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Protein

Hsp70-Hsp90 organizing protein 1

Gene

HOP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates the association of the molecular chaperones HSP70 and HSP90. Mediates nuclear encoded chloroplast preproteins binding to HSP90 prior to chloroplastic sorting (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

ReactomeiR-ATH-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)

Names & Taxonomyi

Protein namesi
Recommended name:
Hsp70-Hsp90 organizing protein 1
Short name:
AtHop1
Alternative name(s):
Stress-induced-phosphoprotein 1
Short name:
STI1
Gene namesi
Name:HOP1
Ordered Locus Names:At1g12270
ORF Names:F5O11.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G12270
TAIRilocus:2034620 AT1G12270

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004267011 – 572Hsp70-Hsp90 organizing protein 1Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity
Acetylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9LNB6

PTM databases

iPTMnetiQ9LNB6

Expressioni

Gene expression databases

ExpressionAtlasiQ9LNB6 baseline and differential
GenevisibleiQ9LNB6 AT

Interactioni

Subunit structurei

Co-chaperone that forms a complex with HSP70 and HSP90 and preproteins (e.g. chloroplast preproteins) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi23021, 1 interactor
STRINGi3702.AT1G12270.1

Structurei

3D structure databases

ProteinModelPortaliQ9LNB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 35TPR 1Add BLAST34
Repeati37 – 69TPR 2Add BLAST33
Repeati70 – 103TPR 3Add BLAST34
Domaini133 – 172STI1 1Add BLAST40
Repeati244 – 277TPR 4Add BLAST34
Repeati279 – 311TPR 5Add BLAST33
Repeati319 – 356TPR 6Add BLAST38
Repeati358 – 382TPR 7Add BLAST25
Repeati383 – 416TPR 8Add BLAST34
Repeati418 – 450TPR 9Add BLAST33
Repeati451 – 484TPR 10Add BLAST34
Domaini521 – 560STI1 2Add BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi241 – 258Bipartite nuclear localization signalSequence analysisAdd BLAST18

Domaini

The tetratricopeptide repeat (TPR) domain, forming a carboxylate clamp (CC), mediates interaction with the highly conserved 'EEVD' motif at the C-terminal ends of HSP90 and HSP70.By similarity

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0548 Eukaryota
ENOG410XTCJ LUCA
HOGENOMiHOG000186562
InParanoidiQ9LNB6
KOiK09553
OMAiEPMEENL
OrthoDBiEOG093608J7
PhylomeDBiQ9LNB6

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR006636 STI1_HS-bd
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00727 STI1, 2 hits
SM00028 TPR, 9 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 9 hits
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q9LNB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEAKAKGN AAFSSGDFTT AINHFTEAIA LAPTNHVLFS NRSAAHASLH
60 70 80 90 100
QYAEALSDAK ETIKLKPYWP KGYSRLGAAH LGLNQFELAV TAYKKGLDVD
110 120 130 140 150
PTNEALKSGL ADAEASVARS RAAPNPFGDA FQGPEMWTKL TSDPSTRGFL
160 170 180 190 200
QQPDFVNMMQ EIQKNPSSLN LYLKDQRVMQ SLGVLLNVKF RPPPPQGDEA
210 220 230 240 250
EVPESDMGQS SSNEPEVEKK REPEPEPEPE VTEEKEKKER KEKAKKEKEL
260 270 280 290 300
GNAAYKKKDF ETAIQHYSTA IEIDDEDISY LTNRAAVYLE MGKYNECIED
310 320 330 340 350
CNKAVERGRE LRSDYKMVAR ALTRKGTALT KMAKCSKDYE PAIEAFQKAL
360 370 380 390 400
TEHRNPDTLK RLNDAERAKK EWEQKQYFDP KLGDEEREKG NDFFKEQKYP
410 420 430 440 450
EAIKHYTEAI KRNPNDHKAY SNRAASYTKL GAMPEGLKDA EKCIELDPTF
460 470 480 490 500
SKGYSRKAAV QFFLKEYDNA METYQAGLEH DPSNQELLDG VKRCVQQINK
510 520 530 540 550
ANRGDLTPEE LKERQAKGMQ DPEIQNILTD PVMRQVLSDL QENPSAAQKH
560 570
MQNPMVMNKI QKLISAGIVQ MK
Length:572
Mass (Da):64,585
Last modified:October 1, 2000 - v1
Checksum:i57F1BADE195D7C63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025416 Genomic DNA Translation: AAF79628.1
CP002684 Genomic DNA Translation: AEE28860.1
AY064967 mRNA Translation: AAL38384.1
BT000651 mRNA Translation: AAN18217.1
AJ319538 mRNA Translation: CAC85343.1
PIRiH86257
RefSeqiNP_172691.1, NM_101099.5
UniGeneiAt.26887

Genome annotation databases

EnsemblPlantsiAT1G12270.1; AT1G12270.1; AT1G12270
GeneIDi837781
GrameneiAT1G12270.1; AT1G12270.1; AT1G12270
KEGGiath:AT1G12270

Similar proteinsi

Entry informationi

Entry nameiHSOP1_ARATH
AccessioniPrimary (citable) accession number: Q9LNB6
Secondary accession number(s): Q7Y1Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health