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Protein

Protein phosphatase 2C 7

Gene

HAB2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, seed germination and inhibition of vegetative growth.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi242Manganese 1By similarity1
Metal bindingi242Manganese 2By similarity1
Metal bindingi243Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi432Manganese 2By similarity1
Metal bindingi492Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processAbscisic acid signaling pathway
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C 7 (EC:3.1.3.16)
Short name:
AtPP2C07
Alternative name(s):
Protein HYPERSENSITIVE TO ABA 2
Protein phosphatase 2C HAB2
Short name:
PP2C HAB2
Gene namesi
Name:HAB2
Ordered Locus Names:At1g17550
ORF Names:F1L3.32
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G17550
TAIRilocus:2007943 AT1G17550

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000034452520 – 511Protein phosphatase 2C 7Add BLAST492

Proteomic databases

PaxDbiQ9LNP9
PRIDEiQ9LNP9

Expressioni

Tissue specificityi

Expressed in seeds.1 Publication

Inductioni

Repressed by MYB44. Induced by ABA.3 Publications

Gene expression databases

ExpressionAtlasiQ9LNP9 baseline and differential
GenevisibleiQ9LNP9 AT

Interactioni

Subunit structurei

Interacts with PYL13.1 Publication

Protein-protein interaction databases

BioGridi23570, 2 interactors
DIPiDIP-48989N
IntActiQ9LNP9, 3 interactors
STRINGi3702.AT1G17550.1

Structurei

3D structure databases

ProteinModelPortaliQ9LNP9
SMRiQ9LNP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 501PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST314

Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
HOGENOMiHOG000233896
InParanoidiQ9LNP9
KOiK14497
OMAiRRILAWH
OrthoDBiEOG09360DDO
PhylomeDBiQ9LNP9

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LNP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEISPAVAL TLGLANTMCD SGISSTFDIS ELENVTDAAD MLCNQKRQRY
60 70 80 90 100
SNGVVDCIMG SVSEEKTLSE VRSLSSDFSV TVQESEEDEP LVSDATIISE
110 120 130 140 150
GLIVVDARSE ISLPDTVETD NGRVLATAII LNETTIEQVP TAEVLIASLN
160 170 180 190 200
HDVNMEVATS EVVIRLPEEN PNVARGSRSV YELECIPLWG TISICGGRSE
210 220 230 240 250
MEDAVRALPH FLKIPIKMLM GDHEGMSPSL PYLTSHFFGV YDGHGGAQVA
260 270 280 290 300
DYCHDRIHSA LAEEIERIKE ELCRRNTGEG RQVQWEKVFV DCYLKVDDEV
310 320 330 340 350
KGKINRPVVG SSDRMVLEAV SPETVGSTAV VALVCSSHII VSNCGDSRAV
360 370 380 390 400
LLRGKDSMPL SVDHKPDRED EYARIEKAGG KVIQWQGARV SGVLAMSRSI
410 420 430 440 450
GDQYLEPFVI PDPEVTFMPR AREDECLILA SDGLWDVMSN QEACDFARRR
460 470 480 490 500
ILAWHKKNGA LPLAERGVGE DQACQAAAEY LSKLAIQMGS KDNISIIVID
510
LKAQRKFKTR S
Length:511
Mass (Da):56,062
Last modified:July 22, 2008 - v2
Checksum:i167CB9D9D5FF9A59
GO

Sequence cautioni

The sequence AAF79469 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti475Q → R in BAC43252 (PubMed:11910074).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022492 Genomic DNA Translation: AAF79469.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE29605.1
CP002684 Genomic DNA Translation: ANM60722.1
AK118656 mRNA Translation: BAC43252.1
RefSeqiNP_001322988.1, NM_001332312.1
NP_173199.2, NM_101618.3
UniGeneiAt.41827

Genome annotation databases

EnsemblPlantsiAT1G17550.1; AT1G17550.1; AT1G17550
AT1G17550.2; AT1G17550.2; AT1G17550
GeneIDi838330
GrameneiAT1G17550.1; AT1G17550.1; AT1G17550
AT1G17550.2; AT1G17550.2; AT1G17550
KEGGiath:AT1G17550

Similar proteinsi

Entry informationi

Entry nameiP2C07_ARATH
AccessioniPrimary (citable) accession number: Q9LNP9
Secondary accession number(s): Q8GWS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: April 25, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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