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Q9LNP9

- P2C07_ARATH

UniProt

Q9LNP9 - P2C07_ARATH

Protein

Protein phosphatase 2C 7

Gene

HAB2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi242 – 2421Manganese 1By similarity
    Metal bindingi242 – 2421Manganese 2By similarity
    Metal bindingi243 – 2431Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi432 – 4321Manganese 2By similarity
    Metal bindingi492 – 4921Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. abscisic acid-activated signaling pathway Source: UniProtKB-KW
    2. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Abscisic acid signaling pathway

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G17550-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 2C 7 (EC:3.1.3.16)
    Short name:
    AtPP2C07
    Alternative name(s):
    Protein HYPERSENSITIVE TO ABA 2
    Protein phosphatase 2C HAB2
    Short name:
    PP2C HAB2
    Gene namesi
    Name:HAB2
    Ordered Locus Names:At1g17550
    ORF Names:F1L3.32
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G17550.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 511492Protein phosphatase 2C 7PRO_0000344525Add
    BLAST

    Proteomic databases

    PaxDbiQ9LNP9.
    PRIDEiQ9LNP9.

    Expressioni

    Tissue specificityi

    Expressed in seeds.1 Publication

    Inductioni

    Repressed by MYB44. Induced by ABA.3 Publications

    Gene expression databases

    GenevestigatoriQ9LNP9.

    Interactioni

    Protein-protein interaction databases

    BioGridi23570. 2 interactions.
    DIPiDIP-48989N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LNP9.
    SMRiQ9LNP9. Positions 179-510.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini187 – 494308PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233896.
    InParanoidiQ8GWS8.
    KOiK14497.
    OMAiGYTSICG.
    PhylomeDBiQ9LNP9.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9LNP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEISPAVAL TLGLANTMCD SGISSTFDIS ELENVTDAAD MLCNQKRQRY    50
    SNGVVDCIMG SVSEEKTLSE VRSLSSDFSV TVQESEEDEP LVSDATIISE 100
    GLIVVDARSE ISLPDTVETD NGRVLATAII LNETTIEQVP TAEVLIASLN 150
    HDVNMEVATS EVVIRLPEEN PNVARGSRSV YELECIPLWG TISICGGRSE 200
    MEDAVRALPH FLKIPIKMLM GDHEGMSPSL PYLTSHFFGV YDGHGGAQVA 250
    DYCHDRIHSA LAEEIERIKE ELCRRNTGEG RQVQWEKVFV DCYLKVDDEV 300
    KGKINRPVVG SSDRMVLEAV SPETVGSTAV VALVCSSHII VSNCGDSRAV 350
    LLRGKDSMPL SVDHKPDRED EYARIEKAGG KVIQWQGARV SGVLAMSRSI 400
    GDQYLEPFVI PDPEVTFMPR AREDECLILA SDGLWDVMSN QEACDFARRR 450
    ILAWHKKNGA LPLAERGVGE DQACQAAAEY LSKLAIQMGS KDNISIIVID 500
    LKAQRKFKTR S 511
    Length:511
    Mass (Da):56,062
    Last modified:July 22, 2008 - v2
    Checksum:i167CB9D9D5FF9A59
    GO

    Sequence cautioni

    The sequence AAF79469.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti475 – 4751Q → R in BAC43252. (PubMed:11910074)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC022492 Genomic DNA. Translation: AAF79469.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE29605.1.
    AK118656 mRNA. Translation: BAC43252.1.
    RefSeqiNP_173199.2. NM_101618.2.
    UniGeneiAt.41827.

    Genome annotation databases

    EnsemblPlantsiAT1G17550.1; AT1G17550.1; AT1G17550.
    GeneIDi838330.
    KEGGiath:AT1G17550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC022492 Genomic DNA. Translation: AAF79469.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE29605.1 .
    AK118656 mRNA. Translation: BAC43252.1 .
    RefSeqi NP_173199.2. NM_101618.2.
    UniGenei At.41827.

    3D structure databases

    ProteinModelPortali Q9LNP9.
    SMRi Q9LNP9. Positions 179-510.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 23570. 2 interactions.
    DIPi DIP-48989N.

    Proteomic databases

    PaxDbi Q9LNP9.
    PRIDEi Q9LNP9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G17550.1 ; AT1G17550.1 ; AT1G17550 .
    GeneIDi 838330.
    KEGGi ath:AT1G17550.

    Organism-specific databases

    TAIRi AT1G17550.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233896.
    InParanoidi Q8GWS8.
    KOi K14497.
    OMAi GYTSICG.
    PhylomeDBi Q9LNP9.

    Enzyme and pathway databases

    BioCyci ARA:AT1G17550-MONOMER.

    Gene expression databases

    Genevestigatori Q9LNP9.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Gain-of-function and loss-of-function phenotypes of the protein phosphatase 2C HAB1 reveal its role as a negative regulator of abscisic acid signalling."
      Saez A., Apostolova N., Gonzalez-Guzman M., Gonzalez-Garcia M.P., Nicolas C., Lorenzo O., Rodriguez P.L.
      Plant J. 37:354-369(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY ABA.
    5. "Plant PP2C phosphatases: emerging functions in stress signaling."
      Schweighofer A., Hirt H., Meskiene I.
      Trends Plant Sci. 9:236-243(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    6. "ABA-hypersensitive germination3 encodes a protein phosphatase 2C (AtPP2CA) that strongly regulates abscisic acid signaling during germination among Arabidopsis protein phosphatase 2Cs."
      Yoshida T., Nishimura N., Kitahata N., Kuromori T., Ito T., Asami T., Shinozaki K., Hirayama T.
      Plant Physiol. 140:115-126(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY ABA, TISSUE SPECIFICITY.
    7. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    8. "Overexpression of AtMYB44 enhances stomatal closure to confer abiotic stress tolerance in transgenic Arabidopsis."
      Jung C., Seo J.S., Han S.W., Koo Y.J., Kim C.H., Song S.I., Nahm B.H., Choi Y.D., Cheong J.-J.
      Plant Physiol. 146:623-635(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY MYB44.

    Entry informationi

    Entry nameiP2C07_ARATH
    AccessioniPrimary (citable) accession number: Q9LNP9
    Secondary accession number(s): Q8GWS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3