

Organism-specific databases

TAIRiAT1G17500.

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiQ9LNQ4.
KOiK01530.
OMAiMPKWWYL.
OrthoDBiEOG0936012H.
PhylomeDBiQ9LNQ4.

Enzyme and pathway databases

BioCyciARA:AT1G17500-MONOMER.
ReactomeiR-ATH-6798695. Neutrophil degranulation.
R-ATH-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiQ9LNQ4.

Gene expression databases

GenevisibleiQ9LNQ4. AT.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALA4_ARATH
AccessioniPrimary (citable) accession number: Q9LNQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.