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Q9LNP9 (P2C07_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 2C 7

Short name=AtPP2C07
EC=3.1.3.16
Alternative name(s):
Protein HYPERSENSITIVE TO ABA 2
Protein phosphatase 2C HAB2
Short name=PP2C HAB2
Gene names
Name:HAB2
Ordered Locus Names:At1g17550
ORF Names:F1L3.32
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Tissue specificity

Expressed in seeds. Ref.6

Induction

Repressed by MYB44. Induced by ABA. Ref.4 Ref.6 Ref.8

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Sequence caution

The sequence AAF79469.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 511492Protein phosphatase 2C 7
PRO_0000344525

Regions

Domain187 – 494308PP2C-like

Sites

Metal binding2421Manganese 1 By similarity
Metal binding2421Manganese 2 By similarity
Metal binding2431Manganese 1; via carbonyl oxygen By similarity
Metal binding4321Manganese 2 By similarity
Metal binding4921Manganese 2 By similarity

Experimental info

Sequence conflict4751Q → R in BAC43252. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9LNP9 [UniParc].

Last modified July 22, 2008. Version 2.
Checksum: 167CB9D9D5FF9A59

FASTA51156,062
        10         20         30         40         50         60 
MEEISPAVAL TLGLANTMCD SGISSTFDIS ELENVTDAAD MLCNQKRQRY SNGVVDCIMG 

        70         80         90        100        110        120 
SVSEEKTLSE VRSLSSDFSV TVQESEEDEP LVSDATIISE GLIVVDARSE ISLPDTVETD 

       130        140        150        160        170        180 
NGRVLATAII LNETTIEQVP TAEVLIASLN HDVNMEVATS EVVIRLPEEN PNVARGSRSV 

       190        200        210        220        230        240 
YELECIPLWG TISICGGRSE MEDAVRALPH FLKIPIKMLM GDHEGMSPSL PYLTSHFFGV 

       250        260        270        280        290        300 
YDGHGGAQVA DYCHDRIHSA LAEEIERIKE ELCRRNTGEG RQVQWEKVFV DCYLKVDDEV 

       310        320        330        340        350        360 
KGKINRPVVG SSDRMVLEAV SPETVGSTAV VALVCSSHII VSNCGDSRAV LLRGKDSMPL 

       370        380        390        400        410        420 
SVDHKPDRED EYARIEKAGG KVIQWQGARV SGVLAMSRSI GDQYLEPFVI PDPEVTFMPR 

       430        440        450        460        470        480 
AREDECLILA SDGLWDVMSN QEACDFARRR ILAWHKKNGA LPLAERGVGE DQACQAAAEY 

       490        500        510 
LSKLAIQMGS KDNISIIVID LKAQRKFKTR S 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Functional annotation of a full-length Arabidopsis cDNA collection."
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K.
Science 296:141-145(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Gain-of-function and loss-of-function phenotypes of the protein phosphatase 2C HAB1 reveal its role as a negative regulator of abscisic acid signalling."
Saez A., Apostolova N., Gonzalez-Guzman M., Gonzalez-Garcia M.P., Nicolas C., Lorenzo O., Rodriguez P.L.
Plant J. 37:354-369(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY ABA.
[5]"Plant PP2C phosphatases: emerging functions in stress signaling."
Schweighofer A., Hirt H., Meskiene I.
Trends Plant Sci. 9:236-243(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[6]"ABA-hypersensitive germination3 encodes a protein phosphatase 2C (AtPP2CA) that strongly regulates abscisic acid signaling during germination among Arabidopsis protein phosphatase 2Cs."
Yoshida T., Nishimura N., Kitahata N., Kuromori T., Ito T., Asami T., Shinozaki K., Hirayama T.
Plant Physiol. 140:115-126(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY ABA, TISSUE SPECIFICITY.
[7]"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[8]"Overexpression of AtMYB44 enhances stomatal closure to confer abiotic stress tolerance in transgenic Arabidopsis."
Jung C., Seo J.S., Han S.W., Koo Y.J., Kim C.H., Song S.I., Nahm B.H., Choi Y.D., Cheong J.-J.
Plant Physiol. 146:623-635(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY MYB44.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC022492 Genomic DNA. Translation: AAF79469.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29605.1.
AK118656 mRNA. Translation: BAC43252.1.
RefSeqNP_173199.2. NM_101618.2.
UniGeneAt.41827.

3D structure databases

ProteinModelPortalQ9LNP9.
SMRQ9LNP9. Positions 179-510.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid23570. 2 interactions.
DIPDIP-48989N.

Proteomic databases

PaxDbQ9LNP9.
PRIDEQ9LNP9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G17550.1; AT1G17550.1; AT1G17550.
GeneID838330.
KEGGath:AT1G17550.

Organism-specific databases

TAIRAT1G17550.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000233896.
InParanoidQ8GWS8.
KOK14497.
OMAGYTSICG.
PhylomeDBQ9LNP9.

Enzyme and pathway databases

BioCycARA:AT1G17550-MONOMER.

Gene expression databases

GenevestigatorQ9LNP9.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP2C07_ARATH
AccessionPrimary (citable) accession number: Q9LNP9
Secondary accession number(s): Q8GWS8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: May 14, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names