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Protein

Protein phosphatase 2C 7

Gene

HAB2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi242Manganese 1By similarity1
Metal bindingi242Manganese 2By similarity1
Metal bindingi243Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi432Manganese 2By similarity1
Metal bindingi492Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processAbscisic acid signaling pathway
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C 7 (EC:3.1.3.16)
Short name:
AtPP2C07
Alternative name(s):
Protein HYPERSENSITIVE TO ABA 2
Protein phosphatase 2C HAB2
Short name:
PP2C HAB2
Gene namesi
Name:HAB2
Ordered Locus Names:At1g17550
ORF Names:F1L3.32
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G17550.
TAIRilocus:2007943. AT1G17550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000034452520 – 511Protein phosphatase 2C 7Add BLAST492

Proteomic databases

PaxDbiQ9LNP9.
PRIDEiQ9LNP9.

Expressioni

Tissue specificityi

Expressed in seeds.1 Publication

Inductioni

Repressed by MYB44. Induced by ABA.3 Publications

Gene expression databases

ExpressionAtlasiQ9LNP9. baseline and differential.
GenevisibleiQ9LNP9. AT.

Interactioni

Subunit structurei

Interacts with PYL13.1 Publication

Protein-protein interaction databases

BioGridi23570. 2 interactors.
DIPiDIP-48989N.
STRINGi3702.AT1G17550.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LNP9.
SMRiQ9LNP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 501PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST314

Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
HOGENOMiHOG000233896.
InParanoidiQ9LNP9.
KOiK14497.
OMAiQELCERN.
OrthoDBiEOG09360DDO.
PhylomeDBiQ9LNP9.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiView protein in Pfam
PF00481. PP2C. 1 hit.
SMARTiView protein in SMART
SM00332. PP2Cc. 1 hit.
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiView protein in PROSITE
PS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LNP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEISPAVAL TLGLANTMCD SGISSTFDIS ELENVTDAAD MLCNQKRQRY
60 70 80 90 100
SNGVVDCIMG SVSEEKTLSE VRSLSSDFSV TVQESEEDEP LVSDATIISE
110 120 130 140 150
GLIVVDARSE ISLPDTVETD NGRVLATAII LNETTIEQVP TAEVLIASLN
160 170 180 190 200
HDVNMEVATS EVVIRLPEEN PNVARGSRSV YELECIPLWG TISICGGRSE
210 220 230 240 250
MEDAVRALPH FLKIPIKMLM GDHEGMSPSL PYLTSHFFGV YDGHGGAQVA
260 270 280 290 300
DYCHDRIHSA LAEEIERIKE ELCRRNTGEG RQVQWEKVFV DCYLKVDDEV
310 320 330 340 350
KGKINRPVVG SSDRMVLEAV SPETVGSTAV VALVCSSHII VSNCGDSRAV
360 370 380 390 400
LLRGKDSMPL SVDHKPDRED EYARIEKAGG KVIQWQGARV SGVLAMSRSI
410 420 430 440 450
GDQYLEPFVI PDPEVTFMPR AREDECLILA SDGLWDVMSN QEACDFARRR
460 470 480 490 500
ILAWHKKNGA LPLAERGVGE DQACQAAAEY LSKLAIQMGS KDNISIIVID
510
LKAQRKFKTR S
Length:511
Mass (Da):56,062
Last modified:July 22, 2008 - v2
Checksum:i167CB9D9D5FF9A59
GO

Sequence cautioni

The sequence AAF79469 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti475Q → R in BAC43252 (PubMed:11910074).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022492 Genomic DNA. Translation: AAF79469.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29605.1.
CP002684 Genomic DNA. Translation: ANM60722.1.
AK118656 mRNA. Translation: BAC43252.1.
RefSeqiNP_001322988.1. NM_001332312.1.
NP_173199.2. NM_101618.3.
UniGeneiAt.41827.

Genome annotation databases

EnsemblPlantsiAT1G17550.1; AT1G17550.1; AT1G17550.
AT1G17550.2; AT1G17550.2; AT1G17550.
GeneIDi838330.
GrameneiAT1G17550.1; AT1G17550.1; AT1G17550.
AT1G17550.2; AT1G17550.2; AT1G17550.
KEGGiath:AT1G17550.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiP2C07_ARATH
AccessioniPrimary (citable) accession number: Q9LNP9
Secondary accession number(s): Q8GWS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: June 7, 2017
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families