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Protein

Probable protein phosphatase 2C 13

Gene

At1g48040

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi121 – 1211Manganese 1By similarity
Metal bindingi121 – 1211Manganese 2By similarity
Metal bindingi122 – 1221Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi297 – 2971Manganese 2By similarity
Metal bindingi340 – 3401Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G48040-MONOMER.
ReactomeiREACT_247278. ISG15 antiviral mechanism.
REACT_259981. Regulation of AMPK activity via LKB1.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 13 (EC:3.1.3.16)
Short name:
AtPP2C13
Gene namesi
Ordered Locus Names:At1g48040
ORF Names:F21D18.27, T2J15.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G48040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Probable protein phosphatase 2C 13PRO_0000367944Add
BLAST

Proteomic databases

PRIDEiQ9LNF4.

Expressioni

Gene expression databases

GenevestigatoriQ9LNF4.

Structurei

3D structure databases

ProteinModelPortaliQ9LNF4.
SMRiQ9LNF4. Positions 65-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini77 – 342266PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ9LNF4.
KOiK14803.
OMAiCHISAPK.
PhylomeDBiQ9LNF4.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LNF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSQTMVAE AEIRVLDVKC HISAPKDQKN FQIDEVRVSE SVRAEISGSA
60 70 80 90 100
ETPRFGSGMS CVTTTIGESA SDFIPTIRSG SFADIRSRET MEDEHICIDD
110 120 130 140 150
LSAHLGSYNF SVPSAFYGVF DGHGGPEAAI FMKENLTRLF FQDAVFPEMP
160 170 180 190 200
SIVDAFFLEE LENSHRKAFA LADLAMADET IVSGSCGTTA LTALIIGRHL
210 220 230 240 250
LVANAGDCRA VLCRRGVAVD MSFDHRSTYE PERRRIEDLG GYFEDGYLNG
260 270 280 290 300
VLAVTRAIGD WELKNPFTDS SSPLISDPEI GQIILTEDDE FLILACDGIW
310 320 330 340 350
DVLSSQNAVS NVRQGLRRHG DPRQCAMELG KEAARLQSSD NMTVIVICFS
360 370 380
SVPSSPKQPQ RRRLRFCVSD EARARLQAML AGE
Length:383
Mass (Da):42,106
Last modified:April 14, 2009 - v2
Checksum:i4304B1895B801ECF
GO

Sequence cautioni

The sequence AAF79528.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAG51521.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601E → G in BAD44439 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023673 Genomic DNA. Translation: AAF79528.1. Different initiation.
AC051631 Genomic DNA. Translation: AAG51521.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE32241.1.
AK176010 mRNA. Translation: BAD43773.1.
AK176676 mRNA. Translation: BAD44439.1.
BT015400 mRNA. Translation: AAU05523.1.
RefSeqiNP_175238.2. NM_103700.3.
UniGeneiAt.38490.

Genome annotation databases

EnsemblPlantsiAT1G48040.1; AT1G48040.1; AT1G48040.
GeneIDi841222.
KEGGiath:AT1G48040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023673 Genomic DNA. Translation: AAF79528.1. Different initiation.
AC051631 Genomic DNA. Translation: AAG51521.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE32241.1.
AK176010 mRNA. Translation: BAD43773.1.
AK176676 mRNA. Translation: BAD44439.1.
BT015400 mRNA. Translation: AAU05523.1.
RefSeqiNP_175238.2. NM_103700.3.
UniGeneiAt.38490.

3D structure databases

ProteinModelPortaliQ9LNF4.
SMRiQ9LNF4. Positions 65-349.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9LNF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G48040.1; AT1G48040.1; AT1G48040.
GeneIDi841222.
KEGGiath:AT1G48040.

Organism-specific databases

TAIRiAT1G48040.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ9LNF4.
KOiK14803.
OMAiCHISAPK.
PhylomeDBiQ9LNF4.

Enzyme and pathway databases

BioCyciARA:AT1G48040-MONOMER.
ReactomeiREACT_247278. ISG15 antiviral mechanism.
REACT_259981. Regulation of AMPK activity via LKB1.

Gene expression databases

GenevestigatoriQ9LNF4.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Arabidopsis ORF clones."
    Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-383.
    Strain: cv. Columbia.
  5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C13_ARATH
AccessioniPrimary (citable) accession number: Q9LNF4
Secondary accession number(s): Q67XZ2, Q67ZV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: January 7, 2015
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.