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Q9LNP9

- P2C07_ARATH

UniProt

Q9LNP9 - P2C07_ARATH

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Protein
Protein phosphatase 2C 7
Gene
HAB2, At1g17550, F1L3.32
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi242 – 2421Manganese 1 By similarity
Metal bindingi242 – 2421Manganese 2 By similarity
Metal bindingi243 – 2431Manganese 1; via carbonyl oxygen By similarity
Metal bindingi432 – 4321Manganese 2 By similarity
Metal bindingi492 – 4921Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. abscisic acid-activated signaling pathway Source: UniProtKB-KW
  2. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Abscisic acid signaling pathway

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G17550-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C 7 (EC:3.1.3.16)
Short name:
AtPP2C07
Alternative name(s):
Protein HYPERSENSITIVE TO ABA 2
Protein phosphatase 2C HAB2
Short name:
PP2C HAB2
Gene namesi
Name:HAB2
Ordered Locus Names:At1g17550
ORF Names:F1L3.32
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G17550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 511492Protein phosphatase 2C 7
PRO_0000344525Add
BLAST

Proteomic databases

PaxDbiQ9LNP9.
PRIDEiQ9LNP9.

Expressioni

Tissue specificityi

Expressed in seeds.1 Publication

Inductioni

Repressed by MYB44. Induced by ABA.3 Publications

Gene expression databases

GenevestigatoriQ9LNP9.

Interactioni

Protein-protein interaction databases

BioGridi23570. 2 interactions.
DIPiDIP-48989N.

Structurei

3D structure databases

ProteinModelPortaliQ9LNP9.
SMRiQ9LNP9. Positions 179-510.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 494308PP2C-like
Add
BLAST

Sequence similaritiesi

Belongs to the PP2C family.
Contains 1 PP2C-like domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ8GWS8.
KOiK14497.
OMAiGYTSICG.
PhylomeDBiQ9LNP9.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LNP9-1 [UniParc]FASTAAdd to Basket

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MEEISPAVAL TLGLANTMCD SGISSTFDIS ELENVTDAAD MLCNQKRQRY    50
SNGVVDCIMG SVSEEKTLSE VRSLSSDFSV TVQESEEDEP LVSDATIISE 100
GLIVVDARSE ISLPDTVETD NGRVLATAII LNETTIEQVP TAEVLIASLN 150
HDVNMEVATS EVVIRLPEEN PNVARGSRSV YELECIPLWG TISICGGRSE 200
MEDAVRALPH FLKIPIKMLM GDHEGMSPSL PYLTSHFFGV YDGHGGAQVA 250
DYCHDRIHSA LAEEIERIKE ELCRRNTGEG RQVQWEKVFV DCYLKVDDEV 300
KGKINRPVVG SSDRMVLEAV SPETVGSTAV VALVCSSHII VSNCGDSRAV 350
LLRGKDSMPL SVDHKPDRED EYARIEKAGG KVIQWQGARV SGVLAMSRSI 400
GDQYLEPFVI PDPEVTFMPR AREDECLILA SDGLWDVMSN QEACDFARRR 450
ILAWHKKNGA LPLAERGVGE DQACQAAAEY LSKLAIQMGS KDNISIIVID 500
LKAQRKFKTR S 511
Length:511
Mass (Da):56,062
Last modified:July 22, 2008 - v2
Checksum:i167CB9D9D5FF9A59
GO

Sequence cautioni

The sequence AAF79469.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti475 – 4751Q → R in BAC43252. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC022492 Genomic DNA. Translation: AAF79469.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29605.1.
AK118656 mRNA. Translation: BAC43252.1.
RefSeqiNP_173199.2. NM_101618.2.
UniGeneiAt.41827.

Genome annotation databases

EnsemblPlantsiAT1G17550.1; AT1G17550.1; AT1G17550.
GeneIDi838330.
KEGGiath:AT1G17550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC022492 Genomic DNA. Translation: AAF79469.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE29605.1 .
AK118656 mRNA. Translation: BAC43252.1 .
RefSeqi NP_173199.2. NM_101618.2.
UniGenei At.41827.

3D structure databases

ProteinModelPortali Q9LNP9.
SMRi Q9LNP9. Positions 179-510.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 23570. 2 interactions.
DIPi DIP-48989N.

Proteomic databases

PaxDbi Q9LNP9.
PRIDEi Q9LNP9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G17550.1 ; AT1G17550.1 ; AT1G17550 .
GeneIDi 838330.
KEGGi ath:AT1G17550.

Organism-specific databases

TAIRi AT1G17550.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233896.
InParanoidi Q8GWS8.
KOi K14497.
OMAi GYTSICG.
PhylomeDBi Q9LNP9.

Enzyme and pathway databases

BioCyci ARA:AT1G17550-MONOMER.

Gene expression databases

Genevestigatori Q9LNP9.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Gain-of-function and loss-of-function phenotypes of the protein phosphatase 2C HAB1 reveal its role as a negative regulator of abscisic acid signalling."
    Saez A., Apostolova N., Gonzalez-Guzman M., Gonzalez-Garcia M.P., Nicolas C., Lorenzo O., Rodriguez P.L.
    Plant J. 37:354-369(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY ABA.
  5. "Plant PP2C phosphatases: emerging functions in stress signaling."
    Schweighofer A., Hirt H., Meskiene I.
    Trends Plant Sci. 9:236-243(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  6. "ABA-hypersensitive germination3 encodes a protein phosphatase 2C (AtPP2CA) that strongly regulates abscisic acid signaling during germination among Arabidopsis protein phosphatase 2Cs."
    Yoshida T., Nishimura N., Kitahata N., Kuromori T., Ito T., Asami T., Shinozaki K., Hirayama T.
    Plant Physiol. 140:115-126(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY ABA, TISSUE SPECIFICITY.
  7. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  8. "Overexpression of AtMYB44 enhances stomatal closure to confer abiotic stress tolerance in transgenic Arabidopsis."
    Jung C., Seo J.S., Han S.W., Koo Y.J., Kim C.H., Song S.I., Nahm B.H., Choi Y.D., Cheong J.-J.
    Plant Physiol. 146:623-635(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY MYB44.

Entry informationi

Entry nameiP2C07_ARATH
AccessioniPrimary (citable) accession number: Q9LNP9
Secondary accession number(s): Q8GWS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: May 14, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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